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Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin
Open accessAbstract
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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“However, the role of senescent cells in skin function is complex because they seem to have both beneficial and detrimental effects, depending on the context.57”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [57]
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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · cited 2×
“Senescent cells increase with age in both the epidermis and dermis, as determined by elevated levels of senescenceassociated β-galactosidase activity and p16 expression (Dimri et al., 1995; Krishnamurthy et al., 2004; Ressler et al., 2006; Waaijer et al., 2012).”
BackgroundMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792 · cited 1×
“The proliferative phase begins with the formation of granulation tissue and collagen deposition, and the wound closes by epithelialization and the contraction of differentiated myofibroblasts, which are specialized contractile fibroblasts (Guo and Dipietro, 2010).”
BackgroundTumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1×
“Because wound healing and cancer share several molecular and cellular events (Dvorak, 1986; Feng et al., 2010), senescent cells may have an essential role in promoting wound healing while preventing cancer initiation.”
BackgroundMyofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · cited 3×
“Wound contraction is important for wound closure during the proliferative phase (Midwood et al., 2004) and proceeds through the formation of newly synthesized granulation tissue and the activation of contraction in myofibroblasts (Tomasek et al., 2002).”
BackgroundInfluentialClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1×
“Indeed, removal of senescent cells in a premature aging mouse model reduced selected age-related pathologies, such as sarcopenia, cataracts, and loss of subdermal adipose tissue (Baker et al., 2011).”
BackgroundHuman skin wounds: A major and snowballing threat to public health and the economy
Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00543.x · Cited by 2,965 · cited 2×
“Because chronic wounds fail to progress through the different stages of the wound-healing process (Sen et al., 2009), an excessive number of senescent cells may restrict cell proliferation and disrupt paracrine signaling cascades, thereby retarding the ability of wounds to resolve after injury.”
BackgroundInfluentialAging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 4×
“Cellular senescence is a complex stress response that renders cells incapable of cell division, even in the presence of growth stimuli (Campisi, 2013).”
BackgroundInfluentialThe role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · cited 1×
“Senescent cells can alter tissue homeostasis and promote age-related diseases, including degenerative pathologies and cancers (Campisi, 2013; van Deursen, 2014).”
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Cellular senescence promotes adverse effects of chemotherapy and cancer relapse
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338
“We and others have suggested that the secretory phenotype associated with senescent cells (SASP) can serve several biological functions, either beneficial or deleterious (29).”
BackgroundSelf-citationSenescent cells: an emerging target for diseases of ageing
Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284
Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
Lee, H. J., Hong, Y., & Kim, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212489 · Cited by 276
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
Salzer, M. C., Lafzi, A., Berenguer, A., Youssif, C., Castellanos‐Martín, A., Solanas, G., Peixoto, F. O., Attolini, C. S., Prats, N., Aguilera, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.012 · Cited by 246
Connective tissue and fibroblast senescence in skin aging
Wlaschek, M., Maity, P., Makrantonaki, E., & Scharffetter-Kochanek, K. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.010 · Cited by 245
Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging
Fitsiou, E., Pulido, T., Campisi, J., Alimirah, F., & Demaria, M. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.09.031 · Cited by 237
Skin Structure–Function Relationships and the Wound Healing Response to Intrinsic Aging
Blair, M. J., Jones, J. D., Woessner, A. E., & Quinn, K. P. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.1021 · Cited by 236
“Cellular senescence occurs naturally to maintain healthy skin, but the amount of senescent cells in the epidermis and dermis increases significantly with advanced age.95,96 When the elderly suffer a cutaneous wound, the effects of increased senescence can directly impair skin regeneration and hinder migratory potentia…”
BackgroundInfluentialPilkington, S. M., Bulfone‐Paus, S., Griffiths, C. E. M., & Watson, R. E. B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.006 · Cited by 235
DiLoreto, R., & Murphy, C. T. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1084 · Cited by 192
“, 2014), as well as in age-related pathologies (van Deursen, 2014; Demaria et al., 2015), including neurodegenerative”
BackgroundOn the evolution of cellular senescence
Kowald, A., Passos, J. F., & Kirkwood, T. B. L. (2020) · Aging Cell · doi:10.1111/acel.13270 · Cited by 189
“…for several biological processes that are not related to aging, such as limiting liver fibrosis (Krizhanovsky et al., 2008), accelerating and improving wound healing (Demaria et al., 2014, 2015), tissue regeneration (Ritschka et al., 2017) and limb regeneration of salamanders (Yun et al., 2015).”
