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An endocannabinoid mechanism for stress-induced analgesia
Open accessAbstract
Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid CB(1) receptors in the periaqueductal grey matter of the midbrain prevents non-opioid stress-induced analgesia. In this region, stress elicits the rapid formation of two endogenous cannabinoids, the lipids 2-arachidonoylglycerol (2-AG) and anandamide. A newly developed inhibitor of the 2-AG-deactivating enzyme, monoacylglycerol lipase, selectively increases 2-AG concentrations and, when injected into the periaqueductal grey matter, enhances stress-induced analgesia in a CB1-dependent manner. Inhibitors of the anandamide-deactivating enzyme fatty-acid amide hydrolase, which selectively elevate anandamide concentrations, exert similar effects. Our results indicate that the coordinated release of 2-AG and anandamide in the periaqueductal grey matter might mediate opioid-independent stress-induced analgesia. These studies also identify monoacylglycerol lipase as a previously unrecognized therapeutic target.
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“Monoacylglycerol lipase (MGL) is a key enzyme implicated in the hydrolysis of 2-AG.33, 34”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [33]
Citations
Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
Self-citationImmunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586
A second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496
Self-citationBrain monoglyceride lipase participating in endocannabinoid inactivation
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373
Self-citationModulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293
Self-citationIncreased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,078
Self-citation
Research works printed but not linked: 1
- Walker, J. M. & Hohmann, A. G. in Cannabinoids—Handbook of Experimental Pharmacology (ed. Pertwee, R.) 509–554 (Springer, Berlin, 2005)
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Keown, O. P., Winterburn, T. J., Wainwright, C. L., MacRury, S. M., Neilson, I. L., Barrett, F., Leslie, S. J., & Megson, I. L. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03697.x · Cited by 28
Samineni, V. K., Premkumar, L. S., & Faingold, C. L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.041 · Cited by 28
Targeting the endogenous cannabinoid system to treat neuropathic pain
Lau, B. K., & Vaughan, C. W. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00028 · Cited by 27
Vecchiarelli, H. A., Morena, M., Lee, T. T. ‐., Nastase, A. S., Aukema, R. J., Leitl, K. D., Gray, J. M., Petrie, G. N., Tellez-Monnery, K., & Hill, M. N. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100470 · Cited by 29
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Gallagher, C. I., Ha, D. A., Harvey, R. J., & Vandenberg, R. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000583 · Cited by 26
Brose, S. A., Golovko, S. A., & Golovko, M. Y. (2016) · Lipids · doi:10.1007/s11745-016-4144-y · Cited by 26
Esmaeili, M. H., Reisi, Z., Ezzatpanah, S., & Haghparast, A. (2016) · European Journal of Pain · doi:10.1002/ejp.899 · Cited by 26
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Ferreira, R. C. M., Castor, M. G. M. E., Piscitelli, F., Marzo, V. D., Duarte, I. D. G., & Romero, T. R. L. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.12.002 · Cited by 26
Dean, C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00391.2010 · Cited by 26
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Dimitrov, E. L., Petrus, E., & Usdin, T. B. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.08.004 · Cited by 26
Kurrikoff, K., Inno, J., Matsui, T., & Vasar, E. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06160.x · Cited by 26
Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice
Xiong, Y., Yao, H., Cheng, Y., Gong, D., Liao, X., & Wang, R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.098 · Cited by 25
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Wolkers, C. P. B., Barbosa, A., Menescal-de-Oliveira, L., & Hoffmann, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071175 · Cited by 25
Berdan, C. A., Erion, K., Burritt, N. E., Corkey, B. E., & Deeney, J. T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149008 · Cited by 26
Lee, M. T., Chiu, Y., Chiu, Y.-C., Hor, C. C., Lee, H., Guerrini, R., Calò, G., & Chiou, L. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-019-0590-1 · Cited by 25
