PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Zhang, Jiwang, Grindley, Justin C., Yin, Tong, Jayasinghe, Sachintha, He, Xi C., Ross, Jason T., Haug, Jeffrey S., Rupp, Dawn, Porter-Westpfahl, Kimberly S., Wiedemann, Leanne M., Wu, Hong, Li, Linheng·2006·Nature

DOI 10.1038/nature04747

Cited by (814)

Items 301–400 of 814

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Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways
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Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia
Julianne N. P. Smith, Vikramjit Singh Kanwar, Katherine C. MacNamara · 2016 · Frontiers in Immunology
Ectopic miR-125a expression induces long-term repopulating stem cell capacity in mouse and human hematopoietic progenitors
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CD81 Is Essential for the Re-entry of Hematopoietic Stem Cells to Quiescence following Stress-Induced Proliferation Via Deactivation of the Akt Pathway
Kuanyin K. Lin, Lara Rossi, Nathan C. Boles, Brian E. Hall, Thaddeus C. George, Margaret A. Goodell · 2011 · PLoS Biology
Urothelial carcinoma: Stem cells on the edge
William D. Brandt, William H. Matsui, Jonathan E. Rosenberg, Xiaobing He, Shizhang Ling, Edward M. Schaeffer, David Monty Berman · 2009 · Cancer and Metastasis Reviews
SALL4 is a key transcription regulator in normal human hematopoiesis
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Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis
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STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling
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FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells
Dewen You, Junping Xin, Andrew G. Volk, Wei Wei, Rachel Schmidt, Gina M. Scurti, Sucha Nand, Eun-Kyoung Yim Breuer, Paul C. Kuo, Peter Breslin et al. · 2015 · Cell Reports
The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
Jing Wang, Fei Han, Juan Wu, Szu-Wei Lee, Chia‐Hsin Chan, Ching‐Yuan Wu, Wei‐Lei Yang, Yuan Gao, Xian Zhang, Yun Seong Jeong et al. · 2011 · Blood
TORC1 is required to balance cell proliferation and cell death in planarians
Kimberly C. Tu, Bret J. Pearson, Alejandro Sánchez Alvarado · 2012 · Developmental Biology
Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes
Jingyao Zhao, Xufeng Chen, Guangrong Song, Jiali Zhang, Haifeng Liu, Xiaolong Liu · 2016 · Proceedings of the National Academy of Sciences
The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage
Sojeong Jun, Swetha Mahesula, Thomas P. Mathews, Misty S. Martin-Sandoval, Zhiyu Zhao, Elena Piskounova, Michalis Agathocleous · 2021 · Cell Metabolism
PTEN: a default gate-keeping tumor suppressor with a versatile tail
Xinjiang Wang, Xuejun Jiang · 2008 · Cell Research
The Cytosolic Protein G0S2 Maintains Quiescence in Hematopoietic Stem Cells
Takeshi Yamada, Chun Shik Park, Audrea M. Burns, Daisuke Nakada, H. Daniel Lacorazza · 2012 · PLoS ONE
PRL2/PTP4A2 Phosphatase Is Important for Hematopoietic Stem Cell Self-Renewal
Michihiro Kobayashi, Yunpeng Bai, Yuanshu Dong, Hao Yu, Sisi Chen, Rui Gao, Lujuan Zhang, Mervin C. Yöder, Reuben Kapur, Zhong‐Yin Zhang et al. · 2014 · Stem Cells
EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer
Jinkyung Kim, Hye Suk Kang, Yujin Lee, Heon‐Jin Lee, Jieun Yun, Jung Hyu Shin, Chang Woo Lee, Byoung‐Mog Kwon, Su‐Hyung Hong · 2014 · Cancer Letters
Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS
An, Ningfei, Khan, Saira, Imgruet, Molly K., Gurbuxani, Sandeep K., Konecki, Stephanie N., Burgess, Michael R., McNerney, Megan E. · 2018 · Blood
Hypoxia and HIFs in regulating the development of the hematopoietic system
Parisa Imanirad, Elaine Anne Dzierzak · 2013 · Blood Cells Molecules and Diseases
The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells
