The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Abstract
Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. Here we show that angiotensin-converting enzyme 2 (ace2) maps to a defined quantitative trait locus (QTL) on the X chromosome in three different rat models of hypertension. In all hypertensive rat strains, ACE2 messenger RNA and protein expression were markedly reduced, suggesting that ace2 is a candidate gene for this QTL. Targeted disruption of ACE2 in mice results in a severe cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart. Genetic ablation of ACE on an ACE2 mutant background completely rescues the cardiac phenotype. But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Ang II binds the ATR1 (Ang II receptor 1) receptor leading to release of TNF α and IL-6, 55 which is associated with hypertension, diabetes, and heart disease 52,56,57 -major comorbidities in severe COVID-19.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [52]
In the citing paper
“ACE2 not only functions as a viral receptor for SARSCoV-2 but also regulates blood pressure.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [52]
Citations
Cites
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Self-citationGlobal Burden of Cardiovascular Diseases
Yusuf, S., Reddy, S., Ôunpuu, S., & Anand, S. S. (2001) · Circulation · doi:10.1161/hc4601.099487 · Cited by 3,014
Handbook of Proteolytic Enzymes
(2004) · Elsevier eBooks · doi:10.1016/c2009-0-03628-9 · Cited by 2,623
Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 2,485
A Human Homolog of Angiotensin-converting Enzyme
Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,041
Garg, R. (1995) · JAMA · doi:10.1001/jama.273.18.1450 · Cited by 1,993
Carretero, O. A., & Oparil, S. (2000) · Circulation · doi:10.1161/01.cir.101.3.329 · Cited by 1,155
The Handbook of proteolytic enzymes
Barrett, A. J., Rawlings, N. D., & Woessner, J. F. (1998) · Cited by 1,119
Spradling, A. C., Stern, D., Beaton, A., Rehm, E. J., Laverty, T., Mozden, N., Misra, S., & Rubin, G. M. (1999) · Genetics · doi:10.1093/genetics/153.1.135 · Cited by 786
Cited by
Sorted by citations
Items 101–200 of 999
Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles
Zisman, L. S., Keller, R. S., Weaver, B. A., Lin, Q., Speth, R. C., Bristow, M. R., & Canver, C. C. (2003) · Circulation · doi:10.1161/01.cir.0000094734.67990.99 · Cited by 309
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis
Lovren, F., Pan, Y., Quan, A., Teoh, H., Wang, G., Shukla, P. C., Levitt, K., Oudit, G. Y., Al-Omran, M. A., Stewart, D. J., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00331.2008 · Cited by 307
Self-citationTargeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2
Wysocki, J. A., Ye, M., Rodríguez, E., González‐Pacheco, F. R., Barrios, C., Evora, K., Schuster, M., Loibner, H., Brosnihan, K. B., Ferrario, C. M., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138420 · Cited by 301
Self-citationGender and the renin–angiotensin–aldosterone system
Komukai, K., Mochizuki, S., & Yoshimura, M. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00854.x · Cited by 295
Wolf, G., & Ritz, E. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00145.x · Cited by 287
ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good
Xu, P., Sriramula, S., & Lazartigues, E. D. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00222.2010 · Cited by 286
Current status of potential therapeutic candidates for the COVID-19 crisis
Zhang, J., Xie, B., & Hashimoto, K. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.046 · Cited by 287
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
Yang, P., Gu, H., Zhao, Z., Wang, W., Cao, B., Lai, C., Yang, X., Zhang, L., Duan, Y., Zhang, S., et al. (2014) · Scientific Reports · doi:10.1038/srep07027 · Cited by 283
Self-citationDouglas, G. C., O’Bryan, M. K., Hedger, M. P., Lee, D. K. L., Yarski, M. A., Smith, A. I., & Lew, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0443 · Cited by 283
Camargo, S. M. R., Singer, D., Makrides, V., Huggel, K., Pos, K. M., Wagner, C. A., Kuba, K., Danilczyk, U. G., Skovby, F., Kleta, R., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.055 · Cited by 279
Self-citationBody Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 298
ACE2 of the heart: From angiotensin I to angiotensin (1–7)
Keidar, S., KAPLAN, M., & Gamliel-Lazarovich, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.006 · Cited by 279
