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Cited by 398Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells

Harris, Kenneth D., Henze, Darrell A., Hirase, Hajime, Leinekugel, Xavier, Dragoi, George, Czurkó, Andras, Buzsáki, György·2002·Nature
DOI 10.1038/nature00808
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Abstract

According to the temporal coding hypothesis, neurons encode information by the exact timing of spikes. An example of temporal coding is the hippocampal phase precession phenomenon, in which the timing of pyramidal cell spikes relative to the theta rhythm shows a unidirectional forward precession during spatial behaviour. Here we show that phase precession occurs in both spatial and non-spatial behaviours. We found that spike phase correlated with instantaneous discharge rate, and processed unidirectionally at high rates, regardless of behaviour. The spatial phase precession phenomenon is therefore a manifestation of a more fundamental principle governing the timing of pyramidal cell discharge. We suggest that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes.

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Crossref · 10.1038/nature00808

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Metadata

Authors
Harris, K. D., Henze, D. A., Hirase, H., Leinekugel, X., Dragoi, G., Czurkó, A., & Buzsáki, G.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
Buzsáki, György
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2002-06
Volume
417
Issue
6890
Pages
738-741
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature00808
OpenAlex
W1991417588
Cited by
398
References
26
Citations by year
2026: 6 · 2025: 8 · 2024: 18 · 2023: 31 · 2022: 12 · 2021: 10 · 2020: 13 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 11 · 2015: 21 · 2014: 21 · 2013: 22 · 2012: 17
FWCI
9.01
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
phase precession, hippocampal pyramidal neurons, theta oscillations, temporal coding, spike timing, spatial behavior, somatic inhibition, hippocampus
MeSH terms
Action Potentials, Analysis of Variance, Animals, Computer Simulation, Dendrites, Kinetics, Male, Motor Activity, Sleep, REM, Theta Rhythm, Pyramidal Cells, Rats

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