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Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues
Open accessAbstract
Background/objective In mice, a high-fat diet (HFD) induces obesity, insulin resistance and myostatin production. We tested whether inhibition of myostatin in mice can reverse these HFD-induced abnormalities.Subjects/methods C57BL/6 mice were fed a HFD for 16 weeks including the final 4 weeks some mice were treated with an anti-myostatin peptibody. Body composition, the respiratory exchange ratio plus glucose and insulin tolerance tests were examined. Myostatin knock down in C2C12 cells was performed using small hairpin RNA lentivirus. Adipose tissue-derived stem cells were cultured to measure their responses to conditioned media from C2C12 cells lacking myostatin, or to recombinant myostatin or irisin. Isolated peritoneal macrophages were treated with myostatin or irisin to determine whether myostatin or irisin induce inflammatory mechanisms.Results In HFD-fed mice, peptibody treatment stimulated muscle growth and improved insulin resistance. The improved glucose and insulin tolerances were confirmed when we found increased muscle expression of p-Akt and the glucose transporter, Glut4. In HFD-fed mice, the peptibody suppressed macrophage infiltration and the expression of proinflammatory cytokines in both the muscle and adipocytes. Inhibition of myostatin caused the conversion of white (WAT) to brown adipose tissue, whereas stimulating fatty acid oxidation and increasing energy expenditure. The related mechanism is a muscle-to-fat cross talk mediated by irisin. Myostatin inhibition increased peroxisome proliferator-activated receptor gamma, coactivator 1α expression and irisin production in the muscle. Irisin then stimulated WAT browning. Irisin also suppresses inflammation and stimulates macrophage polarization from M1 to M2 types.Conclusions These results uncover a metabolic pathway from an increase in myostatin that suppresses irisin leading to the activation of inflammatory cytokines and insulin resistance. Thus, myostatin is a potential therapeutic target to treat insulin resistance of type II diabetes as well as the shortage of brown/beige fat in obesity.
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“In vitro trials demonstrate that myostatin inhibitors increase muscle mass and strength446, suppress irisin, downregulate inflammatory cytokines and improve insulin resistance447.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [447]
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“It contributes to the induction of PGC-1α, FNDC5, and irisin in SkM [27,49,133].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [49]
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“The possibility of an inter-myokine axis with irisin [44,49] and crosstalk with follistatin could represent a mechanism through which myostatin is decreased by exercise.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [49]
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“As also shown in Figure 2 (to facilitate sequence flow, the steps appear numbered as they are introduced in the main text in italics), in the short term, irisin might directly favor a shift from M1 Mφ to a M2 phenotype [49,59], as well as decrease the expression of TLR4, TNF-α, IL-1β, MCP-1, and IL-6 by adipocytes and Mφ [51,53,59] (1a), while increasing IL-10 [59] (1b) and antioxidant cellular me”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [49]
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Citations
Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
Double muscling in cattle due to mutations in the myostatin gene
McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039
Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399
Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260
Mutations in myostatin ( GDF8 ) in Double-Muscled Belgian Blue and Piedmontese Cattle
Kambadur, R., Sharma, M., Smith, T. P. L., & Bass, J. J. (1997) · Genome Research · doi:10.1101/gr.7.9.910 · Cited by 1,204
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Zhou, X., Wang, J. L., Lu, J., Song, Y., Kwak, K. S., Jiao, Q., Rosenfeld, R., Chen, Q., Boone, T. C., Simonet, W. S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.011 · Cited by 960
Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
Chondronikola, M., Volpi, E., Børsheim, E., Porter, C. C., Annamalai, P., Enerbäck, S., Lidell, M. E., Saraf, M. K., Labbé, S. M., Hurren, N. M., et al. (2014) · Diabetes · doi:10.2337/db14-0746 · Cited by 803
Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling
Yadav, H., Quijano, C., Kamaraju, A. K., Gavrilova, O., Malek, R., Chen, W., Zerfas, P., Zhigang, D., Wright, E. C., Stuelten, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.013 · Cited by 709
Adiponectin: action, regulation and association to insulin sensitivity
Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00159.x · Cited by 660
Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635
Endurance training in humans: aerobic capacity and structure of skeletal muscle.