BackgroundPatil, P. R., Dong, Q. D., Wang, D., Chang, J., Wiley, C. D., Demaria, M., Lee, J., Kang, J. D., Niedernhofer, L. J., Robbins, P. D., et al. (2019) · Aging Cell · doi:10.1111/acel.12927 · Cited by 170
Gruber, F., Kremslehner, C., Eckhart, L., & Tschachler, E. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2019.110780 · Cited by 166
The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging
Ghosh, K., & Capell, B. C. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.06.621 · Cited by 171
“…the SASP has also been associated with a host of deleterious effects, ranging from skin aging (through MMP1-mediated collagen breakdown) and osteoarthritis to cardiovascular disease and diabetes (Demaria et al., 2015; Fyhrquist et al., 2013; Greene and Loeser, 2015; Munoz-Espin and Serrano, 2014).”
BackgroundInfluentialExtracellular matrix alterations in senescent cells and their significance in tissue homeostasis
Mavrogonatou, E., Pratsinis, H., Papadopoulou, A., Karamanos, N. K., & Kletsas, D. (2019) · Matrix Biology · doi:10.1016/j.matbio.2017.10.004 · Cited by 153
The costs and benefits of senotherapeutics for human health
Raffaele, M., & Vinciguerra, M. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00300-7 · Cited by 140
Lang, A., Grether‐Beck, S., Singh, M., Kuck, F., Jakob, S., Kefalas, A., Altinoluk-Hambüchen, S., Graffmann, N., Schneider, M., Lindecke, A., et al. (2016) · Aging · doi:10.18632/aging.100905 · Cited by 142
Boyajian, J. L., Ghebretatios, M., Schaly, S., Islam, P., & Prakash, S. (2021) · Nutrients · doi:10.3390/nu13124550 · Cited by 115
“As a result, the SASP factors work transiently in a beneficial manner to perform immune surveillance, promote tissue repair and homeostasis and suppress tumorigenesis [12,14,24,25].”
BackgroundRey, M. J. D., Valín, Á., Usategui, A., Ergueta, S., Martín, E., Municio, C., Cañete, J. D. D., Blanco, F. J., Criado, G., & Pablos, J. L. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0169-4 · Cited by 120
How good is the evidence that cellular senescence causes skin ageing?
Low, E., Alimohammadiha, G., Smith, L. A., Costello, L., Przyborski, S. A., von Zglinicki, T., & Miwa, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101456 · Cited by 116
“greatly enhanced age-related phenotypes in the skin (Davis et al., 2007; Demaria et al., 2015; Liu et al., 2006).”
BackgroundInfluentialScarless wound healing: From development to senescence
Pratsinis, H., Mavrogonatou, E., & Kletsas, D. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.011 · Cited by 103
Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss
Shin, W., Rosin, N. L., Sparks, H. D., Sinha, S., Rahmani, W. M., Sharma, N. C., Workentine, M., Abbasi, S., Labit, E., Stratton, J. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.03.019 · Cited by 105
Cellular senescence and tumor promotion: Is aging the key?
Loaiza, N., & Demaria, M. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.01.007 · Cited by 101
Self-citationThe role of senescence in cancer development
Mavrogonatou, E., Pratsinis, H., & Kletsas, D. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.018 · Cited by 95
Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders
Bellei, B., & Picardo, M. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100981 · Cited by 93
Current Concepts in Debridement: Science and Strategies
Anghel, E. L., DeFazio, M. V., Barker, J. C., Janis, J. E., & Attinger, C. E. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002651 · Cited by 82
Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?
