Designing materials for biology and medicine

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609

Biomaterials Science: An Introduction to Materials in Medicine

Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (1996) · doi:10.1016/c2009-0-02433-7 · Cited by 5,125

Tissue microarrays for high-throughput molecular profiling of tumor specimens

Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101

A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

Morice, M., Serruys, P. W. J. C., Sousa, J. E., Fajadet, J. C., Hayashi, E. B., Perin, M. A., Colombo, A., Schuler, G. C., Barragan, P. T., Guagliumi, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012843 · Cited by 4,028

Biodegradable Long-Circulating Polymeric Nanospheres

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951

Printing Proteins as Microarrays for High-Throughput Function Determination

MacBeath, G., & Schreiber, S. L. (2000) · Science · doi:10.1126/science.289.5485.1760 · Cited by 2,767

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

Fodor, S. P. A., Read, J., Pirrung, M. C., Stryer, L., Lu, A. T., & Solas, D. W. (1991) · Science · doi:10.1126/science.1990438 · Cited by 2,697

Shape-Memory Polymers

Lendlein, A., Kelch, S., Kratz, K., Schulte, J., & Schauer, S. (2002) · Elsevier eBooks · doi:10.1002/0471238961.1908011612051404.a01 · Cited by 2,687

Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications

Lendlein, A., & Langer, R. (2002) · Science · doi:10.1126/science.1066102 · Cited by 2,146

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

Bell, E., Ivarsson, B., & Merrill, C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1274 · Cited by 2,069

Drug Delivery and Targeting

Hillery, A. M., Lloyd, A. W., & Swarbrick, J. (2016) · CRC Press eBooks · doi:10.1201/b12801 · Cited by 2,031

Global Analysis of Protein Activities Using Proteome Chips

Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Jansen, R., Bidlingmaier, S., Houfek, T., et al. (2001) · Science · doi:10.1126/science.1062191 · Cited by 1,884

Synthetic DNA delivery systems

Luo, D., & Saltzman, W. M. (2000) · Nature Biotechnology · doi:10.1038/71889 · Cited by 1,625

Gene silencing in mammals by small interfering RNAs

McManus, M. T., & Sharp, P. A. (2002) · Nature Reviews Genetics · doi:10.1038/nrg908 · Cited by 1,400

Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation

Vacanti, J. P., & Langer, R. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90247-7 · Cited by 1,335

Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials

Hartgerink, J. D., Beniash, E., & Stupp, S. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072699999 · Cited by 1,241

A reversibly antigen-responsive hydrogel

Miyata, T., Asami, N., & Uragami, T. (1999) · Nature · doi:10.1038/21619 · Cited by 1,175

New Challenges in Biomaterials

Peppas, N. A., & Langer, R. (1994) · Science · doi:10.1126/science.8134835 · Cited by 1,163

A Reversibly Switching Surface

Lahann, J., Mitragotri, S., Tran, T.-N., Kaido, H., Sundaram, J., Choi, I. S., Hoffer, S., Somorjai, G. A., & Langer, R. (2003) · Science · doi:10.1126/science.1078933 · Cited by 1,118

[12] DNA arrays for analysis of gene expression

Eisen, M. B., & Brown, P. O. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)03014-1 · Cited by 1,043

Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions

Haab, B. B., Dunham, M. J., & Brown, P. O. (2001) · Genome biology · doi:10.1186/gb-2001-2-2-research0004 · Cited by 887

A controlled-release microchip

Santini, J. T., Cima, M. J., & Langer, R. (1999) · Nature · doi:10.1038/16898 · Cited by 873

Protein chip technology

Zhu, H., & Snyder, M. P. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(02)00005-4 · Cited by 872

Biologically erodable microspheres as potential oral drug delivery systems

Mathiowitz, E., Jacob, J. S., Jong, Y. S., Carino, G. P., Chickering, D. E., Chaturvedi, P., Santos, C. A., Vijayaraghavan, K., Montgomery, S., Bassett, M., et al. (1997) · Nature · doi:10.1038/386410a0 · Cited by 823

Peptide chips for the quantitative evaluation of protein kinase activity

Houseman, B. T., Huh, J. H., Kron, S. J., & Mrksich, M. (2002) · Nature Biotechnology · doi:10.1038/nbt0302-270 · Cited by 689

Shape‐Memory Polymers

Behl, M., & Lendlein, A. (2011) · Wiley eBooks · doi:10.1002/0471238961.1908011612051404.a01.pub2 · Cited by 665

Drugs on Target

Langer, R. (2001) · Science · doi:10.1126/science.1063273 · Cited by 580

Lack of Pain Associated with Microfabricated Microneedles

Kaushik, S., Hord, A. H., Denson, D. D., McAllister, D. V., Smitra, S., Allen, M. G., & Prausnitz, M. R. (2001) · Anesthesia & Analgesia · doi:10.1213/00000539-200102000-00041 · Cited by 578

Transdermal photopolymerization for minimally invasive implantation

Elisseeff, J. H., Anseth, K. S., Sims, D. C., McIntosh, W., Randolph, M. A., & Langer, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3104 · Cited by 576

