Cited by 205Schizophrenia research and treatmentAdvanced MRI Techniques and ApplicationsNeurotransmitter Receptor Influence on Behavior

Imaging glutamate in schizophrenia: review of findings and implications for drug discovery

Poels, E M P, Kegeles, L S, Kantrowitz, J T, Slifstein, M, Javitt, D C, Lieberman, J A, Abi-Dargham, A, Girgis, R R·2014·Molecular Psychiatry

Abstract

Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D(2)-type dopamine receptors. Given the limitations of these medications, substantial efforts have been made to identify alternative neurochemical targets for treatment development in SCZ. One such target is brain glutamate. The objective of this article is to review and synthesize the proton magnetic resonance spectroscopy ((1)H MRS) and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) investigations that have examined glutamatergic indices in SCZ, including those of modulatory compounds such as glutathione (GSH) and glycine, as well as data from ketamine challenge studies. The reviewed (1)H MRS and PET/SPECT studies support the theory of hypofunction of the N-methyl-D-aspartate receptor (NMDAR) in SCZ, as well as the convergence between the dopamine and glutamate models of SCZ. We also review several advances in MRS and PET technologies that have opened the door for new opportunities to investigate the glutamate system in SCZ and discuss some ways in which these imaging tools can be used to facilitate a greater understanding of the glutamate system in SCZ and the successful and efficient development of new glutamate-based treatments for SCZ.

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Crossref · 10.1038/mp.2013.136

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Authors
Poels, E. M. P., Kegeles, L. S., Kantrowitz, J. T., Slifstein, M., Javitt, D. C., Lieberman, J. A., Abi-Dargham, A., & Girgis, R. R.
Affiliations
New York State Psychiatric Institute (US)
Corresponding author
Girgis, R R
Venue
Molecular Psychiatry
Published
2013-10-29
Volume
19
Issue
1
Pages
20-29
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W1997446269
Cited by
205
References
142
Citations by year
2026: 1 · 2025: 9 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 21 · 2019: 18 · 2018: 21 · 2017: 23 · 2016: 21 · 2015: 35 · 2014: 22
FWCI
3.55
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • F. Hoffmann-La Roche
  • National Institutes of Health (5p50mh066171-05)
  • National Institute of Mental Health (P50MH066171-01A1)
  • National Center for Research Resources (KL2RR024157)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
schizophrenia, glutamate, NMDA receptor hypofunction, glutamate imaging, 1H NMR, glutathione, glycine
MeSH terms
Animals, Humans, Schizophrenia, Glutamic Acid, Drug Discovery, Neuroimaging

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