RETRACTED: IL-12 Deficiency Exacerbates Inflammatory Responses in UV-Irradiated Skin and Skin Tumors

Meeran, Syed M.; Punathil, Thejass; Katiyar, Santosh K.

doi:10.1038/jid.2008.140

Cited by 73Skin Protection and AgingNonmelanoma Skin Cancer StudiesPsoriasis: Treatment and Pathogenesis

RETRACTED: IL-12 Deficiency Exacerbates Inflammatory Responses in UV-Irradiated Skin and Skin Tumors

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Meeran, Syed M., Punathil, Thejass, Katiyar, Santosh K.·2008·Journal of Investigative Dermatology

DOI 10.1038/jid.2008.140PMC PMC2574589

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Abstract

IL-12 deficiency has been shown to promote photocarcinogenesis in mice. As UVB-induced inflammation is an important tumor-promoting event in the development of skin tumors, we determined the effects of IL-12-deficiency on UVB-induced inflammatory responses in mice. For this purpose, IL-12-knockout (IL-12 KO) and their wild-type counterparts were subjected to a photocarcinogenesis protocol; skin and tumor samples were collected at the termination of the experiment, and analyzed for biomarkers of inflammation and their mediators. We found that the levels of infiltrating leukocytes, myeloperoxidase, proliferating cell-nuclear antigen (PCNA), COX-2, PGE2, and the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6 were higher in the UVB-exposed skin of IL-12 KO than in that of wild-type mice. In a short-term experiment, pretreatment of IL-12 KO mice with rIL-12 (50 ng per mouse) before each exposure to UVB increased the repair rate of UVB-induced cyclobutane pyrimidine dimers, while inhibiting UVB-induced increases in myeloperoxidase, COX-2, PGE2, PCNA, TNF-alpha, and IL-1beta in the skin as compared with non-rIL-12-treated IL-12 KO mice. Similarly, tumors of IL-12 KO mice expressed higher levels of inflammatory responses than those of wild-type mice. Together, our data suggest that IL-12 KO mice are more susceptible to both UVB-induced inflammation and photocarcinogenesis because of the deficiency in the repair of UVB-induced DNA damage.

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The MPO system has been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis.
“beyond a role in cutaneous innate immunity, the MPO system has also been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis (51–59).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [53]

