The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Unexpected complexity of the Wnt gene family in a sea anemone
Abstract
The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis, a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nematostella has several clusters of homeobox genes (56)(57)(58), but only those on scaffolds 3 and 61 are embedded within the ancestral eumetazoan Hox context, providing independent support for the assignment of these homeobox genes as bona fide Nematostella Hox genes (54,56,59).”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [58]
In the citing paper
“S. purpuratus has WntA, previously reported as being absent from deuterostomes (29).”
From The Genome of the Sea Urchin Strongylocentrotus purpuratus (2006) · cites this paper as [29]
In the citing paper
“These patterns are reminiscent of the nested expression domains of Wnt ligands in the Nematostella embryos 20 .”
From Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans (2014) · cites this paper as [20]
Citations
Cites
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,537
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,540
WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599
Estimating metazoan divergence times with a molecular clock
Peterson, K. J., Lyons, J. B., Nowak, K. S., Takacs, C. M., Wargo, M. J., & McPeek, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401670101 · Cited by 461
Function and evolution of the plant MADS-box gene family
Ng, M., & Yanofsky, M. F. (2001) · Nature Reviews Genetics · doi:10.1038/35056041 · Cited by 438
Hox genes and chordate evolution.
Holland, P., & Garcia-Fernàndez, J. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0034 · Cited by 432
Evolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins
King, N., Hittinger, C. T., & Carroll, S. B. (2003) · Science · doi:10.1126/science.1083853 · Cited by 424
Origins of Bilateral Symmetry: Hox and Dpp Expression in a Sea Anemone
Finnerty, J. R., Pang, K., Burton, P., Paulson, D., & Martindale, M. Q. (2004) · Science · doi:10.1126/science.1091946 · Cited by 407
Self-citationMartindale, M. Q., Pang, K., & Finnerty, J. R. (2004) · Development · doi:10.1242/dev.01119 · Cited by 396
Self-citationChristian, J. L., McMahon, J. A., McMahon, A. P., & Moon, R. T. (1991) · Development · doi:10.1242/dev.111.4.1045 · Cited by 374
Flagged first, then by citations
Research works printed but not linked: 2
- Bridge D., 1995, Mol. Biol. Evol., 12, 679
- Technau U., 2003, Int. J. Dev. Biol., 47, 531
Cited by
Sorted by citations
Items 101–200 of 600
Lee, P. N., Kumburegama, S., Marlow, H. Q., Martindale, M. Q., & Wikramanayake, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.040 · Cited by 135
Self-citationMatus, D. Q., Magie, C. R., Pang, K., Martindale, M. Q., & Thomsen, G. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.032 · Cited by 134
Self-citationEvolutionary developmental biology and genomics
Cañestro, C., Yokoi, H., & Postlethwait, J. H. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2226 · Cited by 141
Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer
Nakamura, Y., Tsiairis, C. D., Özbek, S., & Holstein, T. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018109108 · Cited by 134
Self-citationRichards, G. S., & Rentzsch, F. (2014) · Development · doi:10.1242/dev.112029 · Cited by 110
A Developmental Perspective: Changes in the Position of the Blastopore during Bilaterian Evolution
Martindale, M. Q., & Hejnol, A. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.024 · Cited by 131
Self-citationThe making of Wnt: new insights into Wnt maturation, sorting and secretion
Coudreuse, D. Y. M., & Korswagen, H. C. (2006) · Development · doi:10.1242/dev.02699 · Cited by 129
Matus, D. Q., Thomsen, G. H., & Martindale, M. Q. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.052 · Cited by 129
Self-citationThe Physiology and Molecular Biology of Sponge Tissues
Leys, S. P., & Hill, A. (2012) · Advances in Marine Biology · doi:10.1016/b978-0-12-394283-8.00001-1 · Cited by 128
Heparan sulfate proteoglycans and the emergence of neuronal connectivity
Vactor, D. V., Wall, D. P., & Johnson, K. G. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.01.011 · Cited by 126
Wnt8 Is Required for Growth-Zone Establishment and Development of Opisthosomal Segments in a Spider
McGregor, A. P., Pechmann, M., Schwager, E. E., Feitosa, N. M., Kruck, S., Aranda, M., & Damen, W. G. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.08.045 · Cited by 126
Cnidarians and ancestral genetic complexity in the animal kingdom
Miller, D. J., Ball, E. E., & Technau, U. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.08.002 · Cited by 123
Self-citationMorphogens, morphostats, microarchitecture and malignancy
Potter, J. D. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2146 · Cited by 125
Clytia hemisphaerica: a jellyfish cousin joins the laboratory
Houliston, E., Momose, T., & Manuel, M. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.01.008 · Cited by 128
On the evolution of bilaterality
Genikhovich, G., & Technau, U. (2017) · Development · doi:10.1242/dev.141507 · Cited by 118
Self-citationGenomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi
Pang, K., Ryan, J. F., Program, N. C. S., Mullikin, J. C., Baxevanis, A. D., & Martindale, M. Q. (2010) · EvoDevo · doi:10.1186/2041-9139-1-10 · Cited by 115
Self-citationAxial Patterning and Diversification in the Cnidaria Predate the Hox System
Kamm, K., Schierwater, B., Jakob, W., Dellaporta, S. L., & Miller, D. J. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.036 · Cited by 116
Early evolution of symmetry and polarity in metazoan body plans
Manuel, M. (2008) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2008.07.009 · Cited by 123
The Dawn of Developmental Signaling in the MetazoaPreprint
Richards, G. S., & Degnan, B. M. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.028 · Cited by 117
Stem cell dynamics in Cnidaria: are there unifying principles?
