Nucleus Accumbens deep brain stimulation for alcohol addiction – safety and clinical long-term results of a pilot trial
Open accessAbstract
We report on the long-term clinical outcome (up to 8 years) of 5 patients who received deep brain stimulation (DBS) of the nucleus accumbens to treat their long-lasting and treatment-resistant alcohol addiction. All patients reported a complete absence of craving for alcohol; 2 patients remained abstinent for many years and 3 patients showed a marked reduction of alcohol consumption. No severe or long-standing side effects occurred. Therefore, DBS could be a promising, novel treatment option for severe alcohol addiction, but larger clinical trials are needed to further investigate the efficacy of DBS in addiction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a study of five participants with treatment-resistant alcohol use disorder who received DBS of the NAc, all reported a complete absence of craving for alcohol up to 8 years following DBS implantation; two patients remained abstinent for several years, and three showed a marked reduction of alcohol consumption.
“In a study of five participants with treatment-resistant alcohol use disorder who received DBS of the NAc, all reported a complete absence of craving for alcohol up to 8 years following DBS implantation; two patients remained abstinent for several years, and three showed a marked reduction of alcohol consumption [90].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554 · see citing works
The Development and Maintenance of Drug Addiction
Wise, R. A., & Koob, G. F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.261 · Cited by 561 · see citing works
The clinical significance of drug craving
Tiffany, S. T., & Wray, J. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06298.x · Cited by 556 · see citing works
Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.013 · Cited by 513 · see citing works
Maisel, N. C., Blodgett, J. C., Wilbourne, P. L., Humphreys, K., & Finney, J. W. (2013) · Addiction · doi:10.1111/j.1360-0443.2012.04054.x · Cited by 470 · see citing works
The dark side of emotion: the addiction perspective
Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433 · see citing works
Human alcohol-related neuropathology
de la Monte, S. M., & Kril, J. J. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1233-3 · Cited by 416 · see citing works
Alcohol use disorders and mortality: a systematic review and meta-analysis
Roerecke, M., & Rehm, J. (2013) · Addiction · doi:10.1111/add.12231 · Cited by 326 · see citing works
Alcohol and the Human Brain: A Systematic Review of Different Neuroimaging Methods
Bühler, M., & Mann, K. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01540.x · Cited by 310 · see citing works
Beck, A., Wüstenberg, T., Genauck, A., Wrase, J., Schlagenhauf, F., Smolka, M. N., Mann, K. F., & Heinz, A. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2026 · Cited by 269 · see citing works
Durazzo, T. C., Tosun, D., Buckley, S. T., Gazdzinski, S. P., Mon, A., Fryer, S. L., & Meyerhoff, D. J. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01452.x · Cited by 237 · see citing works
Roerecke, M., & Rehm, J. T. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu018 · Cited by 205 · see citing works
Müller, U., Sturm, V., Voges, J., Heinze, H. –., Galazky, I., Heldmann, M., Scheich, H., & Bogerts, B. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1233489 · Cited by 173 · see citing works
Self-citationDeep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction
Kuhn, J., Möller, M., Treppmann, J. F., Bartsch, C., Lenartz, D., Gruendler, T. O. J., Maarouf, M., Brosig, A., Barnikol, U. B., Klosterkötter, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.196 · Cited by 147 · see citing works
Self-citationDeep brain stimulation of the nucleus accumbens for the treatment of addiction
Müller, U., Voges, J., Steiner, J. H., Galazky, I., Heinze, H., Möller, M., Pisapia, J. M., Halpern, C. H., Caplan, A. L., Bogerts, B., et al. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06834.x · Cited by 120 · see citing works
Self-citationPierce, R. C., & Vassoler, F. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3214-6 · Cited by 75 · see citing works
Deep Brain Stimulation for Refractory Cocaine Dependence
Gonçalves-Ferreira, A., do Couto, F. S., Campos, A. R., Neto, L. L., Gonçalves-Ferreira, D., & Teixeira, J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.023 · Cited by 75 · see citing works
Early application of deep brain stimulation: Clinical and ethical aspects
