The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Lysogeny in nature: mechanisms, impact and ecology of temperate phages
Open accessAbstract
Viruses that infect bacteria (phages) can influence bacterial community dynamics, bacterial genome evolution and ecosystem biogeochemistry. These influences differ depending on whether phages establish lytic, chronic or lysogenic infections. Although the first two produce virion progeny, with lytic infections resulting in cell destruction, phages undergoing lysogenic infections replicate with cells without producing virions. The impacts of lysogeny are numerous and well-studied at the cellular level, but ecosystem-level consequences remain underexplored compared to those of lytic infections. Here, we review lysogeny from molecular mechanisms to ecological patterns to emerging approaches of investigation. Our goal is to highlight both its diversity and importance in complex communities. Altogether, using a combined viral ecology toolkit that is applied across broad model systems and environments will help us understand more of the diverse lifestyles and ecological impacts of lysogens in nature.
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Cites
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Self-citationProphages and bacterial genomics: what have we learned so far?
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Lytic to temperate switching of viral communities
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Phage therapy: From biological mechanisms to future directions
Strathdee, S. A., Hatfull, G. F., Mutalik, V. K., & Schooley, R. T. (2023) · Cell · doi:10.1016/j.cell.2022.11.017 · Cited by 817
Phages and their potential to modulate the microbiome and immunity
Federici, S., Nobs, S. P., & Elinav, E. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00532-4 · Cited by 222
Small protein modules dictate prophage fates during polylysogeny
Silpe, J. E., Duddy, O. P., Johnson, G. E., Beggs, G. A., Hussain, F. A., Forsberg, K. J., & Bassler, B. L. (2023) · Nature · doi:10.1038/s41586-023-06376-y · Cited by 52
Metadata
- Authors
- Howard-Varona, C., Hargreaves, K. R., Abedon, S. T., & Sullivan, M. B.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-14
- Volume
- 11
- Issue
- 7
- Pages
- 1511-1520
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2610162525
- Cited by
- 894
- References
- 99
- FWCI
- 38.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Howard-Varona, C., Hargreaves, K. R., Abedon, S. T., & Sullivan, M. B. (2017). Lysogeny in nature: mechanisms, impact and ecology of temperate phages. The ISME Journal. https://doi.org/10.1038/ismej.2017.16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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