Changes in the Ceramide Profile of Atopic Dermatitis Patients

Epidermal Lipids, Barrier Function, and Desquamation

Elias, P. M. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.12 · Cited by 1,356

Decreased Level of Ceramides in Stratum Corneum of Atopic Dermatitis: An Etiologic Factor in Atopic Dry Skin?

Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040

Ceramide and cholesterol composition of the skin of patients with atopic dermatitis

Nardo, A. D. (1998) · Acta Dermato Venereologica · doi:10.1080/00015559850135788 · Cited by 483

Ceramide composition of the psoriatic scale

Motta, S., Monti, M., Sesana, S., Caputo, R., Carelli, S., & Ghidoni, R. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(93)90135-n · Cited by 435

Characterization of overall ceramide species in human stratum corneum

Masukawa, Y., Narita, H., Shimizu, E., Kondo, N., Sugai, Y., Oba, T., Homma, R., Ishikawa, J., Takagi, Y., Kitahara, T., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800014-jlr200 · Cited by 322

Stratum corneum lipid abnormalities in atopic dermatitis

Yamamoto, A., Serizawa, S., Ito, M., & Sato, Y. (1991) · Archives of Dermatological Research · doi:10.1007/bf01106105 · Cited by 272

Deficiency of Epidermal Protein-Bound ω-Hydroxyceramides in Atopic Dermatitis

Macheleidt, O., Sandhoff, K., & Kaiser, H. W. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01833.x · Cited by 236

Comprehensive quantification of ceramide species in human stratum corneum

Masukawa, Y., Narita, H., Sato, H., Naoe, A., Kondo, N., Sugai, Y., Oba, T., Homma, R., Ishikawa, J., Takagi, Y., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.d800055-jlr200 · Cited by 228

Two Ceramide Subfractions Detectable in Cer(AS) Position by HPTLC in Skin Surface Lipids of Non-Lesional Skin of Atopic Eczema

Bleck, O., Abeck, D., Ring, J., Hoppe, U., Vietzke, J., Wolber, R., Brandt, O., & Schreiner, V. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00809.x · Cited by 135

Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin

Farwanah, H., Raith, K., Neubert, R. H. H., & Wohlrab, J. (2005) · Archives of Dermatological Research · doi:10.1007/s00403-005-0551-2 · Cited by 123

Role of Ceramide in the Barrier Function of the Stratum Corneum, Implications for the Pathogenesis of Atopic Dermatitis

Imokawa, G. (2014) · Journal of Clinical & Experimental Dermatology Research · doi:10.4172/2155-9554.1000206 · Cited by 43

Effects of omega-O-acylceramide structures and concentrations in healthy and diseased skin barrier lipid membrane models

Opálka, L., Kováčik, A., Pullmannová, P., Maixner, J., & Vávrová, K. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000420 · Cited by 43

Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition

Rousel, J., Nădăban, A., Saghari, M., Pagan, L., Zhuparris, A., Theelen, B., Gambrah, T., van der Wall, H. E. C., Vreeken, R. J., Feiss, G. L., et al. (2023) · Experimental Dermatology · doi:10.1111/exd.14952 · Cited by 43

Nutrition and skin

Pappas, A., Liakou, A. Ι., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9374-z · Cited by 47

Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis

Ito, S., Ishikawa, J., Naoe, A., Yoshida, H., Hachiya, A., Fujimura, T., Kitahara, T., & Takema, Y. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13777 · Cited by 42

A novel mechanism for improvement of dry skin by dietary milk phospholipids: Effect on epidermal covalently bound ceramides and skin inflammation in hairless mice

Morifuji, M., Oba, C., Ichikawa, S., Ito, K., Kawahata, K., Asami, Y., Ikegami, S., Itoh, H., & Sugawara, T. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.02.017 · Cited by 41

Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices

Mieremet, A., Rietveld, M. H., Absalah, S., van Smeden, J., Bouwstra, J. A., & Ghalbzouri, A. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174478 · Cited by 40

Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

Miyamoto, M., Itoh, N., Sawai, M., Sassa, T., & Kihara, A. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.689 · Cited by 40

Metabolomic Analysis of Skin Biopsies from Patients with Atopic Dermatitis Reveals Hallmarks of Inflammation, Disrupted Barrier Function and Oxidative Stress

