Translating Glutamate: From Pathophysiology to Treatment
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On 21 to 22 June 2010, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, discussed the role of glutamate in neuropsychiatric disease at the meeting “Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System.”
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Treatment of adult rodents with NMDAR antagonists triggers acute schizophrenia-related behaviours, including deficits in attention/vigilance, learning and memory, and sensory gating.
“As in humans, treatment of adult rodents with NMDAR antagonists triggers acute schizophrenia-related behaviours, including deficits in attention and/ or vigilance, learning and memory and sensory gating, broadly mimicking the symptoms of patients with schizophrenia 10,15,23,24 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [15]
Behavioral, neurophysiological and functional imaging studies show that indicators of sensory dysfunction in patients with schizophrenia can be mimicked by treating healthy individuals with NMDAR antagonists.
“Subsequent behavioral, neurophysiological and functional imaging studies have supported the NMDAR hypofunction hypothesis of schizophrenia, showing that indicators of sensory dysfunction in patients with schizophrenia -such as mismatch negativity (MMN) and changes in auditory and visual event-related potentials -can be mimicked by treating otherwise healthy individuals with NMDAR antagonists 12,15”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [15]
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- Authors
- Javitt, D. C., Schoepp, D., Kalivas, P. W., Volkow, N. D., Zarate, C., Merchant, K., Bear, M. F., Umbricht, D., Hajos, M., Potter, W. Z., & Lee, C.-M.
- Affiliations
- Columbia University (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Medical University of South Carolina (US)
- National Institute on Drug Abuse (US)
- National Institutes of Health (US)
- Eli Lilly (United States) (US)
- Massachusetts Institute of Technology (US)
- F. Hoffmann-La Roche AG (CH)
- Neuroscience Department, CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA.
- Foundation for the National Institutes of Health (US)
- AstraZeneca (Sweden) (SE)
- Corresponding author
- Javitt, Daniel C.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2011-09-28
- Volume
- 3
- Issue
- 102
- Pages
- 102mr2-102mr2
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3273336
- OpenAlex
- W1559706924
- Cited by
- 168
- References
- 150
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 14 · 2018: 10 · 2017: 10 · 2016: 5 · 2015: 19 · 2014: 19 · 2013: 19 · 2012: 22
- Type
- conference abstract
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R37MH049334, R37MH49334, P50MH086385, ZIAMH002857)
- National Institute on Drug Abuse (R01DA03383, R01DA003383)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046943)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- glutamate, glutamatergic neurotransmission, neuropsychiatric disorders, schizophrenia, drug addiction, autism spectrum disorder, depression, biomarkers, translational model, drug development, target engagement
- MeSH terms
- Animals, Clinical Trials as Topic, Congresses as Topic, Humans, Nervous System Diseases, Neurotransmitter Agents, Glutamic Acid, Mice, Translational Research, Biomedical
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