The DOI matches its Crossref record; 73 of the 77 references it cites were found in a registry or an index.
The Prevalence and Odds of Depressive Symptoms and Clinical Depression in Psoriasis Patients: A Systematic Review and Meta-Analysis
Open accessAbstract
The reported prevalence of depression in psoriasis varies substantially. This study aims to determine the prevalence and odds of depressive symptoms and clinical depression in psoriasis. A systematic literature search was conducted. Mean questionnaire values and proportions for depressive symptoms and clinical depression were pooled according to different assessment methods. In controlled studies, standardized mean differences (SMDs) and odds ratio (OR) compared depression in psoriasis patients with controls using the random-effect model. The majority of the 98 eligible studies were conducted in tertiary centers without a control group. The prevalence of depressive symptoms was 28% using questionnaires and the prevalence of clinical depression was 12% using International Classification of Diseases codes, 19% using Diagnostic and Statistical Manual of Mental Disorders IV, and 9% for antidepressant use. Psoriasis patients had significantly more depressive symptoms (SMD 1.16; 95% confidence interval (CI) 0.67-1.66), and population-based studies showed that they were at least one and a half times more likely to experience depression (OR 1.57; 95% CI 1.40-1.76) and used more antidepressants than did controls (OR 4.24, 95% CI 1.53-11.76). More than 10% of psoriasis patients suffer from clinical depression, and twice as many have depressive symptoms. The high prevalence of these symptoms is likely to be affected by the tertiary study populations and differential misclassification using questionnaires, where psoriasis-related symptoms may be detected as depressive symptoms.
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“The prevalence of depression among psoriasis patients and the significant OR of 3.02 are in accordance with a recent meta-analysis of 98 studies, showing that >10% of psoriasis patients have clinical depression (Dowlatshahi et al., 2013).”
From The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries (2015) · cites this paper as Dowlatshahi et al., 2013
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Pathophysiology, Clinical Presentation, and Treatment of Psoriasis
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Metadata
- Authors
- Dowlatshahi, E. A., Wakkee, M., Arends, L. R., & Nijsten, T.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Nijsten, Tamar
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 134
- Issue
- 6
- Pages
- 1542-1551
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2005241673
- Cited by
- 436
- References
- 77
- Citations by year
- 2026: 33 · 2025: 41 · 2024: 33 · 2023: 40 · 2022: 30 · 2021: 47 · 2020: 41 · 2019: 37 · 2018: 46 · 2017: 31 · 2016: 29 · 2015: 16 · 2014: 9
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- psoriasis, depression, depressive symptoms, prevalence, antidepressant use, psychiatric comorbidity, tertiary care hospital patients
- MeSH terms
- Antidepressive Agents, Depression, Humans, Psoriasis, Quality of Life, Surveys and Questionnaires, Risk Factors, Prevalence, Confidence Intervals, Odds Ratio
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