Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin
Open accessAbstract
In photoaged skin, wrinkles result from an increased degradation and a decreased de novo synthesis of collagen fibers. At the molecular level, photoaged skin is characterized by increased amounts of large-scale deletions of the mitochondrial (mt) genome such as the 4,977 bp common deletion. The common deletion can be generated in dermal fibroblasts through repetitive ultraviolet (UV) A irradiation, and this was found to be associated with an increased expression of the collagen-degrading enzyme matrix metalloproteinase-1 (MMP-1). These studies did not clarify whether increased MMP-1 expression was caused by a disturbance of mtDNA integrity or whether it occurred independently. We have therefore generated a phenocopy of cells bearing large-scale deletions of mtDNA by gradually depleting the mtDNA from unirradiated human skin fibroblasts. Gradual depletion of mtDNA caused a gene expression profile, which was reminiscent of that observed in photoaged skin. Accordingly, in these cells an increased expression of MMP-1 without a concomitant change in tissue inhibitor metalloproteinase-1 as well as a decreased expression of collagen type 1 alpha-1, that is, a gene involved in collagen de novo synthesis, was observed. This altered gene expression resulted from intracellular, mitochondria-derived oxidative stress. Our results support the concept that disruption of mt integrity, for example, by UV-induced mtDNA mutagenesis, is of pathogenetic relevance for photoaging of human skin.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxidative stress and damage elicited by mtDNA mutations lead to mitochondrial dysfunction and increase the susceptibility of affected skin tissue cells to apoptosis upon UV irradiation.
“Taken together, the results from the other investigators and our laboratory indicate that oxidative stress and damage elicited by mtDNA mutations not only lead to mitochondrial dysfunction but also increase the susceptibility of affected skin tissue cells to apoptosis upon UV irradiation [54–56].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [56]
The Introduction (page unavailable) reports that UVA-induced mtDNA mutations in human dermal fibroblasts were associated with reduced measures of mitochondrial function, and that antioxidants normalized both the mutations and their functional consequences. The Discussion (page unavailable) also reports decreased mitochondrial function after partial mtDNA depletion. Neither passage shows that affected skin cells become more susceptible to apoptosis upon UV irradiation. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · cited 2× · see citing works
“In general, the gene expression pattern that we have described for EtBr-treated fibroblasts shares several features with the secretory phenotype of senescent cells (Campisi, 2005).”
BackgroundMitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165 · see citing works
Mechanisms of photoaging and chronological skin aging
Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849 · see citing works
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091 · see citing works
Butow, R. A., & Avadhani, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00179-0 · Cited by 882 · see citing works
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508886102 · Cited by 555 · see citing works
Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
LEE, H.-C., YIN, P.-H., LU, C.-Y., CHI, C.-W., & WEI, Y.-H. (2000) · Biochemical Journal · doi:10.1042/bj3480425 · Cited by 551 · cited 1× · see citing works
“In replicative senescence, a long-term increase in mt mass mediated by oxidative stress has been described (Lee et al., 2000).”
