Cyclooxygenase‐deficient Mice: A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512 · see citing works

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

Oshima, M., Dinchuk, J. E., Kargman, S., Oshima, H., Hancock, B. C., Kwong, E. C., Trzăskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,363 · see citing works

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,292 · see citing works

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272 · see citing works

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164 · see citing works

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Kujubu, D. A., Fletcher, B. S., Varnum, B. C., Lim, R. W., & Herschman, H. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98774-0 · Cited by 1,786 · see citing works

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L., & Simmons, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2692 · Cited by 1,707 · see citing works

Aspirin Use and Reduced Risk of Fatal Colon Cancer

Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,682 · see citing works

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591 · see citing works

Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice

Lim, H. J., Paria, B. C., Das, S., Dinchuk, J. E., Langenbach, R. I., Trzăskos, J. M., & Dey, S. K. (1997) · Cell · doi:10.1016/s0092-8674(00)80402-x · Cited by 1,426 · see citing works

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

Meade, E. A., Smith, W. L., & DeWitt, D. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53294-4 · Cited by 1,262 · see citing works

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., & Worley, P. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90192-t · Cited by 1,224 · see citing works

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

Sano, H., Kawahito, Y., Wilder, R. L., Hashiramoto, A., Mukai, S., Asai, K., Kimura, S., Kato, H., Kondo, M., & Hla, T. (1995) · PubMed · Cited by 1,126 · see citing works

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

Langenbach, R. J., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kluckman, K. D., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90126-4 · Cited by 1,120 · see citing works

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110 · see citing works

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

Morham, S. G., Langenbach, R. J., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J. C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90125-6 · Cited by 1,080 · see citing works

Cytoprotection by prostaglandins

Robert, A. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90235-x · Cited by 1,074 · see citing works

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., JAFFEE, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., et al. (1995) · Nature · doi:10.1038/378406a0 · Cited by 967 · see citing works

Aspirin use and risk of fatal cancer.

Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W. D., & Heath, C. W. (1993) · PubMed · Cited by 870 · see citing works

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

Harris, R. C., McKanna, J. A., Akai, Y., Jacobson, H. R., DuBois, R. N., & Breyer, M. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117620 · Cited by 856 · see citing works

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

Kargman, S., O’Neill, G. P., Vickers, P. J., Evans, J. F., Mancini, J. A., & Jothy, S. (1995) · PubMed · Cited by 831 · see citing works

Pharmacological analysis of cyclooxygenase-1 in inflammation

Smith, C., Zhang, Y., Koboldt, C. M., Muhammad, J., Zweifel, B. S., Shaffer, A. F., Talley, J. J., Masferrer, J. L., Seibert, K., & Isakson, P. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13313 · Cited by 802 · see citing works

Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs

Vane, J. R., & Botting, R. M. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00203-9 · Cited by 723 · see citing works

Prostaglandin Endoperoxide H Synthases-1 and -2

Smith, W. L., & DeWitt, D. L. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60430-7 · Cited by 711 · see citing works

Towards a better aspirin

Vane, J. R. (1994) · Nature · doi:10.1038/367215a0 · Cited by 698 · see citing works

Aspirin and the potential role of prostaglandins in colon cancer.

Marnett, L. J. (1992) · PubMed · Cited by 685 · see citing works

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano‐Coico, L., Shiff, S. I., & Rigas, B. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00181-5 · Cited by 604 · see citing works

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

DeWitt, D. L., & Smith, W. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1412 · Cited by 598 · see citing works

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572 · see citing works

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

O’Banion, M. K., Sadowski, H. B., Winn, V. D., & Young, D. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54491-4 · Cited by 557 · see citing works

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

Boolbol, S. K., Dannenberg, A. J., Chadburn, A., Martucci, C., Guo, X., Ramonetti, J. T., Abreu-Goris, M., Newmark, H. L., Lipkin, M. L., DeCosse, J. J., et al. (1996) · PubMed · Cited by 545 · see citing works

A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

Rosenberg, L. A., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Stolley, P. D., & Shapiro, S. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.5.355 · Cited by 500 · see citing works

