Cited by 398Genomic variations and chromosomal abnormalitiesChromosomal and Genetic VariationsGenome Rearrangement Algorithms

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A genome-wide comparison of recent chimpanzee and human segmental duplications

Cheng, Ze, Ventura, Mario, She, Xinwei, Khaitovich, Philipp, Graves, Tina, Osoegawa, Kazutoyo, Church, Deanna, DeJong, Pieter, Wilson, Richard K., Pääbo, Svante, Rocchi, Mariano, Eichler, Evan E.·2005·Nature

DOI 10.1038/nature04000

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Abstract

We present a global comparison of differences in content of segmental duplication between human and chimpanzee, and determine that 33% of human duplications (> 94% sequence identity) are not duplicated in chimpanzee, including some human disease-causing duplications. Combining experimental and computational approaches, we estimate a genomic duplication rate of 4-5 megabases per million years since divergence. These changes have resulted in gene expression differences between the species. In terms of numbers of base pairs affected, we determine that de novo duplication has contributed most significantly to differences between the species, followed by deletion of ancestral duplications. Post-speciation gene conversion accounts for less than 10% of recent segmental duplication. Chimpanzee-specific hyperexpansion (> 100 copies) of particular segments of DNA have resulted in marked quantitative differences and alterations in the genome landscape between chimpanzee and human. Almost all of the most extreme differences relate to changes in chromosome structure, including the emergence of African great ape subterminal heterochromatin. Nevertheless, base per base, large segmental duplication events have had a greater impact (2.7%) in altering the genomic landscape of these two species than single-base-pair substitution (1.2%).

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Tüzün, E., Sharp, A. J., Bailey, J. A., Kaul, R., Morrison, V., Pertz, L. M., Haugen, E., Hayden, H. S., Albertson, D. G., Pinkel, D., et al. (2005) · Nature Genetics · doi:10.1038/ng1562 · Cited by 1,000
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References
Diogo, R. (2012) · Science Publishers eBooks · doi:10.1201/b11605-6
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Bibliography
(2007) · Elsevier eBooks · doi:10.1016/b978-012372576-9/50018-8
Bibliography
(2009) · Wiley eBooks · doi:10.1002/9780470551455.biblio
Peer Review #2 of "Identification of genes involved in the evolution of human intelligence through combination of inter-species and intra-species genetic variations (v0.2)"
(2020) · PeerJ · doi:10.7287/peerj.8912v0.2/reviews/2
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Bibliography
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21719-7.10000-1
Primate genomics
Ankel‐Simons, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21719-7.00014-x
eLife Assessment: DNA replication errors are a major source of adaptive gene amplification
Braun, S. J. (2024) · eLife · doi:10.7554/elife.98934.1.sa3
Reviewer #1 (Public Review): DNA replication errors are a major source of adaptive gene amplification
(2024) · eLife · doi:10.7554/elife.98934.1.sa2
Reviewer #3 (Public Review): DNA replication errors are a major source of adaptive gene amplification
(2024) · eLife · doi:10.7554/elife.98934.1.sa0
Reviewer #2 (Public Review): DNA replication errors are a major source of adaptive gene amplification
(2024) · eLife · doi:10.7554/elife.98934.1.sa1
Template switching during DNA replication is a prevalent source of adaptive gene amplificationPreprint
Chuong, J. N., Nun, N. B., Suresh, I., Matthews, J. C., De, T., Avecilla, G., Abdul‐Rahman, F., Brandt, N., Ram, Y., & Gresham, D. (2024) · eLife · doi:10.7554/elife.98934.2
CNVviso: Visualisation Solution for Copy Number Variation Data from Ultra-Low Coverage Whole-Genome Sequencing in Preimplantation Genetic Testing
Huu, A. N., Hong, N. T. T., Bich, H. B., Quang, T. V., Pham, D. T., & Thi, H. L. (2024) · Current Bioinformatics · doi:10.2174/0115748936340523241113051828
Molecular characterisation of glycine–N–acyltransferase from two primates : the vervet monkey and the chacma baboon
Mahlanza, M. C. (2011) · Boloka Institutional Repository (North-west University)
Phylogenetic Relationships of Hominids: Biomolecular Approach
Disotell, T. R. (2014) · Springer eBooks · doi:10.1007/978-3-642-39979-4_59
Additional file 1 of PhaseDancer: a novel targeted assembler of segmental duplications unravels the complexity of the human chromosome 2 fusion going from 48 to 46 chromosomes in hominin evolution
Poszewiecka, B., Gogolewski, K., Karolak, J. A., Stankiewicz, P., & Gambin, A. (2024) · Figshare · doi:10.6084/m9.figshare.26616739
Additional file 2 of PhaseDancer: a novel targeted assembler of segmental duplications unravels the complexity of the human chromosome 2 fusion going from 48 to 46 chromosomes in hominin evolution
Poszewiecka, B., Gogolewski, K., Karolak, J. A., Stankiewicz, P., & Gambin, A. (2024) · Figshare · doi:10.6084/m9.figshare.26616742
Optimisation de la différenciation neuronale et musculaire de cellules pluripotentes induites humaines pour la modélisation des maladies rares : exemple du syndrome de DiGeorge
Badja, C. (2015) · theses.fr (ABES) · doi:10.70675/a4483a23z2b5dz4594zb5b2z73a07d60bfec
Genomic-microbial coevolution in human development: chromosome 2 fusion, and human accelerated regions
Singh, S., Shahadab, M., Sachin, K., Pandey, R. K., Trivedi, P., Mishra, A. K., & Jha, H. C. (2026) · Mammalian Genome · doi:10.1007/s00335-026-10228-1
Specializations of human cerebral cortex
Preuss, T. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00064-6
Can We Understand Parameter Values in the Human Genome?
Li, W. (2013) · Springer proceedings in complexity · doi:10.1007/978-3-319-00395-5_128
Twelve Years of Neandertal Genetic Discoveries: State-of-the-Art and Future Challenges
Orlando, L., & Hänni, C. (2011) · Vertebrate paleobiology and paleoanthroplogy series/Vertebrate paleobiology and paleoanthropology series · doi:10.1007/978-94-007-0492-3_21