BackgroundThe Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria
Clayton, D. A., Doda, J. N., & Friedberg, E. C. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.7.2777 · Cited by 531 · see citing works
Ji, L. L., Gómez‐Cabrera, M. C., & Viña, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.061 · Cited by 445 · see citing works
Fisher, G. J., Talwar, H. S., Lin, J., Lin, P., McPhillips, F., Wang, Z., Li, X., Wan, Y., Kang, S., & Voorhees, J. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2153 · Cited by 392 · see citing works
Berneburg, M., Grether‐Beck, S., Kürten, V., Ruzicka, T., Briviba, K., Sies, H., & Krutmann, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15345 · Cited by 369 · see citing works
Self-citationJauslin, M. L., Meier, T., Smith, R. A. J., & Murphy, P. M. (2003) · The FASEB Journal · doi:10.1096/fj.03-0240fje · Cited by 358 · see citing works
Fligiel, S., Varani, J., Datta, S. C., Kang, S., Fisher, G. J., & Voorhees, J. J. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12148.x · Cited by 283 · see citing works
Loeb, L. A., Wallace, D. C., & Martin, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509776102 · Cited by 226 · see citing works
Brenneisen, P., Briviba, K., Wlaschek, M., Wenk, J., & Scharffetter‐Kochanek, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00404-2 · Cited by 199 · see citing works
Induction of the Photoaging-Associated Mitochondrial Common Deletion In Vivo in Normal Human Skin
Berneburg, M., Plettenberg, H., Medve-König, K., Pfahlberg, A., Gers-Barlag, H., Gefeller, O., & Krutmann, J. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22502.x · Cited by 193 · see citing works
Self-citationLu, C.-Y., Lee, H.-C., Fahn, H.-J., & Wei, Y.-H. (1999) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(98)00220-6 · Cited by 186 · see citing works
Berneburg, M., Gattermann, N., Stege, H., Grewe, M., Vogelsang, K., Ruzicka, T., & Krutmann, J. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08654.x · Cited by 157 · see citing works
Self-citationManiura‐Weber, K. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh921 · Cited by 145 · see citing works
Mitochondrial DNA Deletions in Human Skin Reflect Photo- Rather Than Chronologic Aging
Birch‐Machin, M. A., Tindall, M., Turner, R., Haldane, F., & Rees, J. L. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00099.x · Cited by 141 · see citing works
Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells
Seidel-Rogol, B. L. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.9.1929 · Cited by 132 · see citing works
Mitochondrial biology, degenerative diseases and aging
Wallace, D. C., Brown, M. D., Melov, S., Graham, B. H., & Lott, M. T. (1998) · BioFactors · doi:10.1002/biof.5520070303 · Cited by 119 · see citing works
Marusich, M. F., Robinson, B. H., Taanman, J., Kim, S. J., Schillace, R. V., Smith, J. L., & Capaldi, R. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00061-6 · Cited by 111 · see citing works
Koch, H., Wittern, K., & Bergemann, J. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01513.x · Cited by 109 · see citing works
Berneburg, M., Gremmel, T., Kürten, V., Schröeder, P., Hertel, I., von Mikecz, A. H., Wild, S., Chen, M., Declercq, L., Matsui, M. S., et al. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23806.x · Cited by 94 · see citing works
Self-citationKing, M. E., Godman, G. C., & King, D. W. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.53.1.127 · Cited by 90 · see citing works
Wiseman, A., & Attardi, G. M. (1978) · Molecular and General Genetics MGG · doi:10.1007/bf00270321 · Cited by 85 · see citing works
Photoageing-associated mitochondrial DNA length mutations in human skin
Lee, H., Wei, Y., & Yang, J. (1995) · Archives of Dermatological Research · doi:10.1007/bf00371736 · Cited by 84 · see citing works
Hayashi, J., Ohta, S., Kagawa, Y., Takai, D., Miyabayashi, S., Tada, K., Fukushima, H., Inui, K., Okada, S., & Goto, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32274-3 · Cited by 78 · see citing works
Krutmann, J., & Gilchrest, B. A. (2006) · Springer eBooks · doi:10.1007/3-540-32953-6_4 · Cited by 75 · see citing works
Self-citationUltraviolet A radiation-induced expression of human genes: molecular and photobiological mechanisms.
Grether‐Beck, S., Buettner, R., & Krutmann, J. (1997) · PubMed · Cited by 75 · see citing works
Self-citationBetacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation
Eicker, J., Kürten, V., Wild, S., Riss, G., Góralczyk, R., Krutmann, J., & Berneburg, M. (2003) · Photochemical & Photobiological Sciences · doi:10.1039/b300808h · Cited by 55 · see citing works
Self-citationMitochondrial Dysfunction and Cell Senescence: Cause or Consequence?
