The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
A synthetic Escherichia coli predator–prey ecosystem
Open accessAbstract
We have constructed a synthetic ecosystem consisting of two Escherichia coli populations, which communicate bi-directionally through quorum sensing and regulate each other's gene expression and survival via engineered gene circuits. Our synthetic ecosystem resembles canonical predator-prey systems in terms of logic and dynamics. The predator cells kill the prey by inducing expression of a killer protein in the prey, while the prey rescue the predators by eliciting expression of an antidote protein in the predator. Extinction, coexistence and oscillatory dynamics of the predator and prey populations are possible depending on the operating conditions as experimentally validated by long-term culturing of the system in microchemostats. A simple mathematical model is developed to capture these system dynamics. Coherent interplay between experiments and mathematical analysis enables exploration of the dynamics of interacting populations in a predictable manner.
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Cites
Mechanisms of Maintenance of Species Diversity
Chesson, P. (2000) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.31.1.343 · Cited by 6,645
Stability and Complexity in Model Ecosystems
May, R. M. (2001) · Princeton University Press eBooks · doi:10.1515/9780691206912 · Cited by 5,183
A synthetic oscillatory network of transcriptional regulators
Elowitz, M. B., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,630
Construction of a genetic toggle switch in Escherichia coli
Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000) · Nature · doi:10.1038/35002131 · Cited by 4,268
STABILITY AND COMPLEXITY IN MODEL ECOSYSTEMS
Schoener, T. W. (1974) · Evolution · doi:10.1111/j.1558-5646.1974.tb00784.x · Cited by 3,928
Mathematical Biology: I. An Introduction
(2002) · Interdisciplinary Applied Mathematics · doi:10.1007/b98868 · Cited by 1,763
Lutz, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1203 · Cited by 1,693
Foundations for engineering biology
Endy, D. (2005) · Nature · doi:10.1038/nature04342 · Cited by 1,511
Evolutionary Dynamics of Biological Games
Nowak, M. A., & Sigmund, K. (2004) · Science · doi:10.1126/science.1093411 · Cited by 1,184
A synthetic multicellular system for programmed pattern formation
Basu, S., Gerchman, Y., Collins, C. H., Arnold, F. H., & Weiss, R. (2005) · Nature · doi:10.1038/nature03461 · Cited by 1,154
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Purnick, P. E. M., & Weiss, R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2698 · Cited by 1,181
Designing microbial consortia with defined social interactions
Kong, W., Meldgin, D. R., Collins, J. J., & Lu, T. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0091-7 · Cited by 327
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Duncker, K. E., Holmes, Z. A., & You, L. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01699-9 · Cited by 196
Self-citationA stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis
Scott, S. R., Din, M. O., Bittihn, P., Xiong, L., Tsimring, L. S., & Hasty, J. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.83 · Cited by 173
Construction of stable microbial consortia for effective biochemical synthesis
Jiang, Y., Wu, R., Zhang, W., Xin, F., & Jiang, M. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.05.008 · Cited by 86
Metadata
- Authors
- Balagaddé, F. K., Song, H., Ozaki, J., Collins, C. H., Barnet, M., Arnold, F. H., Quake, S. R., & You, L.
- Venue
- Molecular Systems Biology
- Published
- 2008-01
- Volume
- 4
- Issue
- 1
- Pages
- 187-187
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2145352273
- Cited by
- 482
- References
- 40
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Balagaddé, F. K., Song, H., Ozaki, J., Collins, C. H., Barnet, M., Arnold, F. H., Quake, S. R., & You, L. (2008). A synthetic Escherichia coli predator–prey ecosystem. Molecular Systems Biology. https://doi.org/10.1038/msb.2008.24
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
