A biometric study of human basal metabolism
Open accessAbstract
HARRIS AND BENEDICT tance less than 8ep from the point P, then X and P lie together in a connected sub-set of M every point of which is at a distance of less than e from the point P. The set M is said to be uniformly connected im kleinen if for every positive number e there exists a positive num- ber 68 such that if P1 and P2 are two points of M at a distance apart less than 58 then they lie together in a connected sub-set of M every point of which is at a distance of less than e from P1. Cf.
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In a study of 395 inpatients referred for nutritional support, no single prediction equation was accurate (within 90-110% of measured REE) in the majority of the population.
“In this study the authors concluded that no single prediction equation was accurate (i.e.within 90e110% of measured REE) in the majority of the population.”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [63]
The Abstract identifies the study population as 136 men, 103 women, and 94 newborn infants who were presumably in good health—not 395 inpatients referred for nutritional support. It presents regression equations for predicting basal metabolism but does not report the claimed 90–110% accuracy assessment or conclusion. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredSeveral factors can influence RMR and the energy expenditure of PA.
“Several factors can influence RMR and the EE of PA;38, 39, 40”
From 2024 Adult Compendium of Physical Activities: A third update of the energy costs of human activities (2024) · cites this paper as [38]
The Abstract identifies age, weight, stature, sex, food intake, and muscular activity as factors relevant to basal metabolism or its measurement. It does not address factors that influence energy expenditure during physical activity, so that part of the sentence is unsupported by this source. (LLM, conf=0.86)
Experimental — accuracy not yet measuredStudies consistently note differences in RMR based on age, sex, height, and body weight or body composition and recommend accounting for these factors to estimate RMR when measured RMR values are unavailable.
“Studies consistently note differences in RMR based on age, sex, height, and body weight or body composition and recommend accounting for these factors to estimate RMR when measured RMR values are unavailable to use as the denominator in computing METs (i.e., relative METs).38,39,42”
From 2024 Adult Compendium of Physical Activities: A third update of the energy costs of human activities (2024) · cites this paper as [38]
Kozey et al. have proposed a corrected MET to adjust for individual differences in RMR using the Harris-Benedict RMR equation.
“Kozey et al.43 have proposed a corrected MET to adjust for individual differences in RMR using the Harris-Benedict RMR equation.38”
From 2024 Adult Compendium of Physical Activities: A third update of the energy costs of human activities (2024) · cites this paper as [38]
The 1985 FAO/WHO/UNU approach to the estimation of energy requirements is a refinement of the method first described by Bedale.
“It is, therefore, of interest to note that the 1985 FAO/WHO/UNU 1 approach to the estimation of energy requirements is a refinement of the method first described by Bedale 12 .”
From Basal metabolic rate studies in humans: measurement and development of new equations (2005) · cites this paper as [12]
The paper’s Abstract describes measurements of basal metabolism and equations for predicting daily heat production. A search for Bedale and the 1985 FAO/WHO/UNU approach found no passage addressing whether that approach refined Bedale’s method. (LLM, conf=0.76)
Experimental — accuracy not yet measured
The first comprehensive study to use BMR as the basis to estimate human energy requirements and hence food requirements was described by Bedale.
“While BMR measurements were used in clinical diagnosis during the early part of the 20th century, the first comprehensive study to use BMR as the basis to estimate human energy requirements and hence food requirements was described by Bedale 12 .”
From Basal metabolic rate studies in humans: measurement and development of new equations (2005) · cites this paper as [12]
The Abstract describes measuring and predicting basal metabolism and mentions possible applications to rationing. It does not mention Bedale or establish which study first used BMR to estimate human energy and food requirements (searched: Bedale, first comprehensive study, food requirements). (LLM, conf=0.76)
Experimental — accuracy not yet measuredThis lower heat production in women is partly compensated for by their lower body surface area, but not completely.
“This lower heat production in women is partly compensated for by their lower body surface area, but not completely [66].”
From Drivers of diversity in human thermal perception – A review for holistic comfort models (2018) · cites this paper as [66]
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- Authors
- Harris, J. A., & Benedict, F. G.
- Affiliations
- Carnegie Institution for Science (US)
- Nutrition Laboratory and Station for Experimental Evolution, Carnegie Institution of Washington
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1918-12
- Volume
- 4
- Issue
- 12
- Pages
- 370-373
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1091498
- OpenAlex
- W2155941545
- Cited by
- 1,980
- References
- 0
- Citations by year
- 2026: 82 · 2025: 114 · 2024: 146 · 2023: 151 · 2022: 132 · 2021: 151 · 2020: 169 · 2019: 159 · 2018: 122 · 2017: 131 · 2016: 106 · 2015: 73 · 2014: 78 · 2013: 70 · 2012: 70
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Health Sciences › Medicine › Surgery › Biomedical and Chemical Research
- Keywords
- basal metabolic rate, human metabolism, biometric variation, Harris-Benedict equation, metabolic rate
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