Phages and their potential to modulate the microbiome and immunity

Federici, Sara; Nobs, Samuel P.; Elinav, Eran

doi:10.1038/s41423-020-00532-4

Cited by 222Bacteriophages and microbial interactionsCRISPR and Genetic EngineeringVirus-based gene therapy research

Phages and their potential to modulate the microbiome and immunity

Open access

Federici, Sara, Nobs, Samuel P., Elinav, Eran·2021·Cellular & Molecular Immunology

DOI 10.1038/s41423-020-00532-4PMC PMC8115240

Open this paper in CoChat — free account

Abstract

Bacteriophages (hence termed phages) are viruses that target bacteria and have long been considered as potential future treatments against antibiotic-resistant bacterial infection. However, the molecular nature of phage interactions with bacteria and the human host has remained elusive for decades, limiting their therapeutic application. While many phages and their functional repertoires remain unknown, the advent of next-generation sequencing has increasingly enabled researchers to decode new lytic and lysogenic mechanisms by which they attack and destroy bacteria. Furthermore, the last decade has witnessed a renewed interest in the utilization of phages as therapeutic vectors and as a means of targeting pathogenic or commensal bacteria or inducing immunomodulation. Importantly, the narrow host range, immense antibacterial repertoire, and ease of manipulating phages may potentially allow for their use as targeted modulators of pathogenic, commensal and pathobiont members of the microbiome, thereby impacting mammalian physiology and immunity along mucosal surfaces in health and in microbiome-associated diseases. In this review, we aim to highlight recent advances in phage biology and how a mechanistic understanding of phage-bacteria-host interactions may facilitate the development of novel phage-based therapeutics. We provide an overview of the challenges of the therapeutic use of phages and how these could be addressed for future use of phages as specific modulators of the human microbiome in a variety of infectious and noncommunicable human diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41423-020-00532-4

