Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort
Open accessAbstract
Urinary albumin excretion is a powerful predictor of progressive cardiovascular and renal disease. In rats and humans, administration of a synthetic vasopressin analogue, 1-desamino-8-D-arginine-vasopressin, increases urinary albumin excretion; however, it is unknown if endogenous vasopressin levels influence albumin excretion. To determine this we measured copeptin, a marker of endogenous vasopressin levels, and its association with urinary albumin excretion in 7593 patients in the PREVEND study, a prospective population based, observational cohort. Urinary albumin excretion was measured in two consecutive 24-h urine samples by nephelometry while copeptin was measured by an immunoassay. Median copeptin concentrations were significantly higher in males than females and high levels were associated with significantly lower 24-h urine volumes of high osmolarity. With increasing quintiles of copeptin levels, the percentage of microalbuminuric subjects increased from 13 to 25 for males and from 8 to15 for females. This association was independent of age and other potential confounders; however, we found an interaction between age and copeptin in their association with urinary albumin excretion. Our study shows that plasma copeptin levels are associated with microalbuminuria, consistent with the hypothesis that vasopressin is involved in urinary albumin excretion. If future studies show that this association is causal, then drinking more water or pharmacological intervention to decrease plasma vasopressin may have beneficial effects on the kidney, especially in the elderly.
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Epidemiological studies in humans are consistent with vasopressin contributing to albuminuria and diabetes-induced nephropathy.
“Epidemiological studies in humans are consistent with these findings [21][22][23].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [22]
Water intake alters vasopressin secretion, and vasopressin and copeptin secretion depends on the level of hydration.
“Water intake alters vasopressin secretion.”
From Low Water Intake and Risk for New-Onset Hyperglycemia (2011) · cites this paper as [10]
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- Authors
- Meijer, E., Bakker, S. J. L., Halbesma, N., de Jong, P. E., Struck, J., & Gansevoort, R. T.
- Affiliations
- University Medical Center Groningen (NL)
- Leiden University Medical Center (NL)
- Corresponding author
- Gansevoort, Ron T.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 77
- Issue
- 1
- Pages
- 29-36
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2138960844
- Cited by
- 123
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 12 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 9
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Nierstichting
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- copeptin, vasopressin, microalbuminuria, urinary albumin excretion, age interaction, sex differences, PREVEND study, kidney disease, cardiovascular risk
- MeSH terms
- Adult, Age Factors, Albumins, Albuminuria, Cross-Sectional Studies, Female, Glycopeptides, Humans, Male, Middle Aged, Prospective Studies, Sex Factors, Vasopressins, Cohort Studies, Biomarkers
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