Woopen, C., Pauls, K. A. M., Koy, A., Moro, E., & Timmermann, L. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.002 · Cited by 53 · see citing works
Too Difficult to Stop: Mechanisms Facilitating Relapse in Alcohol Dependence
Garbusow, M., Sebold, M., Beck, A., & Heinz, A. (2014) · Neuropsychobiology · doi:10.1159/000362838 · Cited by 46 · see citing works
Proposals to trial deep brain stimulation to treat addiction are premature
Carter, A., & Hall, W. (2011) · Addiction · doi:10.1111/j.1360-0443.2010.03245.x · Cited by 42 · see citing works
Naqvi, N. H. (2015) · Alcohol research · doi:10.35946/arcr.v37.1.03 · Cited by 38 · see citing works
Ethical Issues Raised by Proposals to Treat Addiction Using Deep Brain Stimulation
Carter, A., Bell, E. C., Racine, É., & Hall, W. (2010) · Neuroethics · doi:10.1007/s12152-010-9091-3 · Cited by 34 · see citing works
Pisapia, J. M., Halpern, C. H., Müller, U., Vinai, P., Wolf, J. A., Whiting, D. M., Wadden, T. A., Baltuch, G. H., & Caplan, A. L. (2013) · AJOB Neuroscience · doi:10.1080/21507740.2013.770420 · Cited by 33 · see citing works
Self-citationIs deep brain stimulation a treatment option for addiction?
Luigjes, J., van den Brink, W., Schuurman, P. R., Kuhn, J., & Denys, D. A. J. P. (2015) · Addiction · doi:10.1111/add.12773 · Cited by 21 · see citing works
DEEP BRAIN STIMULATION FOR THE TREATMENT OF ADDICTION
Kuhn, J., Möller, M., Müller, U., Bogerts, B., Mann, K. F., & Gruendler, T. O. J. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03452.x · Cited by 16 · see citing works
Self-citationTiefe Hirnstimulation in der Psychiatrie: Ethische Aspekte
Müller, U., Bogerts, B., Voges, J., Galazky, I., Kohl, S., Heinze, H., Kuhn, J., & Steiner, J. H. (2014) · Psychiatrische Praxis · doi:10.1055/s-0034-1370015 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The dopamine motive system: implications for drug and food addiction
Volkow, N. D., Wise, R. A., & Baler, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.130 · Cited by 939 · see citing works
Cooper, S., Robison, A. J., & Mazei‐Robison, M. S. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0525-z · Cited by 264 · see citing works
Jakobs, M., Fomenko, A., Lozano, A. M., & Kiening, K. L. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809575 · Cited by 229 · see citing works
A systematic review and meta-analysis of neuromodulation therapies for substance use disorders
Mehta, D. D., Praecht, A., Ward, H. B., Sanches, M., Sorkhou, M., Tang, V. M., Steele, V. R., Hanlon, C. A., & George, T. P. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01776-0 · Cited by 157 · see citing works
A review of brain stimulation methods to treat substance use disorders
Coles, A. S., Kozak, K., & George, T. P. (2018) · The American Journal on Addictions · doi:10.1111/ajad.12674 · Cited by 150 · see citing works
Efficacy of invasive and non-invasive brain modulation interventions for addiction
Luigjes, J., Segrave, R., de Joode, N., Figee, M., & Denys, D. (2019) · Neuropsychology Review · doi:10.1007/s11065-018-9393-5 · Cited by 125 · see citing works
Mahoney, J. J., Hanlon, C. A., Marshalek, P. J., Rezai, A. R., & Krinke, L. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117149 · Cited by 121 · see citing works
Spagnolo, P. A., & Goldman, D. A. (2016) · Brain · doi:10.1093/brain/aww284 · Cited by 84 · see citing works
Treatment for Substance Use Disorder with Co-Occurring Mental Illness
Iqbal, M. N., Levin, C. J., & Levin, F. R. (2019) · Focus · doi:10.1176/appi.focus.20180042 · Cited by 66 · see citing works
Anterior Cingulate Cortex in Addiction: New Insights for Neuromodulation
Zhao, Y., Sallie, S. N., Cui, H., Zeng, N., Du, J., Yuan, T., Li, D., De Ridder, D., & Zhang, C. (2021) · Neuromodulation: Technology at the Neural Interface · doi:10.1111/ner.13291 · Cited by 71 · see citing works
Bach, P., Luderer, M., Müller, U. J., Jakobs, M., Baldermann, J. C., Voges, J., Kiening, K., Lux, A., Visser-Vandewalle, V., the DeBraSTRA study group, et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02337-1 · Cited by 65 · see citing works
Self-citationTanabe, J., Regner, M. F., Sakai, J. T., Martínez, D., & Gowin, J. L. (2019) · British Journal of Radiology · doi:10.1259/bjr.20180942 · Cited by 54 · see citing works
Davidson, B., Giacobbe, P., George, T. P., Nestor, S. M., Rabin, J. S., Goubran, M., Nyman, A. J., Baskaran, A., Meng, Y., Pople, C. B., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01677-6 · Cited by 52 · see citing works
Deep Brain Stimulation for Addictive Disorders—Where Are We Now?