Cites

240 of 240 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Phages can enhance antitumor immunity.
“Phages can eliminate cancer-associated bacteria, remodel the tumor microenvironment, enhance antitumor immunity, and deliver targeted therapeutic payloads.”
From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [21]
The Introduction reports that phage-based antigen presentation can induce potent T-cell immunity, but does not identify this as antitumor immunity. It only speculates that phage immunomodulation may enable future cancer immunotherapies; it does not establish that phages enhance antitumor immunity. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Phage DNA and structural proteins engage pattern recognition receptors within innate immune pathways, thereby enhancing antitumor immune responses.
“Additionally, phage DNA and structural proteins engage pattern recognition receptors within innate immune pathways, thereby enhancing antitumor immune responses [21,23–26]”
From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [21]
The Introduction (page unavailable) reports that phages can be recognized by innate Toll-like receptors, including TLR9, and that phage components can elicit immune responses. It does not establish that both phage DNA and structural proteins engage pattern-recognition receptors to enhance antitumor immunity; it only speculates that phage immunomodulation might enable future cancer immunotherapies. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Phages reshape tumor-associated bacterial communities.
“Indirectly, phages reshape tumor-associated bacterial communities, depleting protumorigenic taxa and altering microbial metabolites that regulate inflammation, genotoxic stress, and therapeutic response [20–23]”
From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [21]
The Introduction reports that phages can affect the gut microbiome and its metabolites. The Concluding remarks suggest that phage-directed elimination of disease-associated bacteria may eventually benefit neoplastic disorders, but the paper does not report that phages reshape tumor-associated bacterial communities or deplete protumorigenic taxa. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Phages deplete protumorigenic taxa.
“Indirectly, phages reshape tumor-associated bacterial communities, depleting protumorigenic taxa and altering microbial metabolites that regulate inflammation, genotoxic stress, and therapeutic response [20–23]”
From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [21]
The Concluding remarks (page unavailable) suggest that neoplastic disorders may benefit from phage-directed elimination of disease-associated bacteria. They present this as a potential therapy, not evidence that phages deplete protumorigenic taxa in tumor-associated communities. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Phages alter microbial metabolites that regulate inflammation, genotoxic stress, and therapeutic response.
“Indirectly, phages reshape tumor-associated bacterial communities, depleting protumorigenic taxa and altering microbial metabolites that regulate inflammation, genotoxic stress, and therapeutic response [20–23]”
From Phage therapy in oncology: opportunities for cancer prevention and treatment (2026) · cites this paper as [21]
The Introduction (page unavailable) says phages strongly affect the gut metabolite repertoire through their effects on the microbiome. It does not establish that those metabolite changes regulate inflammation, genotoxic stress, or therapeutic response; its discussions of immunity and therapy do not link those outcomes to metabolites. (LLM, conf=0.87)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works
Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859 · see citing works
Self-citation
Viruses in the sea
Suttle, C. A. (2005) · Nature · doi:10.1038/nature04160 · Cited by 2,186 · see citing works
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works
Ecology of prokaryotic viruses
Weinbauer, M. G. (2003) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2003.08.001 · Cited by 1,776 · see citing works
Bacteriophage Therapy
Sulakvelidze, A., Alavidze, Z., & Morris, J. G. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.3.649-659.2001 · Cited by 1,569 · see citing works
Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus
Dedrick, R. M., Guerrero-Bustamante, C. A., Garlena, R. A., Russell, D. A., Ford, K., Harris, K., Gilmour, K. C., Soothill, J. S., Jacobs‐Sera, D., Schooley, R. T., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0437-z · Cited by 1,418 · see citing works
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works
Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection
Schooley, R. T., Biswas, B., Gill, J. J., Hernandez-Morales, A., Lancaster, J., Lessor, L., Barr, J. J., Reed, S. L., Rohwer, F., Benler, S., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00954-17 · Cited by 1,254 · see citing works
Viruses in the faecal microbiota of monozygotic twins and their mothers
Reyes, A., Haynes, M. R., Hanson, N., Angly, F. E., Heath, A. C., Rohwer, F. L., & Gordon, J. I. (2010) · Nature · doi:10.1038/nature09199 · Cited by 1,198 · see citing works
Temporal Stability of the Human Skin Microbiome
Oh, J., Byrd, A. L., Park, M., Kong, H. H., & Segre, J. A. (2016) · Cell · doi:10.1016/j.cell.2016.04.008 · Cited by 1,036 · see citing works
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
Le Roy, T., Llopis, M., Lepage, P., Bruneau, A., Rabot, S., Bevilacqua, C., Martin, P., Philippe, C., Walker, F., Bado, A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303816 · Cited by 1,001 · see citing works
Phage diversity, genomics and phylogeny
Dion, M. B., Oechslin, F., & Moineau, S. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0311-5 · Cited by 960 · see citing works
Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation
Atarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., Kiguchi, Y., Yasuma, K., Watanabe, E., Tanoue, T., et al. (2017) · Science · doi:10.1126/science.aan4526 · Cited by 957 · see citing works
Self-citation
Bacteriophage adhering to mucus provide a non–host-derived immunity
Barr, J. J., Auro, R., Furlan, M., Whiteson, K., Erb, M. L., Pogliano, J., Stotland, A. B., Wolkowicz, R., Cutting, A. S., Doran, K. S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305923110 · Cited by 944 · see citing works
The human gut virome: inter-individual variation and dynamic response to diet
Minot, S., Sinha, R., Chen, J., Li, H., Keilbaugh, S. A., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2011) · Genome Research · doi:10.1101/gr.122705.111 · Cited by 935 · see citing works
Lysogeny in nature: mechanisms, impact and ecology of temperate phages
Howard‐Varona, C., Hargreaves, K. R., Abedon, S. T., & Sullivan, M. B. (2017) · The ISME Journal · doi:10.1038/ismej.2017.16 · Cited by 886 · see citing works
A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic‐resistant Pseudomonas aeruginosa ; a preliminary report of efficacy
Wright, A., Hawkins, C., Änggård, E., & Harper, D. R. (2009) · Clinical Otolaryngology · doi:10.1111/j.1749-4486.2009.01973.x · Cited by 869 · see citing works
Bacteriophage Host Range and Bacterial Resistance
Hyman, P., & Abedon, S. T. (2010) · Advances in applied microbiology · doi:10.1016/s0065-2164(10)70007-1 · Cited by 823 · see citing works
A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes
Dutilh, B. E., Cassman, N. A., McNair, K., Sanchez, S. E., Silva, A. E. T., Boling, L., Barr, J. J., Speth, D. R., Seguritan, V., Aziz, R. K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5498 · Cited by 799 · see citing works
Potential roles of gut microbiome and metabolites in modulating ALS in mice
Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., Kleimeyer, C., Moresi, C., Harnik, Y., Zur, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1443-5 · Cited by 700 · see citing works
Self-citation
Cryptic prophages help bacteria cope with adverse environments
Wang, X., Kim, Y., Ma, Q., Hong, S. H., Pokusaeva, K., Sturino, J. M., & Wood, T. K. (2010) · Nature Communications · doi:10.1038/ncomms1146 · Cited by 677 · see citing works
Explaining Microbial Population Genomics through Phage Predation
Rodriguez-Valera, F., Martin-Cuadrado, A.-B., Rodriguez-Brito, B., Pašić, L., Thingstad, T. F., Rohwer, F., & Mira, A. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2235 · Cited by 663 · see citing works
Communication between viruses guides lysis–lysogeny decisions
Erez, Z., Steinberger-Levy, I., Voichek, M., Doron, S., Stokar-Avihail, A., Peleg, Y., Melamed, S., Leavitt, A., Savidor, A., Albeck, S., et al. (2017) · Nature · doi:10.1038/nature21049 · Cited by 653 · see citing works
Early life dynamics of the human gut virome and bacterial microbiome in infants
Lim, E. S., Zhou, Y., Zhao, G., Bauer, I. K., Droit, L., Ndao, I. M., Warner, B. B., Tarr, P. I., Wang, D., & Holtz, L. R. (2015) · Nature Medicine · doi:10.1038/nm.3950 · Cited by 644 · see citing works
Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients
Kelly, C. R., Ihunnah, C., Fischer, M., Khoruts, A., Surawicz, C., Afzali, A., Aroniadis, O., Barto, A., Borody, T., Giovanelli, A., et al. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.133 · Cited by 636 · see citing works
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis
Gogokhia, L., Buhrke, K., Bell, R. S., Hoffman, B., Brown, D. G., Hanke‐Gogokhia, C., Ajami, N. J., Wong, M. C., Ghazaryan, A., Valentine, J. F., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.008 · Cited by 613 · see citing works
Targeting mechanisms of tailed bacteriophages
Nóbrega, F. L., Vlot, M., de Jonge, P. A., Dreesens, L. L., Beaumont, H. J. E., Lavigne, R., Dutilh, B. E., & Brouns, S. J. J. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0070-8 · Cited by 601 · see citing works
Rapid evolution of the human gut virome
Minot, S. S., Bryson, A. L., Chehoud, C., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300833110 · Cited by 593 · see citing works
The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair
Fineran, P. C., Blower, T. R., Foulds, I. J., Humphreys, D. P., Lilley, K. S., & Salmond, G. P. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808832106 · Cited by 574 · see citing works
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573 · see citing works
Human Volunteers Receiving Escherichia coli Phage T4 Orally: a Safety Test of Phage Therapy
Bruttin, A., & Brüssow, H. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.7.2874-2878.2005 · Cited by 563 · see citing works
Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh
Sarker, S. A., Sultana, S., Reuteler, G., Moine, D., Descombes, P., Charton, F., Bourdin, G., McCallin, S. E., Ngom‐Bru, C., Neville, T., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2015.12.023 · Cited by 543 · see citing works
Healthy human gut phageome
Manrique, P., Bolduc, B., Walk, S. T., John van der, O. O. S. T., de Vos, W. M., & Young, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601060113 · Cited by 538 · see citing works
Cyclic GMP–AMP signalling protects bacteria against viral infection
Cohen, D., Melamed, S., Millman, A., Shulman, G., Oppenheimer‐Shaanan, Y., Kacen, A., Doron, S., Amitai, G., & Sorek, R. (2019) · Nature · doi:10.1038/s41586-019-1605-5 · Cited by 537 · see citing works
Isolation of Phages for Phage Therapy: A Comparison of Spot Tests and Efficiency of Plating Analyses for Determination of Host Range and Efficacy
Mirzaei, M. K., & Nilsson, A. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118557 · Cited by 522 · see citing works
Repeatability and Contingency in the Evolution of a Key Innovation in Phage Lambda
Meyer, J. R., Dobias, D. T., Weitz, J. S., Barrick, J. E., Quick, R. T., & Lenski, R. E. (2012) · Science · doi:10.1126/science.1214449 · Cited by 512 · see citing works
Phage treatment of an aortic graft infected withPseudomonas aeruginosa
Chan, B. K., Turner, P. E., Kim, S., Mojibian, H. R., Elefteriades, J. A., & Narayan, D. (2018) · Evolution Medicine and Public Health · doi:10.1093/emph/eoy005 · Cited by 502 · see citing works
STUDIES ON THE VIRULENCE OF BACTERIOPHAGE-INFECTED STRAINS OF CORYNEBACTERIUM DIPHTHERIAE
Freeman, V. J. (1951) · Journal of Bacteriology · doi:10.1128/jb.61.6.675-688.1951 · Cited by 496 · see citing works
A new perspective on lysogeny: prophages as active regulatory switches of bacteria
Feiner, R., Argov, T., Rabinovich, L., Sigal, N., Borovok, I., & Herskovits, A. A. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3527 · Cited by 491 · see citing works
Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen
Roach, D. R., Leung, C. Y., Henry, M., Morello, E., Singh, D., Santo, J. P. D., Weitz, J. S., & Debarbieux, L. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.018 · Cited by 489 · see citing works
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
Sweere, J. M., Belleghem, J. D. V., Ishak, H. D., Bach, M. S., Popescu, M. C., Sunkari, V. G., Kaber, G., Manasherob, R., Suh, G. A., Cao, X., et al. (2019) · Science · doi:10.1126/science.aat9691 · Cited by 482 · see citing works