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Rauch, L., Schönbächler, G., & Noakes, T. D. (2013) · Sports Medicine · doi:10.1007/s40279-013-0025-1 · Cited by 25
Fan, S.-F., & Yazulla, S. (2007) · Visual Neuroscience · doi:10.1017/s095252380707006x · Cited by 25
Sabom, M. (2008) · The Journal of near-death studies · doi:10.17514/jnds-2008-26-3-p181-218 · Cited by 24
Identification ofN‐arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1receptors
Redmond, W. J., Cawston, E. E., Grimsey, N. L., Stuart, J. M., Edington, A. R., Glass, M., & Connor, M. A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13341 · Cited by 24
Butler, R. K., Ford, G. K., Hogan, M., Roche, M., Doyle, K., Kelly, J. P., Kendall, D. A., Chapman, V., & Finn, D. P. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111413823 · Cited by 24
Rahn, E. J., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2010) · The AAPS Journal · doi:10.1208/s12248-009-9170-8 · Cited by 24
Self-citationCannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective
Karst, M., & Wippermann, S. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780802691951 · Cited by 24
Endogenous cannabinoid modulation of restraint stress‐induced analgesia in thermal nociception
Atwal, N., Winters, B. L., & Vaughan, C. W. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14884 · Cited by 25
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Christie, M. J., & Mallet, C. (2009) · Science Signaling · doi:10.1126/scisignal.288pe57 · Cited by 24
Inhibitors of monoacylglycerol lipase as novel analgesics
Hohmann, A. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707153 · Cited by 24
Self-citationNeurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome
Forteza, F., Giorgini, G., & Raymond, F. (2021) · Cells · doi:10.3390/cells10040938 · Cited by 23
Winters, B. L., Lau, B. K., & Vaughan, C. W. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0997-22.2022 · Cited by 23
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?
Fowler, C. J., & Ghafouri, N. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.07.002 · Cited by 23
Deng, L., Lee, W.-H., Xu, Z., Makriyannis, A., & Hohmann, A. G. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.10.007 · Cited by 23
Self-citationWatabiki, T., Tsuji, N., Kiso, T., 徹, 小., Narazaki, F., & Kakimoto, S. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.10.007 · Cited by 23
Kaczocha, M., Azim, S., Nicholson, J., Rebecchi, M. J., Lu, Y., Feng, T., Romeiser, J. L., Reinsel, R. A., Rizwan, S., Shodhan, S., et al. (2018) · BMC Anesthesiology · doi:10.1186/s12871-018-0489-5 · Cited by 23
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McGurk, K. A., Williams, S. G., Guo, H., Watkins, H. C., Farrall, M., Cordell, H. J., Nicolaou, A., & Keavney, B. D. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab002 · Cited by 24
Batista, P. A., Fogaça, M. V., & Guimarães, F. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.019 · Cited by 25
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Fowler, C. J. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0001-6 · Cited by 23
Tarzia, G., Antonietti, F., Duranti, A., Tontini, A., Mor, M., Rivara, S., Traldi, P., Astarita, G., King, A. R., Clapper, J. R., et al. (2007) · Annali di Chimica · doi:10.1002/adic.200790073 · Cited by 23
Self-citationAlger, B. E. (2005) · Science s STKE · doi:10.1126/stke.3092005pe51 · Cited by 23
Kalbasi Anaraki, D., Sianati, S., Sadeghi, M., Ghasemi, M., Javadi, P., Ejtemaei Mehr, S., & Dehpour, A. R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.055 · Cited by 22
Carloni, S., Alconada, D. A., Girelli, S., Duranti, A., Tontini, A., Piomelli, D., Hilario, E., Alvarez, A. A., & Balduini, W. (2012) · Pediatric Research · doi:10.1038/pr.2012.91 · Cited by 22
Self-citationNeuroanatomical substrates involved in cannabinoid modulation of defensive responses
Moreira, F. A., Aguiar, D., Resstel, L. B. M., Lisboa, S. F. D. S., Campos, A. C., Gomes, F. V., & Guimarães, F. S. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400651 · Cited by 24
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Aaltonen, N., Kędzierska, E., Orzelska‐Górka, J., Lehtonen, M., Navia‐Paldanius, D., Jakupović, H., Savinainen, J. R., Nevalainen, T., Laitinen, J. T., Parkkari, T., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.233114 · Cited by 22