Abbadie, C., Pluquet, O., & Pourtier, A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2587-9 · Cited by 77
Cavinato, M. S., Kozieł, R., Romani, N., Weinmüllner, R., Jenewein, B., Hermann, M., Dubrac, S., Ratzinger, G., Grillari, J., Schmuth, M., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw150 · Cited by 82
Narzt, M.-S., Pils, V., Kremslehner, C., Nagelreiter, I.-M., Schosserer, M., Bessonova, E., Bayer, A., Reifschneider, R., Terlecki-Zaniewicz, L., Waidhofer-Söllner, P., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.020 · Cited by 73
Regulation of the Wound Healing Response during Aging
Ding, X., Kakanj, P., Leptin, M., & Eming, S. A. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.014 · Cited by 78
Targeting senescent cells: possible implications for delaying skin aging: a mini-review
Velarde, M. C., & Demaria, M. (2016) · Gerontology · doi:10.1159/000444877 · Cited by 69
Song, H., Zhang, S., Zhang, L., & Li, B. (2017) · Nutrients · doi:10.3390/nu9111209 · Cited by 70
“In the chronologically aged skin, dermal collagen fiber became sparse, fragmented and disorganized [35,36].”
BackgroundFibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing
Gauthier, V., Kyriazi, M., Nefla, M., Pucino, V., Raza, K., Buckley, C. D., & Alsaleh, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1137659 · Cited by 63
“Frontiers in Immunology 09 dependent (94).”
BackgroundSenescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration
Farsam, V., Basu, A., Gatzka, M., Treiber, N., Schneider, L. A., Mulaw, M. A., Lucas, T., Kochanek, S., Dummer, R., Levesque, M. P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13446 · Cited by 59
“com/oncotarget incidence of cancer [9, 11, 47].”
tBHP treatment as a model for cellular senescence and pollution-induced skin aging
Wedel, S., Martic, I., Hrapovic, N., Fabre, S., Madreiter‐Sokolowski, C. T., Haller, T., Pierer, G., Ploner, C., Jansen‐Dürr, P., & Cavinato, M. S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111318 · Cited by 62
“Aged skin tissue is characterized by an accumulation of senescent cells that eventually impairs tissue health and composition (Demaria et al., 2015).”
BackgroundAnti-Aging Activity and Modes of Action of Compounds from Natural Food Sources
Song, L., & Zhang, S. (2023) · Biomolecules · doi:10.3390/biom13111600 · Cited by 58
Novel approaches for managing aged skin and nonmelanoma skin cancer
Todorova, K. A., & Mandinova, A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.004 · Cited by 59
Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage
Davinelli, S., Bertoglio, J. C., Polimeni, A., & Scapagnini, G. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171109102426 · Cited by 57
Senescence and tumor suppression
Hinds, P. W., & Pietruska, J. R. (2017) · F1000Research · doi:10.12688/f1000research.11671.1 · Cited by 56
Cellular senescence and wound healing in aged and diabetic skin
Kita, A., Yamamoto, S., Saito, Y., & Chikenji, T. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1344116 · Cited by 64
“Typically, wound healing involves dynamic and interactive stages, including (i) hemostasis, (ii) in fl ammation, (iii) proliferation, and (iv) remodeling, which partially overlap (Singer and Clark, 1999; Demaria et al., 2015).”
BackgroundMavrogonatou, E., Konstantinou, A., & Kletsas, D. (2018) · Biogerontology · doi:10.1007/s10522-018-9753-9 · Cited by 55
“Secretion of SASP factors by senescent fibroblasts may in turn influence surrounding cells and skin homeostasis, in general, under normal conditions and may also play a pivotal role in the microenvironment of the wound (Demaria et al. 2015), seriously affecting tissue repair and thus leading to the development of non-…”
Elevated skin senescence in young mice causes delayed wound healing
Thanapaul, R. J. R. S., Shvedova, M., Shin, G. H., Crouch, J. D., & Roh, D. S. (2022) · GeroScience · doi:10.1007/s11357-022-00551-1 · Cited by 52
Endocrine Controls of Skin Aging
Böhm, M., Stegemann, A., Paus, R., Kleszczyński, K., Maity, P., Wlaschek, M., & Scharffetter‐Kochanek, K. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnae034 · Cited by 59
The senescence-associated secretory phenotype: Fueling a wound that never heals
Pulido, T., Velarde, M. C., & Alimirah, F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111561 · Cited by 54
Convective exosome-tracing microfluidics for analysis of cell-non-autonomous neurogenesis
Oh, H. J., Shin, Y., Chung, S. H., Hwang, D. W., & Lee, D. S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.006 · Cited by 50
Zorina, A. I., Zorin, V. L., Isaev, A. A., Kudlay, D. A., Vasileva, M., & Kopnin, P. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050247 · Cited by 53
“SASP includes many proinflammatory cytokines/chemokines, growth factors, matrix metalloproteinases (MMPs), and other soluble factors [66,68].”
