Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

Sodium/Calcium Exchange: Its Physiological Implications

Blaustein, M. P., & Lederer, W. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.3.763 · Cited by 1,737

Excitation-Contraction Coupling and Cardiac Contractile Force

Bers, D. M., & Zhu, Y. (2010) · Journal of Cardiovascular Disease Research · doi:10.1016/s0975-3583(10)11011-0 · Cited by 1,606

Excitation-Contraction Coupling and Cardiac Contractile Force

Bers, D. M. (2001) · Developments in cardiovascular medicine · doi:10.1007/978-94-010-0658-3 · Cited by 1,543

Molecular and Cellular Mechanisms of Cardiac Arrhythmias

Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,003

Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.

Bennett, V., & Baines, A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 993

Excitation-Contraction Coupling and Cardiac Contractile Force

Bers, D. M. (1993) · Developments in cardiovascular medicine · doi:10.1007/978-94-017-1512-6 · Cited by 777

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

Gomez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758

Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.

Kass, R. S., Lederer, W. J., Tsien, R. W., & Weingart, R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012416 · Cited by 633

AnkyrinG Is Required for Clustering of Voltage-gated Na Channels at Axon Initial Segments and for Normal Action Potential Firing

Zhou, D., Lambert, S., Malen, P. L., Carpenter, S., Boland, L. M., & Bennett, V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1295 · Cited by 568

Sodium-Calcium Exchange: A Molecular Perspective

Philipson, K. D., & Nicoll, D. A. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.111 · Cited by 540

Drug-induced prolongation of the QT interval

Roden, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032426 · Cited by 1,965

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Myerburg, R. J., Quiñones, M. A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.010 · Cited by 1,975

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten‐Jacobs, L. C. A., Giese, A., van der Laan, S. W., Grétarsdóttir, S., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0058-3 · Cited by 1,583

Inositol Trisphosphate Receptor Ca2+Release Channels

Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society

Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178233 · Cited by 1,080

Molecular Physiology of Cardiac Repolarization

Nerbonne, J. M., & Kass, R. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00002.2005 · Cited by 1,104

FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death

Wehrens, X. H. T., Lehnart, S. E., Huang, F., Vest, J. A., Reiken, S. R., Mohler, P. J., Sun, J., Guatimosim, S., Song, L., Rosemblit, N., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00434-3 · Cited by 760

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Moss, A. J., Myerburg, R. J., et al. (2006) · EP Europace · doi:10.1093/europace/eul108 · Cited by 741

Sudden Cardiac Death Prediction and Prevention

Fishman, G. I., Chugh, S. S., Dimarco, J., Albert, C. M., Anderson, M. E., Bonow, R. O., Buxton, A. E., Chen, P., Estes, M., Jouven, X., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.976092 · Cited by 633

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing

Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2005.01.020 · Cited by 560

Mutant Caveolin-3 Induces Persistent Late Sodium Current and Is Associated With Long-QT Syndrome

Vatta, M., Ackerman, M. J., Ye, B., Makielski, J. C., Ughanze, E. E., Taylor, E. W., Tester, D. J., Balijepalli, R. C., Foell, J. D., Li, Z., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.635268 · Cited by 554

Recent advances in the molecular pathophysiology of atrial fibrillation

Wakili, R., Voigt, N., Kääb, S., Dobrev, D., & Nattel, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46315 · Cited by 543

Mechanisms of sudden cardiac death

Rubart, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26381 · Cited by 515

Protection from Cardiac Arrhythmia Through Ryanodine Receptor-Stabilizing Protein Calstabin2

Wehrens, X. H. T., Lehnart, S. E., Reiken, S. R., Deng, S., Vest, J. A., Cervantes, D. O., Coromilas, J., Landry, D. W., & Marks, A. R. (2004) · Science · doi:10.1126/science.1094301 · Cited by 482

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

Kozyrev, S. V., Abelson, A.-K., Wojcik, J., Zaghlool, A., Reddy, M., Sánchez, E., Gunnarsson, I., Svenungsson, E., Sturfelt, G. K., Jönsen, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.79 · Cited by 474

Overview of Basic Mechanisms of Cardiac Arrhythmia

Antzelevitch, C. N., & Burashnikov, A. (2011) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2010.10.012 · Cited by 472

Genetic Testing in the Long QT Syndrome

Napolitano, C., Priori, S. G., Schwartz, P. J., Bloise, R., Ronchetti, E., Nastoli, J., Bottelli, G., Cerrone, M., & Leonardi, S. (2005) · JAMA · doi:10.1001/jama.294.23.2975 · Cited by 464