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19
Liu, X., Li, Z., Liu, S., Sun, J., Chen, Z., Jiang, M., Zhang, Q., Wei, Y., Wang, X., Huang, Y.-Y., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.04.008 · Cited by 285
Li, W., Wong, S.-K., Li, F., Kuhn, J. H., Huang, I., Choe, H., & Farzan, M. (2006) · Journal of Virology · doi:10.1128/jvi.80.9.4211-4219.2006 · Cited by 278
Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury
Wong, D., Oudit, G. Y., Reich, H. N., Kassiri, Z., Zhou, J., Liu, Q. C., Backx, P. H., Penninger, J. M., Herzenberg, A. M., & Scholey, J. W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060977 · Cited by 267
Self-citationPrada, J. A. H., Ferreira, A. J., Katovich, M. J., Shenoy, V., Qi, Y., Santos, R. A. S., Castellano, R. K., Lampkins, A. J., Gubala, V., Ostrov, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108944 · Cited by 273
Ocaranza, M. P., Godoy, I. E., Jalil, J., Varas‐Godoy, M., Collantes, P., Pinto, M., Román, M., Ramirez, C., Copaja, M., Dı́az-Araya, G., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000237862.94083.45 · Cited by 273
Koka, V., Huang, X. R., Chung, A. C. K., Wang, W., Truong, L. D., & Lan, H. Y. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070762 · Cited by 272
Angiotensin-I-converting enzyme and its relatives.
Riordan, J. F. (2003) · Genome biology · doi:10.1186/gb-2003-4-8-225 · Cited by 272
Angiotensin-Converting Enzyme II in the Heart and the Kidney
Danilczyk, U. G., & Penninger, J. M. (2006) · Circulation Research · doi:10.1161/01.res.0000205761.22353.5f · Cited by 271
Self-citationCOVID-19, Renin-Angiotensin System and Endothelial Dysfunction
Amraei, R., & Rahimi, N. (2020) · Cells · doi:10.3390/cells9071652 · Cited by 281
The renin-angiotensin-aldosterone system, glucose metabolism and diabetes
Giacchetti, G., Sechi, L. A., Rilli, S., & Carey, R. M. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.02.003 · Cited by 267
Castrop, H., Höcherl, K., Kurtz, A., Schweda, F., Todorov, V., & Wagner, C. (2010) · Physiological Reviews · doi:10.1152/physrev.00011.2009 · Cited by 265
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19
Zipeto, D., Palmeira, J. D. F., Argañaraz, G. A., & Argañaraz, E. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576745 · Cited by 269
Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II
Matsusaka, T., Niimura, F., Shimizu, A., Pastan, I. H., Saito, A., Kobori, H., Nishiyama, A., & Ichikawa, I. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011121159 · Cited by 263
Furuhashi, M., Moniwa, N., Mita, T., Fuseya, T., Ishimura, S., Ohno, K., Shibata, S., Tanaka, M., Watanabe, Y. S., Akasaka, H., et al. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu086 · Cited by 263
Santos, R. A. S. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01274 · Cited by 260
Ferrario, C. M., Jessup, J. A., Gallagher, P. E., Averill, D. B., Brosnihan, K. B., Tallant, E. A., Smith, R. D., & Chappell, M. C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00675.x · Cited by 259
Self-citationDistribution of Angiotensin-(1-7) and ACE2 in Human Placentas of Normal and Pathological Pregnancies
Valdés, G., Neves, L. A. A., Anton, L., Corthorn, J. L., Chacón, C., Germaín, A., Merrill, D., Ferrario, C. M., Sarao, R., Penninger, J. M., et al. (2005) · Placenta · doi:10.1016/j.placenta.2005.02.015 · Cited by 256
Self-citationThe Role of ACE2 in Cardiovascular Physiology
Oudit, G. Y., Crackower, M. A., Backx, P. H., & Penninger, J. M. (2003) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(02)00233-5 · Cited by 255
Self-citationChen, J., & Subbarao, K. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141706 · Cited by 256
Reich, H. N., Oudit, G. Y., Penninger, J. M., Scholey, J. W., & Herzenberg, A. M. (2008) · Kidney International · doi:10.1038/ki.2008.497 · Cited by 249
Self-citationFernandes, T. L., Hashimoto, N. Y., Magalhães, F. D. C., Fernandes, F. B., Casarini, D. E., Carmona, A. K., Krieger, J. E., Phillips, M. I., & de Oliveira, E. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.168252 · Cited by 253
Hanff, T., Harhay, M. O., Brown, T. S., Cohen, J. B., & Mohareb, A. M. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa329 · Cited by 257
Detection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure
Epelman, S., Tang, W. H. W., Chen, S. Y., Lente, F. V., Francis, G. S., & Sen, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.088 · Cited by 251
What’s new in the renin-angiotensin system?
