Cited by 522Advanced MRI Techniques and ApplicationsMuscle metabolism and nutritionCardiovascular and exercise physiology

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Blood lactate is an important energy source for the human brain.

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van Hall, Gerrit, Stømstad, Morten, Rasmussen, Peter, Jans, Øle, Zaar, Morten, Gam, Christian, Quistorff, Bjørn, Secher, Niels H, Nielsen, Henning B·2009·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.2009.35

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Abstract

Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 μmol per kg bw per min), and during 30mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89 ± 0.08, 3.9 ± 0.3, and 6.9 ± 1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06 ± 0.01 to an uptake of 0.16 ± 0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28 ± 0.16 mmol/min. Most 13 C-label from cerebral [1- 13 C]lactate uptake was released as 13 CO 2 with 100% ± 24%, 86% ± 15%, and 87% ± 30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8% ± 2%, 19% ± 4%, and 27% ± 4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.

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Authors: van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B.
Affiliations: Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
University of Copenhagen (DK)
ORCID: Rasmussen, Peter
Quistorff, Bjørn
Secher, Niels H
Nielsen, Henning B
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2009-04-01
Volume: 29
Issue: 6
Pages: 1121-1129
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.2009.35
OpenAlex: W2117825985
Cited by: 522
References: 45
Citations by year: 2026: 34 · 2025: 35 · 2024: 29 · 2023: 32 · 2022: 29 · 2021: 34 · 2020: 46 · 2019: 22 · 2018: 44 · 2017: 33 · 2016: 23 · 2015: 34 · 2014: 31 · 2013: 33 · 2012: 19
FWCI: 15.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: blood lactate, brain energy metabolism, lactate oxidation, brain glucose uptake, physical activity, hyperlactatemia
MeSH terms: Adult, Brain, Energy Metabolism, Glucose, Humans, Kinetics, Male, Lactic Acid, Carbohydrate Metabolism

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Blood lactate is an important energy source for the human brain.

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