Plasma Copeptin and Renal Outcomes in Patients With Type 2 Diabetes and Albuminuria
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OBJECTIVE: Plasma copeptin, a surrogate for vasopressin, was associated with albuminuria in population-based studies. These associations are consistent with the effect of vasopressin on albuminuria observed in humans and rodents. The objective of this study was to determine whether plasma copeptin is an independent marker of risk of renal events in people with type 2 diabetes and albuminuria. RESEARCH DESIGN AND METHODS: We studied 3,101 participants of the DIABHYCAR trial (6-year follow-up) with type 2 diabetes and albuminuria. A renal event was defined as doubling of serum creatinine or development of end-stage renal disease. RESULTS: During follow-up, 86 renal events occurred in 76 subjects (2.45%). Incidences by tertiles of baseline plasma copeptin were 1.06% (T1), 1.45% (T2), and 4.84% (T3). They were 2.43% (T1), 5.11% (T2), and 11.81% (T3) for the subset of subjects with macroalbuminuria at baseline (n = 729). Hazard ratio for plasma copeptin tertiles as a risk for renal events was 4.79 (95% CI, 2.48–9.24; P < 0.0001; for T3 vs. T1). In a stepwise regression analysis, urinary albumin excretion and plasma copeptin remained positively associated and HDL cholesterol and estimated glomerular filtration rate were inversely associated with the incidence of renal events. These independent predictors explained ∼18% of the variance of the outcome. The yearly variations of estimated glomerular filtration rate by copeptin tertiles were −1.43 ± 0.51 (T1), −2.29 ± 0.49 (T2), and −3.52 ± 0.44 mL/min/1.73 m2 per year (T3) (P = 0.005) in subjects with macroalbuminuria. CONCLUSIONS: Plasma copeptin may help to identify subjects with diabetic chronic kidney disease who are at high risk for renal function decline.
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Epidemiological studies in humans are consistent with vasopressin contributing to albuminuria and diabetes-induced nephropathy.
“Epidemiological studies in humans are consistent with these findings [21][22][23].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [23]
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- Authors
- Velho, G., Bouby, N., Hadjadj, S., Matallah, N., Mohammedi, K., Fumeron, F., Potier, L., Bellili-Munoz, N., Taveau, C., Alhenc-Gelas, F., Bankir, L., Marre, M., & Roussel, R.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- INSERM, Research Unit 695, Paris, France
- INSERM, Research Unit 872, Paris, France
- Corresponding author
- Velho, Gilberto
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2013-10-15
- Volume
- 36
- Issue
- 11
- Pages
- 3639-3645
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3816878
- OpenAlex
- W2105820627
- Cited by
- 89
- References
- 39
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 12 · 2014: 7
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- vasopressin, type 2 diabetes, albuminuria, macroalbuminuria, diabetic nephropathy, end-stage renal disease, renal function decline, estimated glomerular filtration rate, HDL cholesterol, risk indicators
- MeSH terms
- Aged, Albuminuria, Arginine Vasopressin, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Glomerular Filtration Rate, Glycopeptides, Humans, Kidney Failure, Chronic, Kidney Function Tests, Male, Middle Aged, Biomarkers
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