Cited by 424Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyStress Responses and Cortisol

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The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

Uher, R, McGuffin, P·2010·Molecular Psychiatry

DOI 10.1038/mp.2009.123

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Abstract

An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression.

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Authors: Uher, R., & McGuffin, P.
Affiliations: King's College London (GB)
Corresponding author: Uher, R
ORCID: Uher, R
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2009-12-22
Volume: 15
Issue: 1
Pages: 18-22
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/mp.2009.123
OpenAlex: W1989784453
Cited by: 424
References: 26
Citations by year: 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 31 · 2019: 21 · 2018: 9 · 2017: 25 · 2016: 26 · 2015: 33 · 2014: 40 · 2013: 53 · 2012: 49
FWCI: 22.11
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: serotonin transporter gene, serotonin transporter, environmental adversity, etiology of depression, gene-environment interaction, length polymorphism, self-report measures, contextual assessment, adolescent boys, sex differences, developmental stages, protective mechanisms
MeSH terms: Depression, Environment, Humans, Polymorphism, Genetic, Meta-Analysis as Topic, Serotonin Plasma Membrane Transport Proteins

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The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

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