Yuen, J., Kouzani, A. Z., Berk, M., Tye, S. J., Rusheen, A. E., Blaha, C. D., Bennet, K. E., Lee, K. H., Shin, H., Kim, J. H., et al. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01229-4 · Cited by 52 · see citing works
New steps for treating alcohol use disorder
Campbell, E. J., Lawrence, A. J., & Perry, C. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4887-7 · Cited by 47 · see citing works
Brocka, M., Helbing, C., Vincenz, D., Scherf, T., Montag, D., Goldschmidt, J., Angenstein, F., & Lippert, M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.059 · Cited by 41 · see citing works
Neuromodulation for substance addiction in human subjects: A review
Bari, A., DiCesare, J. A. T., Babayan, D., Runcie, M., Sparks, H. D., & Wilson, B. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.013 · Cited by 41 · see citing works
Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction: Two Case Reports
Ge, S., Chen, Y., Li, N., Qu, L., Li, Y., Jing, J., Wang, X., Wang, J., & Wang, X. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.11.056 · Cited by 40 · see citing works
Yan, H., Shlobin, N. A., Jung, Y., Zhang, K. K., Warsi, N. M., Kulkarni, A. V., & Ibrahim, G. M. (2022) · Journal of neurosurgery · doi:10.3171/2022.5.jns212548 · Cited by 39 · see citing works
Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman
Tronnier, V. M., Rasche, D., Thorns, V., Alvarez‐Fischer, D., Münte, T. F., & Zurowski, B. (2018) · Neurocase · doi:10.1080/13554794.2018.1431678 · Cited by 37 · see citing works
Neurobiological mechanisms and related clinical treatment of addiction: a review
Fang, Y., Sun, Y., Liu, Y., Liu, T., Hao, W., & Liao, Y. (2022) · Psychoradiology · doi:10.1093/psyrad/kkac021 · Cited by 38 · see citing works
Biomarkers and neuromodulation techniques in substance use disorders
Habelt, B., Arvaneh, M., Bernhardt, N. R., & Minev, I. R. (2020) · Bioelectronic Medicine · doi:10.1186/s42234-020-0040-0 · Cited by 33 · see citing works
Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review
Hassan, O., Phan, S., Wiecks, N., Joaquin, C., & Bondarenko, V. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01415-y · Cited by 35 · see citing works
Burchi, E., Makris, N., Lee, M. R., Pallanti, S., & Hollander, E. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00070 · Cited by 34 · see citing works
Bina, R. W., & Langevin, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00300 · Cited by 35 · see citing works
The nucleus accumbens and alcoholism: a target for deep brain stimulation
Ho, A. L., Salib, A.-M. N., Pendharkar, A. V., Sussman, E. S., Giardino, W. J., & Halpern, C. H. (2018) · Neurosurgical FOCUS · doi:10.3171/2018.5.focus18157 · Cited by 34 · see citing works
Deep Brain Stimulation in Drug Addiction Treatment: Research Progress and Perspective
Chang, R., Peng, J., Chen, Y., Liao, H., Zhao, S., Zou, J., & Tan, S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.858638 · Cited by 35 · see citing works
Safety and Feasibility of Nucleus Accumbens Surgery for Drug Addiction: A Systematic Review
Navarro, P. A., Paranhos, T., Lovo, E. E., de Oliveira‐Souza, R., Gorgulho, A. A., Salles, A. D., & López, W. O. C. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13348 · Cited by 27 · see citing works
Maatoug, R., Bihan, K., Duriez, P., Podevin, P., Silveira-Reis-Brito, L., Benyamina, A., Valero‐Cabré, A., & Millet, B. (2021) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2021.152257 · Cited by 29 · see citing works
Neurosurgical treatment for addiction: lessons from an untold story in China and a path forward
Ma, S., Zhang, C., Yuan, T., Steele, J. D., Voon, V., & Sun, B. (2019) · National Science Review · doi:10.1093/nsr/nwz207 · Cited by 25 · see citing works
