The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project
Open accessAbstract
The combination of serum β2-microglobulin and albumin levels has been shown to be highly prognostic in myeloma as the International Staging System (ISS). The aim of this study was to assess the independent contributions of ISS stage and cytogenetic abnormalities in predicting outcomes. A retrospective analysis of international studies looking at both ISS and cytogenetic abnormalities was performed in order to assess the potential role of combining ISS stage and cytogenetics to predict survival. This international effort used the International Myeloma Working Group database of 12 137 patients treated worldwide for myeloma at diagnosis, of whom 2309 had cytogenetic studies and 5387 had analyses by fluorescent in situ hybridization (iFISH). Comprehensive analyses used 2642 patients with sufficient iFISH data available. Using the comprehensive iFISH data, combining both t(4;14) and deletion (17p), along with ISS stage, significantly improved the prognostic assessment in terms of progression-free survival and overall survival. The additional impact of patient age and use of high-dose therapy was also demonstrated. In conclusion, the combination of iFISH data with ISS staging significantly improves risk assessment in myeloma.
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Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma
San Miguel, J. F., Schlag, R., Khuageva, N. K., Dimopoulos, M. A., Shpilberg, O., Kropff, M., Spicka, I., Petrucci, M. T., Palumbo, A., Samoilova, O. S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801479 · Cited by 1,899
Cited by
Palumbo, A., Avet-Loiseau, H., Oliva, S., Lokhorst, H. M., Goldschmidt, H., Rosinol, L., Richardson, P., Caltagirone, S., Lahuerta, J. J., Facon, T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.2267 · Cited by 2,210
Self-citationWalker, B. A., Boyle, E. M., Wardell, C. P., Murison, A., Begum, D. B., Dahir, N. M., Proszek, P. Z., Johnson, D. C., Kaiser, M. F., Melchor, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.1503 · Cited by 567
Self-citationPrognostic role of circulating exosomal miRNAs in multiple myeloma
Manier, S., Liu, C.-J., Avet-Loiseau, H., Park, J., Shi, J., Campigotto, F., Salem, K. Z., Huynh, D., Glavey, S. V., Rivotto, B., et al. (2017) · Blood · doi:10.1182/blood-2016-09-742296 · Cited by 266
Self-citationNeben, K., Jauch, A., Hielscher, T., Hillengass, J., Lehners, N., Seckinger, A., Granzow, M., Raab, M. S., Ho, A. D., Goldschmidt, H., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.4923 · Cited by 233
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Metadata
- Authors
- Avet-Loiseau, H., Durie, B. G. M., Cavo, M., Attal, M., Gutierrez, N., Haessler, J., Goldschmidt, H., Hajek, R., Lee, J. H., Sezer, O., Barlogie, B., Crowley, J., Fonseca, R., Testoni, N., Ross, F., Rajkumar, S. V., Sonneveld, P., Lahuerta, J., Moreau, P., Morgan, G., & on behalf of the International Myeloma Working Group
- Venue
- Leukemia
- Published
- 2012-10-03
- Volume
- 27
- Issue
- 3
- Pages
- 711-717
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2080218360
- Cited by
- 181
- References
- 1
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Avet-Loiseau, H., Durie, B. G. M., Cavo, M., Attal, M., Gutierrez, N., Haessler, J., Goldschmidt, H., Hajek, R., Lee, J. H., Sezer, O., Barlogie, B., Crowley, J., Fonseca, R., Testoni, N., Ross, F., Rajkumar, S. V., Sonneveld, P., Lahuerta, J., Moreau, P., . . . on behalf of the International Myeloma Working Group. (2013). Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project. Leukemia. https://doi.org/10.1038/leu.2012.282
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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