Emerging biological materials through molecular self-assembly

Zhang, S. (2002) · Biotechnology Advances · doi:10.1016/s0734-9750(02)00026-5 · Cited by 558

Protein Microchips: Use for Immunoassay and Enzymatic Reactions

Arenkov, P., Kukhtin, A., Gemmell, A., Voloshchuk, S. G., Chupeeva, V. V., & Mirzabekov, A. D. (2000) · Analytical Biochemistry · doi:10.1006/abio.1999.4363 · Cited by 522

Carbohydrate Arrays for the Evaluation of Protein Binding and Enzymatic Modification

Houseman, B. T., & Mrksich, M. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00124-2 · Cited by 508

Semi‐Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery

Anderson, D. G., Lynn, D. M., & Langer, R. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200351244 · Cited by 506

Analysis of intact tetraether lipids in archaeal cell material and sediments by high performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

Hopmans, E. C., Schouten, S., Pancost, R. D., van der Meer, M. T. J., & Damsté, J. S. S. (2000) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(20000415)14:7 · Cited by 486

Synthesis and RGD peptide modification of a new biodegradable copolymer: poly(lactic acid-co-lysine)

Barrera, D. A., Zylstra, E., Lansbury, P. T., & Langer, R. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00076a077 · Cited by 456

Hydrogels and drug delivery

Peppas, N. A. (1997) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(97)80103-3 · Cited by 454

Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control

Sosnowski, R. G., Tu, E. L., Butler, W. F., O’Connell, J. P., & Heller, M. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1119 · Cited by 451

Extracellular matrix assembly and structure

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Multi-pulse drug delivery from a resorbable polymeric microchip device

Grayson, A. C. R., Choi, I. S., Tyler, B. M., Wang, P. P., Brem, H., Cima, M. J., & Langer, R. (2003) · Nature Materials · doi:10.1038/nmat998 · Cited by 444

Protein-based materials, toward a new level of structural control

van Hest, J. C. M., & Tirrell, D. A. (2001) · Chemical Communications · doi:10.1039/b105185g · Cited by 416

Accelerated Discovery of Synthetic Transfection Vectors: Parallel Synthesis and Screening of a Degradable Polymer Library

Lynn, D. M., Anderson, D. G., Putnam, D. A., & Langer, R. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016288p · Cited by 395

Engineering growing tissues

Alsberg, E., Anderson, K. W., Albeiruti, A., Rowley, J. A., & Mooney, D. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192291499 · Cited by 391

Microfabrication Technology for Vascularized Tissue Engineering

Borenstein, J. T., Terai, H., King, K. R., Weinberg, E. J., Mofrad, M. R. K., & Vacanti, J. P. (2002) · Biomedical Microdevices · doi:10.1023/a:1016040212127 · Cited by 362

Generation of Synthetic Elastin-Mimetic Small Diameter Fibers and Fiber Networks

Huang, L., McMillan, R. A., Apkarian, R. P., Pourdeyhimi, B., Conticello, V. P., & Chaikof, E. L. (2000) · Macromolecules · doi:10.1021/ma991858f · Cited by 353

Micropattern Formation in Supported Lipid Membranes

Groves, J. T., & Boxer, S. G. (2002) · Accounts of Chemical Research · doi:10.1021/ar950039m · Cited by 352

Selective immobilization of proteins to self-assembled monolayers presenting active site-directed capture ligands

Hodneland, C. D., Lee, Y., Min, D., & Mrksich, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072685299 · Cited by 343

Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial

Cook, A. D., Hrkach, J. S., Gao, N. N., Johnson, I. M., Pajvani, U. B., Cannizzaro, S. M., & Langer, R. (1997) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19970615)35:4 · Cited by 320

Biologically Engineered Protein-graft-Poly(ethylene glycol) Hydrogels: A Cell Adhesive and Plasmin-Degradable Biosynthetic Material for Tissue Repair

Halstenberg, S., Panitch, A., Rizzi, S. C., Hall, H., & Hubbell, J. A. (2002) · Biomacromolecules · doi:10.1021/bm015629o · Cited by 315

Biocompatibility of the Bioelastic Materials, Poly(GVGVP) and Its γ-Irradiation Cross-Linked Matrix: Summary of Generic Biological Test Results

Urry, D. W., Parker, T. M., Reid, M. C., & Gowda, D. C. (1991) · Journal of Bioactive and Compatible Polymers · doi:10.1177/088391159100600306 · Cited by 268

Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists

McGall, G. H., Labadie, J. W., Brock, P. J., Wallraff, G. M., Nguyen, T., & Hinsberg, W. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13555 · Cited by 246

Hybridization Enhancement Using Cavitation Microstreaming

Liu, R. H., Lenigk, R., Druyor-Sanchez, R. L., Yang, J., & Grodzinski, P. A. (2003) · Analytical Chemistry · doi:10.1021/ac026267t · Cited by 244

Where a Pill Won't Reach

Langer, R. (2003) · Scientific American · doi:10.1038/scientificamerican0403-50 · Cited by 232

