WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Abstract
Members of the Wnt/wingless family of secreted proteins act as short-range inducers and long-range organizers during axis formation, organogenesis and tumorigenesis in many developing tissues. Wnt signalling pathways are conserved in nematodes, insects and vertebrates. Despite its developmental significance, the evolutionary origin of Wnt signalling is unclear. Here we describe the molecular characterization of members of the Wnt signalling pathway--Wnt, Dishevelled, GSK3, beta-Catenin and Tcf/Lef--in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria. Wnt and Tcf are expressed in the putative Hydra head organizer, the upper part of the hypostome. Wnt, beta-Catenin and Tcf are transcriptionally upregulated when head organizers are established early in bud formation and head regeneration. Wnt and Tcf expression domains also define head organizers created by de novo pattern formation in aggregates. Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals.
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A growing body of cnidarian molecular data suggests that these animals use essentially the same genes for axis formation, development, and body function maintenance as bilaterians.
“A growing set of molecular data from cnidarians suggests that these”
From Evolutionary aspects of developmentally regulated helix-loop-helix transcription factors in striated muscle of jellyfish (2003) · cites this paper as Hobmayer et al., 2000
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- Authors
- Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W.
- Affiliations
- Technische Universität Darmstadt (DE)
- Institut de Biologie du Développement Marseille (FR)
- Corresponding author
- Hobmayer, Bert
- Venue
- Nature
- Published
- 2000-09
- Volume
- 407
- Issue
- 6801
- Pages
- 186-189
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1784854092
- Cited by
- 599
- References
- 36
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 20 · 2023: 19 · 2022: 32 · 2021: 37 · 2020: 27 · 2019: 24 · 2018: 15 · 2017: 20 · 2016: 17 · 2015: 19 · 2014: 14 · 2013: 15 · 2012: 30
- FWCI
- 31.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- TUbilio (Technical University of Darmstadt) (submittedVersion)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- Wnt signaling, axis formation, Hydra, head organizer, hypostome, Dishevelled, glycogen synthase kinase-3, β-catenin, TCF/LEF, head regeneration, bud formation, Cnidaria
- MeSH terms
- Dishevelled Proteins, Animals, Cytoskeletal Proteins, Hydra, Molecular Sequence Data, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Polymerase Chain Reaction, Body Patterning, Organizers, Embryonic, Zebrafish Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin
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