Kuhn, J. H., Li, W., Choe, H., & Farzan, M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4242-5 · Cited by 253
ACE inhibition, ACE2 and angiotensin-(17) axis in kidney and cardiac inflammation and fibrosis
Silva, A. C. S. E., & Teixeira, M. M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.018 · Cited by 248
Oudit, G. Y., Kassiri, Z., PATEL, M., Chappell, M. C., BUTANY, J. W., Backx, P. H., Tsushima, R. G., Scholey, J. W., Khokha, R., & Penninger, J. M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.007 · Cited by 246
Self-citationAngiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus
Gu, H., Xie, Z., Li, T., Zhang, S., Lai, C., Zhu, P., Wang, K., Han, L., Duan, Y., Zhao, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep19840 · Cited by 247
The angiotensin converting enzyme (ACE)
Coates, D. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00309-6 · Cited by 244
Essential role for collectrin in renal amino acid transport
Danilczyk, U. G., Sarao, R., Remy, C., Benabbas, C., Stange, G., Richter, A. A., Arya, S., Pospisilik, J. A., Singer, D., Camargo, S. M. R., et al. (2006) · Nature · doi:10.1038/nature05475 · Cited by 240
Self-citationACE2 – From the renin–angiotensin system to gut microbiota and malnutrition
Perlot, T., & Penninger, J. M. (2013) · Microbes and Infection · doi:10.1016/j.micinf.2013.08.003 · Cited by 242
Self-citationMas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism
Santos, S. H. S., Fernandes, L. R., Mário, É. G., Ferreira, A. V. M., Pôrto, L. C. J., Alvarez-Leite, J. I., Botion, L. M., Bäder, M., Alenina, N. V., & Santos, R. A. S. (2007) · Diabetes · doi:10.2337/db07-0953 · Cited by 240
Cellular entry of the SARS coronavirus
Hofmann, H., & Pöhlmann, S. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.08.008 · Cited by 244
Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7)
Ferrario, C. M. (2005) · Hypertension · doi:10.1161/01.hyp.0000196268.08909.fb · Cited by 239
Self-citationRenal ACE2 expression in human kidney disease
Lely, A. T., Hamming, I., van Goor, H., & Navis, G. (2004) · The Journal of Pathology · doi:10.1002/path.1670 · Cited by 239
Zhang, R., Wu, Y., Zhao, M. L., Liu, C., Zhou, L., Shen, S.-M., Liao, S., Yang, K., Li, Q. Y., & Wan, H. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90415.2008 · Cited by 236
Huentelman, M. J., Grobe, J. L., Vázquez, J., Stewart, J. M., Mecca, A. P., Katovich, M. J., Ferrario, C. M., & Raizada, M. K. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031096 · Cited by 237
Self-citationImpairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice
Santos, R. A. S., Castro, C. H., Gava, E., Pinheiro, S. V. B., Almeida, A. P., de Paula, R. D., Cruz, J. S., Ramos, A. S., Rosa, K. T., Irigoyen, M. C., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000215289.51180.5c · Cited by 236
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
He, S., Wang, L.-H., Liu, Y., Li, Y., Chen, H.-T., Xu, J.-H., Peng, W., Lin, G.-W., Wei, P.-P., Li, B., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02210-0 · Cited by 237
AT2 receptors: Functional relevance in cardiovascular disease
Jones, E. S., Vinh, A., McCarthy, C. A., Gaspari, T. A., & Widdop, R. E. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.009 · Cited by 237
Tomasoni, D., Italia, L., Adamo, M., Inciardi, R. M., Lombardi, C., Solomon, S. D., & Metra, M. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1871 · Cited by 236
Dexamethasone for the Treatment of Coronavirus Disease (COVID-19): a Review