Yafeng Zhang, Zhengmin Yang, Yonghao Cao, Shijian Zhang, Hai Li, Ying Huang, Yu‐Qiang Ding, Xiaolong Liu · 2008 · Biochemical Journal
The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology
Alberto Maria Martelli, Camilla Evangelisti, Francesca Chiarini, Cecilia Grimaldi, James Andrew McCubrey · 2010 · Cancers
Somatic stem cells and the origin of cancer
Jose Angel Martinez-Climent, Enrique José Andreu, Felipe Prósper · 2006 · Clinical & Translational Oncology
Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α
Kira Gritsman, Haluk Yuzugullu, Thanh Von, Howard Yan, Linda K. Clayton, Christine M. Fritsch, Sauveur-Michel Maira, Gregory J. Hollingworth, Christine H. Choi, Tulasi Khandan et al. · 2014 · Journal of Clinical Investigation
Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
Alyson K. Baker, Ruipeng Wang, Nigel Mackman, James P. Luyendyk · 2009 · Molecular Immunology
Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia
Fang-Fang Huang, Dengshu Wu, Li Zhang, Yanhui Yu, Xiaoyu Yuan, Wenjin Li, Xiaoping Chen, Xielan Zhao, Fangping Chen, Hui Zeng · 2013 · Cancer Letters
Deletion of Pten Expands Lung Epithelial Progenitor Pools and Confers Resistance to Airway Injury
Caterina Tiozzo, Stijn De Langhe, Mingke Yu, Vedang A. Londhe, Gianni Carraro, Min Li, Changgong Li, Yiming Xing, Stewart A. Anderson, Zea Borok et al. · 2009 · American Journal of Respiratory and Critical Care Medicine
Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention
Weihuan Wang, Shuiliang Yu, Grant Zimmerman, Yiwei Wang, Jay Myers, Vionnie W.C. Yu, Dan Huang, Xiaoran Huang, Jeongsup Shim, Yuanshuai Huang et al. · 2015 · Stem Cells
A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell
Keisuke Ito, Rosa Bernardi, Pier Paolo Pandolfi · 2009 · Current Opinion in Genetics & Development
MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes
Yan Li, Rui Cao, YuanBo Liu, Lian-Zhao Wang, Bo Pan, Xiaoyan Lv, Hu Jiao, Qiang Zhuang, Xuejian Sun, Ran Xiao · 2016 · Scientific Reports
Regulatory Role of Quiescence in the Biological Function of Cancer Stem Cells
Sau Har Lee, Tamika C. Reed-Newman, Shrikant Anant, Thamil Selvee Ramasamy · 2020 · Stem Cell Reviews and Reports
Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
Stefan Horn, Ulla Bergholz, Manfred Jücker, James Andrew McCubrey, Lorenz H. P. Trümper, Carol Stocking, Jörg Bäsecke · 2008 · Oncogene
Disruption of Prostate Epithelial Differentiation Pathways and Prostate Cancer Development
Sander B. Frank, Cindy K. Miranti · 2013 · Frontiers in Oncology
The Transcriptional Coactivator Cbp Regulates Self-Renewal and Differentiation in Adult Hematopoietic Stem Cells
Wai-In Chan, Rebecca Hannah, Mark A. Dawson, Clare Pridans, Donna Foster, Anagha Joshi, Berthold Göttgens, Jan M. van Deursen, Brian J.P. Huntly · 2011 · Molecular and Cellular Biology
Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3β pathway in human colon cancer
Fei Gao, Wei Huang, YuQin Zhang, Shaohui Tang, Lin Zheng, Feng Ma, Yiming Wang, Hui Tang, Xin Li · 2015 · Oncotarget
Soluble growth factors stimulate spermatogonial stem cell divisions that maintain a stem cell pool and produce progenitors in vitro
Kevin T. Ebata, Jonathan R. Yeh, Xiangfan Zhang, Makoto C. Nagano · 2011 · Experimental Cell Research
Interferon-α signaling promotes embryonic HSC maturation
Peter Geon Kim, Matthew C. Canver, Catherine Rhee, Samantha J. Ross, June V. Harriss, Ho-Chou Tu, Stuart H. Orkin, Haley O. Tucker, George Q. Daley · 2016 · Blood
The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis
Jeffrey L. Kurkewich, Justin M. Hansen, Nathan Klopfenstein, Helen Zhang, Christian Wood, Austin C. Boucher, Joseph W. Hickman, David E. Muench, H. Leighton Grimes, Richard E. Dahl · 2017 · PLoS Genetics
Molecular regulation of hematopoietic stem cell quiescence
Zhe Chen, Qian Guo, Guanbin Song, Yu Hou · 2022 · Cellular and Molecular Life Sciences