Bacteriophage Therapy Rescues Mice Bacteremic from a Clinical Isolate of Vancomycin-Resistant Enterococcus faecium
Biswas, B., Adhya, S. L., Washart, P., Paul, B., Trostel, A. N., Powell, B. S., Carlton, R., & Merril, C. R. (2002) · Infection and Immunity · doi:10.1128/iai.70.1.204-210.2002 · Cited by 479 · see citing works
Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial
Rhoads, D. D., Wolcott, R. D., Kuskowski, M. A., Wolcott, B. M., Ward, L. S., & Sulakvelidze, A. (2009) · Journal of Wound Care · doi:10.12968/jowc.2009.18.6.42801 · Cited by 468 · see citing works
Metagenomic Analysis of Respiratory Tract DNA Viral Communities in Cystic Fibrosis and Non-Cystic Fibrosis Individuals
Willner, D., Furlan, M., Haynes, M., Schmieder, R., Angly, F. E., Silva, J., Tammadoni, S., Nosrat, B., Conrad, D., & Rohwer, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007370 · Cited by 441 · see citing works
Going viral: next-generation sequencing applied to phage populations in the human gut
Reyes, A., Semenkovich, N. P., Whiteson, K., Rohwer, F. L., & Gordon, J. I. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2853 · Cited by 433 · see citing works
Viral and microbial community dynamics in four aquatic environments
Rodriguez-Brito, B., Li, L., Wegley, L., Furlan, M., Angly, F. E., Breitbart, M., Buchanan, J. T., Desnues, C., Dinsdale, E. A., Edwards, R. A., et al. (2010) · The ISME Journal · doi:10.1038/ismej.2010.1 · Cited by 430 · see citing works
Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing
Ando, H., Lemire, S., Pires, D. P., & Lu, T. K. (2015) · Cell Systems · doi:10.1016/j.cels.2015.08.013 · Cited by 429 · see citing works
Vaginal microbiome transplantation in women with intractable bacterial vaginosis
Lev‐Sagie, A., Goldman‐Wohl, D., Cohen, Y., Dori-Bachash, M., Leshem, A., Mor, U., Strahilevitz, J., Moses, A. E., Shapiro, H., Yagel, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0600-6 · Cited by 418 · see citing works
Self-citation
Gut mucosal virome alterations in ulcerative colitis
Zuo, T., Lu, X., Zhang, Y., Cheung, C. P., Lam, S., Zhang, F., Tang, W., Ching, J. Y. L., Zhao, R., Chan, P. K. S., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-318131 · Cited by 417 · see citing works
Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System
Van Belleghem, J. D., Dąbrowska, K., Vaneechoutte, M., Barr, J. J., & Bollyky, P. L. (2018) · Viruses · doi:10.3390/v11010010 · Cited by 408 · see citing works
Anti-CRISPR: discovery, mechanism and function
Pawluk, A., Davidson, A. R., & Maxwell, K. L. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.120 · Cited by 398 · see citing works
Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms
Chaudhry, W. N., Concepción‐Acevedo, J., Park, T. H., Andleeb, S., Bull, J. J., & Levin, B. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168615 · Cited by 398 · see citing works
Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers
Nguyen, S., Baker, K., Padman, B. S., Patwa, R. R., Dunstan, R. A., Weston, T. A., Schlosser, K., Bailey, B., Lithgow, T. J., Lazarou, M., et al. (2017) · mBio · doi:10.1128/mbio.01874-17 · Cited by 383 · see citing works
A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision
Silpe, J. E., & Bassler, B. L. (2018) · Cell · doi:10.1016/j.cell.2018.10.059 · Cited by 364 · see citing works
Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles
Furfaro, L. L., Payne, M. S., & Chang, B. J. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00376 · Cited by 362 · see citing works
Modular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis
Conceição‐Neto, N., Zeller, M., Lefrère, H., Bruyn, P. D., Beller, L., Deboutte, W., Yinda, C. K., Lavigne, R., Maes, P., Ranst, M. A. V., et al. (2015) · Scientific Reports · doi:10.1038/srep16532 · Cited by 356 · see citing works
Gnotobiotic mouse model of phage–bacterial host dynamics in the human gut
Reyes, A., Wu, M., McNulty, N. P., Rohwer, F. L., & Gordon, J. I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319470110 · Cited by 355 · see citing works
Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome
Zuo, T., Wong, S. H., Lam, K., Lui, R. N.-S., Cheung, K., Tang, W., Ching, J. Y. L., Chan, P. K. S., Chan, M. C. W., Wu, J. C., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-313952 · Cited by 344 · see citing works
Sexual Risk Factors and Bacterial Vaginosis: A Systematic Review and Meta‐Analysis
Fethers, K. A., Fairley, C. K., Hocking, J. S., Gurrin, L. C., & Bradshaw, C. S. (2008) · Clinical Infectious Diseases · doi:10.1086/592974 · Cited by 338 · see citing works
Fecal microbiota transplantation for the improvement of metabolism in obesity: The FMT-TRIM double-blind placebo-controlled pilot trial
Yu, E. W.-Y., Gao, L., Stastka, P., Cheney, M. C., Mahabamunuge, J., Soto, M. T., Ford, C. B., Bryant, J. A., Henn, M. R., & Hohmann, E. L. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003051 · Cited by 336 · see citing works
Evidence of a robust resident bacteriophage population revealed through analysis of the human salivary virome
Pride, D. T., Salzman, J., Haynes, M., Rohwer, F., Davis-Long, C., White, R. A., Loomer, P., Armitage, G. C., & Relman, D. A. (2012) · The ISME Journal · doi:10.1038/ismej.2011.169 · Cited by 335 · see citing works
DISARM is a widespread bacterial defence system with broad anti-phage activities
Ofir, G., Melamed, S., Sberro, H., Mukamel, Z., Silverman, S., Yaakov, G., Doron, S., & Sorek, R. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0051-0 · Cited by 333 · see citing works
Synergistic interaction between phage therapy and antibiotics clears Pseudomonas aeruginosa infection in endocarditis and reduces virulence
Oechslin, F., Piccardi, P., Mancini, S., Gabard, J., Moreillon, P., Entenza, J. M., Resch, G., & Que, Y. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw632 · Cited by 327 · see citing works
Gut DNA viromes of Malawian twins discordant for severe acute malnutrition
Reyes, A., Blanton, L. V., Cao, S., Zhao, G., MANARY, M. J., Trehan, I., Smith, M. I., Wang, D., Virgin, H. W., Rohwer, F. L., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514285112 · Cited by 321 · see citing works
ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis
Shkoporov, A. N., Khokhlova, E. V., Fitzgerald, C. B., Stockdale, S. R., Draper, L. A., Ross, R. P., & Hill, C. (2018) · Nature Communications · doi:10.1038/s41467-018-07225-7 · Cited by 314 · see citing works
The Human Skin Double-Stranded DNA Virome: Topographical and Temporal Diversity, Genetic Enrichment, and Dynamic Associations with the Host Microbiome
Hannigan, G. D., Meisel, J. S., Tyldsley, A. S., Zheng, Q., Hodkinson, B. P., SanMiguel, A. J., Minot, S. S., Bushman, F. D., & Grice, E. A. (2015) · mBio · doi:10.1128/mbio.01578-15 · Cited by 312 · see citing works
Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model
McVay, C. S., Velásquez, M., & Fralick, J. A. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01028-06 · Cited by 308 · see citing works
Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections
Debarbieux, L., Leduc, D., Maura, D., Morello, E., Criscuolo, A., Grossi, O., Balloy, V., & Touqui, L. (2010) · The Journal of Infectious Diseases · doi:10.1086/651135 · Cited by 304 · see citing works
Mammalian Host-Versus-Phage immune response determines phage fate in vivo
Hodyra-Stefaniak, K., Miernikiewicz, P., Drapała, J., Drab, M., Jończyk-Matysiak, E., Lecion, D., Kaźmierczak, Z., Beta, W., Majewska, J., Harhala, M., et al. (2015) · Scientific Reports · doi:10.1038/srep14802 · Cited by 302 · see citing works
Duodenal Infusion of Donor Feces for Recurrent Clostridium Difficile
Mathew, S., Barton, J., & Ong, A. W. (2019) · CRC Press eBooks · doi:10.1201/9780429316944-30 · Cited by 282 · see citing works
Variable assortment of prophages provides a transferable repertoire of pathogenic determinants in Salmonella
Figueroa‐Bossi, N., Uzzau, S., Maloriol, D., & Bossi, L. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02234.x · Cited by 277 · see citing works
Decision Making at a Subcellular Level Determines the Outcome of Bacteriophage Infection
Zeng, L., Skinner, S. O., Zong, C. C., Sippy, J., Feiss, M. G., & Golding, I. (2010) · Cell · doi:10.1016/j.cell.2010.03.034 · Cited by 272 · see citing works
Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model
Lood, R., Winer, B. Y., Pelzek, A. J., Díez‐Martínez, R., Thandar, M., Euler, C. W., Schuch, R., & Fischetti, V. A. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04641-14 · Cited by 272 · see citing works
The diversity-generating benefits of a prokaryotic adaptive immune system
van Houte, S., Ekroth, A. K. E., Broniewski, J. M., Chabas, H., Ashby, B., Bondy‐Denomy, J., Gandon, S., Boots, M., Paterson, S., Buckling, A. G. J., et al. (2016) · Nature · doi:10.1038/nature17436 · Cited by 271 · see citing works
Phage as a Modulator of Immune Responses
Górski, A., Międzybrodzki, R., Borysowski, J., Dąbrowska, K., Wierzbicki, P., Kniotek, M., Korczak-Kowalska, G., Olszowska-Zaremba, N., Łusiak-Szelachowska, M., Kłak, M., et al. (2012) · Advances in virus research · doi:10.1016/b978-0-12-394438-2.00002-5 · Cited by 268 · see citing works
A composite bacteriophage alters colonization by an intestinal commensal bacterium
Duerkop, B. A., Clements, C. V., Rollins, D., Rodrigues, J. L. M., & Hooper, L. V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206136109 · Cited by 259 · see citing works
Diversity and Abundance of Single-Stranded DNA Viruses in Human Feces
Kim, M., Park, E., Roh, S. W., & Bae, J. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06331-11 · Cited by 249 · see citing works
Global phylogeography and ancient evolution of the widespread human gut virus crAssphage
Edwards, R. A., Vega, A. A., Norman, H. M., Ohaeri, M. C., Levi, K., Dinsdale, E. A., Cinek, O., Aziz, R. K., McNair, K. A., Barr, J. J., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0494-6 · Cited by 247 · see citing works
Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo
Nale, J. Y., Spencer, J., Hargreaves, K. R., Buckley, A. M., Trzepiński, P., Douce, G. R., & Clokie, M. R. J. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01774-15 · Cited by 244 · see citing works
Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh
Sarker, S. A., McCallin, S. E., Barretto, C., Berger, B. W., Pittet, A.-C., Sultana, S., Krause, L., Huq, S., Bibiloni, R., Bruttin, A., et al. (2012) · Virology · doi:10.1016/j.virol.2012.09.002 · Cited by 240 · see citing works
Fecal microbiota transplantation in patients with primary sclerosing cholangitis: a pilot clinical trial
Allegretti, J. R., Kassam, Z., Carrellas, M., Mullish, B. H., Marchesi, J. R., Pechlivanis, A., Smith, M., Gerardin, Y., Timberlake, S., Pratt, D. S., et al. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000115 · Cited by 234 · see citing works
Intestinal microbiota in health and disease
Kåhrström, C. T., Pariente, N., & Weiss, U. K. (2016) · Nature · doi:10.1038/535047a · Cited by 231 · see citing works
Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity
Landsberger, M., Gandon, S., Meaden, S., Rollie, C., Chevallereau, A., Chabas, H., Buckling, A. G. J., Westra, E. R., & van Houte, S. (2018) · Cell · doi:10.1016/j.cell.2018.05.058 · Cited by 228 · see citing works
Modified Bases in Bacteriophage DNAs
Warren, R. A. J. (1980) · Annual Review of Microbiology · doi:10.1146/annurev.mi.34.100180.001033 · Cited by 227 · see citing works
Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri
Oh, J., Alexander, L. M., Pan, M., Schueler, K. L., Keller, M. P., Attie, A., Walter, J., & van Pijkeren, J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.016 · Cited by 224 · see citing works
Characterization of virus-like particles associated with the human faecal and caecal microbiota
Hoyles, L., McCartney, A. L., Neve, H., Gibson, G. R., Sanderson, J. D., Heller, K. J., & van Sinderen, D. (2014) · Research in Microbiology · doi:10.1016/j.resmic.2014.10.006 · Cited by 223 · see citing works
Prophage Excision Activates Listeria Competence Genes that Promote Phagosomal Escape and Virulence
Rabinovich, L., Sigal, N., Borovok, I., Nir‐Paz, R., & Herskovits, A. A. (2012) · Cell · doi:10.1016/j.cell.2012.06.036 · Cited by 221 · see citing works
The Fiber Gap and the Disappearing Gut Microbiome: Implications for Human Nutrition
Deehan, E. C., & Walter, J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.001 · Cited by 221 · see citing works
Lysogeny is prevalent and widely distributed in the murine gut microbiota
Kim, M., & Bae, J. (2018) · The ISME Journal · doi:10.1038/s41396-018-0061-9 · Cited by 217 · see citing works
Persisting Bacteriophage Infections, Lysogeny, and Phage Conversions
Barksdale, L., & ARDEN, S. B. (1974) · Annual Review of Microbiology · doi:10.1146/annurev.mi.28.100174.001405 · Cited by 214 · see citing works
Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies
Dąbrowska, K., & Abedon, S. T. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-19 · Cited by 214 · see citing works
CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiomePreprint
Stern, A., Mick, E., Tirosh, I., Sagy, O., & Sorek, R. (2012) · Genome Research · doi:10.1101/gr.138297.112 · Cited by 212 · see citing works