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test

Kapplinger, J. D., Tester, D. J., Salisbury, B. A., Carr, J. L., Harris‐Kerr, C., Pollevick, G. D., Wilde, A. A. M., & Ackerman, M. J. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.05.021 · Cited by 450

Drug-Induced Long QT Syndrome

Kannankeril, P. J., Roden, D. M., & Darbar, D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003723 · Cited by 441

Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators

Patterson, R. L., Boehning, D. F., & Snyder, S. H. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.161303 · Cited by 438

Mutation in Glycerol-3-Phosphate Dehydrogenase 1–Like Gene ( GPD1-L ) Decreases Cardiac Na + Current and Causes Inherited Arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.703330 · Cited by 437

The genetic basis of long QT and short QT syndromes: A mutation update

Hedley, P. L., Jørgensen, P., Schlamowitz, S., Wangari, R., Moolman‐Smook, J. C., Brink, P. A., Kanters, J. K., Corfield, V. A., & Christiansen, M. (2009) · Human Mutation · doi:10.1002/humu.21106 · Cited by 422

Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families

Behr, E. R., Dalageorgou, C., Christiansen, M., Syrris, P., Hughes, S., Tome, M., Rowland, E., Jeffery, S., & McKenna, W. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn219 · Cited by 417

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

Lehnart, S. E., Mongillo, M., Bellinger, A. M., Lindegger, N., Chen, B.-X., HSUEH, W. H., Reiken, S. R., Wronska, A., Drew, L., Ward, C. W., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35346 · Cited by 413

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases

Wilde, A. A. M., Semsarian, C., Márquez, M. F., Shamloo, A. S., Ackerman, M. J., Ashley, E. A., Sternick, E. B., Barajas-Martínez, H., Behr, E. R., Bezzina, C. R., et al. (2022) · EP Europace · doi:10.1093/europace/euac030 · Cited by 421

Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement

Brugada, J., Blom, N. A., Sarquella‐Brugada, G., Blomström‐Lundqvist, C., Deanfield, J. E., Janoušek, J., Abrams, D. J., Bauersfeld, U., Brugada, R., Drago, F., et al. (2013) · EP Europace · doi:10.1093/europace/eut082 · Cited by 397

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Wilke, R. A., Lin, D. W., Roden, D. M., Watkins, P. B., Flockhart, D. A., Zineh, I., Giacomini, K. M., & Krauss, R. M. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2423 · Cited by 400

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome

Adler, A., Novelli, V., Amin, A. S., Abiusi, E., Care, M. E., Nannenberg, E. A., Feilotter, H. E., Amenta, S., Mazzà, D., Bikker, H., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043132 · Cited by 397

Identification of a KCNE2 Gain-of-Function Mutation in Patients with Familial Atrial Fibrillation

Yang, Y., Xia, M., Jin, Q., Bendahhou, S., Shi, J., Chen, Y., Liang, B., Lin, J., Liu, Y., Liu, B., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425342 · Cited by 388

FXYD proteins: new regulators of Na-K-ATPase

Geering, K. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00126.2005 · Cited by 372

Na v 1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Na v 1.5 on the surface of cardiomyocytes

Mohler, P. J., Rivolta, I., Napolitano, C., Lemaillet, G., Lambert, S., Priori, S. G., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403711101 · Cited by 359

Postmortem Long QT Syndrome Genetic Testing for Sudden Unexplained Death in the Young

Tester, D. J., & Ackerman, M. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.010 · Cited by 355

Calcium and Arrhythmogenesis

ter Keurs, H. E. D. J., & Boyden, P. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00011.2006 · Cited by 353

Genetic Testing for Long-QT Syndrome

Kapa, S., Tester, D. J., Salisbury, B. A., Harris‐Kerr, C., Pungliya, M. S., Alders, M. M., Wilde, A. A. M., & Ackerman, M. J. (2009) · Circulation · doi:10.1161/circulationaha.109.863076 · Cited by 345

Drug‐Induced Torsades de Pointes and Implications for Drug Development

Fenichel, R. R., Malík, M., Antzelevitch, C. N., Sanguinetti, M. C., Roden, D. M., Priori, S. G., Ruskin, J. N., Lipicky, R. J., Cantilena, L. R., & Independent Academic Task Force (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.03534.x · Cited by 343

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

Mohler, P. J., Splawski, I., Napolitano, C., Bottelli, G., Sharpe, L. M., Timothy, K. W., Priori, S. G., Keating, M. T., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402546101 · Cited by 323