Hoppeler, H., Howald, H., Conley, K., Lindstedt, S. L., Claassen, H., Vock, P., & Weibel, E. R. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.2.320 · Cited by 623
Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
Waldén, T. B., Hansen, I. R., Timmons, J. A., Cannon, B., & Nedergaard, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2011 · Cited by 591
Smad2 and 3 transcription factors control muscle mass in adulthood
Sartori, R., Milan, G., Patron, M., Mammucari, C., Blaauw, B., Abraham, R., & Sandri, M. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00104.2009 · Cited by 517
Suppression of body fat accumulation in myostatin-deficient mice
McPherron, A. C., & Lee, S.-J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213562 · Cited by 505
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 479
Meng, F., & Lowell, C. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1661 · Cited by 475
Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes
Vegiopoulos, A., Müller‐Decker, K., Strzoda, D., Schmitt, I. M., Chichelnitskiy, E., Ostertag, A., Díaz, M. B., Rozman, J., de Angelis, M. H., Nüsing, R. M., et al. (2010) · Science · doi:10.1126/science.1186034 · Cited by 463
Guo, T., Jou, W., Chanturiya, T., Portas, J., Gavrilova, O., & McPherron, A. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004937 · Cited by 402
Zhang, L., Rajan, V., Lin, E., Hu, Z., Han, H. Q., Zhou, X., Song, Y., Min, H., Wang, X., Du, J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-176917 · Cited by 323
Self-citationMyostatin Knockout in Mice Increases Myogenesis and Decreases Adipogenesis
Lin, J., Arnold, H. B., Della-Fera, M. A., Azain, M. J., Hartzell, D. L., & Baile, C. A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6500 · Cited by 313
Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301
Dela, F., Larsen, J. J., Mikines, K. J., Ploug, T., Petersen, L. N., & Galbo, H. (1995) · Diabetes · doi:10.2337/diab.44.9.1010 · Cited by 286
Significance of skeletal muscle oxidative enzyme enhancement with endurance training.
Gollnick, P. D., & Saltin, B. (1982) · Clinical Physiology · doi:10.1111/j.1475-097x.1982.tb00001.x · Cited by 277
Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass
Zhang, L., Pan, J. S.-C., Dong, Y., Tweardy, D. J., Dong, Y., Garibotto, G., & Mitch, W. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.012 · Cited by 263
Self-citationRole of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
Jørgensen, S. B., Richter, E. A., & Wojtaszewski, J. F. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109942 · Cited by 261
IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II–Induced Muscle Wasting
Zhang, L., Du, J., Hu, Z., Han, G., Delafontaine, P., García, G., & Mitch, W. E. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008060628 · Cited by 246
Self-citationGirgenrath, S., Song, K., & Whittemore, L.-A. (2004) · Muscle & Nerve · doi:10.1002/mus.20175 · Cited by 238
Hennebry, A., Berry, C., Siriett, V., O'Callaghan, P., Chau, L., Watson, T. J., Sharma, M., & Kambadur, R. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00259.2007 · Cited by 193
LeBrasseur, N. K., Schelhorn, T. M., Bernardo, B. L., Cosgrove, P. G., Loria, P. M., & Brown, T. A. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp068 · Cited by 180
Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development
Ferrer-Martı́nez, A., Ruiz‐Lozano, P., & Chien, K. R. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10099 · Cited by 169
Zhang, C., McFarlane, C., Lokireddy, S., Bonala, S., Ge, X., Masuda, S., Gluckman, P. D., Sharma, M., & Kambadur, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2079-7 · Cited by 158
Wilkes, J. J., Lloyd, D. J., & Gekakis, N. (2009) · Diabetes · doi:10.2337/db08-0245 · Cited by 156
Metabolic Actions of Adipocyte Hormones: Focus on Adiponectin
Ahima, R. S. (2006) · Obesity · doi:10.1038/oby.2006.276 · Cited by 147
The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity
Akpan, I., Goncalves, M. D., Dhir, R., Yin, X., Pistilli, E. E., Bogdanovich, S., Khurana, T. S., Ucran, J., Lachey, J., & Ahima, R. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.162 · Cited by 140
Dyck, D. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-037 · Cited by 136
Kelly, D. P. (2012) · Science · doi:10.1126/science.1221688 · Cited by 133
Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation.