Virome Diversity Correlates with Intestinal Microbiome Diversity in Adult Monozygotic Twins
Moreno-Gallego, J. L., Chou, S., Rienzi, S. C. D., Goodrich, J. K., Spector, T. D., Bell, J. T., Youngblut, N. D., Hewson, I., Reyes, A., & Ley, R. E. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.019 · Cited by 211 · see citing works
Viral tagging reveals discrete populations in Synechococcus viral genome sequence space
Deng, L., Ignacio‐Espinoza, J. C., Gregory, A., Poulos, B. T., Weitz, J. S., Hugenholtz, P., & Sullivan, M. B. (2014) · Nature · doi:10.1038/nature13459 · Cited by 210 · see citing works
Efficacy of Bacteriophage Therapy against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice
Watanabe, R., Matsumoto, T., Sano, G., Ishii, Y., Tateda, K., Sumiyama, Y., Uchiyama, J., Sakurai, S., Matsuzaki, S., Imai, S., et al. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00635-06 · Cited by 206 · see citing works
Gut Bacteriophage: Current Understanding and Challenges
Sutton, T., & Hill, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00784 · Cited by 202 · see citing works
Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes
Kleiner, M., Hooper, L. V., & Duerkop, B. A. (2015) · BMC Genomics · doi:10.1186/s12864-014-1207-4 · Cited by 198 · see citing works
Single-virus genomics reveals hidden cosmopolitan and abundant viruses
Martinez‐Hernández, F., Fornas, Ò., Gómez, M. L., Bolduc, B., Peña, M. J. D. L. C., Martínez, J. M., Antón, J., Gasol, J. M., Rosselli, R., Rodríguez‐Valera, F., et al. (2017) · Nature Communications · doi:10.1038/ncomms15892 · Cited by 197 · see citing works
Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice
Chhibber, S., Kaur, S., & Kumari, S. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.2008/002873-0 · Cited by 196 · see citing works
Evaluation of methods to concentrate and purify ocean virus communities through comparative, replicated metagenomics
Hurwitz, B. L., Deng, L., Poulos, B. T., & Sullivan, M. B. (2012) · Environmental Microbiology · doi:10.1111/j.1462-2920.2012.02836.x · Cited by 191 · see citing works
Bacteriophages targeting adherent invasive Escherichia coli strains as a promising new treatment for Crohn's disease
Galtier, M., Sordi, L. D., Sivignon, A., de Vallée, A., Maura, D., Neut, C., Rahmouni, O., Wannerberger, K., Darfeuille–Michaud, A., Desreumaux, P., et al. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw224 · Cited by 190 · see citing works
Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues Mice from Acinetobacter baumannii Wound Infections
Regeimbal, J. M., Jacobs, A. C., Corey, B. W., Henry, M. S., Thompson, M. G., Pavlicek, R. L., Quinones, J., Hannah, R. M., Ghebremedhin, M., Crane, N. J., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02877-15 · Cited by 188 · see citing works
Immunogenicity Studies of Proteins Forming the T4 Phage Head Surface
Dąbrowska, K., Miernikiewicz, P., Piotrowicz, A., Hodyra‐Stefaniak, K., Owczarek, B., Lecion, D., Kaźmierczak, Z. M., Letarov, A. V., & Górski, A. (2014) · Journal of Virology · doi:10.1128/jvi.02043-14 · Cited by 185 · see citing works
Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae
Bao, J., Wu, N., Zeng, Y., Chen, L., Li, L., Yang, L., Zhang, Y., Guo, M., Li, L., Li, J., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1747950 · Cited by 182 · see citing works
Experimental Bacteriophage Protection against Staphylococcus aureus Abscesses in a Rabbit Model
Wills, Q. F., Kerrigan, C., & Soothill, J. S. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1220-1221.2005 · Cited by 181 · see citing works
A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial
Huttner, B. D., LASTOURS, V. D., Wassenberg, M. W. M., Maharshak, N., Mauris, A., Galperine, T. K., Zanichelli, V., Kapel, N., Bellanger, A., Olearo, F., et al. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.12.009 · Cited by 176 · see citing works
Contribution of the Immune Response to Phage Therapy
Krut, O., & Bekeredjian‐Ding, I. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701745 · Cited by 173 · see citing works
Identification and removal of contaminating microbial DNA from PCR reagents: impact on low-biomass microbiome analyses
Stinson, L. F., Keelan, J. A., & Payne, M. S. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.13091 · Cited by 171 · see citing works
Murine colitis reveals a disease-associated bacteriophage community
Duerkop, B. A., Kleiner, M., Páez-Espino, D., Zhu, W., Bushnell, B., Hassell, B., Winter, S., Kyrpides, N. C., & Hooper, L. V. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0210-y · Cited by 165 · see citing works
Adapting Drug Approval Pathways for Bacteriophage-Based Therapeutics
Cooper, C. J., Mirzaei, M. K., & Nilsson, A. S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01209 · Cited by 165 · see citing works
Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation
Draper, L. A., Ryan, F. J., Smith, M. K., Jalanka, J., Mattila, E., Arkkila, P., Ross, R. P., Satokari, R. M., & Hill, C. (2018) · Microbiome · doi:10.1186/s40168-018-0598-x · Cited by 162 · see citing works
Evaluation of the Efficacy of a Bacteriophage in the Treatment of Pneumonia Induced by Multidrug ResistanceKlebsiella pneumoniaein Mice
Cao, F., Wang, X., Wang, L., Li, Z., Che, J., Wang, L., Li, X., Cao, Z., Zhang, J., Jin, L., et al. (2015) · BioMed Research International · doi:10.1155/2015/752930 · Cited by 160 · see citing works
Staphylococcus aureus Bacteriophages Mediating the Simultaneous Lysogenic Conversion of -Lysin, Staphylokinase and Enterotoxin A: Molecular Mechanism of Triple Conversion
Coleman, D. C., Sullivan, D. J., Russell, R. J., Arbuthnott, J. P., Carey, B., & Pomeroy, H. (1989) · Microbiology · doi:10.1099/00221287-135-6-1679 · Cited by 158 · see citing works
Choice of assembly software has a critical impact on virome characterisation
Sutton, T., Clooney, A. G., Ryan, F. J., Ross, R. P., & Hill, C. (2019) · Microbiome · doi:10.1186/s40168-019-0626-5 · Cited by 157 · see citing works
Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity
Borges, A. L., Zhang, J. Y., Rollins, M. F., Osuna, B. A., Wiedenheft, B., & Bondy‐Denomy, J. (2018) · Cell · doi:10.1016/j.cell.2018.06.013 · Cited by 156 · see citing works
Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes
Cornuault, J. K., Petit, M., Mariadassou, M., Benevides, L., Moncaut, E., Langella, P., Sokol, H., & Paepe, M. D. (2018) · Microbiome · doi:10.1186/s40168-018-0452-1 · Cited by 153 · see citing works
Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial
Aroniadis, O. C., Brandt, L. J., Oneto, C., Feuerstadt, P., Sherman, A., Wolkoff, A. W., Kassam, Z., Sadovsky, R. G., Elliott, R. J., Budree, S., et al. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30198-0 · Cited by 153 · see citing works
Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model
Cafora, M., Deflorian, G., Forti, F., Ferrari, L., Binelli, G., Briani, F., Ghisotti, D., & Pistocchi, A. (2019) · Scientific Reports · doi:10.1038/s41598-018-37636-x · Cited by 150 · see citing works
Modeling the Architecture of Depolymerase-Containing Receptor Binding Proteins in Klebsiella Phages
Łątka, A., Leiman, P. G., Drulis‐Kawa, Z., & Briers, Y. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02649 · Cited by 148 · see citing works
Site-specific recombination of T2 phage using IP008 long tail fiber genes provides a targeted method for expanding host range while retaining lytic activity
Mahichi, F., Synnott, A. J., Yamamichi, K., Osada, T., & Tanji, Y. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01588.x · Cited by 147 · see citing works
Metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity
Willner, D. L., Furlan, M., Schmieder, R., Grasis, J. A., Pride, D. T., Relman, D. A., Angly, F. E., Somera, T. M., Mariella, R. P., Rohwer, F. L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000089107 · Cited by 143 · see citing works
Bacteriophages to reduce gut carriage of antibiotic resistant uropathogens with low impact on microbiota composition
Galtier, M., Sordi, L. D., Maura, D., Arachchi, H., Volant, S., Dillies, M., & Debarbieux, L. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13284 · Cited by 143 · see citing works
Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms
Hansen, M. F., Svenningsen, S. L., Røder, H. L., Middelboe, M., & Burmølle, M. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.04.006 · Cited by 143 · see citing works
Phage-Encoded Anti-CRISPR Defenses
Stanley, S. Y., & Maxwell, K. L. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031321 · Cited by 142 · see citing works
Diversity and Ecology of Viruses in Hyperarid Desert Soils
Zablocki, O., Adriaenssens, E. M., & Cowan, D. A. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02651-15 · Cited by 141 · see citing works
A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion
Jahn, M. T., Arkhipova, K., Markert, S. M., Stigloher, C., Lachnit, T., Pita, L., Kupczok, A., Ribes, M., Stengel, S. T., Rosenstiel, P. C., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.019 · Cited by 140 · see citing works
Bacteriophage isolation from human saliva
Bachrach, G., Leizerovici-Zigmond, M., Zlotkin, A., Naor, R., & Steinberg, D. (2003) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2003.01262.x · Cited by 139 · see citing works
Studying the gut virome in the metagenomic era: challenges and perspectives
Garmaeva, S., Sinha, T., Kurilshikov, A., Fu, J., Wijmenga, C., & Zhernakova, A. (2019) · BMC Biology · doi:10.1186/s12915-019-0704-y · Cited by 139 · see citing works
BACTERIOPHAGE THERAPY
Eaton, M. D., & Bayne‐Jones, S. (1934) · JAMA · doi:10.1001/jama.1934.72750490003007 · Cited by 138 · see citing works
Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model
Nath, G., Kishor, C., Mishra, R., Saraf, S., Kumar, M., & Srivastav, A. (2016) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.178615 · Cited by 138 · see citing works
Alteration of tail fiber protein gp38 enables T2 phage to infect Escherichia coli O157:H7
Yoichi, M., Abe, M., Miyanaga, K., Unno, H., & Tanji, Y. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.08.003 · Cited by 136 · see citing works
Bacterial biodiversity drives the evolution of CRISPR-based phage resistance
Alseth, E., Pursey, E., Luján, A. M., McLeod, I., Rollie, C., & Westra, E. R. (2019) · Nature · doi:10.1038/s41586-019-1662-9 · Cited by 136 · see citing works
The role of regulated clinical trials in the development of bacteriophage therapeutics
Parracho, H. M. R. T., Burrowes, B. H., & Enright, M. C. (2012) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000050 · Cited by 133 · see citing works
Bacteriophage therapy: a regulatory perspective
Pelfrene, E., Willebrand, E., Sanches, A., Sebris, Z., & Cavaleri, M. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw083 · Cited by 133 · see citing works
Translocation of Microorganisms Across the Intestinal Wall of the Rat: Effect of Microbial Size and Concentration
Wolochow, H., Hildebrand, G. J., & Lamanna, C. (1966) · The Journal of Infectious Diseases · doi:10.1093/infdis/116.4.523 · Cited by 132 · see citing works
In vivo genetic exchange of a functional domain from a type II A methylase between lactococcal plasmid pTR2030 and a virulent bacteriophage
Hill, C., Miller, L. A., & Klaenhammer, T. R. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.14.4363-4370.1991 · Cited by 129 · see citing works
Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
McCann, A., Ryan, F. J., Stockdale, S. R., Dalmasso, M., Blake, T., Ryan, C. A., Stanton, C., Mills, S., Ross, P. R., & Hill, C. (2018) · PeerJ · doi:10.7717/peerj.4694 · Cited by 129 · see citing works
Nearly Constant Shedding of Diverse Enteric Viruses by Two Healthy Infants
Kapusinszky, B., Minor, P., & Delwart, E. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.01589-12 · Cited by 128 · see citing works
Evaluation of bias induced by viral enrichment and random amplification protocols in metagenomic surveys of saliva DNA viruses
Parras-Moltó, M., Rodríguez-Galet, A., Suárez-Rodríguez, P., & López-Bueno, A. (2018) · Microbiome · doi:10.1186/s40168-018-0507-3 · Cited by 128 · see citing works
Defining the human gut host–phage network through single-cell viral tagging
Džunková, M., Low, S. J., Daly, J. N., Deng, L., Rinke, C., & Hugenholtz, P. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0526-2 · Cited by 127 · see citing works
Bacteriophage Therapy of a Vibrio parahaemolyticus Infection Caused by a Multiple-Antibiotic–Resistant O3:K6 Pandemic Clinical Strain
Jun, J. W., Shin, T. H., Kim, J. H., Shin, S. P., Han, J. E., Heo, G. J., Zoysa, M. D., Shin, G. W., Chai, J. Y., & Park, S. C. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu059 · Cited by 126 · see citing works
A Wake-Up Call: We Need Phage Therapy Now
Moelling, K., Broecker, F., & Willy, C. (2018) · Viruses · doi:10.3390/v10120688 · Cited by 126 · see citing works
The costs of evolving resistance in heterogeneous parasite environments
Koskella, B. L., Lin, D. M., Buckling, A. G. J., & Thompson, J. N. (2011) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2011.2259 · Cited by 126 · see citing works