Development of a Nonviral Gene Delivery Vehicle for Systemic Application

Pun, S. H., & Davis, M. E. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0155768 · Cited by 223

Photopolymerizable degradable polyanhydrides with osteocompatibility

Anseth, K. S., Shastri, V. P., & Langer, R. (1999) · Nature Biotechnology · doi:10.1038/6152 · Cited by 205

Endothelial cell adhesion to the fibronectin CS5 domain in artificial extracellular matrix proteins

Heilshorn, S. C. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00294-1 · Cited by 188

Rapid photopolymerization of immunoprotective gels in contact with cells and tissue

Pathak, C. P., Sawhney, A. S., & Hubbell, J. A. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00047a065 · Cited by 182

Chemiluminescence Detection for Hybridization Assays on the Flow-Thru Chip, a Three-Dimensional Microchannel Biochip

Cheek, B. J., Steel, A. B., Torres, M. P., Yu, Y., & Yang, H. (2001) · Analytical Chemistry · doi:10.1021/ac0108616 · Cited by 152

Synthesis and Characterization of Elastin-Mimetic Protein Gels Derived from a Well-Defined Polypeptide Precursor

McMillan, R. A., & Conticello, V. P. (2000) · Macromolecules · doi:10.1021/ma9921091 · Cited by 141

A programmable intraocular CMOS pressure sensor system implant

Stangel, K., Kolnsberg, S., Hammerschmidt, D., Hosticka, B. J., Trieu, H. K., & Mokwa, W. (2001) · IEEE Journal of Solid-State Circuits · doi:10.1109/4.933466 · Cited by 139

Photomediated Solid-State Cross-Linking of an Elastin−Mimetic Recombinant Protein Polymer

Nagapudi, K., Brinkman, W. T., Leisen, J., Huang, L., McMillan, R. A., Apkarian, R. P., Conticello, V. P., & Chaikof, E. L. (2002) · Macromolecules · doi:10.1021/ma011429t · Cited by 138

Breaking the Degeneracy of the Genetic Code

Kwon, I., Kirshenbaum, K., & Tirrell, D. A. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0350076 · Cited by 131

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

Tang, L., Wu, Y., & Timmons, R. B. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199810)42:1 · Cited by 127

Controlled release microchip

Pakalapati, L. V. V. (2003) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 99

Mechanical Properties of Cross-Linked Synthetic Elastomeric Polypentapeptides

Lee, J., Macosko, C. W., & Urry, D. W. (2001) · Macromolecules · doi:10.1021/ma0017844 · Cited by 92

pH‐Sensitive Hydrogels as Gastrointestinal Tract Absorption Enhancers: Transport Mechanisms of Salmon Calcitonin and Other Model Molecules Using the Caco‐2 Cell Model

Torres‐Lugo, M., García-Fuentes, M., Record, R. D., & Peppas, N. A. (2002) · Biotechnology Progress · doi:10.1021/bp0101379 · Cited by 81

Genotyping on a Thermal Gradient DNA ChipPreprint

Kajiyama, T., Miyahara, Y., Kricka, L. J., Wilding, P. M., Graves, D. J., Surrey, S., & Fortina, P. M. (2003) · Genome Research · doi:10.1101/gr.790603 · Cited by 63

Single chip CMOS imagers and flexible microelectronic stimulators for a retina implant system

Schwarz, M., Ewe, L., Hauschild, R., Hosticka, B. J., Huppertz, J., Kolnsberg, S., Mokwa, W., & Trieu, H. K. (2000) · Sensors and Actuators A Physical · doi:10.1016/s0924-4247(00)00290-9 · Cited by 52

Augmentation of myocardial transfection using TerplexDNA: a novel gene delivery system

Affleck, D. G., Yu, L. M., Bull, D. A., Bailey, S., & Kim, S.-W. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301395 · Cited by 45

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551

Silk-based biomaterials

Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

Boisselier, É., & Astruc, D. (2009) · Chemical Society Reviews · doi:10.1039/b806051g · Cited by 2,832

Synthetic Molecular Motors and Mechanical Machines

Kay, E. R., Leigh, D. A., & Zerbetto, F. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200504313 · Cited by 2,639

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

Chaudhuri, O., Gu, L., Klumpers, D., Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H.-P., Lippens, E., Duda, G. N., et al. (2016) · Nature Materials · doi:10.1038/nmat4489 · Cited by 2,443

Biomaterial

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_1796

News in brief: challenges and directions in biomaterials research - cellular/tissue engineering

Papadaki, M. (2004) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/memb.2004.1360411

Research Status and Progress of Biomedical Materials

Li, H. (2012) · Clinical Medicine & Engineering

Application to Biomaterials

Mubarak, N. M., Anwar, M., Debnath, S., & Sudin, I. (2023) · Springer eBooks · doi:10.1007/978-981-19-9300-8_15 · Cited by 1

Biomateriales en acción: Innovaciones que mejoran nuestra salud

Noriega, O. A. G., Díaz-Cárdenas, M. Y., & Peréz, C. A. G. (2026) · Revista de divulgación científica iBIO