Passos, J. F., von Zglinicki, T., & Saretzki, G. C. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.64 · Cited by 51 · see citing works
Ma, Y., Chen, Y.-C., Lu, C., LIU, C., & Wei, Y. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.006 · Cited by 39 · see citing works
Reversible inhibition of cytochrome oxidase accumulation in human cells by ethidium bromide
Naum, Y., & Pious, D. A. (1971) · Experimental Cell Research · doi:10.1016/0014-4827(71)90010-3 · Cited by 32 · see citing works
Forti, G. C., & Trieff, N. M. (1981) · Teratogenesis Carcinogenesis and Mutagenesis · doi:10.1002/tcm.1770010304 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kohl, E. A., Steinbauer, J., Landthaler, M., & Szeimies, R. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03963.x · Cited by 443 · see citing works
The role of antioxidants in photoprotection: A critical review
Chen, L., Hu, J. Y., & Wang, S. Q. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.02.009 · Cited by 402 · see citing works
Mitochondria in skin health, aging, and disease
Sreedhar, A., Aguilera-Aguirre, L., & Singh, K. K. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2649-z · Cited by 339 · see citing works
Božič, M., Gorgieva, S., & Kokol, V. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.11.006 · Cited by 293 · see citing works
Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
Role of Mitochondria in Photoaging of Human Skin: The Defective Powerhouse Model
Krutmann, J., & Schröeder, P. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.1 · Cited by 198 · see citing works
Self-citationCrane, J. D., MacNeil, L. G., Lally, J. S., Ford, R. J., Bujak, A. L., Brar, I. K., Kemp, B. E., Raha, S., Steinberg, G. R., & Tarnopolsky, M. A. (2015) · Aging Cell · doi:10.1111/acel.12341 · Cited by 179 · see citing works
The emerging challenge in diabetes: The “metabolic memory”
Ceriello, A. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.05.005 · Cited by 174 · see citing works
The regulation of mitochondrial DNA copy number in glioblastoma cells
Dickinson, A., Yeung, K.-Y., Donoghue, J. F., Baker, M. J., Kelly, R. D., McKenzie, M., Johns, T. G., & John, J. C. S. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.115 · Cited by 132 · see citing works
The role of estrogen deficiency in skin ageing and wound healing
Emmerson, E., & Hardman, M. J. (2012) · Biogerontology · doi:10.1007/s10522-011-9322-y · Cited by 118 · see citing works
Stiefel, C., & Schwack, W. (2014) · International Journal of Cosmetic Science · doi:10.1111/ics.12165 · Cited by 114 · see citing works
Behar-Cohen, F., Baillet, G., de Ayguavives, T., García, P. O., Krutmann, J., Peña-garcía, P., Remé, C., & Wolffsohn, J. (2013) · Clinical Ophthalmology · doi:10.2147/opth.s46189 · Cited by 122 · see citing works
Self-citationReversing wrinkled skin and hair loss in mice by restoring mitochondrial function
Singh, B., Schoeb, T. R., Bajpai, P., Slominski, A. T., & Singh, K. K. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0765-9 · Cited by 107 · see citing works
MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair
Swope, V. B., & ABDEL‐MALEK, Z. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092667 · Cited by 105 · see citing works
Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria
Otašević, V., Vučetić, M., Grigorov, I., Martinović, V., & Stančić, A. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5537330 · Cited by 102 · see citing works
Beasley, D. G., & Meyer, T. A. (2010) · American Journal of Clinical Dermatology · doi:10.2165/11537050-000000000-00000 · Cited by 82 · see citing works
Wang, Y. N., Wu, W., Chen, H. C., & Fang, H. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.02.002 · Cited by 82 · see citing works
Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis
Hunt, M., Torres, M. S., Bachar-Wikström, E., & Wikström, J. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1252318 · Cited by 82 · see citing works
A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies