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
Bradley, P. P., Priebat, D. A., Christensen, R. D., & Rothstein, G. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12506462 · Cited by 3,628 · see citing works
The role of cyclooxygenases in inflammation, cancer, and development
Williams, C. S., Mann, M., & DuBois, R. N. (1999) · Oncogene · doi:10.1038/sj.onc.1203286 · Cited by 1,417 · see citing works
Antitumor and antimetastatic activity of interleukin 12 against murine tumors.
Brunda, M. J., Luistro, L. L., Warrier, R. R., Wright, R. B., Hubbard, B. R., Murphy, M. E., Wolf, S. F., & Gately, M. K. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1223 · Cited by 1,197 · see citing works
Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
Trinchieri, G. (1994) · Blood · doi:10.1182/blood.v84.12.4008.bloodjournal84124008 · Cited by 1,045 · see citing works
Recombinant IL-12 administration induces tumor regression in association with IFN- <i>gamma</i> production.
Nastala, C. L., Edington, H. D., McKinney, T. G., Tahara, H., Nalesnik, M. A., Brunda, M. J., Gately, M. K., Wolf, S. F., Schreiber, R. D., Storkus, W. J., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1697 · Cited by 780 · see citing works
COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer
Buckman, S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.723 · Cited by 593 · see citing works
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition
Pentland, A. P., Schoggins, J. W., Scott, G., Khan, K. N. M., & Han, R. (1999) · Carcinogenesis · doi:10.1093/carcin/20.10.1939 · Cited by 328 · see citing works
Interleukin-12
Brunda, M. J. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.2.280 · Cited by 297 · see citing works
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
Schwarz, A., Ständer, S., Berneburg, M., Böhm, M., Kulms, D., van Steeg, H., Grosse-Heitmeyer, K., Krutmann, J., & Schwarz, T. (2002) · Nature Cell Biology · doi:10.1038/ncb717 · Cited by 276 · see citing works
The role of IL‐4, IL‐10, and TNF‐α in the immune suppression induced by ultraviolet radiation
Rivas, J. M., & Ullrich, S. E. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.6.769 · Cited by 223 · see citing works
Photocarcinogenesis: Mechanisms, Models and Human Health Implications: Introduction
Mukhtar, H., & Elmets, C. A. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03040.x · Cited by 219 · see citing works
Localization of Cyclooxygenase-2 in Human Sporadic Colorectal Adenomas
Chapple, K. S., Cartwright, E. J., Hawcroft, G., Tisbury, A., Bonifer, C., Scott, N., Windsor, A. C. J., Guillou, P. J., Markham, A. F., Coletta, P. L., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64759-1 · Cited by 218 · see citing works
Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair
Katiyar, S., Elmets, C. A., & Katiyar, S. K. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.08.004 · Cited by 212 · see citing works
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
Zou, J.-P., Yamamoto, N., Fujii, T., Takenaka, H., Kobayashi, M., Herrmann, S. H., Wolf, S. F., Fujiwara, H., & Hamaoka, T. (1995) · International Immunology · doi:10.1093/intimm/7.7.1135 · Cited by 195 · see citing works
Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (−)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production
Katiyar, S. K., Challa, A., McCormick, T. S., Cooper, K. D., & Mukhtar, H. (1999) · Carcinogenesis · doi:10.1093/carcin/20.11.2117 · Cited by 193 · see citing works
Amount of interleukin 12 available at the tumor site is critical for tumor regression.
Colombo, M. P., Vagliani, M., Spreafico, F., Parenza, M., Chiodoni, C., Melani, C. C., & Stoppacciaro, A. (1996) · PubMed · Cited by 174 · see citing works
Effect of interleukin‐1β, tumour necrosis factor‐α and interferon‐γ on the induction of cyclo‐oxygenase‐2 in cultured human airway smooth muscle cells
Pang, L., & Knox, A. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701152 · Cited by 172 · see citing works
Cyclooxygenase‐deficient Mice: A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis
LANGENBACH, R., LOFTIN, C. D., LEE, C., & TIANO, H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08723.x · Cited by 170 · see citing works
Inhibition of cutaneous ultraviolet light B–mediated inflammation and tumor formation with topical celecoxib treatment
Wilgus, T. A., Koki, A. T., Zweifel, B. S., Kusewitt, D. F., Rubal, P. A., & Oberyszyn, T. M. (2003) · Molecular Carcinogenesis · doi:10.1002/mc.10141 · Cited by 154 · see citing works
Photoaging. Manifestations, prevention, and treatment.
Kligman, L. H. (1986) · PubMed · Cited by 152 · see citing works
An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors.
Scott, K. A., Moore, R. J., Arnott, C. H., East, N., Thompson, R. G., Scallon, B. J., Shealy, D. J., & Balkwill, F. R. (2003) · PubMed · Cited by 150 · see citing works
Photoaging: Manifestations, Prevention, and Treatment
Kligman, L. H. (1989) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30708-0 · Cited by 147 · see citing works
Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer
Chen, L., Chen, D., Block, E., O’Donnell, M. A., Kufe, D. W., & Clinton, S. K. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.351 · Cited by 144 · see citing works
Increased prostaglandins E2 and F2alpha in human skin at 6 and 24 h after ultraviolet B irradiation (290− 320 nm).
Black, A., Greaves, M. W., Hensby, C., & Plummer, N. A. (1978) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1978.tb01650.x · Cited by 139 · see citing works
Photoaging
Kligman, L. H. (1986) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30815-5 · Cited by 137 · see citing works
Ultraviolet B (UVB)-Induced COX-2 Expression in Murine Skin: An Immunohistochemical Study
Athar, M., An, K. P., Morel, K. D., Kim, A. L., Aszterbaum, M., Longley, J. B., Epstein, E. H., & Bickers, D. R. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4201 · Cited by 125 · see citing works
Kinetics of UV Light–induced Cyclobutane Pyrimidine Dimers in Human Skin In Vivo: An Immunohistochemical Analysis of both Epidermis and Dermis
Katiyar, S., Matsui, M., & Mukhtar, H. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0720788koulic2.0.co2 · Cited by 122 · see citing works
Arachidonic Acid Metabolites in Cutaneous Carcinomas
Vanderveen, E. E. (1986) · Archives of Dermatology · doi:10.1001/archderm.1986.01660160063020 · Cited by 109 · see citing works
Grape Seed Proanthocyanidins Induce Apoptosis through p53, Bax, and Caspase 3 Pathways
Roy, A. M., Baliga, M. S., Elmets, C. A., & Katiyar, S. K. (2005) · Neoplasia · doi:10.1593/neo.04412 · Cited by 104 · see citing works
Interleukin 12: Basic Biology and Potential Applications in Cancer Treatment
Robertson, M. J., & Ritz, J. (1996) · The Oncologist · doi:10.1634/theoncologist.1-1-88 · Cited by 98 · see citing works
Oxidative Stress, Disease and Cancer
Singh, K. K. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/p413 · Cited by 86 · see citing works
Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-κB signaling
Katiyar, S. K., & Meeran, S. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.10.049 · Cited by 86 · see citing works
T Cell- and NK Cell-Independent Inhibition of Hepatic Metastases by Systemic Administration of an IL-12-Expressing Recombinant Adenovirus
Siders, W., Wright, P. W., Hixon, J. A., Alvord, W. G., Back, T. C., Wiltrout, R. H., & Fenton, R. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5465 · Cited by 70 · see citing works
Interleukin-12-deficient mice are at greater risk of UV radiation–induced skin tumors and malignant transformation of papillomas to carcinomas
Meeran, S. M., Mantena, S. K., Meleth, S., Elmets, C. A., & Katiyar, S. K. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0003 · Cited by 69 · see citing works
Epidermal Interleukin-1 is Increased in Cutaneous T-Cell Lymphoma
Tron, V. A., Rosenthal, D., & Sauder, D. N. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12456433 · Cited by 60 · see citing works
Enhanced Photocarcinogenesis in Interleukin-12–Deficient Mice
Maeda, A., Schneider, S. W., Kojima, M., Beissert, S., Schwarz, T., & Schwarz, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3614 · Cited by 49 · see citing works
Metabolic Targets of Cancer Chemoprevention: Interruption of Tumor Development by Inhibitors of Arachidonic Acid Metabolism
Marks, F., Fürstenberger, G., & Müller‐Decker, K. (1999) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-59945-3_4 · Cited by 43 · see citing works
Arachidonic Acid Metabolites in Cutaneous Carcinomas
Rustin, M. H. A. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660260027002 · Cited by 42 · see citing works
Oxidative Stress and Photocarcinogenesis: Strategies for Prevention
Katiyar, S. K. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948046_0033 · Cited by 23 · see citing works
Untitled work
(1999) · doi:10.1562/0031-8655(1999)069

