The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Pastorino, Lucia, Sun, Anyang, Lu, Pei-Jung, Zhou, Xiao Zhen, Balastik, Martin, Finn, Greg, Wulf, Gerburg, Lim, Jormay, Li, Shi-Hua, Li, Xiaojiang, Xia, Weiming, Nicholson, Linda K., Lu, Kun Ping·2006·Nature

DOI 10.1038/nature04543

Cited by (488)

Items 301–400 of 488

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Pin1 Flips Alzheimer’s Switch
Felicia A. Etzkorn · 2006 · ACS Chemical Biology
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Susana Ferrão Santos, Bernadette Tasiaux, Christian Sindic, Jean‐Noël Octave · 2010 · Neurobiology of Aging
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Liraglutide Treatment Ameliorates Neurotoxicity Induced by Stable Silencing of Pin1
Marzia Bianchi, Valentina Doria, Maria Rita Braghini, Stefania Petrini, Melania Manco · 2019 · International Journal of Molecular Sciences
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Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity
Fangfang Zhou, Kai Gong, Theo van Laar, Yandao Gong, Long Zhang · 2011 · Biochemical and Biophysical Research Communications
Neighboring phosphoSer‐Pro motifs in the undefined domain of IRAK 1 impart bivalent advantage for Pin1 binding
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Rukhsana Sultana A, Giovanna Cenini, David Allan Butterfield · 2013 · Wiley eBooks
Stability of Pin1 as revealed by thermal and spectroscopic studies
Jing-Zhang Wang, Tao Lin, Guo-Fei Zhu, Linfang Du · 2010 · Journal of Molecular Structure
Pin1, endothelial nitric oxide synthase, and amyloid-β form a feedback signaling loop involved in the pathogenesis of Alzheimer’s disease, hypertension, and cerebral amyloid angiopathy
Jing-Zhang Wang, Wangdong Zhu, Zhongxin Xu, Wen-Tao Du, Hongyan Zhang, Xuewen Sun, Xiao-Hua Wang · 2013 · Medical Hypotheses
The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans
Yingqian Ada Zhan, Frederick Marty Ytreberg · 2015 · Archives of Biochemistry and Biophysics
PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model
Alisia Carnemolla, Silvia Michelazzi, Elena Agostoni · 2017 · Frontiers in Cellular Neuroscience
Uncorrelated Effect of Interdomain Contact on Pin1 Isomerase Activity Reveals Positive Catalytic Cooperativity
Wenkai Zhu, Ying Li, Maili Liu, Jiang Zhu, Yunhuang Yang · 2019 · The Journal of Physical Chemistry Letters
Effects of Pin1 Loss in HdhQ111 Knock-in Mice
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Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoE−/− mice
Er‐shun Liang, Wen Cheng, Ruixue Yang, Wen‐Wu Bai, Xue Liu, Yuxia Zhao · 2017 · Journal of Molecular and Cellular Cardiology
Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor
Jacky Kieran Leung, Yusuke Imamura, Minoru Kato, Jun Wang, Nasrin R. Mawji, Marianne D. Sadar · 2021 · Communications Biology
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David P. Atencio, Cassandra L. Barnes, T. Michael Duncan, Ian M. Willis, Steven D. Hanes · 2014 · G3 Genes Genomes Genetics
Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
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Jack Hearn, Jessica Clark, Philip J. Wilson, Tom J. Little · 2020 · Molecular Ecology
Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer’s Disease
Asami Kondo, Önder Albayram, Xiao Zhen Zhou, Kun Ping Lu · 2016 · Methods in molecular biology
Shrimp miRNA suppresses the stemness of human cancer stem cells via the PIN1 pathway
Siyuan Zhang, Xiaobo Zhang · 2019 · The FASEB Journal
Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation
Jessica Jeong, Muhammad Usman, Yitong Li, Xiao Zhen Zhou, Kun Ping Lu · 2024 · Cells
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Jing-Zhang Wang, Yuhua Zhang, Xuewen Sun, Yali Li, Shu-Rui Li, Yong Zhang, Ting Zhang, Song Guo-qiang · 2013 · Medical Hypotheses
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Jing-Zhang Wang, Shu-Rui Li, Yali Li, Zhang Yong-ze, Ting Zhang, Chaoxian Zhao, Chun-Xia Yao, Linfang Du · 2013 · Medical Hypotheses
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Toshifumi Mori, Shinji Saito · 2020 · Journal of Chemical Theory and Computation
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Prolyl Isomerase Pin1 Regulates Transcription Factor LSF (TFCP2) by Facilitating Dephosphorylation at Two Serine-Proline Motifs
Utsav H. Saxena, Laura Owens, Julie R. Graham, Geoffrey M. Cooper, Ulla M. Hansen · 2010 · Journal of Biological Chemistry
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Marzia Bianchi, Melania Manco · 2018 · International Journal of Molecular Sciences
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Jingming Wang, Bryan K. Chan, Michael Tong, YiTing Paung, Ukhyun Jo, Dwight W. Martin, Markus A. Seeliger, John D. Haley, Hyungjin Kim · 2019 · PLoS Genetics
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Alzheimer‘s disease, oxidative stress and B-vitamin depletion
Andrew McCaddon, Peter R Hudson · 2007 · Future Neurology
The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer
Stefano Stifani · 2018 · Biomolecules
Activity and Affinity of Pin1 Variants
Alexandra Born, Morkos A. Henen, Beat Vögeli · 2019 · Molecules
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Chungwen Liang, Philippe Derreumaux, Normand Mousseau, Guanghong Wei · 2008 · Biophysical Journal
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Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery
Kun Ping Lu, Xiao Zhen Zhou · 2024 · Science Signaling
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Xiaojun Hou, Fan Yang, Angcheng Li, Debao Zhao, Nengjun Ma, Linying Chen, Suijin Lin, Yuanxiang Lin, Long Wang, Xingxue Yan et al. · 2021 · Cerebral Cortex
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