Elevated CNS Inflammation in Patients with Preclinical Alzheimer's Disease
Open accessAbstract
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.
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In AD patients, T cells are present in greater numbers than in non-AD patients.
“In AD patients, it was observed the presence of T cells in greater numbers than in non-AD patients (Monson et al., 2014).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Monson et al., 2014
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- Authors
- Monson, N. L., Ireland, S. J., Ligocki, A. J., Chen, D., Rounds, W. H., Li, M., Huebinger, R. M., Munro Cullum, C., Greenberg, B. M., Stowe, A. M., & Zhang, R.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas, USA
- Texas Health Dallas (US)
- Corresponding author
- Monson, Nancy L
- ORCID
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2013-10-23
- Volume
- 34
- Issue
- 1
- Pages
- 30-33
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC3887357
- OpenAlex
- W2058931739
- Cited by
- 76
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 13 · 2015: 13 · 2014: 6
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Multiple Sclerosis Society
- Multiple Sclerosis Society
- National Institutes of Health (5t32ai005284-45)
- National Institute on Aging (P30AG012300, P30AG-12300, R01AG033106, AG 12300)
- National Institute of Allergy and Infectious Diseases (T32-AI005284)
- National Institute of Neurological Disorders and Stroke (L30 NS084459)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, preclinical Alzheimer's disease, amnestic mild cognitive impairment, neuroinflammation, cerebrospinal fluid, lymphocytes, inflammatory cytokines, multiple sclerosis
- MeSH terms
- Aged, Alzheimer Disease, Demyelinating Diseases, Humans, Lymphocytes, Middle Aged, Multiple Sclerosis, Case-Control Studies, Cytokines, Cell Lineage, Cognitive Dysfunction
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