CoChat
Sign Up
Cited by 258

The DOI matches its Crossref record.

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

Maurer, Marcus, Wedemeyer, Jochen, Metz, Martin, Piliponsky, Adrian M., Weller, Karsten, Chatterjea, Devavani, Clouthier, David E., Yanagisawa, Masashi M., Tsai, Mindy, Galli, Stephen J.·2004·Nature
DOI 10.1038/nature03085
Open this paper in CoChat — free account

Abstract

Endothelin-1 (ET-1) is a 21-amino-acid peptide, derived from vascular endothelial cells, with potent vasoconstrictor activity. ET-1 has been implicated in diverse physiological or pathological processes, including the vascular changes associated with sepsis. However, the factors that regulate ET-1-associated toxicity during bacterial infections, or in other settings, are not fully understood. Both the pathology associated with certain allergic and autoimmune disorders, and optimal host defence against bacterial and parasitic infections are mediated by mast cells. In vitro, mast cells can produce ET-1 (ref. 11), undergo ET-1-dependent and endothelin-A receptor (ET(A))-dependent activation, and release proteases that degrade ET-1 (ref. 14). Although the potential relationships between mast cells and the ET-1 system thus may be complex, the importance of interactions between ET-1 and mast cells in vivo is obscure. Here we show that ET(A)-dependent mast-cell activation can diminish both ET-1 levels and ET-1-induced pathology in vivo, and also can contribute to optimal survival during acute bacterial peritonitis. These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator.

Overview

Integrity signals

Registry

Crossref · 10.1038/nature03085

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 30

  1. Yanagisawa, M. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411–415 (1988) · DOI
  2. Wanecek, M., Weitzberg, E., Rudehill, A. & Oldner, A. The endothelin system in septic and endotoxin shock. Eur. J. Pharmacol. 407, 1–15 (2000) · DOI
  3. Kedzierski, R. M. & Yanagisawa, M. Endothelin system: the double-edged sword in health and disease. Annu. Rev. Pharmacol. Toxicol. 41, 851–876 (2001) · DOI
  4. Szalay, L., Kaszaki, J., Nagy, S. & Boros, M. The role of endothelin-1 in circulatory changes during hypodynamic sepsis in the rat. Shock 10, 123–128 (1998) · DOI
  5. Ornan, D. A., Chaudry, I. H. & Wang, P. The dissociation between upregulated endothelins and hemodynamic responses during polymicrobial sepsis. Biochim. Biophys. Acta 1501, 211–218 (2000) · DOI
  6. Kawakami, T. & Galli, S. J. Regulation of mast-cell and basophil function and survival by IgE. Nature Rev. Immunol. 2, 773–786 (2002) · DOI
  7. Benoist, C. & Mathis, D. Mast cells in autoimmune disease. Nature 420, 875–878 (2002) · DOI
  8. Echtenacher, B., Männel, D. N. & Hültner, L. Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381, 75–77 (1996) · DOI
  9. Malaviya, R., Ikeda, T., Ross, E. & Abraham, S. N. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381, 77–80 (1996) · DOI
  10. Galli, S. J., Chatterjea, D. & Tsai, M. in The Innate Immune Response to Infection (ed. Gordon, S.) 111–132 (ASM, Berlin, 2004)
  11. Ehrenreich, H. et al. Endothelins belong to the assortment of mast cell-derived and mast cell-bound cytokines. New Biol. 4, 147–156 (1992)
  12. Yamamura, H., Nabe, T., Kohno, S. & Ohata, K. Endothelin-1, one of the most potent histamine releasers in mouse peritoneal mast cells. Eur. J. Pharmacol. 265, 9–15 (1994) · DOI
  13. Yamamura, H., Nabe, T., Kohno, S. & Ohata, K. Mechanism of histamine release by endothelin-1 distinct from that by antigen in mouse bone marrow-derived mast cells. Eur. J. Pharmacol. 288, 269–275 (1995) · DOI
  14. Metsärinne, K. P. et al. Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted peptide. Arterioscler. Thromb. Vasc. Biol. 22, 268–273 (2002) · DOI
  15. Kitamura, Y., Go, S. & Hatanaka, K. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood 52, 447–452 (1978) · DOI · Paper page
  16. Galli, S. J., Zsebo, K. M. & Geissler, E. N. The kit ligand, stem cell factor. Adv. Immunol. 55, 1–96 (1994)
  17. Tsai, M., Tam, S. Y., Wedemeyer, J. & Galli, S. J. Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo. Int. J. Hematol. 75, 345–349 (2002) · DOI
  18. Nakano, T. et al. Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer to genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue and mucosal mast cells. J. Exp. Med. 162, 1025–1043 (1985) · DOI · Paper page
  19. Maurer, M. et al. The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells. J. Exp. Med. 188, 2343–2348 (1998) · DOI
  20. Boesiger, J. et al. Mast cells can secrete vascular permeability factor/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of Fcɛ receptor I expression. J. Exp. Med. 188, 1135–1145 (1998) · DOI
  21. Maguire, J. J., Kuc, R. E. & Davenport, A. P. Vasoconstrictor activity of novel endothelin peptide, ET-1(1–31), in human mammary and coronary arteries in vitro. Br. J. Pharmacol. 134, 1360–1366 (2001) · DOI
  22. Opgenorth, T. J. Endothelin receptor antagonism. Adv. Pharmacol. 33, 1–64 (1995) · DOI
  23. Clouthier, D. E., Williams, S. C., Hammer, R. E., Richardson, J. A. & Yanagisawa, M. Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development. Dev. Biol. 261, 506–519 (2003) · DOI
  24. Tsai, M. et al. In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc. Natl Acad. Sci. USA 97, 9186–9190 (2000) · DOI · Paper page
  25. Prodeus, A. P., Zhou, X., Maurer, M., Galli, S. J. & Carroll, M. C. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature 390, 172–175 (1997) · DOI
  26. Ahn, G. Y. et al. The expression of endothelin-1 and its binding sites in mouse skin increased after ultraviolet B irradiation or local injection of tumor necrosis factor alpha. J. Dermatol. 25, 78–84 (1998) · DOI
  27. Sugiura, M., Inagami, T. & Kon, V. Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. Biochem. Biophys. Res. Commun. 161, 1220–1227 (1989) · DOI
  28. Lundblad, R. & Giercksky, K. E. Endothelin concentrations in experimental sepsis: profiles of big endothelin and endothelin 1–21 in lethal peritonitis in rats. Eur. J. Surg. 161, 9–16 (1995)
  29. Boros, M., Szalay, L. & Kaszaki, J. Endothelin-1 induces mucosal mast cell degranulation and tissue injury via ETA receptors. Clin. Sci. (Lond.) 103(suppl. 48), 31S–34S (2002) · DOI
  30. Higginbotham, R. D. Mast cells and local resistance to Russell's viper venom. J. Immunol. 95, 867–875 (1965) · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Maurer, M., Wedemeyer, J., Metz, M., Piliponsky, A. M., Weller, K., Chatterjea, D., Clouthier, D. E., Yanagisawa, M. M., Tsai, M., & Galli, S. J.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2004-11
Volume
432
Issue
7016
Pages
512-516
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature03085
Cited by
258
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review