The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update
Abstract
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression.
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“individuals with one or two copies of the short allele at 5-HTTLPR are at greater risk for MDD than their long-allele homozygous counterparts”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Uher & McGuffin, 2010
In the citing paper
“It is important that the study sample contains adequate numbers of subjects exposed and unexposed to the stressful environment to ensure adequate power”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Uher and McGuffin 2010
In the citing paper
“In a subsequent systematic review, the 14 studies (out of 34 possible studies) included in the Risch report were found to show a statistically significant bias toward negative findings (Uher and McGuffin 2010).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Uher and McGuffin 2010
In the citing paper
“Meta-analyses have supported 111,112 and not supported 113,114 this finding.”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [113]
Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655
Strategy for Investigating Interactions Between Measured Genes and Measured Environments
Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784
Modern Approaches to Conceptualizing and Measuring Human Life Stress
Monroe, S. M. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.4.022007.141207 · Cited by 618
Dohrenwend, B. P. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.477 · Cited by 601
Gene×environment interactions at the serotonin transporter locus
Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.009 · Cited by 576
HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression
Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.008 · Cited by 558
Uher, R., & McGuffin, P. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002067 · Cited by 508
Self-citationKilpatrick, D. G., Koenen, K. C., Ruggiero, K. J., Acierno, R. E., Galea, S., Resnick, H. S., Roitzsch, J. C., Boyle, J. M., & Gelernter, J. E. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06122007 · Cited by 405
Polanczyk, G., Caspi, A., Williams, B., Price, T. S., Danese, A., Sugden, K., Uher, R., Poulton, R., & Moffitt, T. E. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.114 · Cited by 285
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Rayapati, A. O., Venugopalakrishnan, J., Gandham, L., Kanga, F. H., & Martin, C. A. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5999-6_196
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.003.0008
Bibliography: Depression and Dysthymia
(2012) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.10.4.481
Ebstein, R. P., Monakhov, M. V., Lai, P. S., & Shamay‐Tsoory, S. (2011) · Wiley eBooks · doi:10.1002/9781118101803.ch
Faculty Opinions recommendation of Gene-environment interactions in severe mental illness.
RYBAKOWSKI, J. K. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727614575.793539079
Studies of the 5-HTTLPR Serotonin Transporter Polymorphism (literature review)
Proshina, E. A., Bocharov, A. V., Savostyanov, A. N., & Knyazev, G. G. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01314-3
Langevin, S., Boivin, M., Bouliane, M., Côté, S. M., Tremblay, R. E., Turecki, G., Vitaro, F., & Ouellet‐Morin, I. (2023) · CrimRxiv · doi:10.21428/cb6ab371.df48a1a7
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0011
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0006
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0009
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0004
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0008
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0003
Holmes, R. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780199343805.002.0010
Borakhade, H., Onkar, D., & Borakhade, D. K. (2024) · DMIHER International Conference on Artificial Intelligence in Healthcare, Education and Industry (IDICAIHEI) · doi:10.1109/idicaiei61867.2024.10842761
Sepúlveda, D., Thorp, J. G., Lind, P. A., Martin, N. G., Medland, S. E., & Mitchell, B. L. (2025) · Twin Research and Human Genetics · doi:10.1017/thg.2025.10011
Depression and Psychotherapy for Adults in Long-Term Care Facilities
Watts, J. (2015) · ScholarWorks (Walden University)
Zheng, F., Li, C., Hua, R., Liang, J., Gao, D., & Xie, W. (2023) · Figshare · doi:10.6084/m9.figshare.22601650
Traité de régulation des émotions
André, C. (2012) · Carrefour des psychothérapies · doi:10.3917/dbu.mikol.2012.01.0527
Nobile, M. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20121011mn
Biased information processing as an endophenotype for depression.
Vrijsen, J. N. (2014) · Radboud Repository (Radboud University)
Sleep and Psychopathology: Quantitative and Molecular Genetic Research on Comorbidity
Barclay, N. L., & Gregory, A. M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9509-3_5
Metadata
- Authors
- Uher, R., & McGuffin, P.
- Affiliations
- King's College London (GB)
- Corresponding author
- Uher, R
- ORCID
- Uher, R
- Venue
- Molecular Psychiatry
- Published
- 2009-12-22
- Volume
- 15
- Issue
- 1
- Pages
- 18-22
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1989784453
- Cited by
- 424
- References
- 26
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 31 · 2019: 21 · 2018: 9 · 2017: 25 · 2016: 26 · 2015: 33 · 2014: 40 · 2013: 53 · 2012: 49
- FWCI
- 22.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- serotonin transporter gene, serotonin transporter, environmental adversity, etiology of depression, gene-environment interaction, length polymorphism, self-report measures, contextual assessment, adolescent boys, sex differences, developmental stages, protective mechanisms
- MeSH terms
- Depression, Environment, Humans, Polymorphism, Genetic, Meta-Analysis as Topic, Serotonin Plasma Membrane Transport Proteins
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