Gold, D. A., & Jacobs, D. K. (2012) · Development Genes and Evolution · doi:10.1007/s00427-012-0429-1 · Cited by 112
Topological structures and syntenic conservation in sea anemone genomes
Zimmermann, B., Montenegro, J. D., Robb, S. M. C., Fropf, W. J., Weilguny, L., He, S., Chen, S., Lovegrove-Walsh, J., Hill, E. M., Chen, C.-Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44080-7 · Cited by 106
Self-citationCnidarian microRNAs frequently regulate targets by cleavagePreprint
Moran, Y., Fredman, D., Praher, D., Li, X. Z., Wee, L. M., Rentzsch, F., Zamore, P. D., Technau, U., & Seitz, H. (2014) · Genome Research · doi:10.1101/gr.162503.113 · Cited by 113
Self-citationThe evolution of immunity: a low-life perspective
Hemmrich, G., Miller, D. J., & Bosch, T. C. G. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.08.003 · Cited by 112
A genomic view of 500 million years of cnidarian evolution
Steele, R. E., David, C. N., & Technau, U. (2011) · Trends in Genetics · doi:10.1016/j.tig.2010.10.002 · Cited by 111
Self-citationSawa, H., & Korswagen, H. C. (2013) · WormBook · doi:10.1895/wormbook.1.7.2 · Cited by 105
Harterink, M., Kim, D. H., Middelkoop, T. C., Doan, T. D., van Oudenaarden, A., & Korswagen, H. C. (2011) · Development · doi:10.1242/dev.064733 · Cited by 112
Kraus, Y. A., & Technau, U. (2006) · Development Genes and Evolution · doi:10.1007/s00427-005-0038-3 · Cited by 104
Self-citationStellaBase: The Nematostella vectensis Genomics Database
Sullivan, J. C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj020 · Cited by 108
Darras, S., Gerhart, J. C., Terasaki, M. R., Kirschner, M. W., & Lowe, C. J. (2011) · Development · doi:10.1242/dev.059493 · Cited by 107
Rethinking the role of immunity: lessons from Hydra
Bosch, T. C. G. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.008 · Cited by 109
The origin and evolution of Wnt signalling
Holzem, M., Boutros, M., & Holstein, T. W. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00699-w · Cited by 110
Self-citationDuffy, D. J., Plickert, G., Künzel, T., Tilmann, W., & Uri Frank, A. (2010) · Development · doi:10.1242/dev.046631 · Cited by 104
Transcriptome profiling of the dynamic life cycle of the scypohozoan jellyfish Aurelia aurita
Brekhman, V., Malik, A., Haas, B. J., Sher, N., & Lotan, T. (2015) · BMC Genomics · doi:10.1186/s12864-015-1320-z · Cited by 101
Hemmrich, G., & Bosch, T. C. G. (2008) · BioEssays · doi:10.1002/bies.20813 · Cited by 100
Disulfide Bond Requirements for Active Wnt Ligands
MacDonald, B. T., Hien, A., Zhang, X., Iranloye, O., Virshup, D. M., Waterman, M. L., & He, X. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.575027 · Cited by 101
Layden, M. J., Boekhout, M., & Martindale, M. Q. (2012) · Development · doi:10.1242/dev.073221 · Cited by 98
Self-citationEvolution of TNF-induced apoptosis reveals 550 My of functional conservation
Quistad, S. D., Stotland, A. B., Barott, K. L., Smurthwaite, C. A., Hilton, B. J., Grasis, J. A., Wolkowicz, R., & Rohwer, F. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405912111 · Cited by 100
Zmasek, C. M., & Godzik, A. (2011) · Genome biology · doi:10.1186/gb-2011-12-1-r4 · Cited by 100
Goldstone, J. V. (2008) · Cell Biology and Toxicology · doi:10.1007/s10565-008-9107-5 · Cited by 107
Hu, Y., Yu, K., Wang, G., Zhang, D., Shi, C., Ding, Y., Hong, D., Zhang, D., He, H., Sun, L., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.023 · Cited by 98
Plickert, G., Jacoby, V., Uri Frank, A., Müller, W. A., & Mokady, O. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.043 · Cited by 97
Immortality and the base of multicellular life: Lessons from cnidarian stem cells
Watanabe, H., Hoang, V. T., Mättner, R. A., & Holstein, T. W. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.09.008 · Cited by 98