Alhaddad, H., Alasmari, F. F., Alhamadani, B., Wong, W., Bell, R. L., & Sari, Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.10.012 · Cited by 24 · see citing works
State of the Art: Novel Applications for Deep Brain Stimulation
Roy, H., Green, A. L., & Aziz, T. Z. (2017) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12604 · Cited by 23 · see citing works
Alhaddad, H., Wong, W., Abou-Gharbia, M. A., Childers, W. E., Melenski, E., Bell, R. L., & Sari, Y. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001147 · Cited by 22 · see citing works
Deep Brain Stimulation for Refractory Depression, Obsessive-Compulsive Disorder and Addiction
Rezai, A. R., Ranjan, M., Ranjan, N., & Deogaonkar, M. S. (2020) · Neurology India · doi:10.4103/0028-3886.302459 · Cited by 21 · see citing works
Kallupi, M., Kononoff, J., Melas, P. A., Qvist, J. S., de Guglielmo, G., Kandel, E. R., & George, O. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.11.003 · Cited by 21 · see citing works
Wu, H., Kakusa, B. W., Neuner, S., Christoffel, D. J., Heifets, B. D., Malenka, R. C., & Halpern, C. H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2109269118 · Cited by 21 · see citing works
Mahoney, J. J., Koch-Gallup, N., Scarisbrick, D. M., Berry, J. H., & Rezai, A. R. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120253 · Cited by 21 · see citing works
Pol, S., Temel, Y., & Jahanshahi, A. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13165 · Cited by 21 · see citing works
Looking beyond the opioid receptor: A desperate need for new treatments for opioid use disorder
Lee, Y. K., Gold, M. S., & Fuehrlein, B. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120094 · Cited by 19 · see citing works
Neurosurgical neuromodulation therapy for psychiatric disorders
Ranjan, M., Mahoney, J. J., & Rezai, A. R. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00366 · Cited by 20 · see citing works
Müller, U., Mawrin, C., Frodl, T., Dobrowolny, H., Busse, S., Bernstein, H., Bogerts, B., Truebner, K., & Steiner, J. H. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0939-6 · Cited by 18 · see citing works
Self-citationGerchen, M. F., Kirsch, M., Bahs, N., Halli, P., Gerhardt, S., Schäfer, A., Sommer, W. H., Kiefer, F., & Kirsch, P. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1604-3 · Cited by 16 · see citing works
Yuen, J., Goyal, A., Rusheen, A. E., Kouzani, A. Z., Berk, M., Kim, J. H., Tye, S. J., Blaha, C. D., Bennet, K. E., Lee, K. H., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1061578 · Cited by 17 · see citing works
A systematic review of deep brain stimulation for substance use disorders
Dimech, D. Z., Dimech, A.-A. Z., Hughes, M., & Zrinzo, L. U. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03060-1 · Cited by 17 · see citing works
Vannemreddy, P. S. S. V., & Slavin, K. V. (2019) · Neurology India · doi:10.4103/0028-3886.271239 · Cited by 17 · see citing works
Development of a Fully Implantable Stimulator for Deep Brain Stimulation in Mice
Fleischer, M., Endres, H., Sendtner, M., & Volkmann, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00726 · Cited by 15 · see citing works
Deveci, E., Akbaş, F., Ergun, A. S., Kurtulmuş, A., Koçak, A. B., Boyraz, R. K., Tok, O. E., Aydın, M. Ş., Kılıç, Ö., Bozkurt, A., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03130-9 · Cited by 14 · see citing works
Chen, D., Zhao, Z., Shi, J., Li, S., Xu, X., Wu, Z., Tang, Y., Liu, N., Zhou, W., Ni, C., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03156-8 · Cited by 11 · see citing works
Neuromodulatory Treatments for Alcohol Use Disorder: A Review
