The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Blood lactate is an important energy source for the human brain.
Open accessAbstract
Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 μmol per kg bw per min), and during 30mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89 ± 0.08, 3.9 ± 0.3, and 6.9 ± 1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06 ± 0.01 to an uptake of 0.16 ± 0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28 ± 0.16 mmol/min. Most 13 C-label from cerebral [1- 13 C]lactate uptake was released as 13 CO 2 with 100% ± 24%, 86% ± 15%, and 87% ± 30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8% ± 2%, 19% ± 4%, and 27% ± 4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.
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“Most lactate disposal occurs via oxidation in working skeletal muscle during prolonged endurance exercise, but other tissues such as the brain, liver and kidneys are also involved in lactate turnover [121,122,123].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [123]
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“peripheral blood lactate (e.g., from muscles) can cross the blood–brain barrier and provides energy to the brain”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as van Hall et al., 2009
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Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · cited 1×
“In cell cultures, neurons metabolize lactate that has been suggested to originate from astrocytic glycolysis, i.e., the astrocyte-to-neuron lactate shuttle (Pellerin and Magistretti, 1994).”
BackgroundCalculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Brain Metabolism during Fasting*
Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,662
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334
Lactate metabolism: a new paradigm for the third millennium
Gladden, L. B. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058701 · Cited by 1,332
Table of nonprotein respiratory quotient: an update.
Péronnet, F., & Massicotte, D. (1991) · PubMed · Cited by 1,177
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812
Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis
Wolfe, R. R. (1992) · Medical Entomology and Zoology · Cited by 610
Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587
Research works printed but not linked: 4
- Péronnet F, 1991, Can J Sport Sci, 16, 23
- Richter EA, 1988, Am J Physiol, 254, E555
- Stanley WC, 1985, Am J Physiol, 249, E595
- Wolff J, 2004, Non-neuronal cell of the nervous system: Function and dysfunction, 1
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Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Sugar for the brain: the role of glucose in physiological and pathological brain function
Mergenthaler, P., Lindauer, U., Dienel, G. A., & Meisel, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.07.001 · Cited by 1,612
The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285
Metadata
- Authors
- van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B.
- Affiliations
- Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
- University of Copenhagen (DK)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2009-04-01
- Volume
- 29
- Issue
- 6
- Pages
- 1121-1129
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2117825985
- Cited by
- 522
- References
- 45
- Citations by year
- 2026: 34 · 2025: 35 · 2024: 29 · 2023: 32 · 2022: 29 · 2021: 34 · 2020: 46 · 2019: 22 · 2018: 44 · 2017: 33 · 2016: 23 · 2015: 34 · 2014: 31 · 2013: 33 · 2012: 19
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- blood lactate, brain energy metabolism, lactate oxidation, brain glucose uptake, physical activity, hyperlactatemia
- MeSH terms
- Adult, Brain, Energy Metabolism, Glucose, Humans, Kinetics, Male, Lactic Acid, Carbohydrate Metabolism
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