Differential activation of adipogenesis by multiple PPAR isoforms.Preprint

Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 474 · see citing works

The mechanisms of action of nonsteroidal antiinflammatory drugs

Abramson, S. B., & Weissmann, G. (1989) · Arthritis & Rheumatism · doi:10.1002/anr.1780320102 · Cited by 469 · see citing works

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

Merlie, J. P., Fagan, D., Mudd, J. L., & Needleman, P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68959-8 · Cited by 429 · see citing works

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

Dubois, R. N., Radhika, A., Reddy, B., & Entingh, A. J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613017 · Cited by 425 · see citing works

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

Rao, C. V., Rivenson, A., Simi, B., Zang, E. A., Kelloff, G. V., Steele, V. E., & Reddy, B. S. (1995) · PubMed · Cited by 402 · see citing works

Molecular mechanisms of diverse actions of prostanoid receptors

Negishi, M., Sugimoto, Y., & Ichikawa, A. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00146-4 · Cited by 391 · see citing works

Cyclooxygenase-2: Regulation and relevance in inflammation

Mitchell, J. A., Larkin, S. W., & Williams, T. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00212-x · Cited by 375 · see citing works

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

Elder, D. J. E., Halton, D. E., Hague, A., & Paraskeva, C. (1997) · PubMed · Cited by 366 · see citing works

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

Piazza, G. A., Alberts, D. S., Hixson, L. J., Paranka, N. S., Li, H., Finn, T., Bogert, C. L., Guillen, J. M., Brendel, K., Gross, P. H., et al. (1997) · PubMed · Cited by 361 · see citing works

Anovulation in Cyclooxygenase-2-Deficient Mice Is Restored by Prostaglandin E2 and Interleukin-1β*

Davis, B. J., Lennard, D. E., Lee, C. A., Tiano, H. F., Morham, S. G., Wetsel, W. C., & Langenbach, R. J. (1999) · Endocrinology · doi:10.1210/endo.140.6.6715 · Cited by 352 · see citing works

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

Piazza, G. A., Rahm, A. K., Finn, T. S., Fryer, B., Li, H., Stoumen, A. L., Pamukcu, R., & Ahnen, D. J. (1997) · PubMed · Cited by 351 · see citing works

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

Reddy, B. S., Rao, C. V., Rivenson, A., & Kelloff, G. V. (1993) · Carcinogenesis · doi:10.1093/carcin/14.8.1493 · Cited by 344 · see citing works

Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone

Mitchell, J. A., Belvisi, M. G., Akarasereenont, P., Robbins, R., Kwon, O. J., Croxtall, J. J., Barnes, P. J., & Vane, J. R. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17093.x · Cited by 308 · see citing works

Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs

Xie, W., Robertson, D. L., & Simmons, D. L. (1992) · Drug Development Research · doi:10.1002/ddr.430250402 · Cited by 306 · see citing works

Renal Toxicity of the Nonsteroidal Anti-Inflammatory Drugs

Murray, M. D., & Brater, D. C. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.002251 · Cited by 295 · see citing works

Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.

Verma, A. K., Ashendel, C. L., & Boutwell, R. K. (1980) · PubMed · Cited by 271 · see citing works

Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

Kalgutkar, A. S. S., Crews, B. C., Rowlinson, S. W., Garner, C., Seibert, K., & Marnett, L. J. (1998) · Science · doi:10.1126/science.280.5367.1268 · Cited by 257 · see citing works

Opposing actions of prostaglandins and oxytocin determine the onset of murine labor

Gross, G. A., Imamura, T., Luedke, C., Vogt, S. K., Olson, L. M., Nelson, D. M., Sadovsky, Y., & Muglia, L. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11875 · Cited by 238 · see citing works

Nonsteroidal antiinflammatory drugs and the gastrointestinal tract the double-edged sword

Lichtenstein, D. R., Syngal, S., & Wolfe, M. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380103 · Cited by 220 · see citing works

Prostaglandin Synthase-1 and Prostaglandin Synthase-2 Are Coupled to Distinct Phospholipases for the Generation of Prostaglandin D2 in Activated Mast Cells

Reddy, S. T., & Herschman, H. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3231 · Cited by 171 · see citing works

CYCLOOXYGENASE-2 INHIBITORS

Masferrer, J. L., Isakson, P. C., & Seibert, K. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70252-1 · Cited by 165 · see citing works

Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1

Shoemaker, A. R., Gould, K. A., Luongo, C., Moser, A. R., & Dove, W. F. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00041-8 · Cited by 151 · see citing works

Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

Müller‐Decker, K., Scholz, K., Marks, F., & Fürstenberger, G. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940120106 · Cited by 147 · see citing works

Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)

Fürstenberger, G., Gross, M., & Marks, F. (1989) · Carcinogenesis · doi:10.1093/carcin/10.1.91 · Cited by 116 · see citing works

Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?