Ahmed, M. H., & Hassan, A. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00610-8 · Cited by 239
Oudit, G. Y., Herzenberg, A. M., Kassiri, Z., Wong, D., Reich, H. N., Khokha, R., Crackower, M. A., Backx, P. H., Penninger, J. M., & Scholey, J. W. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051091 · Cited by 232
Self-citationThomas, M. C., Pickering, R. J., Tsorotes, D., Koı̈tka, A., Sheehy, K., Bernardi, S., Toffoli, B., Nguyen‐Huu, T., Head, G. A., Fu, Y., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.219279 · Cited by 230
ACE2 gene expression is up-regulated in the human failing heart
Goulter, A. B., Goddard, M. J., Allen, J. C., & Clark, K. L. (2004) · BMC Medicine · doi:10.1186/1741-7015-2-19 · Cited by 231
Iwata, M., Cowling, R. T., Gurantz, D., Moore, C., Zhang, S., Yuan, J. X.-J., & Greenberg, B. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00317.2005 · Cited by 231
The intrarenal renin–angiotensin system and diabetic nephropathy
Carey, R. M., & Siragy, H. M. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00111-5 · Cited by 231
Regulation of ACE2 in cardiac myocytes and fibroblasts
Gallagher, P. E., Ferrario, C. M., & Tallant, E. A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00426.2008 · Cited by 229
Self-citationAngiotensin II and the Endothelium
Watanabe, T., Barker, T., & Berk, B. C. (2005) · Hypertension · doi:10.1161/01.hyp.0000153321.13792.b9 · Cited by 231
Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart
Mercure, C., Yogi, Á., Callera, G. E., Aranha, A. B., Bäder, M., Ferreira, A. J., Santos, R. A. S., Walther, T., Touyz, R. M., & Reudelhuber, T. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.184911 · Cited by 226
Kassiri, Z., Zhong, J., Guo, D., Basu, R., Wang, X., Liu, P. P., Scholey, J. W., Penninger, J. M., & Oudit, G. Y. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.840124 · Cited by 228
Self-citationCardiovascular Manifestations of COVID-19 Infection
Magadum, A., & Kishore, R. (2020) · Cells · doi:10.3390/cells9112508 · Cited by 230
Angiotensin‐Converting Enzyme 2: The First Decade
Clarke, N. E., & Turner, A. J. (2011) · International Journal of Hypertension · doi:10.1155/2012/307315 · Cited by 224
A protein complex in the brush‐border membrane explains a Hartnup disorder allele
Kowalczuk, S., Bröer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. J., & Bröer, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107300 · Cited by 222
Increased ACE 2 and Decreased ACE Protein in Renal Tubules From Diabetic Mice
Ye, M., Wysocki, J. A., Naaz, P., Salabat, M. R., LaPointe, M. S., & BATLLE, D. C. (2004) · Hypertension · doi:10.1161/01.hyp.0000126192.27644.76 · Cited by 221
Expression of ACE and ACE2 in Individuals With Diabetic Kidney Disease and Healthy Controls
Mizuiri, S., Hemmi, H., Arita, M., Ohashi, Y., Tanaka, Y., Miyagi, M., Sakai, K., Ishikawa, Y., Shibuya, K., Hase, H., et al. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.11.022 · Cited by 218
Soler, M. J., Wysocki, J. A., Ye, M., Lloveras, J., Kanwar, Y. S., & BATLLE, D. C. (2007) · Kidney International · doi:10.1038/sj.ki.5002373 · Cited by 215
Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2
Huang, L., Sexton, D. J., Skogerson, K., Devlin, M., Smith, R. G., Sanyal, I., Parry, T. J., Kent, R. B., Enright, J., Wu, Q., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212934200 · Cited by 217
Donoghue, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00177-9 · Cited by 214