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Review: Ultraviolet radiation and skin cancer
Narayanan, D. L., Saladi, R. N., & FOX, J. L. (2010) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2010.04474.x · Cited by 1,186 · see citing works
Ultraviolet light and ocular diseases
Yam, J. C., & Kwok, A. K. H. (2014) · International ophtalmology · doi:10.1007/s10792-013-9791-x · Cited by 294 · see citing works
Defense potential of secondary metabolites in medicinal plants under UV-B stress
Takshak, S., & Agrawal, S. B. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.02.002 · Cited by 240 · see citing works
Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation
Kim, I., & He, Y. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.08.005 · Cited by 225 · see citing works
Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
Kim, H.-S., Kim, M.-J., Kim, E. J., Yang, Y. D., Lee, M., & Lim, J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.008 · Cited by 175 · see citing works
RETRACTED: Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2and prostaglandin E2receptors
Singh, T., Vaid, M., Katiyar, N., Sharma, S., & Katiyar, S. K. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq215 · Cited by 135 · see citing works
Retracted
Inhibition of UVB-Induced Skin Tumor Development by Drinking Green Tea Polyphenols Is Mediated Through DNA Repair and Subsequent Inhibition of Inflammation
Meeran, S. M., Akhtar, S., & Katiyar, S. K. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.354 · Cited by 133 · see citing works
Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs
Laikova, K. V., Oberemok, V. V., Krasnodubets, A. M., Gal’chinsky, N. V., Useinov, R. Z., Novikov, I. A., Temirova, Z. Z., Владимирович, Г. М., Shved, N. A., Kumeiko, V. V., et al. (2019) · Molecules · doi:10.3390/molecules24081516 · Cited by 111 · see citing works
Inflammasome Activation of IL‐1 Family Mediators in Response to Cutaneous Photodamage†
Nasti, T. H., & Timares, L. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01182.x · Cited by 106 · see citing works
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective
Teng, Y., Yu, Y., Li, S., Huang, Y., Xu, D., Tao, X., & Fan, Y. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.666528 · Cited by 115 · see citing works
Dietary Grape Seed Proanthocyanidins Inhibit UVB-Induced Cyclooxygenase-2 Expression and Other Inflammatory Mediators in UVB-Exposed Skin and Skin Tumors of SKH-1 Hairless Mice
Sharma, S. D., & Katiyar, S. K. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0050-9 · Cited by 93 · see citing works
Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation
Vaid, M., Sharma, S. D., & Katiyar, S. K. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq186 · Cited by 79 · see citing works
Silymarin-Loaded Nanostructured Lipid Carrier Gel for The Treatment of Skin Cancer
Iqbal, B., Ali, J., Ganguli, M., Mishra, S., & Baboota, S. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0235 · Cited by 69 · see citing works
Emerging functions of c-kit and its ligand stem cell factor in dendritic cells
Ray, P., Krishnamoorthy, N., & Ray, A. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6752 · Cited by 65 · see citing works
Signaling of c‐kit in dendritic cells influences adaptive immunity
Ray, P., Krishnamoorthy, N., Oriss, T. B., & Ray, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05122.x · Cited by 65 · see citing works
Timosaponin AIII inhibits melanoma cell migration by suppressing COX ‐2 and in vivo tumor metastasis
Kim, K. M., Im, A., Kim, S., Hyun, J. W., & Chae, S. (2015) · Cancer Science · doi:10.1111/cas.12852 · Cited by 62 · see citing works
The many interactions between the innate immune system and the response to radiation
Candéias, S. M., & Testard, I. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.02.007 · Cited by 54 · see citing works
Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
Vaid, M., Singh, T., & Katiyar, S. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021539 · Cited by 52 · see citing works
Retracted
Reflectance Confocal Microscopy of Aging Skin and Skin Cancer
Guida, S., Pellacani, G., Ciardo, S., & Longo, C. (2021) · Dermatology Practical & Conceptual · doi:10.5826/dpc.1103a68 · Cited by 50 · see citing works
Autocrine abscisic acid mediates the UV‐B‐induced inflammatory response in human granulocytes and keratinocytes
Bruzzone, S., Basile, G., Mannino, E., Sturla, L., Magnone, M., Grozio, A., Salis, A., Fresia, C., Vigliarolo, T., Guida, L., et al. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22987 · Cited by 48 · see citing works
Photoprotective effects of Romanian propolis on skin of mice exposed to UVB irradiation
Bolfă, P., Marica, R., Petruta, A., Dezmirean, D., Stan, L., Vlase, L., Damian, G., Cătoi, C., Filip, G. A., & Clichici, S. V. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.078 · Cited by 47 · see citing works
From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention
Mitsiogianni, M., Amery, T., Franco, R., Zoumpourlis, V., Pappa, A., & Panayiotidis, M. I. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.001 · Cited by 48 · see citing works