BackgroundEzure, T., Sugahara, M., & Amano, S. (2019) · BioFactors · doi:10.1002/biof.1512 · Cited by 47
“Demaria pointed out that, although MMPs secreted from senescent cells could chronically impair dermal condition, they contribute to the remodeling or hypertrophy of tissue during wound healing.(3) Thus, SASP could have both positive and negative aspects.”
BackgroundThe role of cellular senescence in aging through the prism of Koch-like criteria
Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45
Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging
Zorina, A. I., Zorin, V. L., Kudlay, D. A., & Kopnin, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116135 · Cited by 46
Durant, F., & Whited, J. L. (2021) · Advanced Science · doi:10.1002/advs.202100407 · Cited by 43
Konstantinow, A., Arnold, A., Djabali, K., Kempf, W., Gutermuth, J., Fischer, T. V., & Biedermann, T. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14489 · Cited by 41
Mehdipour, M., Etienne, J., Chen, C.-C., Gathwala, R., Rehman, M., Kato, C., Liu, C., Liu, Y., Zuo, Y., Conboy, M. J., et al. (2019) · Aging · doi:10.18632/aging.102148 · Cited by 39
“High p16 generally corresponds with senescent cell phenotypes, and there is a profound interest in development of new pharmaceuticals for p16high cell ablation (senolytics) or p16 down-modulation (senomorphics) as a way to increase life-span and/or health-span [16, 38, 42, 56-59].”
BackgroundTissue engineering strategies to bioengineer the ageing skin phenotype in vitro
Costello, L., DiColandrea, T., Tasseff, R. A., Isfort, R. J., Bascom, C., von Zglinicki, T., & Przyborski, S. A. (2022) · Aging Cell · doi:10.1111/acel.13550 · Cited by 33
Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury
Wang, M., Wu, P., Huang, J. G., Liu, W., Qian, H., Sun, Y., & Shi, H. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac037 · Cited by 34
“Senescent cells accumulate in the skin during aging and alter the skin’s microenvironment [174,175].”
BackgroundEffect of Coffee Berry Extract on Anti-Aging for Skin and Hair—In Vitro Approach
Saewan, N. (2022) · Cosmetics · doi:10.3390/cosmetics9030066 · Cited by 41
“The clavation of interstitial collagens and alteration of the extracellular matrix are primarily responsible for the clinical manifestations of skin aging such as wrinkles, sagging, and laxity [43,44].”
BackgroundSenotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
Zonari, A. A. C., Brace, L. E., Al-Katib, K., Porto, W. F., Foyt, D. A., Guiang, M., Cruz, E. A. O., Marshall, B., Salgueiro, W. G., Inan, M. D., et al. (2023) · npj Aging · doi:10.1038/s41514-023-00109-1 · Cited by 41
Zhang, L., Zhang, S., Song, H., & Лі, Б. (2020) · Food & Function · doi:10.1039/d0fo00153h · Cited by 31
Li, T., Lu, H., Zhou, L., Jia, M., Zhang, L., Wu, H., Shan, L., & Efferth, T. (2021) · Cell Proliferation · doi:10.1111/cpr.13212 · Cited by 26
“Human dermal fibroblasts (HDFs) are the primary cell types in dermis layer and are responsible for synthesis of collagen and elastic fibres.(3) With ageing, the quantity and”
BackgroundJarrold, B. B., Tan, C. Y. R., Ho, C. Y., Soon, A. L., Lam, T. T., Yang, X., Nguyen, C., Guo, W., Chew, Y. C., DeAngelis, Y. M., et al. (2022) · Experimental Dermatology · doi:10.1111/exd.14654 · Cited by 28
Mapping cellular senescence networks in human diabetic foot ulcers
Yu, G., Monie, D. D., Khosla, S., Tchkonia, T., Kirkland, J. L., & Wyles, S. P. (2023) · GeroScience · doi:10.1007/s11357-023-00854-x · Cited by 26
“SASP factors, which include pro-inflammatory cytokines, matrix metalloproteinases, and growth factors, can modulate the local microenvironment and disrupt neighboring cells [17, 18].”