Ilves, L., Ottas, A., Kaldvee, B., Abram, K., Soomets, U., Zilmer, M., Jaks, V., & Kingo, K. (2021) · Acta Dermato Venereologica · doi:10.2340/00015555-3766 · Cited by 45

Breaking the Itch–Scratch Cycle: Topical Options for the Management of Chronic Cutaneous Itch in Atopic Dermatitis

Harrison, I. P., & Spada, F. (2019) · Medicines · doi:10.3390/medicines6030076 · Cited by 40

Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum

Jung, K.-M., Kim, S., Joo, K., Lim, S.-H., Shin, J.-H., Roh, J., Kim, E., Park, C. W., & Kim, W.-G. (2021) · Nutrients · doi:10.3390/nu13124372 · Cited by 40

Regenerated keratin membrane to match the in vitro drug diffusion through human epidermis

Selmin, F., Cilurzo, F., Aluigi, A., Franzè, S., & Minghetti, P. (2012) · Results in Pharma Sciences · doi:10.1016/j.rinphs.2012.10.001 · Cited by 39

Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin

Berkers, T., Visscher, D., Gooris, G. S., & Bouwstra, J. A. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2288-y · Cited by 38

Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models

Nădăban, A., Rousel, J., Yachioui, D. E., Gooris, G. S., Beddoes, C. M., Dalgliesh, R. M., Malfois, M., Rißmann, R., & Bouwstra, J. A. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100400 · Cited by 37

The roughness of lip skin is related to the ceramide profile in the stratum corneum

Tamura, E., Ishikawa, J., Naoe, A., & Yamamoto, T. (2016) · International Journal of Cosmetic Science · doi:10.1111/ics.12335 · Cited by 37

Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles

Agrawal, K., Hassoun, L. A., Foolad, N., Borkowski, K., Pedersen, T. L., Sivamani, R. K., & Newman, J. W. I. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.05.001 · Cited by 36

Contribution of Palmitic Acid to Epidermal Morphogenesis and Lipid Barrier Formation in Human Skin Equivalents

Mieremet, A., Helder, R. W. J., Nădăban, A., Gooris, G. S., Boiten, W. A., Ghalbzouri, A. E., & Bouwstra, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236069 · Cited by 37

Dry skin in the winter is related to the ceramide profile in the stratum corneum and can be improved by treatment with a E ucalyptus extract

Ishikawa, J., Yoshida, H., Ito, S., Naoe, A., Fujimura, T., Kitahara, T., Takema, Y., Zerweck, C. R., & Grove, G. L. (2013) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12019 · Cited by 37

Omega- O -Acylceramides in Skin Lipid Membranes: Effects of Concentration, Sphingoid Base, and Model Complexity on Microstructure and Permeability

Opálka, L., Kováčik, A., Maixner, J., & Vávrová, K. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b03082 · Cited by 37

Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women

Mori, S., Shiraishi, A., Epplen, K., Butcher, D., Murase, D., Yasuda, Y., & Murase, T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0608-1 · Cited by 37

Effects of glucocorticoids on stratum corneum lipids and function in human skin—A detailed lipidomic analysis

Røpke, M. A., Alonso, C., Jung, S., Norsgaard, H., Richter, C., Darvin, M. E., Litman, T., Vogt, A., Lademann, J. M., Blume‐Peytavi, U., et al. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.08.009 · Cited by 35

Lipidomics for translational skin research: A primer for the uninitiated

Kendall, A. C., Koszyczarek, M. M., Jones, E. A., Hart, P. J., Towers, M. W., Griffiths, C. E. M., Morris, M. R., & Nicolaou, A. (2018) · Experimental Dermatology · doi:10.1111/exd.13558 · Cited by 35

Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix model

Beddoes, C. M., Gooris, G. S., & Bouwstra, J. A. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m087106 · Cited by 35

Topical therapy of atopic dermatitis with a focus on pimecrolimus

Luger, T. A., Paller, A. S., Irvine, A. D., Sidbury, R., Eichenfield, L. F., Werfel, T., & Bieber, T. R. M. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17272 · Cited by 42

Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis

Pavel, P., Leman, G., Hermann, M., Ploner, C., Eichmann, T. O., Minzaghi, D., Radner, F. P. W., Frari, B. D., Gruber, R. W., & Dubrac, S. (2021) · JID Innovations · doi:10.1016/j.xjidi.2021.100033 · Cited by 35

Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function

Ishikawa, J., Shimotoyodome, Y., Chen, S., Ohkubo, K., Takagi, Y., Fujimura, T., Kitahara, T., & Takema, Y. (2011) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2011.00675.x · Cited by 35

The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Schild, J., Kalvodová, A., Zbytovská, J., Farwick, M., & Pyko, C. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12972 · Cited by 47

Interleukin-4 and Atopic Dermatitis: Why Does it Matter? A Narrative Review

Torres, T. R., Mendes‐Bastos, P., Cruz, M. J., Duarte, B., Filipe, P., Lopes, M. J. P., & Gonçalo, M. (2025) · Dermatology and Therapy · doi:10.1007/s13555-025-01352-y · Cited by 43

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation

Nakamura, Y., Matsuzaka, T., Tahara‐Hanaoka, S., Shibuya, K., Shimano, H., Nakahashi-Oda, C., & Shibuya, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1226-1 · Cited by 34

Developmental alterations of physical properties and components of neonatal-infantile stratum corneum of upper thighs and diaper-covered buttocks during the 1st year of life

Minami‐Hori, M., Honma, M., Fujii, M., Nomura, W., Kanno, K., Hayashi, T., Nakamura, E., Nagaya, K., Miyauchi, Y., Fujimura, T., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.08.015 · Cited by 35

The Role of Immune Defects and Colonization ofStaphylococcus aureusin the Pathogenesis of Atopic Dermatitis

Nowicka, D., & Grywalska, E. (2018) · Analytical Cellular Pathology · doi:10.1155/2018/1956403 · Cited by 35

Structural modification of the skin barrier by OH radicals: a reactive molecular dynamics study for plasma medicine

der Paal, J. V., Verlackt, C. C. W., Yusupov, M., Neyts, E. C., & Bogaerts, A. (2015) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/48/15/155202 · Cited by 32

Comparison of linoleic acid-containing water-in-oil emulsion with urea-containing water-in-oil emulsion in the treatment of atopic dermatitis: a randomized clinical trial

Nasrollahi, S. A., Ayatollahi, A., Yazdanparast, T., Samadi, A., Hosseini, H., Shamsipour, M., Akhlaghi, A. A., Yadangi, S., Abels, C., & Firooz, A. (2018) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s145561 · Cited by 32

Derailed Ceramide Metabolism in Atopic Dermatitis (AD): A Causal Starting Point for a Personalized (Basic) Therapy

Blaess, M. F., & Deigner, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163967 · Cited by 32

Skin microbiota analysis in human 3D skin models—“Free your mice”

Emmert, H., Rademacher, F., Gläser, R., & Harder, J. (2020) · Experimental Dermatology · doi:10.1111/exd.14164 · Cited by 32

Atopic Dermatitis: The Fate of the Fat

Pavel, P., Blunder, S., Moosbrugger‐Martinz, V., Elias, P. M., & Dubrac, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042121 · Cited by 32

Scalable Synthesis of Human Ultralong Chain Ceramides

Opálka, L., Kováčik, A., Sochorová, M., Roh, J., Kuneš, J., Lenčo, J., & Vávrová, K. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02816 · Cited by 31

The impact of recent advances in lipidomics and redox lipidomics on dermatological research

Грубер, Ф., Kremslehner, C., & Narzt, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.019 · Cited by 32

Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy

Kendall, A. C., Pilkington, S. M., Wray, J. R., Newton, V. L., Griffiths, C. E. M., Bell, M., Watson, R. E. B., & Nicolaou, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-26095-0 · Cited by 31

Reevaluation of the non-lesional dry skin in atopic dermatitis by acute barrier disruption: an abnormal permeability barrier homeostasis with defective processing to generate ceramide

Sugiura, A., Nomura, T., Mizuno, A., & Imokawa, G. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1430-x · Cited by 32

Atopic Dermatitis Is a Barrier Issue, Not an Allergy Issue

Kraft, M., & Prince, B. T. (2019) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2019.07.005 · Cited by 30