Alberts, D. S., Hixson, L. J., Ahnen, D. J., Bogert, C. L., Einspahr, J. G., Paranka, N. S., Brendel, K., Gross, P. H., Pamukcu, R., & Burt, R. W. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590804 · Cited by 100 · see citing works

R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.

Wechter, W. J., Kantoci, D., Murray, E. D., Quiggle, D. D., Leipold, D. D., Gibson, K. M., & McCracken, J. D. (1997) · PubMed · Cited by 98 · see citing works

Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression

Narko, K., Ristimaki, A. P., MacPhee, M. J., Smith, E., Haudenschild, C. C., & Hla, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21455 · Cited by 97 · see citing works

Multiple Controls in Inflammation

Cirino, G. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00215-3 · Cited by 95 · see citing works

Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21

Lim, I. K., Lee, M. S., Ryu, M. S., Park, T. J., Fujiki, H., Eguchi, H., & Paik, W. K. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199809)23:1 · Cited by 74 · see citing works

Constitutive expression of prostaglandin endoperoxide G/H synthetase (PGHS)-2 but not PGHS-1 in hum an tracheal epithelial cells in vitro

Walenga, R. W., KESTER, M. A., Coroneos, E., Butcher, S., Dwivedi, R., & Statt, C. (1996) · Prostaglandins · doi:10.1016/s0090-6980(96)00101-3 · Cited by 51 · see citing works

Renal Toxicity of Non-Steroidal Anti-Inflammatory Drugs

Black, H. E. (1986) · Toxicologic Pathology · doi:10.1177/019262338601400110 · Cited by 51 · see citing works

Renal Effects of Over‐the‐Counter Analgesics

Whelton, A. (1995) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1995.tb04088.x · Cited by 47 · see citing works

Renal Toxicity of Non-Steroidal Anti-Inflammatory Drugs

Murray, M. D. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.33.1.435 · Cited by 25 · see citing works

Radical causes of cancer

Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690 · see citing works

Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms

Nichols, J. A., & Katiyar, S. K. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-1001-3 · Cited by 1,103 · see citing works

Intake of high-fat diet stimulates the risk of ultraviolet radiation-induced skin tumors and malignant progression of papillomas to carcinoma in skh-1 hairless mice

Vaid, M., Singh, T., Prasad, R., & Katiyar, S. K. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.030 · Cited by 18 · see citing works

Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling

Paccani, S. R., Patrussi, L., Ulivieri, C., Masferrer, J. L., D'Elios, M. M., & Baldari, C. T. (2005) · Blood · doi:10.1182/blood-2004-04-1299 · Cited by 17 · see citing works

Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse

Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13 · see citing works

AMP deaminase isozymes in human tissues

Ogasawara, N., Goto, H., Yamada, Y., et al. (1982) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(82)90337-3 · Cited by 131 · see citing works

Human enolase isozymes: electrophoretic and biochemical evidence for three loci

Pearce, J. M., Edwards, Y. H., & Harris, H. (1976) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1976.tb00130.x · Cited by 61 · see citing works

Superoxide Dismutase Isozymes in Different Human Tissues, Their Genetic Control and Intracellular Localization

Beckman, G., Lundgren, E., & Tärnvik, A. (1973) · Human Heredity · doi:10.1159/000152594 · Cited by 75 · see citing works

Organ-specific distribution of isozymes of 5′-nucleotide phosphodiesterase in mouse

Gross, S. C., Watabe, M., Goodarzi, G., et al. (1990) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(90)90323-l · Cited by 4 · see citing works

STUDIES OF ISOZYMES IN THE TISSUES OF RATTUS NIVIVENTER

BiQian, F. (1997) · Acta Theriologica Sinica