Self-citationChiori, R., Jager, M., Denker, E., Wincker, P., Silva, C. D., Guyader, H. L., Manuel, M., & Quéinnec, É. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004231 · Cited by 101
Shinzato, C., Inoue, M., & Kusakabe, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085182 · Cited by 98
Evolution of eumetazoan nervous systems: insights from cnidarians
Kelava, I., Rentzsch, F., & Technau, U. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0065 · Cited by 84
Self-citationFatty acylation of Wnt proteins.
Nile, A. H., & Hannoush, R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2005 · Cited by 93
Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion
Nygaard, R., Yu, J., Kim, J., Ross, D. R., Parisi, G., Clarke, O. B., Virshup, D. M., & Mancia, F. (2020) · Cell · doi:10.1016/j.cell.2020.11.038 · Cited by 93
McGregor, A. P., Hilbrant, M., Pechmann, M., Schwager, E. E., Prpíc, N.-M., & Damen, W. G. M. (2008) · BioEssays · doi:10.1002/bies.20744 · Cited by 93
The Hydra model: disclosing an apoptosis-driven generator of Wnt-based regeneration
Galliot, B., & Chera, S. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.05.006 · Cited by 93
Matus, D. Q., Thomsen, G. H., & Martindale, M. Q. (2007) · Development Genes and Evolution · doi:10.1007/s00427-006-0122-3 · Cited by 92
Self-citationPETERSON, K. J., SUMMONS, R. E., & DONOGHUE, P. C. J. (2007) · Palaeontology · doi:10.1111/j.1475-4983.2007.00692.x · Cited by 93
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Watanabe, H., Kuhn, A., Fushiki, M., Agata, K., Özbek, S., Fujisawa, T., & Holstein, T. W. (2014) · Nature Communications · doi:10.1038/ncomms6536 · Cited by 79
Self-citationWNT/β-Catenin Signalling and Epithelial Patterning in the Homoscleromorph Sponge Oscarella
Lapébie, P., Gazave, E., Ereskovsky, A. V., Derelle, R., Bézac, C., Renard, E., Houliston, E., & Borchiellini, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005823 · Cited by 91
Bolognesi, R., Beermann, A., Farzana, L., Wittkopp, N., Lutz, R., Balavoine, G., Brown, S. J., & Schröder, R. (2008) · Development Genes and Evolution · doi:10.1007/s00427-007-0170-3 · Cited by 88
Phylogenetic evidence for the modular evolution of metazoan signalling pathways
Babonis, L. S., & Martindale, M. Q. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0477 · Cited by 91
Self-citationChera, S., de Rosa, R., Miljkovic‐Licina, M., Dobretz, K., Ghila, L., Kaloulis, K., & Galliot, B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02807 · Cited by 90
Surprising complexity of the ancestral apoptosis network
Zmasek, C. M., Zhang, Q., Ye, Y., & Godzik, A. (2007) · Genome biology · doi:10.1186/gb-2007-8-10-r226 · Cited by 89
Hox genes are not always Colinear
Monteiro, A. S., & Ferrier, D. E. K. (2006) · International Journal of Biological Sciences · doi:10.7150/ijbs.2.95 · Cited by 86
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
Richards, G. S., & Rentzsch, F. (2015) · Development · doi:10.1242/dev.123745 · Cited by 80
An evolutionary conserved role of Wnt signaling in stem cell fate decision
Teo, R., Möhrlen, F., Plickert, G., Müller, W. A., & Frank, U. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.009 · Cited by 89
Gene Expansion and Retention Leads to a Diverse Tyrosine Kinase Superfamily in Amphioxus
D’Aniello, S., Irimia, M., Maeso, I., Pascual‐Anaya, J., Jiménez‐Delgado, S., Bertrand, S., & García‐Fernàndez, J. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn132 · Cited by 89
Evolution of the Animal Apoptosis NetworkPreprint
Zmasek, C. M., & Godzik, A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008649 · Cited by 88
Windsor, P. J., & Leys, S. P. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00434.x · Cited by 84
Croce, J. C., Wu, S.-Y., Byrum, C. A., Xu, R., Duloquin, L., Wikramanayake, A. H., Gache, C., & McClay, D. R. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.045 · Cited by 84