Salib, A.-M. N., Ho, A. L., Sussman, E. S., Pendharkar, A. V., & Halpern, C. H. (2018) · Brain Sciences · doi:10.3390/brainsci8060095 · Cited by 11 · see citing works
Sobstyl, M. R., Kupryjaniuk, A., & Mierzejewski, P. (2021) · Neurologia i Neurochirurgia Polska · doi:10.5603/pjnns.a2021.0065 · Cited by 11 · see citing works
Giménez, S., Millan, A., Mora-Morell, A., Ayuso, N., Gastaldo-Jordán, I., & Pardo, M. (2024) · Molecules · doi:10.3390/molecules29153580 · Cited by 10 · see citing works
Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry
Borrego, M. B., Chan, A. E., & Ozburn, A. R. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109074 · Cited by 11 · see citing works
Versalovic, E., Klein, E. P., Goering, S., Ngo, Q., Gliske, K., Boulicault, M., Sullivan, L. S., Thomas, M. J., & Widge, A. S. (2023) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001150 · Cited by 9 · see citing works
Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
Shaheen, N., Shaheen, A., Sarica, C., Singh, A. K., Zanaty, M., Johari, K., Yang, A., Zesiewicz, T. A., Dalm, B., Bezchlibnyk, Y. B., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1231760 · Cited by 9 · see citing works
Casquero‐Veiga, M., Hadar, R., Pascau, J., Winter, C., Desco, M., & Soto‐Montenegro, M. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168689 · Cited by 9 · see citing works
Eskandari, K., Fattahi, M., Yazdanian, H., & Haghparast, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03818-3 · Cited by 7 · see citing works
How Treatment-Refractory Addiction Is Defined: A Scoping Review
Bormann, N. L., Burson, J. R., Burson, E. M., McGinnis, M. T., Karpyak, V. M., Coombes, B. J., Gold, M. S., & Oesterle, T. (2025) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001527 · Cited by 7 · see citing works
Kuijper, F. M., Mahajan, U. V., Ku, S., Barbosa, D. A. N., Alessi, S. M., Stein, S. C., Kampman, K. M., Bentzley, B. S., & Halpern, C. H. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13410 · Cited by 7 · see citing works
Modern neurosurgical techniques for psychiatric disorders
Salles, A. D., Lucena, L., Paranhos, T., Ferragut, M. A., de Oliveira‐Souza, R., & Gorgulho, A. A. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.025 · Cited by 7 · see citing works
Shi, Z., Wen, K., Sammudin, N. H., LoRocco, N. C., & Zhuang, X. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03013-0 · Cited by 7 · see citing works
Khosravi, M. (2025) · Brain Sciences · doi:10.3390/brainsci15111244 · Cited by 6 · see citing works
Deep brain stimulation as a therapeutic option for obesity: A critical review
Betry, C., Thobois, S., Laville, M., & Disse, E. (2018) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2018.02.004 · Cited by 6 · see citing works
Maladaptive Memory Mechanisms in Addiction and Relapse
Rich, M. T., & Torregrossa, M. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00008-7 · Cited by 6 · see citing works
Seddighfar, M., Bahmani, Z., & Haghparast, A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111383 · Cited by 5 · see citing works
Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking
Chan, A. E., Anderson, J. Q., Grigsby, K. B., Jensen, B. E., Ryabinin, A. E., & Ozburn, A. R. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06875-y · Cited by 5 · see citing works
Edemann-Callesen, H., Barak, S., Hadar, R., & Winter, C. (2020) · Current Addiction Reports · doi:10.1007/s40429-020-00316-w · Cited by 5 · see citing works
Hauser, S. R., Wilden, J. A., Batra, V., & Rodd, Z. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805373-7.00022-0 · Cited by 5 · see citing works
