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Ghrelin mediated neuroprotection - A possible therapy for Parkinson's disease?

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Multifunctional Actions of Ninjinyoeito, a Japanese Kampo Medicine: Accumulated Scientific Evidence Based on Experiments With Cells and Animal Models, and Clinical Studies

Miyano, K., Nonaka, M., Uzu, M., Ohshima, K., & Uezono, Y. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00093 · Cited by 38 · see citing works

Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies

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Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1

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Role of Sirtuins in Maintenance of Genomic Stability: Relevance to Cancer and Healthy Aging

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High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats’ brain: the toxic role of high-fat diet

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Phytotherapy for Cachexia: Where Do We Stand?

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Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor

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Regulatory effects of ghrelin on endoplasmic reticulum stress, oxidative stress, and autophagy: Therapeutic potential

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Enhancement of adaptive immune responses of aged mice by dietary intake of β-glucans, with special emphasis on anti-aging activity

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Omics biomarkers for frailty in older adults

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Vulnerability to psychological stress‐induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius

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Acute But Not Chronic Calorie Restriction Defends against Stress-Related Anxiety and Despair in a GHS-R1a-Dependent Manner.

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Selective neuronal vulnerability in Alzheimer’s disease

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Combating cellular senescence by sirtuins: Implications for atherosclerosis

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Acylated ghrelin protects against doxorubicin‐induced nephropathy by activating silent information regulator 1

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Impact of Ninjin’yoeito on frailty and short life in klotho-hypomorphic (kl/kl) mice

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Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice

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A low-salt diet increases the expression of renal sirtuin 1 through activation of the ghrelin receptor in rats

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Genus Sapium (Euphorbiaceae): A review on traditional uses, phytochemistry, and pharmacology

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Ghrelin Enhancer, the Latest Evidence of Rikkunshito

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Ghrelin mediated hippocampal neurogenesis.

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Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

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Less is more: Caloric regulation of neurogenesis and adult brain function

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Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats

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Developmental stage-dependent relationships between ghrelin levels and hippocampal white matter connections in low-weight anorexia nervosa and atypical anorexia nervosa

Breithaupt, L. E., Chunga-Iturry, N., Lyall, A. E., Karayumak, S. C., Becker, K. R., Thomas, J. J., Slattery, M. J., Makris, N., Plessow, F., Pasternak, O., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104722 · Cited by 19 · see citing works

A review of frequently used Kampo prescriptions. Part 5. Rikkunshito

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Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma

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Kampo medicine for the holistic approach to older adults with heart failure

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Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction

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Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition

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Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1

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A Comprehensive Review of Essential Aspects of Molecular Pathophysiological Mechanisms with Emerging Interventions for Sarcopenia in Older People

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L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice

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Sirtuin-1 regulates organismal growth by altering feeding behavior and intestinal morphology in planarians

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Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor

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A traditional herbal medicine rikkunshito prevents angiotensin II-Induced atrial fibrosis and fibrillation

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Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice

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Heal the heart through gut (hormone) ghrelin: a potential player to combat heart failure

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Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness: A retrospective pilot study

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Atractylodes Lancea and Its Constituent, Atractylodin, Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK Activation

Song, G. Y., Kim, S. M., Back, S. H., Yang, S.-B., & Yang, Y. M. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.083 · Cited by 11 · see citing works

Endogenous Vasoactive Peptides and Vascular Aging‐Related Diseases

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Multifaceted dynamics of circadian timing system influence aging and longevity

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Influence of food on the gastric motor effect of the Kampo medicine rikkunshito in rat

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Application of Kampo medicines for the palliation of cancer cachexia

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Ghrelin/GHS-R1a signaling plays different roles in anxiety-related behaviors after acute and chronic caloric restriction.

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Open Label Trial of the Efficacy and Safety Profile of Rikkunshito used for the Treatment of Gastrointestinal Symptoms in Patients with Parkinson’s Disease: A Pilot Study

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A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives

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Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway

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Soy‐ f ortelin: A ghrelin sensitivity‐enhancing peptide that stimulates food intake in aged mice

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α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence

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Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells

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Role of PKA and PI3K in leptin and ghrelin regulation of adaptive subpopulations of regulatory CD4+ T-lymphocyte formation

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Identification of a Putative β‐Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR)

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Hyperphosphatemia Contributes to Skeletal Muscle Atrophy in Mice

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Elevated phosphate levels in CKD – a direct threat for the heart

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Dietary buckwheat enhances sirtuin1 without calorie restriction

