The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Open accessAbstract
Formation of the vertebrate heart requires a complex interplay of several temporally regulated signalling cascades. In Xenopus laevis, cardiac specification occurs during gastrulation and requires signals from the dorsal lip and underlying endoderm. Among known Xenopus Wnt genes, only Wnt-11 shows a spatiotemporal pattern of expression that correlates with cardiac specification, which indicates that Wnt-11 may be involved in heart development. Here we show, through loss- and gain-of-function experiments, that XWnt-11 is required for heart formation in Xenopus embryos and is sufficient to induce a contractile phenotype in embryonic explants. Treating the mouse embryonic carcinoma stem cell line P19 with murine Wnt-11 conditioned medium triggers cardiogenesis, which indicates that the function of Wnt-11 in heart development has been conserved in higher vertebrates. XWnt-11 mediates this effect by non-canonical Wnt signalling, which is independent of β-catenin and involves protein kinase C and Jun amino-terminal kinase. Our results indicate that the cardiac developmental program requires non-canonical Wnt signal transduction.
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Functional interaction of β-catenin with the transcription factor LEF-1
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Self-citationDjiane, A., Riou, J.-F., Umbhauer, M., Boucaut, J.-C., & Shi, D.-L. (2000) · Development · doi:10.1242/dev.127.14.3091 · Cited by 316
Dishevelled: at the crossroads of divergent intracellular signaling pathways
Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00046-5 · Cited by 275
Cited by
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Secreted antagonists of the Wnt signalling pathway
Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Wagner, W., Wein, F., Seckinger, A., Frankhauser, M., Wirkner, U., Krause, U., Blake, J., Schwager, C., Eckstein, V., Ansorge, W., et al. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.07.003 · Cited by 1,259
Function and biological roles of the Dickkopf family of Wnt modulators
Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995
Metadata
- Authors
- Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M.
- Venue
- Nature
- Published
- 2002-08
- Volume
- 418
- Issue
- 6898
- Pages
- 636-641
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2092664596
- Cited by
- 539
- References
- 4
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- green
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