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Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
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“A study showed that miR-155 plays a significant role in monocyte differentiation through combinatorial regulation. They expressed that miR-155 can lead to cell cycle arrest, apoptosis and differentiation (Forrest et al. 2010).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Forrest et al. 2010
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Citations
Cites
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 1×
“We hypothesize that apoptosis by mir-155 occurs by targeting anti-apoptotic factors (similar to BCL2 targeting by mir-15/16 (29)) and predict RPS6KA3, SGK3, RHEB and KRAS as likely targets (40-43) three of which have supporting protein level evidence as targets (RPS6KA3, RHEB and KRAS) (44, 45).”
Background
Research works printed but not linked: 50
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Metadata
- Authors
- Forrest, A. R. R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., de Hoon, M. J. L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A., & Suzuki, H.
- Venue
- Leukemia
- Published
- 2009-12-03
- Volume
- 24
- Issue
- 2
- Pages
- 460-466
- ISSN
- 0887-6924
- 1476-5551
- Cited by
- 223
- References
- 3
- Language
- en
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- CoChat. (2026). Citation check: Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. https://app.cochat.ai/papers/10.1038/leu.2009.246
- The paper
- Forrest, A. R. R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., de Hoon, M. J. L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D. A., & Suzuki, H. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia. https://doi.org/10.1038/leu.2009.246