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The effect of a pharmaceutical ghrelin agonist on lifespan in <scp>C57BL</scp>/<scp>6J</scp> male mice: A controlled experiment

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Sijunzi Decoction treatment improved depression with qi deficiency/fatigue in the strain-dependent manner, involved in anti-inflammation in the hippocampus and muscles

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Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice

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Psychological stress in aged female mice causes acute hypophagia independent of central serotonin 2C receptor activation

Matsumoto, C., Yamada, C., Sadakane, C., Nahata, M., Hattori, T., & Takeda, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187937 · Cited by 5 · see citing works

Novel in vivo and in vitro mechanisms of positive inotropic effect of atractylodin

Gao, L., Wang, Y., Zhang, W., Zhu, X., Gao, Q., Xiao, Y., Chen, K., Liu, F., & Chen, L. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13406 · Cited by 5 · see citing works

Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells

Kanda, R., Miyagawa, Y., Wada‐Hiraike, O., Hiraike, H., Fukui, S., Nagasaka, K., Ryo, E., Fujii, T., Osuga, Y., & Ayabe, T. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0368 · Cited by 5 · see citing works

Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm

Cecati, M., Fumarola, S., Vaiasicca, S., Cianfruglia, L., Vignini, A., Giannubilo, S. R., Emanuelli, M., & Ciavattini, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030902 · Cited by 6 · see citing works

The effect of ghrelin and adenosine mono phosphate kinase (AMPK) on the passive avoidance memory in male wistar rats

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Mechanisms of action of compounds that mimic beneficial effects of calorie restriction such as lifespan extension: Is taurine a promising candidate?

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Survey of problems in Kampo curriculum and the need for interdisciplinary collaboration education in Japanese medical, pharmacy, dental, and nursing departments

Uto, N. S., Amitani, M. S., Amitani, H., Kurazono, S., Kobayashi, Y., Sakaki, M., Suzuki, H., Inui, A., Owaki, T., & Asakawa, A. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102225 · Cited by 3 · see citing works

Mechanism of the color deepening of secretory cavities in Atractylodes lancea during light and air exposure

Lin, H., Guo, X., Sun, H., Wang, Y., Zhang, C., Wan, X., Xiong, F., Li, K., Yang, Y., Lyu, C., et al. (2025) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2025.110032 · Cited by 2 · see citing works

The role of central corticotrophin‐releasing factor receptor signalling in plasma glucose maintenance through ghrelin secretion in calorie‐restricted mice

Kimura, R., Kondo, D., Takemi, S., Fujishiro, M., Tsukahara, S., Sakai, T., & Sakata, I. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12961 · Cited by 2 · see citing works

Functional properties of aged hypothalamic cells

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Soft tissue accumulations of phosphate are not always associated with serum phosphate or with calcifications in mouse models of hyperphosphatemia

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Age-related shifts in ghrelin responsiveness of dorsomedial and ventromedial hypothalamic neurons in rats

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Physical frailty

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Pain and Herbal Medicine: Effectiveness of Japanese Kampo Medicines on Pains Associated with Cancer Patients

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鹿児島大学における漢方医学の臨床, 研究, 教育の展開

網谷, 真., 網谷, 東., 森永明倫, 園田, 拓., 利通, 沖., 孝二郎, 山., 浅川, 明., & 乾明夫 (2016) · 心身医学 · doi:10.15064/jjpm.56.11_1122

Sa2004 Biological Therapy Modulates Gut Microbiota - A Longitudinal Study Across Chronic Inflammatory Diseases

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The Role of Ghrelin and Ghrelin Signaling in Aging

Amitani, M. S., Amitani, H., Cheng, K., Kairupan, T. S., Sameshima, N., Shimoshikiryo, I., Mizuma, K., Rokot, N. T., Nerome, Y., Owaki, T., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071511 · Cited by 50 · see citing works

Sa2001 An Exploratory Study of the Efficacy and Safety of Rikkunshito on Gastrointestinal Symptoms in Patients With Parkinson's Disease

Yamaguchi, N., Ohno, S., Hosomi, E., Hayashi, K., Ochiai, M., Maezawa, K., Yoshida, N., Nomura, K., & Yakabi, K. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)31489-5

Sa2003 Influence of Crohn's Disease-Related Genetic Defects in Innate Immune Function on Ileal- Associated Microbiome

Zhang, Y., Li, E., Gathungu, G. N., Sheikh, S. Z., Sartor, R. B., Davidson, N. O., Ciorba, M. A., Xavier, R. J., Zhu, W., Robertson, C. E., et al. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)31491-3

Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin

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