The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43
Open accessAbstract
Intestinal IgA, which is regulated by gut microbiota, has a crucial role in maintenance of intestinal homeostasis and in protecting the intestines from inflammation. However, the means by which microbiota promotes intestinal IgA responses remain unclear. Emerging evidence suggests that the host can sense gut bacterial metabolites in addition to pathogen-associated molecular patterns and that recognition of these small molecules influences host immune response in the intestines and beyond. We reported here that microbiota metabolite short-chain fatty acid acetate promoted intestinal IgA responses, which was mediated by “metabolite-sensing” GPR43. GPR43−/− mice demonstrated lower levels of intestinal IgA and IgA+ gut bacteria compared with those in wild type (WT) mice. Feeding WT but not GPR43−/− mice acetate but not butyrate promoted intestinal IgA response independent of T cells. Acetate promoted B-cell IgA class switching and IgA production in vitro in the presence of WT but not GPR43−/− dendritic cells (DCs). Mechanistically, acetate-induced DC expression of Aldh1a2, which converts Vitamin A into its metabolite retinoic acid (RA). Moreover, blockade of RA signaling inhibited the acetate induction of B-cell IgA production. Our studies thus identified a new pathway by which microbiota promotes intestinal IgA response through its metabolites.
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“A recent report further demonstrated that SCFA promote intestinal IgA responses.(24) However, the mechanisms by which SCFA regulate intestinal IgA responses are still unknown.”
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Cited by
Short-chain fatty acids: Linking diet, the microbiome and immunity
Mann, E. R., Lam, Y. K., & Uhlig, H. H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01014-8 · Cited by 1,595
An insight into gut microbiota and its functionalities
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Short chain fatty acids in human gut and metabolic health
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Microbes, Metabolites, and the Gut-Lung Axis
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Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835
Metadata
- Authors
- Wu, W., Sun, M., Chen, F., Cao, A. T., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., Liu, Z., & Cong, Y.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 10
- Issue
- 4
- Pages
- 946-956
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2560875835
- Cited by
- 500
- References
- 13
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, W., Sun, M., Chen, F., Cao, A. T., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., Liu, Z., & Cong, Y. (2017). Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunology. https://doi.org/10.1038/mi.2016.114
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