A model of the ACE2 structure and function as a SARS-CoV receptor
Prabakaran, P., Xiao, X., & Dimitrov, D. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.081 · Cited by 206
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
Kondoh, G., Tojo, H., Nakatani, Y., Komazawa, N., Murata, C., Yamagata, K., Maeda, Y., Kinoshita, T., Okabe, M., Taguchi, R., et al. (2005) · Nature Medicine · doi:10.1038/nm1179 · Cited by 211
Walters, P. E., Gaspari, T. A., & Widdop, R. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000160325.59323.b8 · Cited by 206
Banu, N., Panikar, S. S., Leal, L. R., & Leal, A. R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117905 · Cited by 214
Kehoe, P. G., Wong, S., AL Mulhim, N., Palmer, L. E., & Miners, J. S. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0217-7 · Cited by 203
Igase, M., Strawn, W. B., Gallagher, P. E., Geary, R. L., & Ferrario, C. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00068.2005 · Cited by 203
Self-citationEpelman, S., Shrestha, K. L., Troughton, R. W., Francis, G. S., Sen, S., Klein, A. L., & Tang, W. H. W. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2009.01.014 · Cited by 202
ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR
Díez-Freire, C., Vázquez, J., de Adjounian, M. F. C., Ferrari, M., Yuan, L., Silver, X., Torres, R., & Raizada, M. K. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00312.2005 · Cited by 199
Angiotensin-Converting Enzyme 2 (ACE2) in Disease Pathogenesis
Imai, Y., Kuba, K., Ohto‐Nakanishi, T., & Penninger, J. M. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0045 · Cited by 206
Self-citationSoler, M. J., Ye, M., Wysocki, J. A., William, J., Lloveras, J., & BATLLE, D. C. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90488.2008 · Cited by 199
Serfözö, P. D., Wysocki, J. A., Gulua, G., Schulze, A., Ye, M., Liu, P., Jin, J., Bäder, M., Myöhänen, T. T., Garcia-Horsman, A., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.14071 · Cited by 198
Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases
Kuba, K., Imai, Y., & Penninger, J. M. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-1544 · Cited by 201
Self-citationRoles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure
Basu, R., Poglitsch, M., Yogasundaram, H., Thomas, J., Rowe, B. H., & Oudit, G. Y. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.064 · Cited by 199
Self-citationSu, Z., Zimpelmann, J., & Burns, K. D. (2006) · Kidney International · doi:10.1038/sj.ki.5001509 · Cited by 196
Brain renin angiotensin in disease
Phillips, M. I., & de Oliveira, E. M. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0331-5 · Cited by 196
Targeting the renin-angiotensin-aldosterone system in fibrosis
Alqudah, M., Hale, T. M., & Czubryt, M. P. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.04.005 · Cited by 208
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanović, A., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg469 · Cited by 194
Keidar, S., Gamliel-Lazarovich, A., Kaplan, M., Pavlotzky, E., Hamoud, S., Hayek, T., Karry, R., & Abassi, Z. A. (2005) · Circulation Research · doi:10.1161/01.res.0000187500.24964.7a · Cited by 197
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
Bailey, A. L., Dmytrenko, O., Greenberg, L., Bredemeyer, A. L., Ma, P., Liu, J., Penna, V., Winkler, E. S., Sviben, S., Brooks, E., et al. (2021) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2021.01.002 · Cited by 193
Vascular smooth muscle cell motility: From migration to invasion.