Sakai, J. T., Tanabe, J., Battula, S., Zipperly, M. E., Mikulich‐Gilbertson, S. K., Kern, D. S., Thompson, J. A., Ojemann, S., Raymond, K. M., Gerecht, P. D., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1435109 · Cited by 4 · see citing works
Role of deep brain stimulation (DBS) in addiction disorders
Iqbal, J., Mansour, M. N. M., Saboor, H. A., Suyambu, J., Lak, M. A., Zeeshan, M. H., Hafeez, M. H., Arain, M. A., Mehmood, M., Mehmood, D., et al. (2023) · Surgical Neurology International · doi:10.25259/sni_662_2023 · Cited by 4 · see citing works
Alternatives to Pharmacological and Psychotherapeutic Treatments in Psychiatric Disorders
Vetrano, I. G., Bonomo, G., & Messina, G. (2021) · Psychiatry International · doi:10.3390/psychiatryint2010001 · Cited by 4 · see citing works
Herrera, J., Button, M., Doherty-Haigh, P., Szubinski, A., Amir, S., & Schoettner, K. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.07.002 · Cited by 3 · see citing works
Probing the Manipulated Neurochemical Drive in Alcohol Addiction and Novel Therapeutic Advancements
Chouhan, D., Uniyal, A., Gadepalli, A., Akhilesh, A., Tiwari, V., Agrawal, S., Roy, T. K., Shaw, S., Purohit, N., & Tiwari, V. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00073 · Cited by 3 · see citing works
Neurosurgical Treatment for Drug Addiction: Systematic Review
dos Santos, P. L. M., Curti, R. O., & da Silva, L. J. (2020) · Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery · doi:10.1055/s-0040-1702976 · Cited by 3 · see citing works
Gimenez, S., Millan, A., Mora-Morell, A., Ayuso, N., Gastaldo-Jordán, I., & Pardo, M. (2024) · Preprints.org · doi:10.20944/preprints202407.0196.v1 · Cited by 3 · see citing works
Electrical deep neuromodulation in psychiatry
Polosan, M., & Figee, M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.06.007 · Cited by 2 · see citing works
Neuromodulation Techniques in the Treatment of Addictions
Dubuson, M., Dousset, C., Noël, X., & Campanella, S. (2021) · Advances in mental health and addiction · doi:10.1007/978-3-030-82408-2_7 · Cited by 3 · see citing works
Modulation of Alcohol Use Disorder by Brain Stimulation
Barnea‐Ygael, N., & Zangen, A. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_487 · Cited by 2 · see citing works
Opioid reward and deep brain stimulation of the lateral hypothalamic area
Fattahi, M., Rahimpour, M., & Riahi, E. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.10.004 · Cited by 2 · see citing works
Abiola, O. A., Lehmann, C. M., Moussawi, K., & Jalal, H. J. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.01.014 · Cited by 2 · see citing works
The Role of the Neuropsychologist in Deep Brain Stimulation
Tröster, A. I. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809961-2.00011-4 · Cited by 2 · see citing works
Novel Neurostimulation Therapeutic Approaches for Treatment-Resistant Psychiatric Disorders
Koek, R. J., Roach, J., Athanasiou, N., & Korotinsky, A. (2018) · Springer eBooks · doi:10.1007/978-981-10-4358-1_22 · Cited by 2 · see citing works
Harnessing Circuits for the Treatment of Addictive Disorders
Pelloux, Y., & Baunez, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00019-1 · Cited by 2 · see citing works
Mahoney, J. J., Bryant, K. R., & Haut, M. W. (2019) · Springer eBooks · doi:10.1007/978-3-030-14895-9_32 · Cited by 2 · see citing works
Sex differences in nucleus accumbens core circuitry engaged by binge-like ethanol drinkingPreprint
Chan, A. E., Anderson, J. Q., Grigsby, K. B., Jensen, B. E., Ryabinin, A. E., & Ozburn, A. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.15.608144 · Cited by 2 · see citing works
Amurthur, R., Marianayagam, N. J., Park, D. J., Chang, S. D., Schneider, M. B., & Adler, J. R. (2025) · Cureus · doi:10.7759/cureus.88314 · Cited by 1 · see citing works