Shared and Distinct Features of Human Milk and Infant Stool Viromes
Pannaraj, P. S., Ly, M., Cerini, C., Saavedra, M., Aldrovandi, G. M., Saboory, A. A., Johnson, K. M., & Pride, D. T. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01162 · Cited by 125 · see citing works
Viral Evasion of a Bacterial Suicide System by RNA–Based Molecular Mimicry Enables Infectious Altruism
Blower, T. R., Evans, T. J., Przybilski, R., Fineran, P. C., & Salmond, G. P. C. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003023 · Cited by 124 · see citing works
Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant Pseudomonas aeruginosa
Wang, J., Hu, B., Xu, M., Yan, Q., Liu, S., Zhu, X., Sun, Z., Reed, E., Ding, L., Gong, J., et al. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.17.2.309 · Cited by 121 · see citing works
Propionibacterium acnes Bacteriophages Display Limited Genetic Diversity and Broad Killing Activity against Bacterial Skin Isolates
Marinelli, L. J., Fitz‐Gibbon, S. T., Hayes, C. A., Bowman, C. A., Inkeles, M. S., Loncaric, A., Russell, D. A., Jacobs‐Sera, D., Cokus, S. J., Pellegrini, M. A., et al. (2012) · mBio · doi:10.1128/mbio.00279-12 · Cited by 120 · see citing works
Phage–bacteria interaction network in human oral microbiome
Wang, J., Gao, Y., & Zhao, F. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12923 · Cited by 118 · see citing works
Characterization of the nasopharyngeal microbiota in health and during rhinovirus challenge
Allen, E. K., Koeppel, A. F., Hendley, J. O., Turner, S. D., Winther, B., & Sale, M. M. (2014) · Microbiome · doi:10.1186/2049-2618-2-22 · Cited by 118 · see citing works
Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive InfectionIn Vivo
Secor, P. R., Michaels, L. A., Smigiel, K. S., Rohani, M. G., Jennings, L. K., Hisert, K. B., Arrigoni, A., Braun, K. R., Birkland, T. P., Lai, Y., et al. (2016) · Infection and Immunity · doi:10.1128/iai.00648-16 · Cited by 113 · see citing works
The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin
Liu, J., Yan, R., Zhong, Q., Ngo, S., Bangayan, N. J., Nguyen, L., Lui, T., Liu, M., Erfe, M. C. B., Craft, N. A., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.47 · Cited by 111 · see citing works
T4 Phage and Its Head Surface Proteins Do Not Stimulate Inflammatory Mediator Production
Miernikiewicz, P., Dąbrowska, K., Piotrowicz, A., Owczarek, B., Wojas-Turek, J., Kicielińska, J., Rossowska, J., Pajtasz‐Piasecka, E., Hodyra‐Stefaniak, K., Macegoniuk, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071036 · Cited by 110 · see citing works
Targeting of temperate phages drives loss of type I CRISPR–Cas systems
Rollie, C., Chevallereau, A., Watson, B. N. J., Chyou, T., Fradet, O., McLeod, I., Fineran, P. C., Brown, C. M., Gandon, S., & Westra, E. R. (2020) · Nature · doi:10.1038/s41586-020-1936-2 · Cited by 109 · see citing works
High Prevalence of Human Enterovirus A Infections in Natural Circulation of Human Enteroviruses
Witsø, E., Palacios, G. F., Cinek, O., Stene, L. C., Grinde, B., Janowitz, D., Lipkin, W. I., & Rønningen, K. S. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00653-06 · Cited by 108 · see citing works
Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies
Krom, R. J., Bhargava, P., Lobritz, M. A., & Collins, J. J. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b01943 · Cited by 108 · see citing works
Bacteriophage-Resistant Staphylococcus aureus Mutant Confers Broad Immunity against Staphylococcal Infection in Mice
Capparelli, R., Nocerino, N., Lanzetta, R., Silipo, A., Amoresano, A., Giangrande, C., Becker, K., Blaiotta, G., Evidente, A., Cimmino, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011720 · Cited by 105 · see citing works
The oac gene encoding a lipopolysaccharide O-antigen acetylase maps adjacent to the integrase-encoding gene on the genome of Shigella flexneri bacteriophage Sf6
Clark, C. A., Beltrame, J., & Manning, P. A. (1991) · Gene · doi:10.1016/0378-1119(91)90295-m · Cited by 103 · see citing works
Virulent Bacteriophages Can Target O104:H4 Enteroaggregative Escherichia coli in the Mouse Intestine
Maura, D., Galtier, M., Bouguénec, C. L., & Debarbieux, L. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00602-12 · Cited by 100 · see citing works
Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice
Howe, A., Ringus, D. L., Williams, R. J., Choo, Z.-N., Greenwald, S. M., Owens, S. M., Coleman, M. L., Meyer, F., & Chang, E. B. (2015) · The ISME Journal · doi:10.1038/ismej.2015.183 · Cited by 98 · see citing works
Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model
Tetz, G. V., & Tetz, V. (2016) · Gut Pathogens · doi:10.1186/s13099-016-0109-1 · Cited by 93 · see citing works
Spatial disturbances in altered mucosal and luminal gut viromes of diet‐induced obese mice
Kim, M., & Bae, J. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13182 · Cited by 92 · see citing works
Endogenous Type I CRISPR-Cas: From Foreign DNA Defense to Prokaryotic Engineering
Zheng, Y., Li, J., Wang, B., Han, J., Hao, Y., Wang, S., Ma, X., Yang, S., Ma, L., Li, Y., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00062 · Cited by 92 · see citing works
Characterization of a Shiga Toxin-Encoding Temperate Bacteriophage of Shigella sonnei
Strauch, E., Lurz, R., & Beutin, L. (2001) · Infection and Immunity · doi:10.1128/iai.69.12.7588-7595.2001 · Cited by 90 · see citing works
Simultaneous Identification of DNA and RNA Viruses Present in Pig Faeces Using Process-Controlled Deep Sequencing
Sachsenröder, J., Twardziok, S. O., Hammerl, J. A., Janczyk, P., Wrede, P., Hertwig, S. T., & Johne, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034631 · Cited by 89 · see citing works
Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice
Dufour, N., Delattre, R., Chevallereau, A., Ricard, J.-D., & Debarbieux, L. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00379-19 · Cited by 88 · see citing works
T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections
Nishikawa, H., Yasuda, M., Uchiyama, J., Rashel, M., Maeda, Y., Takemura, I., Sugihara, S., Ujihara, T., Shimizu, Y., Shuin, T., et al. (2008) · Archives of Virology · doi:10.1007/s00705-007-0031-4 · Cited by 88 · see citing works
Bacteriophage administration significantly reducesShigellacolonization and shedding byShigella-challenged mice without deleterious side effects and distortions in the gut microbiota
Mai, V., Ukhanova, M., Reinhard, M. K., Li, M., & Sulakvelidze, A. (2015) · Bacteriophage · doi:10.1080/21597081.2015.1088124 · Cited by 87 · see citing works
Identification of a newly isolated lytic bacteriophage against K24 capsular type, carbapenem resistant Klebsiella pneumoniae isolates
Horváth, M., Kovács, T., Valappil, S. K., Ábrahám, H., Rákhely, G., & Schneider, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-62691-8 · Cited by 87 · see citing works
Induction of vaginal Lactobacillus phages by the cigarette smoke chemical benzo[a]pyrene diol epoxide
Pavlova, S. I., & Tao, L. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(00)00003-6 · Cited by 84 · see citing works
Experimental phage therapy against lethal lung-derived septicemia caused by Staphylococcus aureus in mice
Takemura‐Uchiyama, I., Uchiyama, J., Osanai, M., Morimoto, N., Asagiri, T., Ujihara, T., Daibata, M., Sugiura, T., & Matsuzaki, S. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.02.011 · Cited by 84 · see citing works
Analysis of virus genomes from glacial environments reveals novel virus groups with unusual host interactions
Bellas, C. M., Anesio, A. M., & Barker, G. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00656 · Cited by 84 · see citing works
Efficacy of Bacteriophage Treatment in Murine Burn Wound Infection Induced by Klebsiella pneumoniae
Chhibber, S. (2009) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.0808.493 · Cited by 82 · see citing works
Therapeutic effectiveness of bacteriophages in the rescue of mice with extended spectrum beta-lactamase-producing Escherichia coli bacteremia.
Wang, J., Hu, B., Xu, M., Yan, Q., Liu, S., Zhu, X., Sun, Z., Tao, D., Ding, L., Reed, E., et al. (2006) · PubMed · Cited by 81 · see citing works
Stable core virome despite variable microbiome after fecal transfer
Broecker, F., Russo, G., Klumpp, J., & Moelling, K. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1265196 · Cited by 79 · see citing works
Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
Li, Y., Fu, X., Ma, J., Zhang, J., Hu, Y., Dong, W., Wan, Z., Li, Q., Kuang, Y., Lan, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10294-x · Cited by 75 · see citing works
Phage–host interactions during pseudolysogeny
Cenens, W., Makumi, A., Mebrhatu, M. T., Lavigne, R., & Aertsen, A. (2013) · Bacteriophage · doi:10.4161/bact.25029 · Cited by 75 · see citing works
The Microflora of the Face and Acne Lesions
MARPLES, R. R. (1974) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12724285 · Cited by 74 · see citing works
THE BACTERIOPHAGE
Krueger, A. P., & SCRIBNER, E. J. (1941) · JAMA · doi:10.1001/jama.1941.62820190016010 · Cited by 74 · see citing works
Evolution of Pseudomonas aeruginosa Virulence as a Result of Phage Predation
Hosseinidoust, Z., van de Ven, T. G. M., & Tufenkji, N. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01421-13 · Cited by 71 · see citing works
Isolation of bacteriophages from the oral cavity
Hitch, G., Pratten, J. R., & Taylor, P. W. (2004) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2004.01565.x · Cited by 65 · see citing works
Use of bacteriophage typing to distinguish Propionibacterium acne types I and II
WEBSTER, G. F., & Cummins, C. S. (1978) · Journal of Clinical Microbiology · doi:10.1128/jcm.7.1.84-90.1978 · Cited by 65 · see citing works
Identification of predominant culturable vaginal Lactobacillus species and associated bacteriophages from women with and without vaginal discharge syndrome in South Africa
Damelin, L. H., Paximadis, M., Mavri‐Damelin, D., Birkhead, M., Lewis, D. A., & Tiemessen, C. T. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.024463-0 · Cited by 64 · see citing works
B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle
Tian, M., Hua, Z., Hong, S., Zhang, Z., Liu, C., Lin, L., Chen, J., Zhang, W., Zhou, X., Zhang, F., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701067 · Cited by 63 · see citing works
Molecular analysis of a cytotoxin‐converting phage, φCTX, of Pseudomonas aeruginosa: structure of the attP–cos–ctx region and integration into the serine tRNA gene
Hayashi, T., Matsumoto, H., Ohnishi, M., & Terawaki, Y. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01157.x · Cited by 62 · see citing works
Bacteriophage PhiX174's Ecological Niche and the Flexibility of Its Escherichia coli Lipopolysaccharide Receptor
Michel, A. C., Clermont, O., Denamur, É., & Tenaillon, O. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02721-09 · Cited by 61 · see citing works
Transplanting Fecal Virus-Like Particles Reduces High-Fat Diet-Induced Small Intestinal Bacterial Overgrowth in Mice
Lin, D. M., Koskella, B. L., Ritz, N. L., Lin, D., Carroll‐Portillo, A., & Lin, H. C. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00348 · Cited by 61 · see citing works
Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally
Capparelli, R., Ventimiglia, I., Roperto, S., Fenizia, D., & Iannelli, D. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01340.x · Cited by 58 · see citing works
The SopEΦ Phage Integrates into thessrAGeneof Salmonella entericaSerovar Typhimurium A36 and Is Closely Related to the Fels-2 Prophage
Pelludat, C., Mirold, S., & Hardt, W. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.17.5182-5191.2003 · Cited by 57 · see citing works
Active Lysogeny in Listeria Monocytogenes Is a Bacteria-Phage Adaptive Response in the Mammalian Environment
Pasechnek, A., Rabinovich, L., Stadnyuk, O., Azulay, G., Mioduser, J., Argov, T., Borovok, I., Sigal, N., & Herskovits, A. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107956 · Cited by 57 · see citing works
Computational prospecting the great viral unknown
Hurwitz, B. L., U’Ren, J. M., & Youens‐Clark, K. (2016) · FEMS Microbiology Letters · doi:10.1093/femsle/fnw077 · Cited by 56 · see citing works
Evaluation of convenient pretreatment protocols for RNA virus metagenomics in serum and tissue samples
Rosseel, T., Ozhelvaci, O., Freimanis, G., & Borm, S. V. (2015) · Journal of Virological Methods · doi:10.1016/j.jviromet.2015.05.010 · Cited by 54 · see citing works
Recombinant Phage Elicits Protective Immune Response against Systemic S. globosa Infection in Mouse Model
Chen, F., Jiang, R., Wang, Y., Zhu, M., Zhang, X., Dong, S., Shi, H., & Wang, L. (2017) · Scientific Reports · doi:10.1038/srep42024 · Cited by 54 · see citing works
Phage Infection in Vaginal Lactobacilli: An In Vitro Study
Pavlova, S. I., Kılıç, A. O., Mou, S. M., & Tao, L. (1997) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/s1064744997000094 · Cited by 53 · see citing works
From bench to bed and back again: phage therapy of childhood Escherichia coli diarrhea
Sarker, S. A., & Brüssow, H. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13087 · Cited by 51 · see citing works