Authors: Cheng, Z., Ventura, M., She, X., Khaitovich, P., Graves, T., Osoegawa, K., Church, D., DeJong, P., Wilson, R. K., Pääbo, S., Rocchi, M., & Eichler, E. E.
Affiliations: Howard Hughes Medical Institute (US)
University of Bari Aldo Moro (IT)
Max Planck Institute for Evolutionary Anthropology (DE)
Washington University in St. Louis (US)
National Institutes of Health (US)
Corresponding author: Eichler, Evan E.
ORCID: Ventura, Mario
Khaitovich, Philipp
Osoegawa, Kazutoyo
Church, Deanna
Wilson, Richard K.
Pääbo, Svante
Rocchi, Mariano
Eichler, Evan E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-09
Volume: 437
Issue: 7055
Pages: 88-93
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04000
OpenAlex: W1971369643
Cited by: 398
References: 31
Citations by year: 2026: 3 · 2025: 4 · 2024: 17 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 17 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 6 · 2015: 10 · 2014: 15 · 2013: 22 · 2012: 18
FWCI: 27.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders: European Commission
Bundesministerium für Bildung und Forschung
National Institute of General Medical Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
Keywords: segmental duplication, human-chimpanzee comparison, de novo duplication, gene conversion, subtelomeric heterochromatin, gene expression differences, primate genome evolution, human evolution, chimpanzee genome, Y-linked genes, chromosome structure, comparative genomics
MeSH terms: Animals, Pan troglodytes, Gene Conversion, Humans, Species Specificity, Time Factors, Genome, Human, Evolution, Molecular, Computational Biology, Gene Duplication, Genomics, Chromosomes, Mammalian

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A genome-wide comparison of recent chimpanzee and human segmental duplications

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