Microbes, Metabolites, and the Gut-Lung Axis
Open accessAbstract
The microbiota plays an essential role in the education, development, and function of the immune system, both locally and systemically. Emerging experimental and epidemiological evidence highlights a crucial cross-talk between the intestinal microbiota and the lungs, termed the 'gut-lung axis'. Changes in the constituents of the gut microbiome, through either diet, disease or medical interventions (such as antibiotics) is linked with altered immune responses and homeostasis in the airways. The importance of the gut-lung axis has become more evident following the identification of several gut microbe-derived components and metabolites, such as short-chain fatty acids (SCFAs), as key mediators for setting the tone of the immune system. Recent studies have supported a role for SCFAs in influencing hematopoietic precursors in the bone marrow-a major site of innate and adaptive immune cell development. Here, we review the current understanding of host-microbe cross-talk along the gut-lung axis. We highlight the importance of SCFAs in shaping and promoting bone marrow hematopoiesis to resolve airway inflammation and to support a healthy homeostasis.
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Gut dysbiosis disrupts pulmonary immune homeostasis, leading to increased disease susceptibility.
“Some studies have found that gut dysbiosis, disturbance of the structure and function of the gut microbiome, disrupts pulmonary immune homeostasis, thus leading to increased disease susceptibility; the gut-lung axis is the primary cross-talk for this communication.”
From The Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy (2021) · cites this paper as [27]
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- Authors
- Dang, A. T., & Marsland, B. J.
- Affiliations
- Monash University (AU)
- Corresponding author
- Marsland, Benjamin J.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 12
- Issue
- 4
- Pages
- 843-850
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2936757566
- Cited by
- 1,028
- References
- 143
- Citations by year
- 2026: 156 · 2025: 151 · 2024: 189 · 2023: 167 · 2022: 160 · 2021: 129 · 2020: 61 · 2019: 14 · 2013: 1
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut-lung axis, gut microbiota, short-chain fatty acids, bone marrow hematopoiesis, airway inflammation, immune homeostasis, airway immunity, diet and microbiome, antibiotics
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bone Marrow, Energy Metabolism, Fatty Acids, Volatile, Hematopoiesis, Homeostasis, Humans, Intestinal Mucosa, Lung, Gastrointestinal Tract, Immunomodulation, Microbiota, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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