Regulation of barrier immunity and homeostasis by integrin‐mediated transforming growth factor β activation
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Summary: Transforming growth factor β (TGF‐β) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. Various cell types secrete TGF‐β, but always as an inactive complex. Hence, for TGF‐β to function, this latent complex must somehow be activated. Work in recent years has highlighted a critical role for members of the αv integrin family, including αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8 that are involved in TGF‐β activation in various contexts, particularly at barrier sites such as the gut, lung and skin. The integrins facilitating this context‐ and location‐specific regulation can be dysregulated in certain diseases, so are potential therapeutic targets in a number of disorders. In this review, we discuss the role of TGF‐β at these barrier sites with a focus on how integrin‐mediated TGF‐β activation regulates tissue and immune homeostasis, and how this is altered in disease.
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αvβ8-dependent TGF-β activation can occur independently of actin-cytoskeletal force and does not require release of mature TGF-β.
“αvβ8-dependent TGFβ activation can occur independently of actin-cytoskeletal force and does not require release of mature TGF-β97”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [97]
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Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
- Authors
- McEntee, C. P., Gunaltay, S., & Travis, M. A.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Lydia Becker Institute for Immunology and Inflammation Manchester UK
- Corresponding author
- Travis, Mark A.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2019-12-25
- Volume
- 160
- Issue
- 2
- Pages
- 139-148
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC7218408
- OpenAlex
- W2993898094
- Cited by
- 39
- References
- 88
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 4
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, cc-by-nd)
- Funders
- Kenneth Rainin Foundation (KRA000045)
- Wellcome Trust (203128, 203128/Z/16/Z)
- Manchester Collaborative Centre for Inflammation Research
- Medical Research Council (MR/L011840/1)
- Biotechnology and Biological Sciences Research Council (BB/R003114/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- TGF-beta, TGF-beta activation, ITGAV, integrin signaling, barrier immunity, immune homeostasis, intestinal barrier, lung barrier, skin barrier, latent TGF-beta complex, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Homeostasis, Humans, Intestinal Diseases, Intestinal Mucosa, Lung, Lung Diseases, Skin, Skin Diseases, Signal Transduction, Transforming Growth Factor beta, Respiratory Mucosa, Integrin alphaV
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