In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes
Saewan, N., Jimtaisong, A., Panyachariwat, N., & Chaiwut, P. (2023) · Molecules · doi:10.3390/molecules28196830 · Cited by 31
“The primary causes of the clinical signs of aging skin, such as wrinkles, sagging, and laxity, indicate the degradation of interstitial collagens and changes in the extracellular matrix [51,52].”
Changes in Communication between Muscle Stem Cells and their Environment with Aging
Thorley, M., Malatras, A., Duddy, W. J., Gall, L. L., Mouly, V., Butler-Browne, G. S., & Duguez, S. (2015) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-150097 · Cited by 25
“During the last decade, the secretome of senescent cells from different tissues has been investigated and has been described to have an impact on the inflammatory response (by stimulating it in chronic obstructive pulmonary disease [105]) and to be instrumental in poor tissue regeneration (as observed in aged skin [10…”
BackgroundLewińska, A., & Wnuk, M. (2017) · Biogerontology · doi:10.1007/s10522-017-9676-x · Cited by 21
“However, senescent cells are metabolically active or even hyperactive and are able to produce pro-inflammatory factors, namely interleukins, chemokines and growth factors that may have adverse effects on surrounding cells and tissues (Demaria et al. 2015; Kennedy et al. 2014).”
BackgroundInfluentialLINCing Senescence and Nuclear Envelope Changes
Meqbel, B. R. M., Gomes, M., Omer, A., Gallouzi, I., & Horn, H. F. (2022) · Cells · doi:10.3390/cells11111787 · Cited by 23
“In general, senescence is associated with some of the detrimental aspects of aging, such as loss of skin elasticity and increased incidence of cancer; however, in some scenarios, senescence can also contribute to healing [9].”
BackgroundExosomal microRNA-Based therapies for skin diseases
Chen, J., Weiping, L., Yuwei, Y., Bingzheng, F., & Xu, Z. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.12.005 · Cited by 21
“The skin of rodents contains the epidermis and dermis, and the interphase epidermis and dermis is fl at, whereas in humans it is highly undulated [24].”
BackgroundMehdipour, M., Etienne, J., Liu, C., Mehdipour, T., Kato, C., Conboy, M. J., Conboy, I. M., & KIPROV, D. D. (2021) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2021.103162 · Cited by 20
Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan
Kaur, P., Otgonbaatar, A., Ramamoorthy, A., Chua, E. H. Z., Harmston, N., Gruber, J., & Tolwinski, N. S. (2022) · Aging · doi:10.18632/aging.204347 · Cited by 20
“Senescent cells show persistent activation of the mTOR pathway, a state that promotes secretion of a wide range of signaling molecules, including proinflammatory cytokines (43-45).”
BackgroundSenolytics and the compression of late-life mortality
Kowald, A., & Kirkwood, T. B. L. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111588 · Cited by 22
Hwang, S. B., Park, H. J., & Lee, B. (2023) · Marine Drugs · doi:10.3390/md21090475 · Cited by 18
“The skin becomes thinner when its integrity is compromised, thus affecting its wound healing and regenerative abilities [25,26].”
BackgroundJoo, H. J., Ma, D. J., Hwang, J. S., & Shin, Y. J. (2020) · Antioxidants · doi:10.3390/antiox9111085 · Cited by 17
“Senescent cells do not proliferate in response to mitogenic signals, which induces the failure of regeneration in wound healing [40].”
BackgroundTakaya, K., Asou, T., & Kishi, K. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0056 · Cited by 17
Senescent cells: New target for an old treatment?
Demaria, M. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1299666 · Cited by 18
“We and others have suggested that the secretory phenotype associated with senescent cells (SASP) can serve several biological functions, either beneficial or deleterious.(5) Among the deleterious effects, the excessive persistence of senescent cells can disrupt tissue homeostasis and drive the onset or progression of…”
BackgroundHomologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
Ghadaouia, S., Olivier, M., Martinez, A., Kientega, T., Jian, Q., Lambert-Lanteigne, P., Cardin, G. B., Autexier, C., Malaquin, N., & Rodier, F. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab965 · Cited by 17
Clinical Implications of Cellular Senescence on Wound Healing
Resnik, S. G., Egger, A. N., Abujamra, B. A., & Jozic, I. (2020) · Current Dermatology Reports · doi:10.1007/s13671-020-00320-3 · Cited by 18
Pan, Y., Gu, Z., Lyu, Y., Yang, Y., Chung, M., Pan, X., & Cai, S. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0021 · Cited by 15
“64 Nevertheless, the SASP can lead to chronic inflammation and some inevitable, adverse consequences such as degenerative illnesses, cancer, and poor regeneration.”