Integrated metabolomics and lipidomics study of patients with atopic dermatitis in response to dupilumab

Zhang, L., Wen, X., Hou, Y., Yang, Y., Song, W., Zeng, Y., & Sun, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1002536 · Cited by 30

Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role

Imokawa, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041613 · Cited by 29

Profile and quantification of human stratum corneum ceramides by normal-phase liquid chromatography coupled with dynamic multiple reaction monitoring of mass spectrometry: development of targeted lipidomic method and application to human stratum corneum of different age groups

Jia, Z., Zhang, J., Shen, C., & Ma, L. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9775-6 · Cited by 29

Effects of 6-Hydroxyceramides on the Thermotropic Phase Behavior and Permeability of Model Skin Lipid Membranes

Kováčik, A., Šilarová, M., Pullmannová, P., Maixner, J., & Vávrová, K. (2017) · Langmuir · doi:10.1021/acs.langmuir.7b00184 · Cited by 29

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Ishida, K., Takahashi, A., Bito, K., Draelos, Z. D., & Imokawa, G. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.01.014 · Cited by 29

Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by 2H Solid-State NMR Spectroscopy

Stahlberg, S., Lange, S., Dobner, B., & Huster, D. (2016) · Langmuir · doi:10.1021/acs.langmuir.5b04173 · Cited by 28

The Chemistry and Biology of 6‐Hydroxyceramide, the Youngest Member of the Human Sphingolipid Family

Kováčik, A., Roh, J., & Vávrová, K. (2014) · ChemBioChem · doi:10.1002/cbic.201402153 · Cited by 28

Transcription Factor Ctip2 Controls Epidermal Lipid Metabolism and Regulates Expression of Genes Involved in Sphingolipid Biosynthesis during Skin Development

Wang, Z., Kirkwood, J. S., Taylor, A. W., Stevens, J. F., Leid, M. E., Ganguli‐Indra, G., & Indra, A. K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.358 · Cited by 28

Models for the Stratum Corneum Lipid Matrix: Effects of Ceramide Concentration, Ceramide Hydroxylation, and Free Fatty Acid Protonation

Wang, E. J. D., & Klauda, J. B. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b06188 · Cited by 28

Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome

Chen, Y., Peng, C., Zhu, L., Wang, J., Cao, Q., Chen, X., & Li, J. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08995-3 · Cited by 27

Skin Ceramide Profile in Children With Atopic Dermatitis

Shen, C., Zhao, M., Jia, Z., Zhang, J., Jiao, L., & Ma, L. (2018) · Dermatitis · doi:10.1097/der.0000000000000392 · Cited by 27

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development

Li, S., Teegarden, A. T., Bauer, E. M., Choi, J., Messaddeq, N., Hendrix, D. A., Ganguli‐Indra, G., Leid, M. E., & Indra, A. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-13347-7 · Cited by 29

Applying a vernix caseosa based formulation accelerates skin barrier repair by modulating lipid biosynthesis

Boiten, W. A., Berkers, T., Absalah, S., van Smeden, J., Lavrijsen, A. P. M., & Bouwstra, J. A. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m079186 · Cited by 26

Stratum corneum pH and ceramides: Key regulators and biomarkers of skin barrier function in atopic dermatitis

Sakai, T., & Hatano, Y. (2025) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2025.04.001 · Cited by 26

Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

Burger, B., Sagiorato, R. N., Cavenaghi, I., & Rodrigues, H. G. (2023) · Metabolites · doi:10.3390/metabo13020291 · Cited by 25

Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro

Lee, G., Park, J., Lee, H., Kim, K. S., Park, J. H., Kyung, S. Y., Kim, H. S., Yang, H. O., & Jung, B. H. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154818 · Cited by 25

Epidermal permeability barrier function and sphingolipid content in the skin of sphingomyelin synthase 2 deficient mice

Nomoto, K., Itaya, Y., Watanabe, K., Yamashita, T., Okazaki, T., & Tokudome, Y. (2018) · Experimental Dermatology · doi:10.1111/exd.13497 · Cited by 25

Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile

Nojiri, H., Ishida, K., Yao, X., Liu, W., & Imokawa, G. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1833-9 · Cited by 24