Guerra, C. E., Koza, R. A., Walsh, K., Kurtz, D. M., Wood, P. A., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4532 · Cited by 131
Fournier, B., Murray, B., Gutzwiller, S., Marcaletti, S., Marcellin, D., Bergling, S., Brachat, S., Persohn, E., Pierrel, E., Bombard, F., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06575-11 · Cited by 130
Murphy, K. T., Koopman, R., Naim, T., Léger, B., Trieu, J., Ibebunjo, C., & Lynch, G. S. (2010) · The FASEB Journal · doi:10.1096/fj.10-159608 · Cited by 129
A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling
Koncarevic, A., Kajimura, S., Cornwall-Brady, M. R., Andreucci, A., Pullen, A. E., Sako, D., Kumar, R., Grinberg, A. V., Liharska, K., Ucran, J. A., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1016 · Cited by 111
Wang, Y., Huang, L., Abdelrahim, M., Cai, Q., Truong, A. L., Bick, R. J., Poindexter, B. J., & Sheikh‐Hamad, D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0708454 · Cited by 94
Bernardo, B. L., Wachtmann, T. S., Cosgrove, P. G., Kühn, M., Opsahl, A., Judkins, K. M., Freeman, T. B., Hadcock, J. R., & LeBrasseur, N. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011307 · Cited by 68
Resistance to body fat gain in ‘double-muscled’ mice fed a high-fat diet
Hamrick, M. W., Pennington, C., Webb, C. N., & Isales, C. M. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803200 · Cited by 66
Wang, M., Yu, H. M., Kim, Y., Bidwell, C. A., & Kuang, S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.08.040 · Cited by 60
Myostatin Suppression of Akirin1 Mediates Glucocorticoid-Induced Satellite Cell Dysfunction
Dong, Y., Pan, J. S.-C., & Zhang, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058554 · Cited by 59
Self-citationTGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue
Yadav, H., & Rane, S. G. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00035 · Cited by 49
Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis
Dong, Y., Lakhia, R., Thomas, S. S., Dong, Y., Wang, X. H., Silva, K. A. S., & Zhang, L. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00644.2012 · Cited by 43
Self-citationThe therapeutic potential of brown adipose tissue.
Stanford, K. I., & Goodyear, L. J. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2013.09.02 · Cited by 15
Metabolic Characterization of Obesity
Leibel, R. L., & HIRSCH, J. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-6-1000 · Cited by 13
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Metadata
- Authors
- Dong, J., Dong, Y., Dong, Y., Chen, F., Mitch, W. E., & Zhang, L.
- Affiliations
- Baylor College of Medicine (US)
- Sichuan University (CN)
- Corresponding author
- Chen, F
- Zhang, L
- Venue
- International Journal of Obesity
- Published
- 2015-10-05
- Volume
- 40
- Issue
- 3
- Pages
- 434-442
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC4783239
- OpenAlex
- W2235165689
- Cited by
- 212
- References
- 60
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 18 · 2023: 22 · 2022: 28 · 2021: 32 · 2020: 16 · 2019: 21 · 2018: 14 · 2017: 21 · 2016: 10
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R37-DK-37175, R37DK037175, P30DK079638, R01DK037175)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myostatin inhibition, irisin, insulin resistance, high-fat diet, brown adipose tissue browning, white adipose tissue, macrophage polarization, inflammation, PPARγ, PGC-1α, type 2 diabetes, obesity, fatty acid oxidation, energy expenditure
- MeSH terms
- Adipose Tissue, Animals, Disease Models, Animal, Insulin, Insulin Resistance, Male, Mice, Inbred C57BL, Muscle, Skeletal, Receptor Cross-Talk, Lipid Metabolism, Proto-Oncogene Proteins c-akt, Mice, Myostatin, Molecular Targeted Therapy, Diet, High-Fat
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