Louis, S. F., & Zahradka, P. C. (2010) · PubMed Central · Cited by 193
Genome wide analysis of common and specific stress responses in adult drosophila melanogaster
Girardot, F., Monnier, V., & Tricoire, H. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-74 · Cited by 27
Systemic and regional hemodynamic effects of angiotensin-(1–7) in rats
Sampaio, W. O., Nascimento, A. A. S., & Santos, R. A. S. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01145.2002 · Cited by 191
Guy, J. L., Jackson, R. M., Acharya, K. R., Sturrock, E. D., Hooper, N. M., & Turner, A. J. (2003) · Biochemistry · doi:10.1021/bi035268s · Cited by 191
Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents
Gembardt, F., Sterner‐Kock, A., Imboden, H., Spalteholz, M., Reibitz, F., Schultheiß, H., Siems, W., & Walther, T. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.009 · Cited by 190
Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17
Wang, W., McKinnie, S. M. K., Farhan, M., Paul, M., McDonald, T. R., McLean, B. A., Llorens‐Cortés, C., Hazra, S., Murray, A. G., Vederas, J. C., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06892 · Cited by 190
Self-citationFu, J., Zhou, B., Zhang, L., Balaji, K. S., Wei, C., Liu, X., Chen, H., Peng, J., & Fu, J. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05478-4 · Cited by 190
Self-citationApelin is a positive regulator of ACE2 in failing hearts
Sato, T., SUZUKI, T. A., Watanabe, H., Kadowaki, A., Fukamizu, A., Liu, P. P., Kimura, A., Ito, H., Penninger, J. M., Imai, Y., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69608 · Cited by 189
Self-citationACE and ACE2 in kidney disease
Mizuiri, S. (2015) · World Journal of Nephrology · doi:10.5527/wjn.v4.i1.74 · Cited by 187
Rentzsch, B., Todiraş, M., Iliescu, R., Popova, E., Campos, L. A., Oliveira, M. L., Baltatu, O. C., Santos, R. A. S., & Bäder, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114322 · Cited by 187
Santos, R. A. S., Ferreira, A. J., Nadu, A. P., Braga, A. N. G., Almeida, A. P., Campagnole‐Santos, M. J., Baltatu, O. C., Iliescu, R., Reudelhuber, T. L., & Bäder, M. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00227.2003 · Cited by 187
Metadata
- Authors
- Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, C. M., Manoukian, A. S., Chappell, M. C., Backx, P. H., Yagil, Y., & Penninger, J. M.
- Affiliations
- University of Toronto (CA)
- Institute of Molecular Biotechnology (AT)
- University Health Network (CA)
- Barzilai Medical Center (IL)
- Atrium Health Wake Forest Baptist (US)
- Corresponding author
- Penninger, Josef M.
- ORCID
- Venue
- Nature
- Published
- 2002-06
- Volume
- 417
- Issue
- 6891
- Pages
- 822-828
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2025672718
- Cited by
- 1,733
- References
- 44
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 38 · 2023: 88 · 2022: 117 · 2021: 215 · 2020: 311 · 2019: 38 · 2018: 22 · 2017: 33 · 2016: 42 · 2015: 38 · 2014: 53 · 2013: 54 · 2012: 60
- FWCI
- 38.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Amgen
- German-Israeli Foundation for Scientific Research and Development
- Canada Research Chairs
- Israel Science Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- angiotensin-converting enzyme 2, ACE2, cardiac function, hypertension, quantitative trait loci, X chromosome, cardiac contractility, angiotensin II, hypoxia, Acer, cardiac morphogenesis, rat model, mouse knockout
- MeSH terms
- Angiotensin II, Animals, Hypoxia, Blood Pressure, Cloning, Molecular, Drosophila melanogaster, Female, Heart, Hypertension, Peptidyl-Dipeptidase A, Male, Metalloendopeptidases, Myocardial Contraction, Myocardium, X Chromosome, Up-Regulation, Gene Expression Regulation, Enzymologic, Gene Deletion, Mice, Knockout, Quantitative Trait, Heritable, Radiation Hybrid Mapping, Drosophila Proteins, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