Yusoff, A. A. M., Abdullah, W. S. W., Khair, S. Z. N. M., & Radzak, S. M. A. (2019) · Oncology Reviews · doi:10.4081/oncol.2019.409 · Cited by 63 · see citing works
Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
Martic, I., Papaccio, F., Bellei, B., & Cavinato, M. S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1284410 · Cited by 57 · see citing works
Fras‐Zemljič, L., Kokol, V., & Čakara, D. (2011) · Textile Research Journal · doi:10.1177/0040517511404600 · Cited by 54 · see citing works
Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts
Majora, M., Wittkampf, T., Schuermann, B., Schneider, M., Franke, S., Grether‐Beck, S., Wilichowski, E., Bernerd, F., Schröeder, P., & Krutmann, J. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080832 · Cited by 49 · see citing works
Self-citationKasiviswanathan, R., Gustafson, M. A., Copeland, W. C., & Meyer, J. N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.306852 · Cited by 46 · see citing works
Physiology and Pathophysiology of Mitochondrial DNA
Li, H., Liu, D., Lü, J., & Bai, Y. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_2 · Cited by 44 · see citing works
Li, H., Shen, L., Hu, P., Huang, R., Cao, Y., Deng, J., Yuan, W., Liu, D., Yang, J., Gu, H., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.022 · Cited by 43 · see citing works
Chronic actinic damage of facial skin
Bilaç, C., Şahin, M. T., & Öztürkcan, S. (2014) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2014.02.014 · Cited by 39 · see citing works
Orekhov, A. N., Nikiforov, N. G., Ivanova, E. A., & Sobenin, I. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040978 · Cited by 37 · see citing works
Stem cells and aberrant signaling of molecular systems in skin aging
Peng, Y., Xuan, M., Leung, V. Y. L., & Cheng, B. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.006 · Cited by 35 · see citing works
Lithospermum erythrorhizon Extract Protects Keratinocytes and Fibroblasts Against Oxidative Stress
Yoo, H. G., Lee, B. H., Kim, W., Lee, J. S., Kim, G. H., Chun, O. K., Koo, S. I., & Kim, D. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.3088 · Cited by 35 · see citing works
Bhattacharya, S., Yin, J., Huo, W., & Chaum, E. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02937-6 · Cited by 35 · see citing works
Skin ageing and oxidative stress in a narrow-age cohort of older adults
Allerhand, M., Ooi, E., Starr, R. J., Alcorn, M., Penke, L., Drost, E., MacNee, W., Deary, I. J., & Starr, J. M. (2011) · European Geriatric Medicine · doi:10.1016/j.eurger.2011.04.009 · Cited by 25 · see citing works
Gui, Q., Ding, N., Yao, Z., Wu, M., Fu, R., Wang, Y., Zhao, Y., & Zhu, L. (2024) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbae004 · Cited by 25 · see citing works
Catalase, a therapeutic target in the reversal of estrogen-mediated aging
Elliot, S. J., Catanuto, P., Pereira‐Simon, S., Xia, X., Pastar, I., Thaller, S. R., Head, C. R., Stojadinović, O., Tomic‐Canic, M., & Glassberg, M. K. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.06.020 · Cited by 22 · see citing works
Clinical and laboratory skin biomarkers of organ-specific diseases
Zouboulis, C. C., & Makrantonaki, E. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.003 · Cited by 18 · see citing works
Genetic basis for skin youthfulness
Flood, K. S., Houston, N., Savage, K. T., & Kimball, A. B. (2019) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2019.04.007 · Cited by 18 · see citing works
Zanchetta, L. M., Kirk, D., Lyng, F. M., Walsh, J., & Murphy, J. E. J. (2010) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2010.00551.x · Cited by 16 · see citing works
Determination of the Action Spectrum of UVR-Induced Mitochondrial DNA Damage in Human Skin Cells
Latimer, J. A., Lloyd, J. J., Diffey, B. L., Matts, P. J., & Birch-Machin, M. A. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.194 · Cited by 15 · see citing works
