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Applications of genome‐scale metabolic reconstructions
Open accessAbstract
The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.
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Metadata
- Authors
- Oberhardt, M. A., Palsson, B. Ø., & Papin, J. A.
- Venue
- Molecular Systems Biology
- Published
- 2009-01
- Volume
- 5
- Issue
- 1
- Pages
- 320-320
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2098824895
- Cited by
- 828
- References
- 9
- FWCI
- 27.85
- Type
- journal article
- Language
- en
- Open access
- gold
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