SNAREing the Basis of Multicellularity: Consequences of Protein Family Expansion during Evolution
Kloepper, T. H., Kienle, C. N., & Fasshauer, D. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn151 · Cited by 85
SOX7 and SOX18 are essential for cardiogenesis in Xenopus
Zhang, C., Basta, T., & Klymkowsky, M. W. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20565 · Cited by 84
How Hydra senses and destroys microbes
Augustin, R., Fraune, S., & Bosch, T. C. G. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.11.002 · Cited by 83
Cartwright, P., & Collins, A. G. (2007) · Integrative and Comparative Biology · doi:10.1093/icb/icm071 · Cited by 84
Leclère, L., Bause, M., Sinigaglia, C., Steger, J., & Rentzsch, F. (2016) · Development · doi:10.1242/dev.120931 · Cited by 82
Pankow, S., & Bamberger, C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000782 · Cited by 79
An ancient chordin-like gene in organizer formation of Hydra
Rentzsch, F., Guder, C., Vocke, D., Hobmayer, B., & Holstein, T. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604501104 · Cited by 81
Self-citationLayden, M. J., Röttinger, É., Wolenski, F. S., Gilmore, T. D., & Martindale, M. Q. (2013) · Nature Protocols · doi:10.1038/nprot.2013.009 · Cited by 81
Self-citationMarlow, H. Q., Matus, D. Q., & Martindale, M. Q. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.05.022 · Cited by 82
Self-citationGanguly, A., Jiang, J., & Ip, Y. T. (2005) · Development · doi:10.1242/dev.01903 · Cited by 81
Rel homology domain-containing transcription factors in the cnidarian Nematostella vectensis
Sullivan, J. C., Kalaitzidis, D., Gilmore, T. D., & Finnerty, J. R. (2006) · Development Genes and Evolution · doi:10.1007/s00427-006-0111-6 · Cited by 79
The Wnt Signaling Pathway in Familial Exudative Vitreoretinopathy and Norrie Disease
Warden, S. M., Andreoli, C. M., & Mukai, S. (2007) · Seminars in Ophthalmology · doi:10.1080/08820530701745124 · Cited by 79
Evolution of the bilaterian mouth and anus
Nielsen, C., Brunet, T., & Arendt, D. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0641-0 · Cited by 70
Modeling pattern formation in hydra: a route to understanding essential steps in development
Meinhardt, H. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113483hm · Cited by 75
Helm, R. R., Siebert, S., Tulin, S., Smith, J., & Dunn, C. W. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-266 · Cited by 77
Chevalier, S., Martin, A., Leclère, L., Amiel, A., & Houliston, E. (2006) · Development Genes and Evolution · doi:10.1007/s00427-006-0103-6 · Cited by 75
Reitzel, A. M., Burton, P. M., Krone, C., & Finnerty, J. R. (2007) · Invertebrate Biology · doi:10.1111/j.1744-7410.2007.00081.x · Cited by 77
Dunn, S. R., Phillips, W., Spatafora, J. W., Green, D. R., & Weis, V. M. (2006) · Journal of Molecular Evolution · doi:10.1007/s00239-005-0236-7 · Cited by 76
Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development
Darras, S., Fritzenwanker, J. H., Uhlinger, K. R., Farrelly, E. R., Pani, A. M., Hurley, I. A., Norris, R. P., Osovitz, M., Terasaki, M., Wu, M., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003698 · Cited by 75
Expansion of the SOX gene family predated the emergence of the Bilateria
Jager, M., Quéinnec, É., Houliston, E., & Manuel, M. (2006) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2005.12.005 · Cited by 73
Onai, T., Lin, H., Schubert, M., Koop, D., Osborne, P. W., Álvarez, S., Álvarez, R., Holland, N. D., & Holland, L. Z. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.571 · Cited by 75
Surprisingly complex T‐box gene complement in diploblastic metazoans
Yamada, A., Pang, K., Martindale, M. Q., & Tochinai, S. (2007) · Evolution & Development · doi:10.1111/j.1525-142x.2007.00154.x · Cited by 75
Self-citationGómez, C. M. A., Sabin, K. Z., & Echeverri, K. (2020) · Developmental Dynamics · doi:10.1002/dvdy.178 · Cited by 77
Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation
Choe, C. P., Collazo, A., Trinh, L. A., Pan, L., Moens, C. B., & Crump, J. G. (2013) · Developmental Cell · doi:10.1016/j.devcel.2012.12.003 · Cited by 74
Developmental expression of homeobox genes in the ctenophore Mnemiopsis leidyi
Pang, K., & Martindale, M. Q. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0222-3 · Cited by 70
Self-citationCannabinoid receptors in invertebrates
McPartland, J. M., Agraval, J., Gleeson, D. M., Heasman, K. G., & Glass, M. (2005) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2005.01028.x · Cited by 78
Fortress, A. M., & Frick, K. M. (2015) · The Neuroscientist · doi:10.1177/1073858415574728 · Cited by 74
Hox and Wnt pattern the primary body axis of an anthozoan cnidarian before gastrulation
DuBuc, T. Q., Stephenson, T. B., Rock, A. Q., & Martindale, M. Q. (2018) · Nature Communications · doi:10.1038/s41467-018-04184-x · Cited by 73
Self-citationde Jong, D. M., Hislop, N. R., Hayward, D. C., Reece-Hoyes, J. S., Pontynen, P. C., Ball, E. E., & Miller, D. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.034 · Cited by 71
Zhang, F., Qiu, F., Zeng, J., Xu, Z., Tang, Y., Zhao, T., Gou, Y., Su, F., Wang, S., Sun, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37133-4 · Cited by 71
The genetics of colony form and function in Caribbean Acropora corals
Hemond, E. M., Kaluziak, S. T., & Vollmer, S. V. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1133 · Cited by 75
Global cell sorting in the C. elegans embryo defines a new mechanism for pattern formation
Schnabel, R., Bischoff, M., Hintze, A., Schulz, A.-K., Hejnol, A., Meinhardt, H., & Hutter, H. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.004 · Cited by 71
Evolutionary crossroads in developmental biology
Patel, N. H. (2012) · Development · doi:10.1242/dev.085464 · Cited by 77
The function and evolution of Wnt genes in arthropods.
Murat, S., Hopfen, C., & McGregor, A. (2010) · Arthropod structure & development · doi:10.1016/j.asd.2010.05.007 · Cited by 71
Warner, J. F., Guerlais, V., Amiel, A., Johnston, H., Nedoncelle, K., & Röttinger, É. (2018) · Development · doi:10.1242/dev.162867 · Cited by 72
Grammar of protein domain architectures
Yu, L., Tanwar, D. K., Penha, E. D. D. S., Wolf, Y. I., Koonin, E. V., & Basu, M. K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814684116 · Cited by 68
Metadata
- Authors
- Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., & Holstein, T. W.
- Affiliations
- Technische Universität Darmstadt (DE)
- University of Hawaiʻi at Mānoa (US)
- Universität Innsbruck (AT)
- John von Neumann Institute for Computing (DE)
- Heidelberg University (DE)
- Corresponding author
- Martindale, Mark Q.
- Holstein, Thomas W.
- Venue
- Nature
- Published
- 2005-01-13
- Volume
- 433
- Issue
- 7022
- Pages
- 156-160
- ISSN
- 1465-7392 (ISSN-L)
- 0028-0836
- 1476-4679
- OpenAlex
- W2155603123
- Semantic Scholar
- 7e9fcb05458c57b86ed8a841f431aa109a5baea4
- Cited by
- 599
- References
- 30
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 24 · 2023: 14 · 2022: 26 · 2021: 17 · 2020: 17 · 2019: 32 · 2018: 26 · 2017: 17 · 2016: 27 · 2015: 26 · 2014: 28 · 2013: 27 · 2012: 31
- FWCI
- 44.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- Wnt gene family, Nematostella vectensis, Cnidaria, embryonic development, gastrulation, planula larvae, Cambrian explosion, phylogenetic analysis, gene expression patterns
- MeSH terms
- Animals, Bayes Theorem, Cloning, Molecular, Multigene Family, Molecular Sequence Data, Phylogeny, RNA, Messenger, Sea Anemones, Sequence Alignment, Gene Expression Regulation, Developmental, Evolution, Molecular, Intercellular Signaling Peptides and Proteins, Embryonic Development, Wnt Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