Takaya, K., Asou, T., & Kishi, K. (2022) · Cells · doi:10.3390/cells11233749 · Cited by 17
“MMPs secreted by senescent cells may chronically impair skin conditions but contribute to tissue remodeling or hypertrophy during wound healing [32].”
BackgroundThe influence of photodynamic therapy with 5-aminolevulinic acid on senescent skin cancer cells
Grigalavicius, M., Juraleviciute, M., Kwitniewski, M., & Juzeniene, A. (2016) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2016.10.008 · Cited by 14
“cancer has a strong association with aging is that human skin accumulates senescent cells in both the epidermis and dermis [2].”
BackgroundTMPRSS11a is a novel age‐altered, tissue specific regulator of migration and wound healing
Fernández, C., Burgos, A., Morales, D., Rosales‐Rojas, R., Canelo, J., Vergara‐Jaque, A., Vieira, G. V., da Silva, R. A. A., Sales, K. U., Conboy, M. J., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002253rrr · Cited by 15
Fotopoulou, A., Angelopoulou, M. T., Pratsinis, H., Mavrogonatou, E., & Kletsas, D. (2024) · Aging Cell · doi:10.1111/acel.14422 · Cited by 14
“In addition, accumulation of senescent cells has long been observed in aged and sun-exposed skin (Demaria et al., 2015; Ressler et al., 2006 ; Waaijer et al., 2012 ).”
Wlaschek, M., Maity, P., Koroma, A. K., Geiger, H., Singh, K., & Scharffetter‐Kochanek, K. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.024 · Cited by 17
Possibility of inducing tumor cell senescence during therapy (Review)
Wang, G., Cheng, X., Zhang, J., Liao, Y., Jia, Y., & Qing, C. (2021) · Oncology Letters · doi:10.3892/ol.2021.12757 · Cited by 15
Búa, S., Sotiropoulou, P., Sgarlata, C., Borlado, L. R., Eguren, M., Domı́nguez, O., Ortega, S., Malumbres, M., Blanpain, C., & Méndez, J. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1120919 · Cited by 15
“We next tested the ability of K5Cdc6 skin to heal after injury, a complex process that involves an initial coagulation and inflammatory response, followed by a proliferation phase to form granulation tissue and deposit collagen, and a final stage of wound-closing mediated by the contraction of myofibroblasts (reviewed…”
BackgroundAqueous extract of Phragmites communis rhizomes attenuates phototoxicity in skin cells
Kim, S. H., Ha, C. W., Lim, H., Jang, S., Namkoong, S., Hong, S., Kim, Y. K., Kim, J., Lee, S. R., & Sohn, E. (2020) · Molecular & Cellular Toxicology · doi:10.1007/s13273-020-00106-5 · Cited by 13
Revitalizing Aging Skin through Diet
Millar, S. E. (2018) · Cell · doi:10.1016/j.cell.2018.11.016 · Cited by 12
A study on the anti-senescent effects of flavones derived from Prinsepia utilis Royle seed residue
Liu, J., Qu, L., Wang, F., Mei, Z., Wu, X., Wang, B., Liu, H., & He, L. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118021 · Cited by 13
Peropadre, A., Freire, P. F., & Hazen, M. J. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.09.020 · Cited by 12
Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells
Augustyniak, A., & McMahon, H. P. (2023) · Marine Drugs · doi:10.3390/md21060330 · Cited by 11
“The integrity of the skin is disturbed, skin becomes thinner, and wound healing and regenerative abilities are compromised [3,4].”