Vidali, S., Feichtinger, R. G., Emberger, M., Brunner, S. M., Gaisbauer, S., Blatt, T., Smiles, W. J., Kreutzer, C., Weise, J. M., & Kofler, B. (2023) · Experimental Dermatology · doi:10.1111/exd.14778 · Cited by 15 · see citing works
Kohl, E. A., Landthaler, M., & Szeimies, R. (2009) · Der Hautarzt · doi:10.1007/s00105-009-1790-5 · Cited by 14 · see citing works
Makrantonaki, E., Vogel, M., Scharffetter‐Kochanek, K., & Zouboulis, C. C. (2015) · Der Hautarzt · doi:10.1007/s00105-015-3692-z · Cited by 19 · see citing works
HAWK, J. L. M., Young, A. R., & Ferguson, J. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch29 · Cited by 13 · see citing works
Mitochondrial Secrets of Youthfulness
Singh, K. K. (2020) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000007619 · Cited by 10 · see citing works
Gebhard, D., Matt, K., Burger, K., & Bergemann, J. (2014) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21561 · Cited by 9 · see citing works
Kwak, C. S., & Yang, J. (2016) · Asian Journal of Beauty and Cosmetology · doi:10.20402/ajbc.2016.0043 · Cited by 9 · see citing works
Orekhov, A. N., Владимировна, Г. Е., Sukhorukov, V. N., Poznyak, A. V., & Nikiforov, N. G. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201012164330 · Cited by 9 · see citing works
Xiaoli, L., Hu, F., Shihui, H., Niu, X., Li, S., Zhou, W., Xueqin, R., & Jia-fu, W. (2021) · Aging · doi:10.18632/aging.203711 · Cited by 8 · see citing works
Gopaul, R., Knaggs, H. E., & Lephart, J. F. (2011) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2011.00645.x · Cited by 8 · see citing works
Pathomechanisms of Photoaged Skin
Krutmann, J. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_10 · Cited by 7 · see citing works
Self-citationSkin Aging and Oxidative Stress
Starr, J. M., & Starr, R. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405933-7.00002-0 · Cited by 7 · see citing works
Hattingh, A. C., van de Venter, M., & Koekemoer, T. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.017 · Cited by 7 · see citing works
Tissue-specific implications of mitochondrial alterations in aging
Liu, D. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e654 · Cited by 5 · see citing works
SOX9 in Keratinocytes Regulates Claudin 2 Transcription during Skin Aging
Wang, J., Xie, X.-Y., Deng, Y., Yang, H., Du, X., Liu, P., & Du, Y. (2022) · Contrast Media & Molecular Imaging · doi:10.1155/2022/6884308 · Cited by 5 · see citing works
Use of small RNA as antiaging cosmeceuticals.
Zhang, P., Chen, J., Li, T., & Zhu, Y. Y. (2013) · PubMed · Cited by 5 · see citing works
Majora, M., Wittkampf, T., Schuermann, B., Schneider, M., Schroeder, P., & Krutmann, J. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-s1-a65 · Cited by 5 · see citing works
Self-citationNieri, D., Fioramonti, M., Berardinelli, F., Leone, S., Cherubini, R., Nadal, V. D., Gerardi, S., Moreno, S., Nardacci, R., Tanzarella, C., et al. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.05.010 · Cited by 4 · see citing works
Pathomechanisms of Photoaged Skin
Krutmann, J. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_10 · Cited by 4 · see citing works
Self-citationMolekulare Mechanismen der Hautalterung durch UV-Strahlung und andere exogene Noxen
Krutmann, J., Schröder, P., & Morita, A. (2008) · Springer eBooks · doi:10.1007/978-3-540-76821-0_3 · Cited by 3 · see citing works
Self-citationAlterations of Energy Metabolism in Cutaneous Aging
Blatt, T., Wenck, H., & Wittern, K. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_29-2 · Cited by 3 · see citing works
The molecular basis of cutaneous aging
Reddy, K. K., & Gilchrest, B. A. (2011) · Expert Review of Dermatology · doi:10.1586/edm.11.48 · Cited by 3 · see citing works
Performance analysis of melanoma classifier using electrical modeling technique
Roy, T., & Bhattacharjee, P. (2020) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-020-02241-6 · Cited by 3 · see citing works
Alterations of Energy Metabolism in Cutaneous Aging
Blatt, T., Wenck, H., & Wittern, K. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_29 · Cited by 3 · see citing works