Abnormal hematopoiesis in Gab2 mutant mice
Yi Zhang, Ernesto Díaz-Flores, Geqiang Li, Zhengqi Wang, Zizhen Kang, Eleonora Haviernikova, Sara L. Rowe, Cheng‐Kui Qu, William Tse, Kevin Shannon et al. · 2007 · Blood
The role of the PI3K-PKB signaling module in regulation of hematopoiesis
Miranda Buitenhuis, Paul James Coffer · 2009 · Cell Cycle
PTEN Regulates BCRP/ABCG2 and the Side Population through the PI3K/Akt Pathway in Chronic Myeloid Leukemia
Fang-Fang Huang, Li Zhang, Dengshu Wu, Xiaoyu Yuan, Fangping Chen, Hui Zeng, Yanhui Yu, Xielan Zhao · 2014 · PLoS ONE
Upregulation of HES1 Promotes Cell Proliferation and Invasion in Breast Cancer as a Prognosis Marker and Therapy Target via the AKT Pathway and EMT Process
Xiaoying Li, Yu Qing Cao, Mu Li, Feng Jin · 2018 · Journal of Cancer
A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
Haluk Yuzugullu, Lukas Baitsch, Thanh Von, Allison Steiner, Haoxuan Tong, Jing Ni, Linda K. Clayton, Roderick Terry Bronson, Thomas M. Roberts, Kira Gritsman et al. · 2015 · Nature Communications
Wnt Signaling in Normal and Malignant Stem Cells
Dheeraj Bhavanasi, Peter S. Klein · 2016 · Current Stem Cell Reports
The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment
Hanjiao Qin, Linlin Liu, Shu Sun, Dan Zhang, Jiyao Sheng, Bingjin Li, Wei Yang · 2018 · PeerJ
Regulation of Immune Responses and Hematopoiesis by the Rap1 Signal
Nagahiro Minato, Kohei Kometani, Masakazu Hattori · 2007 · Advances in immunology
Leukemia and hematopoietic stem cells: Balancing proliferation and quiescence
Craig D. Jude, Justin Gaudet, Nancy A. Speck, Patricia Ernst · 2008 · Cell Cycle
The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response
Alberto Maria Martelli, Francesca Paganelli, Antonietta Fazio, Chiara Bazzichetto, Fabiana Conciatori, James Andrew McCubrey · 2019 · Cancers
Mgat5 and Pten interact to regulate cell growth and polarity
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Mechanisms involved in hematopoietic stem cell aging
Takeshi Fujino, Shuhei Asada, Susumu Goyama, Toshio Kitamura · 2022 · Cellular and Molecular Life Sciences
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Neha Singh, Shrinidh Joshi, Lirong Guo, Matthew Brandon Baker, Yan Li, Ronald K. Castellano, Mohan K. Raizada, Yagna P. R. Jarajapu · 2015 · American Journal of Physiology-Heart and Circulatory Physiology
MicroRNAs in Oncogenesis and Tumor Suppression
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MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression
Shiyue Mei, Jiaxuan Xin, Yu Liu, Yuan Zhang, Xue Liang, Xiaomin Su, Hui Yan, Yugang Huang, Rongcun Yang · 2015 · PLoS ONE
Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish
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The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells
Mary Mohrin, Danica Chen · 2016 · Current Opinion in Hematology
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors
Shuyang Yu, Fengyin Li, Shaojun Xing, Tianyan Zhao, Weiqun Peng, Hai‐Hui Xue · 2016 · Journal of Biological Chemistry
Morin Inhibits Proliferation and Induces Apoptosis by Modulating the miR-188-5p/PTEN/AKT Regulatory Pathway in CML Cells
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Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation
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Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
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RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors
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Melania Tesio, Amélie Trinquand, Elizabeth A. Macintyre, Vahid Asnafi · 2015 · Oncogene
Hormonal Control of Stem Cell Systems
Dana Gancz, Lilach Gilboa · 2013 · Annual Review of Cell and Developmental Biology
PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1
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