Flagged first, then by citations

2 of the 242 references couldn’t be matched to a known paper.

Sorted by citations

Microbiome and cancer
Cullin, N., Azevedo Antunes, C., Straussman, R., Stein-Thoeringer, C. K., & Elinav, E. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.08.006 · Cited by 578 · see citing works
Self-citation
The gut virome: A new microbiome component in health and disease
Cao, Z., Sugimura, N., Burgermeister, E., Ebert, M. P. A., Zuo, T., & Lan, P. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104113 · Cited by 294 · see citing works
Antibiotic failure: Beyond antimicrobial resistance
de la Fuente‐Núñez, C., Cesaro, A., & Hancock, R. E. W. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101012 · Cited by 263 · see citing works
New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries
Jain, T., Sharma, P., Are, A. C., Vickers, S. M., & Dudeja, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622064 · Cited by 184 · see citing works
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 188 · see citing works
Utilization of the microbiome in personalized medicine
Ratiner, K., Ciocan, D. M., Abdeen, S. K., & Elinav, E. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00998-9 · Cited by 179 · see citing works
Self-citation
Host control of the microbiome: Mechanisms, evolution, and disease
Wilde, J., Slack, E. M. C., & Foster, K. R. (2024) · Science · doi:10.1126/science.adi3338 · Cited by 159 · see citing works
Interactions of Bacteriophages with Animal and Human Organisms—Safety Issues in the Light of Phage Therapy
Podlacha, M., Grabowski, Ł., Kosznik-Kwaśnicka, K., Zdrojewska, K., Stasiłojć, M., Węgrzyn, G., & Węgrzyn, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168937 · Cited by 125 · see citing works
Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort
Nishijima, S., Nagata, N., Kiguchi, Y., Kojima, Y., Miyoshi‐Akiyama, T., Kimura, M., Ohsugi, M., Ueki, K., Oka, S., Mizokami, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32832-w · Cited by 118 · see citing works
The emerging role of the gut microbiota and its application in inflammatory bowel disease
Xiu, W., Peng, J., Cai, P., Xia, Y., Yi, C., Shang, A., Akanyibah, F. A., & Mao, F. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117302 · Cited by 105 · see citing works
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects
Wang, H., Liu, Y., Bai, C., & Leung, S. S. Y. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.017 · Cited by 91 · see citing works
Roles of the gut virome and mycobiome in faecal microbiota transplantation
Lam, S., Bai, X., Shkoporov, A. N., Park, H., Wu, X., Lan, P., & Zuo, T. (2022) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(21)00303-4 · Cited by 89 · see citing works
The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease
Song, X., Dou, X., Chang, J., Zeng, X., Xu, Q., & Xu, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2414805 · Cited by 83 · see citing works
Genome-driven elucidation of phage-host interplay and impact of phage resistance evolution on bacterial fitness
Markwitz, P., Lood, C., Olszak, T., van Noort, V., Lavigne, R., & Drulis‐Kawa, Z. (2021) · The ISME Journal · doi:10.1038/s41396-021-01096-5 · Cited by 78 · see citing works
Engineered reporter phages for detection of Escherichia coli, Enterococcus, and Klebsiella in urine
Meile, S., Du, J., Staubli, S., Großmann, S., Koliwer‐Brandl, H., Piffaretti, P., Leitner, L., Matter, C. I., Baggenstos, J., Hunold, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39863-x · Cited by 67 · see citing works
The regulatory framework for microbiome-based therapies: insights into European regulatory developments
Rodriguez, J., Cordaillat‐Simmons, M., Pot, B., & Druart, C. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00683-0 · Cited by 67 · see citing works
Role of bacteriophages in shaping gut microbial community
Mahmud, M. R., Tamanna, S. K., Akter, S., Mazumder, L., Akter, S., Hasan, M. R., Acharjee, M., Esti, I. Z., Islam, M. S., Shihab, M., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2390720 · Cited by 67 · see citing works
The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health
Emencheta, S. C., Olovo, C. V., Eze, O. C., Kalu, C. F., Berebon, D. P., Onuigbo, E. B., Vila, M. M. D. C., Balcão, V. M., & Attama, A. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102416 · Cited by 68 · see citing works
Prophage Activation in the Intestine: Insights Into Functions and Possible Applications
Hu, J., Ye, H., Wang, S., Wang, J., & Han, D. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.785634 · Cited by 63 · see citing works
Large-scale phage cultivation for commensal human gut bacteria
Shen, J., Zhang, J., Mo, L., Li, Y., Li, Y., Li, C., Kuang, X., Tao, Z., Qu, Z., Wu, L. H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.013 · Cited by 60 · see citing works
Phage predation accelerates the spread of plasmid-encoded antibiotic resistance
Ruan, C., Ramoneda, J., Kan, A., Rudge, T. J., Wang, G., & Johnson, D. R. (2024) · Nature Communications · doi:10.1038/s41467-024-49840-7 · Cited by 59 · see citing works
Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations
Mitropoulou, G., Koutsokera, A., Csajka, C., Blanchon, S., Sauty, A., Brunet, J.-F., von Garnier, C., Resch, G., & Guery, B. P. (2022) · European Respiratory Review · doi:10.1183/16000617.0121-2022 · Cited by 55 · see citing works
Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice
Borin, J. M., Liu, R., Wang, Y., Wu, T., Chopyk, J., Huang, L., Kuo, P., Ghose, C., Meyer, J. R., Tu, X. M., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236750 · Cited by 56 · see citing works
Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants
Kim, A. H., Armah, G. E., Dennis, F. E., Wang, L., Rodgers, R., Droit, L., Baldridge, M. T., Handley, S. A., & Harris, V. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.002 · Cited by 54 · see citing works
The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy
Marchi, J., Zborowsky, S., Debarbieux, L., & Weitz, J. S. (2023) · iScience · doi:10.1016/j.isci.2023.106004 · Cited by 53 · see citing works
Thousands of small, novel genes predicted in global phage genomes
Fremin, B. J., Bhatt, A. S., Kyrpides, N. C., Sengupta, A., Sczyrba, A., da Silva, A. M., Buchan, A., Gaudin, A. C. M., Brune, A., Hirsch, A. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110984 · Cited by 51 · see citing works
Phage therapy: A novel approach against multidrug-resistant pathogens
Kapoor, A., Mudaliar, S. B., Bhat, V. G., Chakraborty, I., Prasad, A. S. B., & Mazumder, N. (2024) · 3 Biotech · doi:10.1007/s13205-024-04101-8 · Cited by 51 · see citing works
Immunomodulatory role of oral microbiota in inflammatory diseases and allergic conditions
Moreno, C. M., Boeree, E., Freitas, C. M. T., & Weber, K. S. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2023.1067483 · Cited by 51 · see citing works
Implication of the Gut Microbiome and Microbial-Derived Metabolites in Immune-Related Adverse Events: Emergence of Novel Biomarkers for Cancer Immunotherapy
Dóra, D., Bokhari, S. M. Z., Aloss, K., Takacs, P., Desnoix, J. Z., Szklenárik, G., Hurley, P. D., & Lohinai, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032769 · Cited by 47 · see citing works
Infant gut DNA bacteriophage strain persistence during the first 3 years of life
Lou, Y. C., Chen, L., Borges, A. L., West-Roberts, J. A., Firek, B., Morowitz, M. J., & Banfield, J. F. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.11.015 · Cited by 45 · see citing works
Phages enhance both phytopathogen density control and rhizosphere microbiome suppressiveness
Wang, X., Wang, S., Huang, M., He, Y., Guo, S., Yang, K., Wang, N., Sun, T., Yang, H., Yang, T., et al. (2024) · mBio · doi:10.1128/mbio.03016-23 · Cited by 45 · see citing works
Ecology of the respiratory tract microbiome
Pérez‐Cobas, A. E., Rodríguez-Beltrán, J., Baquero, F., & Coque, T. M. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.04.006 · Cited by 44 · see citing works
Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia
Dan, J. M., Lehman, S. M., Al-Kolla, R., Penziner, S., Afshar, K., Yung, G., Golts, E. M., Law, N., Logan, C., Kovách, Z., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac368 · Cited by 42 · see citing works
Engineered Living Bacteriophage-Enabled Self-Adjuvanting Hydrogel for Remodeling Tumor Microenvironment and Cancer Therapy
Dong, X., Pan, P., Zhang, Q., Ye, J., & Zhang, X. (2023) · Nano Letters · doi:10.1021/acs.nanolett.2c04279 · Cited by 42 · see citing works
Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives
Raeisi, H., Noori, M., Azimirad, M., Mohebbi, S. R., Aghdaei, H. A., Yadegar, A., & Zali, M. R. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00550-3 · Cited by 42 · see citing works
From microbiome composition to functional engineering, one step at a time
Burz, S. D., Čaušević, S., Co, A. D., Dmitrijeva, M., Engel, P., Garrido‐Sanz, D., Greub, G., Hapfelmeier, S., Hardt, W., Vassily Hatzimanikatis, A., et al. (2023) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00063-23 · Cited by 42 · see citing works
Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications
García-Gutiérrez, E., O’Mahony, A. K., dos Santos, R. S., Marroquí, L., & Cotter, P. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2401654 · Cited by 42 · see citing works
Gut microbiome signatures and host colonization with multidrug-resistant bacteria
Isles, N. S., Mu, A., Kwong, J. C., Howden, B. P., & Stinear, T. P. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.01.013 · Cited by 40 · see citing works
Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics
Porcari, S., Fusco, W. G., Spivak, I., Fiorani, M., Gasbarrini, A., Elinav, E., Cammarota, G., & Ianiro, G. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00357-6 · Cited by 42 · see citing works
Self-citation
A Phage Foundry Framework to Systematically Develop Viral Countermeasures to Combat Antibiotic-Resistant Bacterial Pathogens
Mutalik, V. K., & Arkin, A. P. (2022) · iScience · doi:10.1016/j.isci.2022.104121 · Cited by 32 · see citing works
Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma
Pezzino, S., Sofia, M., Greco, L. P., Litrico, G., Filippello, G., Sarvà, I., Greca, G. L., & Latteri, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021166 · Cited by 39 · see citing works
The role of rhizosphere phages in soil health
Wang, X., Tang, Y., Yue, X., Wang, S., Yang, K., Xu, Y., Shen, Q., Friman, V., & Wei, Z. (2024) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiae052 · Cited by 38 · see citing works
Within-host evolution of the gut microbiome
Đapa, T., Wong, D. P. G. H., Vasquez, K. S., Xavier, K. B., Huang, K. C., & Good, B. H. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102258 · Cited by 36 · see citing works
Latilactobacillus sakei : a candidate probiotic with a key role in food fermentations and health promotion
Yu, L., Chen, Y., Duan, H., Qiao, N., Wang, G., Zhao, J., Zhai, Q., Tian, F., & Chen, W. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2111402 · Cited by 33 · see citing works
The Evolution of Phage Therapy: A Comprehensive Review of Current Applications and Future Innovations
Sahoo, K., & Meshram, S. (2024) · Cureus · doi:10.7759/cureus.70414 · Cited by 32 · see citing works
Temperate Bacteriophages—The Powerful Indirect Modulators of Eukaryotic Cells and Immune Functions
Cieślik, M., Bagińska, N., Jończyk‐Matysiak, E., Węgrzyn, A., Węgrzyn, G., & Górski, A. (2021) · Viruses · doi:10.3390/v13061013 · Cited by 32 · see citing works
Bacteriophage therapy as a treatment option for complex cardiovascular implant infection: The German Heart Center Berlin experience
Tkhilaishvili, T., Potapov, E. V., Starck, C. T., Mulzer, J., Falk, V., Trampuž, A., & Schoenrath, F. (2022) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2022.01.018 · Cited by 32 · see citing works
Emerging technologies in the study of the virome
Smith, S. E., Huang, W., Tiamani, K., Unterer, M., Mirzaei, M. K., & Deng, L. (2022) · Current Opinion in Virology · doi:10.1016/j.coviro.2022.101231 · Cited by 32 · see citing works
Cytokines Meet Phages: A Revolutionary Pathway to Modulating Immunity and Microbial Balance
Cianci, R., Caldarelli, M., Brani, P., Bosi, A., Ponti, A., Giaroni, C., & Baj, A. (2025) · Biomedicines · doi:10.3390/biomedicines13051202 · Cited by 32 · see citing works
Bacteriophages as a potential substitute for antibiotics: A comprehensive review
Kushwaha, S. O., Sahu, S. K., Yadav, V. K., Rathod, M. C., Patel, D. P., Sahoo, D. K., & Patel, A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4022 · Cited by 27 · see citing works