Alterations of Energy Metabolism in Cutaneous Aging
Blatt, T., Wenck, H., & Wittern, K. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_29 · Cited by 2 · see citing works
Solar Radiation Damage to Human Skin Mitochondria
Zanchetta, L. (2010) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d7wk51 · Cited by 2 · see citing works
UV-Strahlung und Pigmentierung
Esser, C., & Krutmann, J. (2010) · Der Hautarzt · doi:10.1007/s00105-009-1914-y · Cited by 2 · see citing works
Self-citationGenetic and Epigenetic Influences on Cutaneous Cellular Senescence
Sarkar, T. J., Hermsmeier, M., Ross, J. L., & Herron, G. S. (2021) · Physiology · doi:10.5772/intechopen.101152 · Cited by 1 · see citing works
Redox state of aging skin: A double-edged sword in wound healing
Chen, Q., Sophabmixay, A., Albertson, T., Ghasb, G., Terzian, A., Yan, L., Young, L. H., & Barsotti, R. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.008 · Cited by 1 · see citing works
Premature Aging of Skin from Environmental Assaults
Krutmann, J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-2029-0.50011-9 · Cited by 1 · see citing works
Self-citationRayonnement solaire : bases physiques, effets cutanés biologiques et cliniques
Meunier, L. (2012) · Cited by 1 · see citing works
Pluripotent stem cells and mitochondrial dysfunction
Kao, L., & Wolvetang, E. J. (2017) · Medical and Clinical Archives · doi:10.15761/mca.1000113 · Cited by 1 · see citing works
Rayonnement solaire : aspects cliniques
Béani, J.-C. (2022) · Annales de Dermatologie et de Vénéréologie - FMC · doi:10.1016/j.fander.2022.01.003 · Cited by 1 · see citing works
Mitochondrial Respiratory Function Decline in Aging and Life-Span Extension by Caloric Restriction
Wu, S., Wu, Y., Wang, C., Lee, W., & Wei, Y. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_7
Irradiazione solare: basi fisiche ed effetti cutanei biologici e clinici
Meunier, L. (2013) · EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei · doi:10.1016/s1776-0313(13)64705-x
Molekulares Verständnis der ex- und intrinsischen Vorgänge
Makrantonaki, E., Vogel, M., Scharffetter‐Kochanek, K., & Zouboulis, C. C. (2016) · ästhetische dermatologie & kosmetologie · doi:10.1007/s12634-016-5177-1
Kasiviswanathan, R., Gustafson, M. A., Copeland, W. C., & Meyer, J. N. (2012)
Radiazione solare: aspetti clinici
Béani, J.-C. (2019) · EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei · doi:10.1016/s1776-0313(20)43314-3
Pathomechanisms of Photoaged Skin
Krutmann, J. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_10-2
Self-citationZhang, C., Wang, M., Li, Y., & Yan, Y. (2024) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23765
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-30287-9.00012-2
Makrantonaki, E., & Kostaras, S. (2025) · Deutsche Dermatologie · doi:10.1007/s15011-025-7042-x
Bhattacharya, S., Yin, J., Huo, W., & Chaum, E. (2022) · Figshare · doi:10.6084/m9.figshare.20098501
- Authors
- Schroeder, P., Gremmel, T., Berneburg, M., & Krutmann, J.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- University of Tübingen (DE)
- Corresponding author
- Krutmann, Jean
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 128
- Issue
- 9
- Pages
- 2297-2303
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2035825200
- Cited by
- 85
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 6
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB728, GRK 1033)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- mitochondrial DNA depletion, photoaging, dermal fibroblasts, MMP-1, mitochondrial oxidative stress, gene expression profiles, collagen degradation, phenocopy
- MeSH terms
- Collagen Type I, alpha 1 Chain, Cell Line, DNA Damage, DNA, Mitochondrial, Enzyme Inhibitors, Ethidium, Fibroblasts, Humans, Models, Biological, Skin, Skin Aging, Gene Deletion, Reactive Oxygen Species, Oxidative Stress, Matrix Metalloproteinase 1, Gene Expression Profiling, Collagen Type I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