Kwon, M.-S., Seo, Y.-J., Shim, E.-J., Lee, J.-K., Jang, J.-E., Park, S.-H., Jung, J.-S., & Suh, H.-W. (2008) · Brain Research · doi:10.1016/j.brainres.2007.11.009 · Cited by 21
New insights on endocannabinoid transmission in psychomotor disorders
Giuffrida, A., & Seillier, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.04.002 · Cited by 24
Expression and Function of Monoacylglycerol Lipase in Mouse β-cells and Human Islets of Langerhans
Li, C., Vilches-Flores, A., Zhao, M., Amiel, S., Jones, P. M., & Persaud, S. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000339069 · Cited by 22
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Glaser, S. T., & Kaczocha, M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.043 · Cited by 22
Wang, Y., & Burrell, B. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00235.2016 · Cited by 21
Rea, K., McGowan, F., Corcoran, L., Roche, M., & Finn, D. P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14376 · Cited by 22
Nithipatikom, K., Endsley, M. P., Pfeiffer, A. W., Falck, J. R., & Campbell, W. B. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m051284 · Cited by 21
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Ebrahimzadeh, M. A., & Haghparast, A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.028 · Cited by 20
Greco, R., Demartini, C., Zanaboni, A. M., Berliocchi, L., Piomelli, D., & Tassorelli, C. (2017) · Cephalalgia · doi:10.1177/0333102417727537 · Cited by 20
Self-citationWang, Y., & Burrell, B. D. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00092.2017 · Cited by 20
Reynoso-Moreno, I., Chicca, A., Flores-Soto, M. E., Paredes, J. M. V., & Gertsch, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00180 · Cited by 20
Tian, X., Liu, T., Li, L., Shao, B., Yao, D., Feng, L., Cui, J., James, T. D., & Ma, X. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05826 · Cited by 20
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Lee, S. H., Raboune, S., Walker, J. M., & Bradshaw, H. B. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11103965 · Cited by 20
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Sütt, S., Raud, S., Areda, T., Reimets, A., Kõks, S., & Vasar, E. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0927-4 · Cited by 22
Viana, T. G., Hott, S. C., Resstel, L. B. M., de Aguiar, D. C., & Moreira, F. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3793-x · Cited by 19
Morgan, A., Adank, D. N., Johnson, K., Butler, E. C., & Patel, S. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14949 · Cited by 20
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Yarushkina, N. I., Bagaeva, T. R., & Filaretova, L. P. (2011) · PubMed · Cited by 19
Cannabinoids for the treatment of neuropsychiatric symptoms, pain and weight loss in dementia
Sherman, C., Ruthirakuhan, M. T., Vieira, D., Lanctôt, K. L., & Herrmann, N. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000399 · Cited by 19
Pietra, A. D., Savinainen, J. R., & Giniatullin, R. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084407 · Cited by 19
Horváth, E., Woodhams, S. G., Nyilas, R., Henstridge, C. M., Kano, M., Sakimura, K., Watanabe, M., & Katona, I. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12470 · Cited by 18
Carnevali, L., Rivara, S., Nalivaiko, E., Thayer, J. F., Vacondio, F., Mor, M., & Sgoifo, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.013 · Cited by 18
Self-citationKhan, A. U., Falconi‐Sobrinho, L. L., dos Anjos‐Garcia, T., Sampaio, M. D. F. D. S., Crippa, J. A. S., Menescal-de-Oliveira, L., & Coimbra, N. C. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05435-5 · Cited by 18
Afzal, O., Altamimi, A. S. A., Shahroz, M. M., Sharma, H. K., Riadi, Y., & Hassan, M. Q. (2021) · Molecules · doi:10.3390/molecules26082389 · Cited by 18
Wilson‐Poe, A. R., Lau, B. K., & Vaughan, C. W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12809 · Cited by 18
Kwok, C. H. T., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., Cooper, A. H., Woodhams, S. G., Sarmad, S., Ortori, C. A., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001027 · Cited by 18
Chapter 16 Endocannabinoid System and Fear Conditioning
Resstel, L. B. M., Moreira, F. A., & Guimarães, F. S. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(09)81016-9 · Cited by 18
Yarushkina, N. I., & Filaretova, L. P. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0445-5 · Cited by 17
