The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin
Open accessAbstract
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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“However, the role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.57”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [57]
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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BackgroundMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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“The proliferative phase begins with the formation of granulation tissue and collagen deposition, and the wound closes by epithelialization and the contraction of differentiated myofibroblasts, which are specialized contractile fibroblasts (Guo and Dipietro, 2010).”
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“Because wound healing and cancer share several molecular and cellular events (Dvorak, 1986; Feng et al., 2010), senescent cells may have an essential role in promoting wound healing while preventing cancer initiation.”
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BackgroundInfluentialClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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“Indeed, removal of senescent cells in a premature aging mouse model reduced selected age-related pathologies, such as sarcopenia, cataracts, and loss of subdermal adipose tissue (Baker et al., 2011).”
BackgroundHuman skin wounds: A major and snowballing threat to public health and the economy
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BackgroundInfluentialAging, Cellular Senescence, and Cancer
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“Cellular senescence is a complex stress response that renders cells incapable of cell division, even in the presence of growth stimuli (Campisi, 2013).”
BackgroundInfluentialThe role of senescent cells in ageing
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“Senescent cells can alter tissue homeostasis and promote age-related diseases, including degenerative pathologies and cancers (Campisi, 2013; van Deursen, 2014).”
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Items 101–127 of 127
Wang, F., Zhou, L., Zhong, Y., Cai, Y., Meng, X., Chen, M., Mao, R., Xiao, X., Yi, C., Guo, Y., et al. (2025) · MedComm · doi:10.1002/mco2.70205 · Cited by 4
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Senescent cells and the dynamics of agingPreprint
Karin, O., Agrawal, A., Porat, Z., Krizhanovsky, V., & Alon, U. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/470500 · Cited by 4
“…effects by impairing tissue function and regeneration, modifying the extracellular matrix, and causing chronic inflammation (Childs et al., 2016; Demaria et al., 2015; Franceschi and Campisi, 2014; Freund et al., 2010; He and Sharpless, 2017; Muñoz-Espín and Serrano, 2014; Van Deursen, 2014;…”
BackgroundTargeting Senescent Cells to Improve Human Health
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“While, extrinsic aging, mainly caused by sun exposure, significantly alters both the epidermis and dermis (Demaria et al. 2015).”
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“RRM2B upregulation was consistent with SASP factor expression RT-PCR results in all senescent cell models showed that RRM2B upregulation in senescent cells was parallel with elevated gene expression levels of SASP factors such as IL6 , IL8 , CDKN2A , MMP3 , and MMP9 (Fig.”
InfluentialBalancing senescence and apoptosis: therapeutic insights into aging and cancer
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“These results agreed with Demaria et al., 2015 who discovered that the dermis of aged skin had sparse, broken-up collagen.”
ResultInvestigating senescence in cellular plasticity and tissue regeneration
Ritschka, B. (2017) · Repositori digital de la UPF (Universitat Pompeu Fabra)
Razali, N., Moriyama, Y., Chiu, Y., Suda, K., & Kono, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.27.497690 · Cited by 1
“Our results showed the upregulation of proinflammatory cytokines, Il-lα, Il-1β, Il-6, Cxcl8, and matrix degrading genes, Mmp1 and Mmp3, that play important roles in wound repair and collagen degradation (22,23).”
ResultCellular senescence during aging
von Zglinicki, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00017-3
Senescent Subtypes Transition ModelPreprint
Singh, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.10.544466
“What determines the phenotype of senescent cells, and whether their effects on the tissue microenvironment are positive or negative? [26] Another interesting hypothesis proposed that senescent cells can be of helper (H) or deleterious (D) subtypes.”
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Secretion of neurotoxic vesicles by muscle cells of ALS patients
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Metadata
- Authors
- Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Velarde, Michael C.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 135
- Issue
- 7
- Pages
- 1722-1726
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4466004
- OpenAlex
- W2067542143
- Cited by
- 127
- References
- 71
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K99-AG041221, P01- AG017242, P01-AG041122, R21-CA166347, R37-AG009909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- senescent cells, senescence-associated secretory phenotype, skin aging, extrinsic aging, intrinsic aging, wound healing, epidermis, dermis, cell-autonomous effects, extracellular matrix
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cell Division, Epidermis, Female, Fibroblasts, Homeostasis, Humans, Male, Sensitivity and Specificity, Skin, Wound Healing, Skin Aging, Cellular Senescence, Mice
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