Barrier Integrity and Immunity: Exploring the Cutaneous Front Line in Health and Disease

Fukuda, K., Ito, Y., & Amagai, M. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082323-030832 · Cited by 28

Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin

Berkers, T., Dijk, L. V., Absalah, S., van Smeden, J., & Bouwstra, J. A. (2016) · Experimental Dermatology · doi:10.1111/exd.13116 · Cited by 23

Probing the role of ceramide hydroxylation in skin barrier lipid models by 2H solid-state NMR spectroscopy and X-ray powder diffraction

Kováčik, A., Vogel, A., Adler, J., Pullmannová, P., Vávrová, K., & Huster, D. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.02.003 · Cited by 23

Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum

Lipsky, Z. W., Marques, C. N. H., & German, G. K. (2020) · Tissue Barriers · doi:10.1080/21688370.2020.1754706 · Cited by 21

Non‐invasive transcriptomic analysis using mRNAs in skin surface lipids obtained from children with mild‐to‐moderate atopic dermatitis

Shima, K., Inoue, T., Uehara, Y., Iwamura, M., Fukagawa, S., Kuwano, T., Tanida, K., Takada, N., Saito‐Abe, M., Yamamoto‐Hanada, K., et al. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18173 · Cited by 22

Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation

Shin, K., Mihara, H., Ishida, K., Uchida, Y., & Park, K. (2022) · Cells · doi:10.3390/cells11111742 · Cited by 22

Comparative analysis of intercellular lipid organization and composition between psoriatic and healthy stratum corneum

Uchino, T., Kamiya, D., Yagi, H., Fujino, H., Hatta, I., Fujimori, S., Miyazaki, Y., Kirishita, Y., Sano, Y., Mizuno, H., et al. (2023) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2023.105305 · Cited by 22

Compromising human skin in vivo and ex vivo to study skin barrier repair

Berkers, T., Boiten, W. A., Absalah, S., van Smeden, J., Lavrijsen, A. P. M., & Bouwstra, J. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.04.005 · Cited by 22

The benefit of a ceramide‐linoleic acid‐containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses

Yang, Q., Liu, M., Li, X., & Zheng, J. (2019) · Dermatologic Therapy · doi:10.1111/dth.13017 · Cited by 24

The Importance of Free Fatty Chain Length on the Lipid Organization in the Long Periodicity Phase

Beddoes, C. M., Rensen, D. E., Gooris, G. S., Malfois, M., & Bouwstra, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073679 · Cited by 26

Skin Barrier Function and Atopic Dermatitis

Rerknimitr, P., Otsuka, A., Nakashima, C., & Kabashima, K. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0232-y · Cited by 21

Stratum Corneum Ceramide Profiles Provide Reliable Indicators of Remission and Potential Flares in Atopic Dermatitis

Sho, Y., Sakai, T., Sato, T., Sonezaki, M., Taima, H., Taguchi, H., Kaizu, K., Nishizaka, T., Takagi, Y., & Hatano, Y. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.06.012 · Cited by 20

Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides

Ota, A., Morita, H., Naganuma, T., Miyamoto, M., Jojima, K., Nojiri, K., Matsuda, J., & Kihara, A. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104603 · Cited by 23

The effect of autophagy-enhancing peptide in moisturizer on atopic dermatitis: a randomized controlled trial

Kwon, S., Lim, C. J., Jung, J., Kim, H. J., Park, K., Shin, J. W., Huh, C., Park, K. C., & Na, J. (2018) · Journal of Dermatological Treatment · doi:10.1080/09546634.2018.1544407 · Cited by 20

Unique skin abnormality in patients with peanut allergy but no atopic dermatitis

Berdyshev, E. V., Goleva, E., Bronova, I. A., Bronoff, A. S., Hoffman, B. C., Ramirez-Gama, M. A., Garcia, S. L., Crumrine, D. A., Elias, P. M., Cho, C. B., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.015 · Cited by 19

Pathogenese des atopischen Ekzems

Scheerer, C., & Eyerich, K. (2018) · Der Hautarzt · doi:10.1007/s00105-018-4127-4 · Cited by 19

Epidermal barrier impairment predisposes for excessive growth of the allergy‐associated yeast Malassezia on murine skin

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