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Viana, T. G., Bastos, J. D. R., Briânis, R. C., Hott, S. C., Machado, F. S. M., Coimbra, C. C., Resstel, L. B. M., de Aguiar, D. C., & Moreira, F. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.022 · Cited by 18
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Araki, M., Ohshima, N., Aso, C., Konishi, A., Obinata, H., Tatei, K., & Izumi, T. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw034 · Cited by 17
Carrascosa, A. J., Navarrete, F., Saldaña, R., García‐Gutiérrez, M. S., Moreno, B. M., Navarro, D., Gómez-Guijarro, F. M., Gasparyan, A., Murcia-Sánchez, E., Torregrosa, A. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116268 · Cited by 16
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Cunha, C. O., Fiamengui, L. M. S. P., Sampaio, F. A., & Conti, P. C. R. (2016) · Revista Dor · doi:10.5935/1806-0013.20160015 · Cited by 16
Tian, G., Paschetto, K. A., Gharahdaghi, F., Gordon, E., Wilkins, D. E., Luo, X., & Scott, C. W. (2011) · Biochemistry · doi:10.1021/bi200552p · Cited by 16
Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses
Aubrey, K. R., Drew, G. M., Jeong, H., Lau, B. K., & Vaughan, C. W. (2016) · The Journal of Physiology · doi:10.1113/jp272292 · Cited by 16
Castelli, R., Scalvini, L., Vacondio, F., Lodola, A., Anselmi, M., Vezzosi, S., Carmi, C., Bassi, M., Ferlenghi, F., Rivara, S., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01679 · Cited by 18
Self-citationCorcoran, L., Mattimoe, D., Roche, M., & Finn, D. P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.14976 · Cited by 17
Altamimi, A. S. A., Bawa, S., Athar, F., Hassan, M. Q., Riadi, Y., & Afzal, O. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13751 · Cited by 16
Okine, B. N., Laughlin, G. M., Gaspar, J. C., Harhen, B., Roche, M., & Finn, D. P. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.013 · Cited by 16
den Boon, F. S., Chameau, P. J. P., Houthuijs, K. J., Bolijn, S., Mastrangelo, N., Kruse, C. G., Maccarrone, M., Wadman, W. J., & Werkman, T. R. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1502-6 · Cited by 18
Wolkers, C. P. B., Barbosa, A., Menescal-de-Oliveira, L., & Hoffmann, A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.038 · Cited by 16
Rea, K., Ford, G. K., Olango, W. M., Harhen, B., Roche, M., & Finn, D. P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12452 · Cited by 16
Seo, Y.-J., Kwon, M., Choi, S., Lee, J.-K., Park, S.-H., Jung, J., Sim, Y., & Suh, H. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0213-1 · Cited by 16
Szabó, M., Agostino, M., Malone, D. T., Yuriev, E., & Capuano, B. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.09.038 · Cited by 16
Bouchet, C. A., McPherson, K. B., Coutens, B., Janowsky, A. J., & Ingram, S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0037-23.2023 · Cited by 15
Batista, L. A., Bastos, J. D. R., & Moreira, F. A. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114566259 · Cited by 15
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Metadata
- Authors
- Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Michael Walker, J., Holmes, P. V., Crystal, J. D., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D.
- Affiliations
- University of Georgia (US)
- University of California, Irvine (US)
- Brown University (US)
- University of Urbino (IT)
- University of Parma (IT)
- Corresponding author
- Hohmann, Andrea G.
- Piomelli, Daniele
- ORCID
- Venue
- Nature
- Published
- 2005-06
- Volume
- 435
- Issue
- 7045
- Pages
- 1108-1112
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2030777873
- Cited by
- 778
- References
- 30
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 22 · 2023: 22 · 2022: 28 · 2021: 26 · 2020: 22 · 2019: 20 · 2018: 29 · 2017: 53 · 2016: 34 · 2015: 38 · 2014: 40 · 2013: 33 · 2012: 45
- FWCI
- 39.98
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- stress-induced analgesia, endocannabinoid system, CB1 receptor, periaqueductal gray, 2-arachidonoylglycerol, anandamide, monoacylglycerol lipase, fatty acid amide hydrolase, opioid-independent analgesia, pain inhibition, stress-related disorders, therapeutic target
- MeSH terms
- Analgesia, Animals, Arachidonic Acids, Biological Transport, Biphenyl Compounds, Glycerides, Hydrolysis, Male, Mesencephalon, Monoacylglycerol Lipases, Stress, Physiological, Rats, Sprague-Dawley, Rats, Wistar, Receptor, Cannabinoid, CB1, Rats, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids, In Vitro Techniques
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