Cited by 600Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

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Unexpected complexity of the Wnt gene family in a sea anemone

Kusserow, Arne, Pang, Kevin, Sturm, Carsten, Hrouda, Martina, Lentfer, Jan, Schmidt, Heiko A., Technau, Ulrich, von Haeseler, Arndt, Hobmayer, Bert, Martindale, Mark Q., Holstein, Thomas W.·2005·Nature

DOI 10.1038/nature03158

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Abstract

The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis, a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans.

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Authors: Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., & Holstein, T. W.
Affiliations: Technische Universität Darmstadt (DE)
University of Hawaiʻi at Mānoa (US)
Universität Innsbruck (AT)
John von Neumann Institute for Computing (DE)
Heidelberg University (DE)
Corresponding author: Martindale, Mark Q.
Holstein, Thomas W.
ORCID: Schmidt, Heiko A.
Technau, Ulrich
Hobmayer, Bert
Martindale, Mark Q.
Holstein, Thomas W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-01-13
Volume: 433
Issue: 7022
Pages: 156-160
ISSN: 1465-7392 (ISSN-L)
0028-0836
1476-4679
DOI: 10.1038/nature03158
OpenAlex: W2155603123
Semantic Scholar: 7e9fcb05458c57b86ed8a841f431aa109a5baea4
Cited by: 599
References: 30
Citations by year: 2026: 14 · 2025: 21 · 2024: 24 · 2023: 14 · 2022: 26 · 2021: 17 · 2020: 17 · 2019: 32 · 2018: 26 · 2017: 17 · 2016: 27 · 2015: 26 · 2014: 28 · 2013: 27 · 2012: 31
FWCI: 44.31
Type: journal article
Language: en
Open access: closed
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
JuSER (Forschungszentrum Jülich) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: Wnt gene family, Nematostella vectensis, Cnidaria, embryonic development, gastrulation, planula larvae, Cambrian explosion, phylogenetic analysis, gene expression patterns
MeSH terms: Animals, Bayes Theorem, Cloning, Molecular, Multigene Family, Molecular Sequence Data, Phylogeny, RNA, Messenger, Sea Anemones, Sequence Alignment, Gene Expression Regulation, Developmental, Evolution, Molecular, Intercellular Signaling Peptides and Proteins, Embryonic Development, Wnt Proteins

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Unexpected complexity of the Wnt gene family in a sea anemone

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