Boismal, F., Peltier, S., So, S. L. K., Chevreux, G., Blondel, L., Serror, K., Setterblab, N., Zuelgaray, E., Boccara, D., Mimoun, M., et al. (2024) · Aging · doi:10.18632/aging.206055 · Cited by 11
Skin microbiome and skin aging: emerging strategies for manipulation
Wang, Z., Yuan, F., Zhong, X., Feng, S., & Song, T. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128285 · Cited by 10
Impaired Wound Repair and Delayed Angiogenesis
Ranzer, M. J., & DiPietro, L. A. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_85 · Cited by 9
Hartinger, R., Singh, K., Leverett, J. C., & Djabali, K. (2024) · Biomolecules · doi:10.3390/biom14101310 · Cited by 8
“The reduction in fibroblast numbers, which are crucial for the synthesis and structural organization of the extracellular matrix, along with an accumulation of senescent cells in both the epidermal and dermal layers impair cell proliferation and contribute to the aging skin phenotype [9,15,16].”
BackgroundPecora, C. D. S., Corduff, N., Carroll, J., Muniz, M., & Sattler, S. (2025) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000006873 · Cited by 8
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging
Takaya, K., & Kishi, K. (2024) · Biogerontology · doi:10.1007/s10522-024-10096-9 · Cited by 10
“Fibroblast senescence is a persistent condition that results in skin aging, general aging, and age-related diseases (Demaria et al. 2015; Lago and Puzzi 2019).”
Acosta, J. B., Mendoza‐Marí, Y., Ojalvo, A. G., Fernández‐Mayola, M., & Nieto, G. G. (2018) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000798 · Cited by 6
Zhelavskyi, M. M., Kernychnyi, S., Dmytriv, O. Y., & Betlinska, T. V. (2022) · Ukrainian Journal of Veterinary and Agricultural Sciences · doi:10.32718/ujvas5-1.02 · Cited by 7
“However, as with apoptosis, senescent cells turn out to have beneficial effects on development, wound healing, and tissue repair (Demaria et al., 2015; Lewis-McDougall et al., 2019).”
BackgroundSenotherapeutic peptide reduces skin biological age and improves skin health markersPreprint
Zonari, A. A. C., Brace, L. E., Al-Katib, K., Porto, W. F., Foyt, D. A., Guiang, M., Cruz, E. A. O., Marshall, B., Salgueiro, W. G., Inan, M. D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.30.362822 · Cited by 7
Anti‐aging and rejuvenating effects and mechanism of Dead Sea water in skin
Yan, X., Bao, X., Cheng, S., Ba, Q., Chang, J., Zhou, K., & Yan, X. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12931 · Cited by 6
“SASP is a secretome of pro-inflammatory cytokines and chemokines, pro-oxidant ROS and degradative proteases [39].”
BackgroundBerlanga‐Acosta, J., Mendoza‐Marí, Y., Ojalvo, A. G., Buxadó, J. A., Fernández‐Mayola, M., & Nieto, G. G. (2019) · Integrative Molecular Medicine · doi:10.15761/imm.1000354 · Cited by 6
Insight into the dichotomous regulation of STING activation in immunotherapy
Hu, Z., Yang, Y. K., Fang, L., Zhou, J., & Zhang, H. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1890118 · Cited by 5
Hautalterung – zelluläre Seneszenz
Scharffetter‐Kochanek, K., Wang, Y., Makrantonaki, E., Crișan, D., Wlaschek, M., Geiger, H., & Maity, P. (2023) · Die Dermatologie · doi:10.1007/s00105-023-05201-x · Cited by 5
The Impact of Lasers and Energy‐Based Devices on Cellular Senescence: A Systematic Review
Kelm, R. C., & Murphrey, M. B. (2025) · Lasers in Surgery and Medicine · doi:10.1002/lsm.70079 · Cited by 5
Metadata
- Authors
- Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Velarde, Michael C.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 135
- Issue
- 7
- Pages
- 1722-1726
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4466004
- OpenAlex
- W2067542143
- Cited by
- 127
- References
- 71
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K99-AG041221, P01- AG017242, P01-AG041122, R21-CA166347, R37-AG009909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- senescent cells, senescence-associated secretory phenotype, skin aging, extrinsic aging, intrinsic aging, wound healing, epidermis, dermis, cell-autonomous effects, extracellular matrix
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cell Division, Epidermis, Female, Fibroblasts, Homeostasis, Humans, Male, Sensitivity and Specificity, Skin, Wound Healing, Skin Aging, Cellular Senescence, Mice
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