Thalamostriatal circuit as a therapeutic target of alcohol use disorder
Song, H., Lee, J., Lee, J., Kim, J., Kim, J., Kang, S., & Kim, J. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107367 · Cited by 1 · see citing works
Neurobiology of deep brain stimulation for psychiatric disorders
Gadot, R., Giridharan, N., Rajesh, S. V., Provenza, N. R., Banks, G. P., Storch, E. A., Goodman, W. K., & Sheth, S. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00023-9 · Cited by 1 · see citing works
Neuromodulation (Brain Stimulation) Technologies for Treatment of Substance Use Disorders
Souki, A., Soleimani, G., Hanlon, C. A., & Ekhtiari, H. (2024) · SAGE Publications Ltd eBooks · doi:10.4135/9781529673913.n37 · Cited by 1 · see citing works
Developing New Indications: Strategies and Hurdles to Discovery
Bina, R. W., & Langevin, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-34906-6_35 · Cited by 1 · see citing works
Mechanisms and Targeting of Deep-Brain Stimulation Therapies
Brinda, A. K., & Johnson, M. D. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_133 · Cited by 1 · see citing works
Dimech, D. Z., & Ranjan, R. (2023) · Health Science Reports · doi:10.1002/hsr2.1409 · Cited by 1 · see citing works
Deep Brain Stimulation for Alcoholism
Kohl, S., & Kuhn, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805353-9.00089-9
Development of brain stimulation
Crowell, A. L., Riva‐Posse, P., & Mayberg, H. S. (2020) · doi:10.1093/med/9780198713005.003.0019
Mechanisms and Targeting of Deep-Brain Stimulation Therapies
Brinda, A. K., & Johnson, M. D. (2022) · Handbook of Neuroengineering · doi:10.1007/978-981-15-2848-4_133-1
Neurosurgery in the Treatment of Alcohol Use Disorder: A Systematic Literature Review
de Almeida, B. V., & da Silva, L. J. (2022) · Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery · doi:10.1055/s-0041-1733866
Autres applications en psychiatrie
Vlaicu, M. B. ̆., & Vlaicu, A. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77862-9.00006-2
Hartong, N., Deliano, M., Kaufmann, J., Sweeney‐Reed, C. M., Voges, J., Galazky, I., & Buentjen, L. (2023) · medRxiv · doi:10.1101/2023.12.04.23296587
Self-citationEstado del arte: nuevas aplicaciones para la estimulación cerebral profunda.
Roy, H., Green, A. L., & Aziz, T. Z. (2018) · NeuroTarget · doi:10.47924/neurotarget2018128
The Future of Alcohol Use Disorder Treatment and Research
Srivastava, A. B., & Wai, J. M. (2024) · Psychiatry update · doi:10.1007/978-3-031-73553-0_15
Dastan, A., Skrzypkowska, P., Szmuda, T., & Zieliński, P. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.04.004
- Authors
- Müller, U., Sturm, V., Voges, J., Heinze, H.-J., Galazky, I., Büntjen, L., Heldmann, M., Frodl, T., Steiner, J., & Bogerts, B.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Cologne (DE)
- Department of Stereotactic Neurosurgery, Otto-von-Guericke-University of Magdeburg, Magdeburg
- Corresponding author
- Müller, U.
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-05-04
- Volume
- 49
- Issue
- 04
- Pages
- 170-173
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2346795379
- Cited by
- 108
- References
- 26
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 14 · 2021: 10 · 2020: 13 · 2019: 7 · 2018: 20 · 2017: 4 · 2016: 2
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- deep brain stimulation, nucleus accumbens, alcoholism, alcohol craving, alcohol abstinence, long-term outcomes
- MeSH terms
- Adult, Alcoholism, Humans, Longitudinal Studies, Middle Aged, Nucleus Accumbens, Pilot Projects, Psychiatric Status Rating Scales, Surveys and Questionnaires, Deep Brain Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