Targeting the human gut microbiome: a comparative review of probiotics, prebiotics, synbiotics, and postbiotics
Sun, C., Zhu, J., Sun, X., Zhang, Z., Sun, Y., Jin, Y., & Wu, T. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.12.032 · Cited by 29 · see citing works
Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma
Tzani-Tzanopoulou, P., Skliros, D., Megremis, S., Xepapadaki, P. V., Andreakos, E., Чанішвілі, Н., Flemetakis, E., Kaltsas, G., Τaka, S., Lebessi, E., et al. (2021) · Frontiers in Allergy · doi:10.3389/falgy.2020.617240 · Cited by 26 · see citing works
Phage Therapy for Mosquito Larval Control: a Proof-of-Principle Study
Tikhe, C. V., & Dimopoulos, G. (2022) · mBio · doi:10.1128/mbio.03017-22 · Cited by 26 · see citing works
Current clinical translation of microbiome medicines
McCoubrey, L. E., Elbadawi, M., & Basit, A. W. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.02.001 · Cited by 25 · see citing works
A Novel Frontier in Gut–Brain Axis Research: The Transplantation of Fecal Microbiota in Neurodegenerative Disorders
Eslami, M., Adampour, Z., Dowlat, B. F., Yaghmayee, S., Tabaei, F. M., Oksenych, V., & Naderian, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040915 · Cited by 26 · see citing works
Unraveling the potential of M13 phages in biomedicine: Advancing drug nanodelivery and gene therapy
Fadaie, M., Dianat‐Moghadam, H., Ghafouri, E., Naderi, S., Darvishali, M. H., Ghovvati, M., Khanahmad, H., Boshtam, M., & Makvandi, P. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117132 · Cited by 24 · see citing works
Presence and Persistence of Putative Lytic and Temperate Bacteriophages in Vaginal Metagenomes from South African Adolescents
Happel, A., Balle, C., Maust, B. S., Konstantinus, I. N., Gill, K., Bekker, L., Froissart, R., Passmore, J.-A. S., Karaöz, U., Varsani, A., et al. (2021) · Viruses · doi:10.3390/v13122341 · Cited by 23 · see citing works
The role of the gut microbiome in disorders of gut–brain interaction
Gawey, B. J., Mars, R. A. T., & Kashyap, P. (2024) · FEBS Journal · doi:10.1111/febs.17200 · Cited by 28 · see citing works
Antimicrobial resistance: use of phage therapy in the management of resistant infections
Ikpe, F., Williams, T., Orok, E. N., & Ikpe, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09870-2 · Cited by 23 · see citing works
The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications
Feng, Z., Burgermeister, E., Philips, A., Zuo, T., & Wen, W. (2025) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbaf010 · Cited by 22 · see citing works
Spontaneous Phage Resistance in Avian Pathogenic Escherichia coli
Sørensen, P. E., Baig, S., Stegger, M., Ingmer, H., Garmyn, A., & Butaye, P. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.782757 · Cited by 21 · see citing works
Material Engineering in Gut Microbiome and Human Health
Yang, L., Hung, L. Y., Zhu, Y., Ding, S., Margolis, K. G., & Leong, K. W. (2022) · Research · doi:10.34133/2022/9804014 · Cited by 24 · see citing works
Microbiome modeling: a beginner's guide
Lange, E., Kranert, L., Krüger, J., Benndorf, D., & Heyer, R. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1368377 · Cited by 21 · see citing works
The human phageome: niche-specific distribution of bacteriophages and their clinical implications
Rybicka, I., & Kaźmierczak, Z. M. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.01788-24 · Cited by 22 · see citing works
Modification of the immune response by bacteriophages alters methicillin-resistant Staphylococcus aureus infection
Suda, T., Hanawa, T., Tanaka, M., Tanji, Y., Miyanaga, K., Hasegawa‐Ishii, S., Shirato, K., Kizaki, T., & Matsuda, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-19922-x · Cited by 19 · see citing works
Fecal virome transplantation: A promising strategy for the treatment of metabolic diseases
Zeng, C., Wan, S., Guo, M., Tan, X.-Z., Zeng, Y., Wu, Q., Xie, J.-J., Yan, P., Long, Y., Zheng, L., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117065 · Cited by 20 · see citing works
The Novel Concept of Synergically Combining: High Hydrostatic Pressure and Lytic Bacteriophages to Eliminate Vegetative and Spore-Forming Bacteria in Food Products
Shymialevich, D., Wójcicki, M., & Sokołowska, B. (2024) · Foods · doi:10.3390/foods13162519 · Cited by 18 · see citing works
Dual Nature of Bacteriophages: Friends or Foes in Minimally Processed Food Products—A Comprehensive Review
Wójcicki, M., Sokołowska, B., Górski, A., & Jończyk‐Matysiak, E. (2025) · Viruses · doi:10.3390/v17060778 · Cited by 18 · see citing works
Phage Therapy in Managing Multidrug-Resistant (MDR) Infections in Cancer Therapy: Innovations, Complications, and Future Directions
Mafe, A. N., & Büsselberg, D. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070820 · Cited by 18 · see citing works
Impact of bacterial infections and spontaneous bacterial peritonitis prophylaxis on phage‐bacterial dynamics in cirrhosis
Bajaj, J. S., Rodríguez, M. P., Fagan, A., McGeorge, S., Sterling, R. K., Lee, H. M., Luketic, V. A., Fuchs, M. A., Davis, B., Sikaroodi, M., et al. (2022) · Hepatology · doi:10.1002/hep.32571 · Cited by 18 · see citing works
A review of bacteriophage and their application in domestic animals in a post-antibiotic era
Guo, X., Luo, G., Hou, F., Zhou, C., Liu, X., Lei, Z., Niu, D. X., Ran, T., & Tan, Z. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174931 · Cited by 18 · see citing works
Characterization and application of a lytic jumbo phage ZPAH34 against multidrug-resistant Aeromonas hydrophila
Hou, Y., Wu, Z., Ren, L., Chen, Y., Zhang, Y., & Zhou, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1178876 · Cited by 17 · see citing works
The role of bacteriophages in shaping bacterial composition and diversity in the human gut
Alkhalil, S. S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1232413 · Cited by 17 · see citing works
Combined Forces Against Bacteria: Phages and Antibiotics
Afrasiabi, S., Partoazar, A., Goudarzi, R., & Dehpour, A. R. (2025) · Health Science Reports · doi:10.1002/hsr2.70956 · Cited by 17 · see citing works
Latest Advances in Inhalable Dry Powder Bacteriophage Therapy for Pulmonary Infections
Encinas-Basurto, D., Martinez-Flores, P. D., García, J., López‐Mata, M. A., García‐González, G., Rodea, G. E., Eedara, B. B., Mansour, H. M., & Juárez, J. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081077 · Cited by 16 · see citing works
Engineering bacteriophages for gut health: precision antimicrobials and beyond
Xu, M., Chen, S., Pei, H.-L., Hu, L., & Zhang, Y.-S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04038-5 · Cited by 17 · see citing works
Phages indirectly maintain tomato plant pathogen defense through regulation of the commensal microbiome
Debray, R., Conover, A. E., & Koskella, B. L. (2025) · ISME Communications · doi:10.1093/ismeco/ycaf065 · Cited by 13 · see citing works
The Respiratory Tract Microbiome and Human Health
de Córdoba‐Ansón, P. F., Linares‐Ambohades, I., Baquero, F., Coque, T. M., & Pérez‐Cobas, A. E. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70147 · Cited by 13 · see citing works
The Role of Intestinal Microbiota and Immune System Interactions in Autoimmune Diseases
Yurtseven, B., Aydemir, E., & Ayaz, F. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s569016 · Cited by 19 · see citing works
Immune Responses to Phage Therapy in Humans: A Review
Bosco, K., Fabijan, A. P., Iredell, J. R., Dąbrowska, K., & Khatami, A. (2026) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiag096 · Cited by 13 · see citing works
Environmental Reservoirs, Genomic Epidemiology, and Mobile Genetic Elements
Motlhalamme, T. Y., Paul, L. V., & Singh, V. (2024) · Springer eBooks · doi:10.1007/978-3-031-65986-7_7 · Cited by 13 · see citing works
Bacterial community of reindeer lichens differs between northern and southern lichen woodlands
Alonso, M., & Villarreal, J. C. (2022) · Canadian Journal of Forest Research · doi:10.1139/cjfr-2021-0272 · Cited by 12 · see citing works
New thoughts on the intestinal microbiome-B cell-IgA axis and therapies in IgA nephropathy
Dang, S., Zhang, X., Zhang, Y., & Zhang, H. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103835 · Cited by 13 · see citing works
Role of bacteria and microbial metabolites in immune modulation during early life
Oldereid, T. S., Jiang, X., Nordhus, K. S., Ponzetta, A., Bjørnholt, J. V., Björkström, N. K., Melum, E., & Rasmussen, H. (2023) · Scandinavian Journal of Immunology · doi:10.1111/sji.13336 · Cited by 12 · see citing works
Concepts and criteria defining emerging microbiome applications
KOSTIC, T. M., Schloter, M., Arruda, P., Berg, G., Charles, T. C., Cotter, P. D., Kiran, G. S., Lange, L., Maguin, E., Meisner, A., et al. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.14550 · Cited by 12 · see citing works
Multi-omics insights into bone tissue injury and healing: bridging orthopedic trauma and regenerative medicine
Yang, L., Xu, Z., Jie, L., Chang, X., Ren, Z., & Xiao, W. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf019 · Cited by 12 · see citing works
Genome-resolving metagenomics reveals wild western capercaillies (Tetrao urogallus) as avian hosts for antibiotic-resistance bacteria and their interactions with the gut-virome community
Rasmussen, J. A., & Chua, P. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127372 · Cited by 11 · see citing works
Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
Istvan, P., Birkeland, E. E., Avershina, E., Kværner, A. S., Bemanian, V., Pardini, B., Tarallo, S., de Vos, W. M., Rognes, T., Berstad, P. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46033-0 · Cited by 13 · see citing works
Ecological management of the microbiota in patients with cancer
Xavier, J. B. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01049-3 · Cited by 14 · see citing works
Urinary Tract Virome as an Urgent Target for Metagenomics
Salabura, A., Łuniewski, A., Kucharska, M., Myszak, D., Dołęgowska, B., Ciechanowski, K., Kędzierska-Kapuza, K., & Wojciuk, B. (2021) · Life · doi:10.3390/life11111264 · Cited by 11 · see citing works
Four Novel Caudoviricetes Bacteriophages Isolated from Baltic Sea Water Infect Colonizers of Aurelia aurita
Stante, M., Weiland‐Bräuer, N., Repnik, U., Werner, A., Chibani, C. M., Bramkamp, M., & Schmitz, R. A. (2023) · Viruses · doi:10.3390/v15071525 · Cited by 11 · see citing works
Does the Human Gut Virome Contribute to Host Health or Disease?
Pavia, G., Marascio, N., Matera, G., & Quirino, A. (2023) · Viruses · doi:10.3390/v15112271 · Cited by 12 · see citing works
Phage therapy in cancer treatment: Mechanisms, emerging innovations, and translational progress
Hsu, C., Polatova, D., Hamad, R. H., Patel, P. N., Akram, M., Singh, G., Arora, V., Nayak, P. P., Kadhem, M., & Hamzah, H. F. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.105085 · Cited by 10 · see citing works
Bacteriophage-based therapies in oral cancer: A new frontier in oncology
Panneerselvam, V. P., Vajravelu, L. K., Lathakumari, R. H., Vimala, P. B., Nair, D. M., & Thulukanam, J. (2025) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2025.03.003 · Cited by 10 · see citing works
Targeting bacterial persistence with bacteriophages: a next-generation antimicrobial strategy
Kim, S. G. (2025) · Virology · doi:10.1016/j.virol.2025.110649 · Cited by 10 · see citing works
The Novel Role of Phage Particles in Chronic Liver Diseases
Chen, L., Hou, X., & Chu, H. (2023) · Microorganisms · doi:10.3390/microorganisms11051181 · Cited by 10 · see citing works
Evaluating the Stability of Lytic and Lysogenic Bacteriophages in Various Protectants
Selcuk, E., Dokuz, S., & Özbek, T. (2024) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2024.01.010 · Cited by 10 · see citing works
Viruses and Mitochondrial Dysfunction in Neurodegeneration and Cognition: An Evolutionary Perspective
Stefano, G. B., Weissenberger, S., Ptáček, R., Anders, M., Raboch, J., & Büttiker, P. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01503-3 · Cited by 10 · see citing works
The Potential Role of Gut Bacteriome Dysbiosis as a Leading Cause of Periprosthetic Infection: A Comprehensive Literature Review
Valtetsiotis, K., Martino, A. C. D., Brunello, M., Tassinari, L., D’Agostino, C., Traina, F., & Faldini, C. (2023) · Microorganisms · doi:10.3390/microorganisms11071778 · Cited by 9 · see citing works
Transcytosis of T4 Bacteriophage Through Intestinal Cells Enhances Its Immune Activation
Carroll‐Portillo, A., Barnes, O., Coffman, C. N., Braun, C. A., Singh, S., & Lin, H. C. (2025) · Viruses · doi:10.3390/v17010134 · Cited by 9 · see citing works