The WAVE regulatory complex links diverse receptors to the actin cytoskeleton

Chen, B., Brinkmann, K., Chen, Z., Pak, C. W., Liao, Y., Shi, S., Henry, L., Grishin, N. V., Bogdan, S., & Rosen, M. K. (2014) · Cell · doi:10.1016/j.cell.2013.11.048 · Cited by 323

Congenital long QT syndrome

Crotti, L., Celano, G., Dagradi, F., & Schwartz, P. J. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-18 · Cited by 311

The QT syndromes: long and short

Morita, H., Wu, J., & Zipes, D. P. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61307-0 · Cited by 311

Predicting drug–hERG channel interactions that cause acquired long QT syndrome

Sanguinetti, M. C., & Mitcheson, J. S. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.01.003 · Cited by 300

The cytoskeleton, cellular motility and the reductionist agenda

Pollard, T. D. (2003) · Nature · doi:10.1038/nature01598 · Cited by 300

Ethnic Differences in Cardiac Potassium Channel Variants: Implications for Genetic Susceptibility to Sudden Cardiac Death and Genetic Testing for Congenital Long QT Syndrome

Ackerman, M. J., Tester, D. J., Jones, G. S., Will, M. L., Burrow, C. R., & Curran, M. E. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1479 · Cited by 295

Long QT syndrome: from channels to cardiac arrhythmias

Moss, A. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25537 · Cited by 293

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

Hólm, H., Gudbjartsson, D. F., Sulem, P., Másson, G., Helgadottir, H. T., Zanon, C., Magnússon, Ó. Þ., Helgason, A., Saemundsdottir, J., Gylfason, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.781 · Cited by 303

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy

Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M., & Ackerman, M. J. (2008) · Neurology · doi:10.1212/01.wnl.0000335760.02995.ca · Cited by 281

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the State of Genetic Testing for Cardiac Diseases

Wilde, A. A. M., Semsarian, C., Márquez, M. F., Shamloo, A. S., Ackerman, M. J., Ashley, E. A., Sternick, E. B., Barajas-Martínez, H., Behr, E. R., Bezzina, C. R., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2022.03.1225 · Cited by 287

miR-1 Overexpression Enhances Ca 2+ Release and Promotes Cardiac Arrhythmogenesis by Targeting PP2A Regulatory Subunit B56α and Causing CaMKII-Dependent Hyperphosphorylation of RyR2

Terentyev, D. A., Belevych, A. E., Terentyeva, R., Martin, M. M., Malana, G. E., Kuhn, D. E., Abdellatif, M., Feldman, D. S., Elton, T. S., & Györke, S. (2009) · Circulation Research · doi:10.1161/circresaha.108.181651 · Cited by 279

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1 , and KCNE2 in drug-induced long QT syndrome patients

Paulussen, A. D. C., Gilissen, R. A. H. J., Armstrong, M., Doevendans, P. A., Verhasselt, P., Smeets, H. J. M., Schulze‐Bahr, E., Haverkamp, W., Breithardt, G., Cohen, N., et al. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0522-z · Cited by 279

Spectrum and Frequency of Cardiac Channel Defects in Swimming-Triggered Arrhythmia Syndromes

Choi, G. R., Kopplin, L. J., Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2004) · Circulation · doi:10.1161/01.cir.0000144471.98080.ca · Cited by 271

Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias

Ouvrard‐Pascaud, A., Sainte–Marie, Y., Bénitah, J., Perrier, R., Soukaseum, C., Cat, A. N. D., Royer, A., Quang, K. L., Charpentier, F., Demolombe, S., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.503706 · Cited by 288

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

Abriel, H. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.08.025 · Cited by 268

Modulation of Cardiac Gap Junction Expression and Arrhythmic Susceptibility

Danik, S. B., Liu, F., Zhang, J., Suk, H. J., Morley, G. E., Fishman, G. I., & Gutstein, D. E. (2004) · Circulation Research · doi:10.1161/01.res.0000148664.33695.2a · Cited by 268

Physicochemical Features of the hERG Channel Drug Binding Site

Fernández, D., Ghanta, A., Kauffman, G. W., & Sanguinetti, M. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310683200 · Cited by 267

Muscle KATPChannels: Recent Insights to Energy Sensing and Myoprotection

Flagg, T. P., Enkvetchakul, D., Koster, J. C., & Nichols, C. G. (2010) · Physiological Reviews · doi:10.1152/physrev.00027.2009 · Cited by 269

Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes

Antzelevitch, C. N. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00355.2007 · Cited by 263

The MinK-related peptides

McCrossan, Z. A., & Abbott, G. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.018 · Cited by 254

Inherited Arrhythmias

Lehnart, S. E., Ackerman, M. J., Benson, D. W., Brugada, R., Clancy, C. E., Donahue, J. K., George, A. L., Grant, A. O., Groft, S. C., January, C. T., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.711689 · Cited by 253

Involvement of lipid rafts and caveolae in cardiac ion channel function.

