Acute effect of ambient ozone on heart rate variability in healthy elderly subjects
Abstract
Acute ambient ozone (O(3)) exposure is associated with the increased mortality and morbidity of cardiovascular diseases. The dysfunction of cardiac autonomic nervous system (ANS), indicated by the disturbed heart rate variability (HRV), may be the most important underlying mechanism. Previous studies reported the heterogeneous associations between O(3) within several hours' exposure and HRV on general elderly subjects, in which poor surrogate of exposure evaluation and different health status of the subjects may be responsible for the heterogeneous associations. No studies were found focusing on the O(3)-mediated HRV effects within several minutes' exposure on healthy older subjects until recently. We measured the real-time 5-min ambient O(3) concentration and HRV frequency indices in 20 healthy elderly subjects in two surveys, with the 1st and 2nd survey in summer and winter, respectively. Mixed-linear model was used to evaluate the associations between the ambient 5-min average O(3) and concurrent 5-min HRV frequency indices measured during the outdoor period. After adjusting the co-pollutants (ambient PM(2.5) and nitrogen oxides concentrations) and subject characteristics, high frequency (HF) changed -4.87% (95% CI -8.62 to -0.97%) per 10 ppb increment of O(3), whereas decreased low frequency (LF) and increased LFHFR were found to be marginally associated with the elevated O(3) (P values were 0.092 and 0.069). We concluded that the ambient O(3) exert transient decrease effects on HRV, which may induce acute cardiac events.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ambient ozone exposure within several minutes can decrease heart rate variability in the healthy elderly subjects.
“Jia et al. showed that ambient ozone exposure within several minutes can decrease heart rate variability in the healthy elderly subjects, suggesting that a dysfunction of cardiac autonomic nervous system may be involved (53).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [53]
Cites
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Heart rate variability: A review
Rajendra Acharya, U., Paul Joseph, K., Kannathal, N., Lim, C. M., & Suri, J. S. (2006) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-006-0119-0 · Cited by 2,820 · see citing works
Impact of Reduced Heart Rate Variability on Risk for Cardiac Events: The Framingham Heart Study
Tsuji, H., Larson, M. G., Venditti, F. J., Manders, E. S., Evans, J. C., Feldman, C. L., & Levy, D. (1996) · Circulation · doi:10.1161/01.cir.94.11.2850 · Cited by 1,762 · see citing works
The role of vagal function in the risk for cardiovascular disease and mortality
Thayer, J. F., & Lane, R. D. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.013 · Cited by 1,033 · see citing works
La Rovere, M. T., Pinna, G. D., Maestri, R., Mortara, A., Capomolla, S., Febo, O., Ferrari, R., Franchini, M., Gnemmi, M., Opasich, C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000047275.25795.17 · Cited by 917 · see citing works
Ambient Pollution and Heart Rate Variability
Gold, D. R., Litonjua, A. A., Schwartz, J. D., Lovett, E. G., Larson, A. C., Nearing, B. D., Allen, G. A., Verrier, M., Cherry, R. C., & Verrier, R. L. (2000) · Circulation · doi:10.1161/01.cir.101.11.1267 · Cited by 869 · see citing works
Ozone in Indoor Environments: Concentration and Chemistry
Weschler, C. J. (2000) · Indoor Air · doi:10.1034/j.1600-0668.2000.010004269.x · Cited by 762 · see citing works
Heart rate variability: A measure of cardiac autonomic tone
Stein, P. K., Bosner, M. S., Kleiger, R. E., & Conger, B. M. (1994) · American Heart Journal · doi:10.1016/0002-8703(94)90059-0 · Cited by 719 · see citing works
Antelmi, I., De Paula, R. S., Shinzato, A. R., Peres, C. A., Mansur, A. J., & Grupi, C. J. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.065 · Cited by 555 · see citing works
Particulate Matter Exposure in Cars Is Associated with Cardiovascular Effects in Healthy Young Men
Riediker, M., Cascio, W. E., Griggs, T. R., Herbst, M., Bromberg, P. A., Neas, L., Williams, R. W., & Devlin, R. B. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200310-1463oc · Cited by 465 · see citing works
Acute Effects of Ozone on Mortality from the “Air Pollution and Health
Gryparis, A., Forsberg, B., Katsouyanni, K., Analitis, A., Touloumi, G., Schwartz, J., Samoli, E., Medina, S., Anderson, H. R., Niciu, E. M., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200403-333oc · Cited by 449 · see citing works
Effects of Air Pollution on Heart Rate Variability: The VA Normative Aging Study
Park, S. K., O’Neill, M. S., Vokonas, P., Sparrow, D., & Schwartz, J. D. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7447 · Cited by 362 · see citing works