Toll-Like Receptor-4 Deficiency Enhances Repair of UVR-Induced Cutaneous DNA Damage by Nucleotide Excision Repair Mechanism
Ahmad, I., Simanyi, E., Guroji, P., Tamimi, I. A., delaRosa, H. J., Nagar, A., Nagar, P., Katiyar, S. K., Elmets, C. A., & Yusuf, N. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.530 · Cited by 43 · see citing works
Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer
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Hewage, S. R. K. M., Piao, M. J., Kim, K. C., Cha, J. W., Han, X., Choi, Y. H., Chae, S., & Hyun, J. W. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.130 · Cited by 37 · see citing works
Antioxidant and Anti‐Inflammatory Effects of Shungite against Ultraviolet B Irradiation‐Induced Skin Damage in Hairless Mice
Sajo, M. E. J., Kim, C.-S., Kim, S., Shim, K. Y., Kang, T.-Y., & Lee, K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7340143 · Cited by 37 · see citing works
Repurposing of Drug Candidates for Treatment of Skin Cancer
Cortés, H., Reyes‐Hernández, O. D., Alcalá-Alcalá, S., Bernal-Chávez, S. A., Caballero-Florán, I. H., González‐Torres, M., Sharifi‐Rad, J., Carmen, M. G., Figueroa‐González, G., & Leyva‐Gómez, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.605714 · Cited by 36 · see citing works
Lonicera caerulea fruits reduce UVA-induced damage in hairless mice
Vostálová, J., Galandáková, A., Palíková, I., Jitka Ulrichová, A., Doležal, D., Lichnovská, R., Vrbková, J., & Svobodová, A. R. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.07.024 · Cited by 34 · see citing works
Leptin deficiency-induced obesity exacerbates ultraviolet B radiation-induced cyclooxygenase-2 expression and cell survival signals in ultraviolet B-irradiated mouse skin
Sharma, S. D., & Katiyar, S. K. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.010 · Cited by 34 · see citing works
Development and characterization of novel 1-(1-Naphthyl)piperazine-loaded lipid vesicles for prevention of UV-induced skin inflammation
Menezes, A. C., Campos, P. M., Euletério, C., Simões, S., Praça, F. S. G., Bentley, M. V. L. B., & Ascenso, A. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.04.023 · Cited by 31 · see citing works
Inhibition of interleukin‐12 and/or interleukin‐23 for the treatment of psoriasis: What is the evidence for an effect on malignancy?
Ergen, E. N., & Yusuf, N. (2018) · Experimental Dermatology · doi:10.1111/exd.13676 · Cited by 31 · see citing works
Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma.
Gao, M. J., Yuan, C., Wang, X., Ban, C., & Zhang, F. (2017) · PubMed Central · Cited by 29 · see citing works
Drug delivery strategies for chemoprevention of UVB ‐induced skin cancer: A review
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Hossain, M. A., & Rahman, M. (2015) · Journal of Textile Science and Technology · doi:10.4236/jtst.2015.13010 · Cited by 28 · see citing works
Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock
Bee, L., Marini, S., Pontarin, G., Ferraro, P., Costa, R., Albrecht, U., & Celotti, L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv081 · Cited by 26 · see citing works
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Hasegawa, T., Shimada, S., Ishida, H., & Nakashima, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077308 · Cited by 26 · see citing works
High-fat diet exacerbates inflammation and cell survival signals in the skin of ultraviolet B-irradiated C57BL/6 mice
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Oka, M., Edamatsu, H., Kunisada, M., Hu, L., Takenaka, N., Sakaguchi, M., Kataoka, T., & Nishigori, C. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.10 · Cited by 24 · see citing works
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Ayroldi, E., Bastianelli, A., Cannarile, L., Petrillo, M. G., Delfino, D. V., & Fierabracci, A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798157649 · Cited by 22 · see citing works
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Yoon, K. S., Huang, X. Z., Yoon, Y., Kim, S., Song, S. B., Chang, B. S., Kim, D.-H., & Lee, K. J. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1671 · Cited by 19 · see citing works
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Retracted
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Retracted
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(2017) · CRC Press eBooks · doi:10.1201/9781315364476-5
Sun protection and skin cancer
Leonforte, F., Smith, A. C. G., Patel, T. M., & Magdum, A. A. (2011) · BMJ · doi:10.1136/sbmj.d6801
Skin Cancer: An Overview
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Franklin, S. J. (2015) · UA Campus Repository (The University of Arizona)
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Usmani, Z., Usmani, Z., Ahmad, A., Jahan, S., Akhtar, M., Aqil, M., & Mujeeb, M. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202502609
Xeroderma pigmentosum : understanding pigmentation in addition to the initiation and progression of skin cancer
Kasraian, Z. (2018) · doi:10.70675/a1868dd1z7486z4a30z9abbz9078cd2b51e3
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Mir, J. E. (2023) · doi:10.70675/f302affeze011z4a0fzb103z37f18487f7b8