Maguy, A., Hébert, T., & Nattel, S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.013 · Cited by 221

Ankyrin-B Coordinates the Na/K ATPase, Na/Ca Exchanger, and InsP3 Receptor in a Cardiac T-Tubule/SR Microdomain

Mohler, P. J., Davis, J. Q., & Bennett, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030423 · Cited by 244

Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits

Lemaillet, G., Walker, B. J., & Lambert, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303327200 · Cited by 243

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

Smyth, J. W., Hong, T., Gao, D., Vogan, J. M., Jensen, B. C., Fong, T. S., Simpson, P. C., Stainier, D. Y. R., Chi, N. C., & Shaw, R. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39740 · Cited by 249

A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

Hund, T. J., Koval, O. M., Li, J., Wright, P. J., Qian, L., Snyder, J. S., Gudmundsson, H., Kline, C. F., Davidson, N. P., Cardona, N., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43621 · Cited by 251

Sema3a maintains normal heart rhythm through sympathetic innervation patterning

Ieda, M., Kanazawa, H., Kimura, K., Hattori, F., Ieda, Y., Taniguchi, M., Lee, J.-K., Matsumura, K., Tomita, Y., Miyoshi, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1570 · Cited by 242

The congenital long QT syndromes from genotype to phenotype: clinical implications

Schwartz, P. J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01583.x · Cited by 236

QTc: how long is too long?

Johnson, J. N., & Ackerman, M. J. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.054734 · Cited by 235

Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3

Cronk, L. B., Ye, B., Kaku, T., Tester, D. J., Vatta, M., Makielski, J. C., & Ackerman, M. J. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.11.030 · Cited by 232

Epinephrine QT Stress Testing in the Evaluation of Congenital Long-QT Syndrome

Vyas, H., Hejlik, J., & Ackerman, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.600445 · Cited by 227

Biology of Cardiac Arrhythmias

Delisle, B. P., Anson, B. D., Rajamani, S., & January, C. T. (2004) · Circulation Research · doi:10.1161/01.res.0000128561.28701.ea · Cited by 227

Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac Arrhythmia

Ueda, K., Nakamura, K., Hayashi, T., Inagaki, N., Takahashi, M., Arimura, T., Morita, H., Higashiuesato, Y., Hirano, Y., Yasunami, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311953200 · Cited by 225

Locus for Atrial Fibrillation Maps to Chromosome 6q14–16

Ellinor, P. T., Shin, J. T., Moore, R. K., Yoerger, D. M., & MacRae, C. A. (2003) · Circulation · doi:10.1161/01.cir.0000077910.80718.49 · Cited by 222

Sinus Node and Atrial Arrhythmias

John, R. M., & Kumar, S. (2016) · Circulation · doi:10.1161/circulationaha.116.018011 · Cited by 219

A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families

Smits, J. P. P., Koopmann, T. T., Wilders, R., Veldkamp, M. W., Opthof, T., Bhuiyan, Z. A., Mannens, M. M. A. M., Balser, J. R., Tan, H. L., & Bezzina, C. R. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.02.024 · Cited by 215

Ion Channels in the Heart

Bartos, D. C., Grandi, E., & Ripplinger, C. M. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140069 · Cited by 215

Predicting disease using genomics

Bell, J. I. (2004) · Nature · doi:10.1038/nature02624 · Cited by 215

Innovative approaches to anti-arrhythmic drug therapy

Nattel, S., & Carlsson, L. G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2112 · Cited by 209

Genetics and genomics of autism spectrum disorder: embracing complexity

De Rubeis, S., & Buxbaum, J. D. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv273 · Cited by 208

Autonomic aspects of arrhythmogenesis: the enduring and the new

Verrier, R. L., & Antzelevitch, C. N. (2003) · Current Opinion in Cardiology · doi:10.1097/00001573-200401000-00003 · Cited by 208

Long QT Syndrome

Goldenberg, I., Zaręba, W., & Moss, A. J. (2008) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2008.07.002 · Cited by 208

Recent advances in understanding sex differences in cardiac repolarization

James, A. F., Choisy, S. C. M., & Hancox, J. C. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.05.010 · Cited by 205

Task Force 7: Arrhythmias

Zipes, D. P., Ackerman, M. J., Estes, N. A. M., Grant, A. O., Myerburg, R. J., & Hare, G. F. V. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.014 · Cited by 206

Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S., Rasmussen, H. B., Ellinor, P. T., Gao, L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.04.017 · Cited by 199

Molecular Basis of Arrhythmias

Shah, M. H., Akar, F. G., & Tomaselli, G. F. (2005) · Circulation · doi:10.1161/circulationaha.104.494476 · Cited by 191

Cardiac T-Tubule Microanatomy and Function

Hong, T., & Shaw, R. M. (2016) · Physiological Reviews · doi:10.1152/physrev.00037.2015 · Cited by 191

Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell InteractionsPreprint

Bennett, V., & Healy, J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003012 · Cited by 191

Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes

Kockskämper, J., Zima, A. V., Roderick, H. L., Pieske, B. M., Blatter, L. A., & Bootman, M. D. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.05.014 · Cited by 186

Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes

Antzelevitch, C. N. (2007) · EP Europace · doi:10.1093/europace/eum166 · Cited by 186

Effect of Clinical Phenotype on Yield of Long QT Syndrome Genetic Testing

Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.056 · Cited by 184

Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin

Bennett, V., & Healy, J. A. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.11.005 · Cited by 184

Multifocal Ectopic Purkinje-Related Premature Contractions

Laurent, G., Saal, S., Amarouch, M., Béziau, D. M., Marsman, R. F. J., Faivre, L. O., Barc, J., Dina, C., Bertaux, G., Barthez, O., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.052 · Cited by 182

Heterogeneity and cardiac arrhythmias: An overview

Antzelevitch, C. N. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.03.036 · Cited by 180

Pathophysiology and pharmacology of the cardiac “late sodium current”

Zaza, A., Belardinelli, L., & Shryock, J. C. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.06.001 · Cited by 177

Sodium channels as macromolecular complexes: Implications for inherited arrhythmia syndromes

Meadows, L. S., & Isom, L. L. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.003 · Cited by 177

KCNQ1 Assembly and Function Is Blocked by Long-QT Syndrome Mutations That Disrupt Interaction With Calmodulin

Ghosh, S., Nunziato, D. A., & Pitt, G. S. (2006) · Circulation Research · doi:10.1161/01.res.0000218863.44140.f2 · Cited by 173

Molecular Pathophysiology of Congenital Long QT Syndrome

Bohnen, M. S., Peng, G., Robey, S., Terrenoire, C., Iyer, V. R., Sampson, K. J., & Kass, R. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00008.2016 · Cited by 174

Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

Lu, Z., Wu, C. C., Jiang, Y., Ballou, L. M., Clausen, C., Cohen, I. S., & Lin, R. Z. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003623 · Cited by 172

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

Scouarnec, S. L., Bhasin, N., Vieyres, C., Hund, T. J., Cunha, S. R., Koval, O. M., Marionneau, C., Chen, B., Wu, Y., Demolombe, S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805500105 · Cited by 170

Voltage-gated Nav channel targeting in the heart requires an ankyrin-G–dependent cellular pathway

Lowe, J. S., Palygin, O., Bhasin, N., Hund, T. J., Boyden, P. A., Shibata, E. F., Anderson, M. E., & Mohler, P. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710107 · Cited by 170

Cardiac Arrest and Sudden Cardiac Death

Myerburg, R. J., & Castellanos, A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00041-x · Cited by 166

Defining the Cellular Phenotype of “Ankyrin-B Syndrome” Variants

Mohler, P. J., Scouarnec, S. L., Denjoy, I., Lowe, J. S., Guicheney, P., Caron, L., Driskell, I. M., Schott, J., NORRIS, K. J., Leenhardt, A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.656512 · Cited by 164

Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies

George, C. H., Jundi, H., Thomas, N. L., Fry, D. L., & Lai, F. A. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.08.115 · Cited by 163

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

Mohler, P. J., Splawski, I., Napolitano, C., Bottelli, G., Sharpe, L. M., Timothy, K. W., Priori, S. G., Keating, M. T., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402546101 · Cited by 323

Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting

Mohler, P. J., & Bennett, V. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000160372.95116.3e · Cited by 66

Ankyrin-B Syndrome: A Case of Sinus Node Dysfunction, Atrial Fibrillation and Prolonged QT in a Young Adult

Robaei, D., Ford, T. J., & Ooi, S. (2014) · Heart Lung and Circulation · doi:10.1016/j.hlc.2014.09.013 · Cited by 15

Defects in Ankyrin-Based Protein Targeting Pathways in Human Arrhythmia

Gudmundsson, H., Jareczek, F. J., & Mohler, P. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-17575-6_25

Cardiac ankyrins in health and disease

Hashemi, S., Hund, T. J., & Mohler, P. J. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.04.010 · Cited by 80