Cited by 3,198Tissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applicationsbiodegradable polymer synthesis and properties

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Designing materials for biology and medicine

Langer, Robert, Tirrell, David A.·2004·Nature

DOI 10.1038/nature02388

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Abstract

Biomaterials have played an enormous role in the success of medical devices and drug delivery systems. We discuss here new challenges and directions in biomaterials research. These include synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies.

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Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609
Biomaterials Science: An Introduction to Materials in Medicine
Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (1996) · doi:10.1016/c2009-0-02433-7 · Cited by 5,125
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101
A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization
Morice, M., Serruys, P. W. J. C., Sousa, J. E., Fajadet, J. C., Hayashi, E. B., Perin, M. A., Colombo, A., Schuler, G. C., Barragan, P. T., Guagliumi, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012843 · Cited by 4,028
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951
Self-citation
Printing Proteins as Microarrays for High-Throughput Function Determination
MacBeath, G., & Schreiber, S. L. (2000) · Science · doi:10.1126/science.289.5485.1760 · Cited by 2,767
Light-Directed, Spatially Addressable Parallel Chemical Synthesis
Fodor, S. P. A., Read, J., Pirrung, M. C., Stryer, L., Lu, A. T., & Solas, D. W. (1991) · Science · doi:10.1126/science.1990438 · Cited by 2,697
Shape-Memory Polymers
Lendlein, A., Kelch, S., Kratz, K., Schulte, J., & Schauer, S. (2002) · Elsevier eBooks · doi:10.1002/0471238961.1908011612051404.a01 · Cited by 2,687
Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications
Lendlein, A., & Langer, R. (2002) · Science · doi:10.1126/science.1066102 · Cited by 2,146
Self-citation
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.
Bell, E., Ivarsson, B., & Merrill, C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1274 · Cited by 2,069

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Authors: Langer, R., & Tirrell, D. A.
Affiliations: California Institute of Technology (US)
ORCID: Tirrell, David A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-04-01
Volume: 428
Issue: 6982
Pages: 487-492
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02388
OpenAlex: W2154157809
Cited by: 3,198
References: 70
Citations by year: 2026: 72 · 2025: 83 · 2024: 69 · 2023: 78 · 2022: 98 · 2021: 124 · 2020: 107 · 2019: 139 · 2018: 193 · 2017: 194 · 2016: 219 · 2015: 194 · 2014: 212 · 2013: 196 · 2012: 197
FWCI: 21.08
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords: biomaterials, tissue engineering, medical devices, drug delivery systems, medical diagnostics, microarray
MeSH terms: Animals, Biocompatible Materials, Humans, Medicine, Tissue Engineering, Protein Array Analysis

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