Air pollution and daily mortality in London: 1987-92
ANDERSON, H. R., de León, A. P., Bland, J. M., Bower, J. S., & Strachan, D. P. (1996) · BMJ · doi:10.1136/bmj.312.7032.665 · Cited by 303 · see citing works
Ozone Exposure and Mortality: An Empiric Bayes Metaregression Analysis
Levy, J. I., Chemerynski, S. M., & Sarnat, J. A. (2005) · Epidemiology · doi:10.1097/01.ede.0000165820.08301.b3 · Cited by 302 · see citing works
Traffic related pollution and heart rate variability in a panel of elderly subjects
Schwartz, J. D. (2005) · Thorax · doi:10.1136/thx.2004.024836 · Cited by 297 · see citing works
Ozone Air Pollution Is Associated With Acute Myocardial Infarction
Ruidavets, J., Cournot, M., Cassadou, S., Giroux, M., Meybeck, M. P., & Ferrières, J. (2005) · Circulation · doi:10.1161/01.cir.0000154546.32135.6e · Cited by 247 · see citing works
Liao, D. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh109 · Cited by 208 · see citing works
Air Pollution and Heart Rate Variability Among the Elderly in Mexico City
Holguín, F., Téllez-Rojo, M. M., Hernández, M., Cortez, M., Chow, J. C., Watson, J. G., Mannino, D. M., & Romieu, I. (2003) · Epidemiology · doi:10.1097/01.ede.0000081999.15060.ae · Cited by 193 · see citing works
Ozone, Suspended Particulates, and Daily Mortality in Mexico City
Borja‐Aburto, V. H., LOOMIS, D. P., Bangdiwala, S. I., Shy, C. M., & Rascón-Pacheco, R. A. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009099 · Cited by 167 · see citing works
CARDIOVASCULAR EFFECTS ASSOCIATED WITH AIR POLLUTION: POTENTIAL MECHANISMS AND METHODS OF TESTING
Utell, M. J., Frampton, M. W., Zaręba, W., Devlin, R. B., & Cascio, W. E. (2002) · Inhalation Toxicology · doi:10.1080/08958370290084881 · Cited by 153 · see citing works
Dietrich, D. F., Schindler, C., Schwartz, J. D., Barthélemy, J., Tschopp, J.-M., Roche, F., von Eckardstein, A., Brändli, O., Leuenberger, P., Gold, D. R., et al. (2006) · EP Europace · doi:10.1093/europace/eul063 · Cited by 150 · see citing works
Wheeler, A. J., Zanobetti, A., Gold, D. R., Schwartz, J. D., Stone, P. H., & Suh, H. H. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8337 · Cited by 123 · see citing works
Kop, W. J., Verdino, R. J., Gottdiener, J. S., O’Leary, S. T., Merz, C. N. B., & Krantz, D. S. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01451-6 · Cited by 120 · see citing works
Lipsett, M. J., Tsai, F. C., Roger, L., Woo, M. A., & Ostro, B. D. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8856 · Cited by 119 · see citing works
Short-Term Effects of Air Pollution on Heart Rate Variability in Senior Adults in Steubenville, Ohio
Luttmann‐Gibson, H., Suh, H. H., Coull, B. A., Dockery, D. W., Sarnat, S. E., Schwartz, J. D., Stone, P. H., & Gold, D. R. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000229781.27181.7d · Cited by 88 · see citing works
Use of an Indoor Air Quality Model (IAQM) to Estimate Indoor Ozone Levels
Hayes, S. R. (1991) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.1991.10466833 · Cited by 84 · see citing works
Hsieh, Y., Yang, Y., Wu, T.-N., & Yang, C. (2010) · Journal of Toxicology and Environmental Health · doi:10.1080/15287391003684789 · Cited by 38 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ozone pollution: A Major health hazard worldwide
Zhang, J. (., Wei, Y., & Fang, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02518 · Cited by 828 · see citing works
The effects of ozone on human health
Nuvolone, D., Petri, D., & Voller, F. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9239-3 · Cited by 619 · see citing works
- Authors
- Jia, X., Song, X., Shima, M., Tamura, K., Deng, F., & Guo, X.
- Affiliations
- Peking University (CN)
- Hyogo Medical University (JP)
- National Institute for Environmental Studies (JP)
- Corresponding author
- Guo, Xinbiao
- Venue
- Journal of Exposure Science & Environmental Epidemiology
- Published
- 2011-04-27
- Volume
- 21
- Issue
- 5
- Pages
- 541-547
- ISSN
- 1559-0631 (ISSN-L)
- 1559-064X
- OpenAlex
- W2063194450
- Cited by
- 59
- References
- 28
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Exposure Science & Environmental Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Natural Science Foundation of China
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- ambient ozone, heart rate variability, older adults, cardiac autonomic nervous system, high-frequency power, low-frequency power, LF/HF ratio, acute air pollution exposure, cardiovascular health, seasonal variation, PM2.5, nitrogen oxides
- MeSH terms
- Aged, Air Pollutants, Blood Pressure, Data Collection, Female, Heart Conduction System, Heart Rate, Humans, Lipids, Male, Middle Aged, Nitrogen Oxides, Ozone, Particle Size, Seasons, Time Factors, Body Mass Index, Case-Control Studies, Particulate Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
