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Cited by 102Sodium Intake and HealthBlood Pressure and Hypertension StudiesNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Low-sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans

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Al-Solaiman, Y, Jesri, A, Zhao, Y, Morrow, J D, Egan, B M·2009·Journal of Human Hypertension
DOI 10.1038/jhh.2009.32PMC PMC2783838
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Abstract

Salt induces oxidative stress in salt-sensitive (SS) animals and man. It is not known whether in SS subjects the low-sodium dietary approaches to stop hypertension (LS-DASH) reduces oxidative stress more than DASH, which is high in antioxidants. To assess the effects of DASH and LS-DASH on oxidative stress, 19 volunteers were studied after 3 weeks of a standardized usual low fruits and vegetables diet (ULFV), followed by 3 weeks on DASH (both diets approximately 120 mmol Na(+) per day), then 3 weeks on LS-DASH (60 mmol Na(+) per day). SS was defined as systolic blood pressure >or=5 mm Hg lower on LS-DASH than DASH. In SS subjects (N=9), systolic blood pressure was lower on LS-DASH (111.0+/-2.0 mm Hg) than DASH (118.0+/-2.2, P<0.01) and ULFV (122.3+/-2.7, P=0.002). In salt-resistant (SR) volunteers (N=10), systolic blood pressure was lower on DASH (113.0+/-1.6) than ULFV (119.0+/-1.8, P<0.05) but not LS-DASH (115.7+/-1.8). Urine F2-isoprostanes, a marker of oxidative stress, were lower in SS subjects on LS-DASH (1.69+/-0.24) than ULFV (3.09+/-0.50, P<0.05) and marginally lower than DASH (2.46+/-0.44, P<0.20). F2-isoprostanes were not different among the three diets in SR volunteers (2.18+/-0.29, 2.06+/-0.29, 2.27+/-0.53, respectively). Aortic augmentation index, a measure of vascular stiffness, was lower in SS subjects on LS-DASH than either DASH or ULFV, and lower on DASH than ULFV in SR volunteers. In SS but not SR subjects, LS-DASH is associated with lower values for F2-isoprostanes and the aortic augmentation index. The results suggest that LS-DASH decreases oxidative stress, improves vascular function and lowers blood pressure in SS but not SR volunteers.

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  1. Chen PY, Gladish RD, Sanders PW . Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats. Hypertension 1998; 31: 918–924. · DOI
  2. Bragulat E, de la Sierra A, Antonio MT, Coca A . Endothelial dysfunction in salt-sensitive essential hypertension. Hypertension 2001; 37: 444–448. · DOI · Paper page

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Metadata

Authors
Al-Solaiman, Y., Jesri, A., Zhao, Y., Morrow, J. D., & Egan, B. M.
Affiliations
  • Medical University of South Carolina (US)
  • Vanderbilt University (US)
Corresponding author
Egan, B M
ORCID
Venue
Journal of Human Hypertension
Publisher
Springer Science and Business Media LLC
Published
2009-04-30
Volume
23
Issue
12
Pages
826-835
ISSN
  • 0950-9240 (ISSN-L)
  • 1476-5527
DOI
10.1038/jhh.2009.32
PMC
PMC2783838
OpenAlex
W2009794559
Cited by
102
References
64
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 6
FWCI
5.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Human Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Medical University of South Carolina
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL04290, K24HL004290, R01HL058794, HL 58794)
  • National Institute of General Medical Sciences (GM 15431, P50GM015431, P01GM015431)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 48831, R01DK048831)
  • National Center on Minority Health and Health Disparities
  • National Center for Research Resources (M01RR001070, RR-01070)
  • National Institute on Minority Health and Health Disparities (P60MD000267, MD00267)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
salt-sensitive hypertension, oxidative stress, F2-isoprostanes, vascular function, aortic augmentation index, vascular stiffness, systolic blood pressure, dietary sodium reduction, antioxidants, hypertension prevention, dietary intervention, blood pressure reduction
MeSH terms
Adult, Aldosterone, Aorta, Blood Pressure, Cardiac Output, Diet, Sodium-Restricted, Elasticity, Electrolytes, Female, Heart Rate, Humans, Hypertension, Insulin, Lipids, Male, Middle Aged, Phenols, Plant Extracts, Potassium Chloride, Renin, Sodium Chloride, Vascular Resistance, Oxidative Stress, F2-Isoprostanes, Young Adult

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