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Meeran, S. M., Mantena, S. K., Meleth, S., Elmets, C. A., & Katiyar, S. K. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0003 · Cited by 69 · see citing works
Enhanced Photocarcinogenesis in Interleukin-12–Deficient Mice
Maeda, A., Schneider, S. W., Kojima, M., Beissert, S., Schwarz, T., & Schwarz, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3614 · Cited by 49 · see citing works
Interleukin-12 and photocarcinogenesis
Katiyar, S. K. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.11.017 · Cited by 31 · see citing works
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Jantschitsch, D., Weichenthal, M., Proksch, E., Schwarz, T., & Schwarz, A. (2012) · Cited by 1 · see citing works

Authors: Meeran, S. M., Punathil, T., & Katiyar, S. K.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Meeran, Syed M.
Katiyar, Santosh K.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2008-11
Volume: 128
Issue: 11
Pages: 2716-2727
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/jid.2008.140
PMC: PMC2574589
OpenAlex: W2032449786
Cited by: 73
References: 42
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 10 · 2012: 1
FWCI: 7.84
Type: journal article
Language: en
Status: Retracted
Update notices: retraction (2008-11-01)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2587 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Nurses Organization of Veterans Affairs
National Center for Complementary and Alternative Medicine (1 RO1 AT002536)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: UVB-induced skin inflammation, photocarcinogenesis, skin tumors, DNA repair, cyclobutane pyrimidine dimers, myeloperoxidase, cyclooxygenase-2, prostaglandin E2, inflammatory cytokines, TNF-α, IL-1β, interleukin-6, retracted article
MeSH terms: Animals, Cell Movement, DNA Damage, Female, Inflammation, Leukocytes, Neoplasms, Radiation-Induced, Skin, Skin Neoplasms, Dinoprostone, Mice, Knockout, Interleukin-12, Proliferating Cell Nuclear Antigen, Cyclin D1, Genetic Predisposition to Disease, Mice, Cyclooxygenase 2

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RETRACTED: IL-12 Deficiency Exacerbates Inflammatory Responses in UV-Irradiated Skin and Skin Tumors

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