The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin
Open accessAbstract
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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“However, the role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.57”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [57]
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · cited 2×
“Senescent cells increase with age in both the epidermis and dermis, as determined by elevated levels of senescenceassociated β-galactosidase activity and p16 expression (Dimri et al., 1995; Krishnamurthy et al., 2004; Ressler et al., 2006; Waaijer et al., 2012).”
BackgroundMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792 · cited 1×
“The proliferative phase begins with the formation of granulation tissue and collagen deposition, and the wound closes by epithelialization and the contraction of differentiated myofibroblasts, which are specialized contractile fibroblasts (Guo and Dipietro, 2010).”
BackgroundTumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1×
“Because wound healing and cancer share several molecular and cellular events (Dvorak, 1986; Feng et al., 2010), senescent cells may have an essential role in promoting wound healing while preventing cancer initiation.”
BackgroundMyofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · cited 3×
“Wound contraction is important for wound closure during the proliferative phase (Midwood et al., 2004) and proceeds through the formation of newly synthesized granulation tissue and the activation of contraction in myofibroblasts (Tomasek et al., 2002).”
BackgroundInfluentialClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1×
“Indeed, removal of senescent cells in a premature aging mouse model reduced selected age-related pathologies, such as sarcopenia, cataracts, and loss of subdermal adipose tissue (Baker et al., 2011).”
BackgroundHuman skin wounds: A major and snowballing threat to public health and the economy
Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00543.x · Cited by 2,965 · cited 2×
“Because chronic wounds fail to progress through the different stages of the wound-healing process (Sen et al., 2009), an excessive number of senescent cells may restrict cell proliferation and disrupt paracrine signaling cascades, thereby retarding the ability of wounds to resolve after injury.”
BackgroundInfluentialAging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 4×
“Cellular senescence is a complex stress response that renders cells incapable of cell division, even in the presence of growth stimuli (Campisi, 2013).”
BackgroundInfluentialThe role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · cited 1×
“Senescent cells can alter tissue homeostasis and promote age-related diseases, including degenerative pathologies and cancers (Campisi, 2013; van Deursen, 2014).”
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1 of the 71 references couldn’t be matched to a known paper.
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Cellular senescence promotes adverse effects of chemotherapy and cancer relapse
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338
“We and others have suggested that the secretory phenotype associated with senescent cells (SASP) can serve several biological functions, either beneficial or deleterious (29).”
BackgroundSelf-citationSenescent cells: an emerging target for diseases of ageing
Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284
Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
Lee, H. J., Hong, Y., & Kim, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212489 · Cited by 276
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
Salzer, M. C., Lafzi, A., Berenguer, A., Youssif, C., Castellanos‐Martín, A., Solanas, G., Peixoto, F. O., Attolini, C. S., Prats, N., Aguilera, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.012 · Cited by 246
Connective tissue and fibroblast senescence in skin aging
Wlaschek, M., Maity, P., Makrantonaki, E., & Scharffetter-Kochanek, K. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.010 · Cited by 245
Metadata
- Authors
- Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Velarde, Michael C.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 135
- Issue
- 7
- Pages
- 1722-1726
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4466004
- OpenAlex
- W2067542143
- Cited by
- 127
- References
- 71
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K99-AG041221, P01- AG017242, P01-AG041122, R21-CA166347, R37-AG009909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- senescent cells, senescence-associated secretory phenotype, skin aging, extrinsic aging, intrinsic aging, wound healing, epidermis, dermis, cell-autonomous effects, extracellular matrix
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cell Division, Epidermis, Female, Fibroblasts, Homeostasis, Humans, Male, Sensitivity and Specificity, Skin, Wound Healing, Skin Aging, Cellular Senescence, Mice
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