Bacteriophages as Immune Modulators: Current Insights and Future Directions
Somsri, K., Sutnu, N., Montathip, S., Bhunyakarnjanarat, T., Schultz, M. J., Doi, K., Chancharoenthana, W., & Leelahavanichkul, A. (2026) · PHAGE · doi:10.1177/26416549251412046 · Cited by 2 · see citing works
Bacteriophage-mediated modulation of microbiota for diseases treatment
Zhang, Y., Li, C., & Zhang, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113856 · Cited by 41 · see citing works
The relationship between the phageome and human health: are bacteriophages beneficial or harmful microbes?
Fernández, L., Duarte, A. C., Rodrı́guez, A., & García, P. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0132 · Cited by 16 · see citing works
Phage-Microbiota Interactions in the Gut: Implications for Health and Therapeutic Strategies
Naderian, R., Alibabaei, F., Paraandavaji, E., Dehghan, P., & Eslami, M. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10784-z · Cited by 6 · see citing works
Bacteriophages as Therapeutic and Biotechnological Agents: Host Interactions, Immune Modulation, and Engineering Strategies
Ali, Z., Rehman, S., & Naseem, S. (2025) · PHAGE · doi:10.1177/26416549251384321

Authors: Federici, S., Nobs, S. P., & Elinav, E.
Affiliations: Weizmann Institute of Science (IL)
German Cancer Research Center (DE)
Corresponding author: Elinav, Eran
ORCID: Federici, Sara
Nobs, Samuel P.
Elinav, Eran
Venue: Cellular & Molecular Immunology
Publisher: Springer Science and Business Media LLC
Published: 2020-09-08
Volume: 18
Issue: 4
Pages: 889-904
ISSN: 1672-7681 (ISSN-L)
2042-0226
DOI: 10.1038/s41423-020-00532-4
PMC: PMC8115240
OpenAlex: W3084223430
Cited by: 222
References: 242
Citations by year: 2026: 49 · 2025: 55 · 2024: 42 · 2023: 38 · 2022: 26 · 2021: 12
FWCI: 1.67
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: bacteriophages, phage therapy, human microbiome, phage-bacteria interactions, antibiotic resistance, immunomodulation, mucosal immunity, commensal bacteria, pathobionts, phage vectors
MeSH terms: Phage Therapy, Animals, Bacteria, Bacterial Infections, Bacteriophages, Humans, Drug Resistance, Multiple, Bacterial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phages and their potential to modulate the microbiome and immunity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks