Cited by 817Hematopoietic Stem Cell TransplantationPI3K/AKT/mTOR signaling in cancerAcute Myeloid Leukemia Research

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Zhang, Jiwang, Grindley, Justin C., Yin, Tong, Jayasinghe, Sachintha, He, Xi C., Ross, Jason T., Haug, Jeffrey S., Rupp, Dawn, Porter-Westpfahl, Kimberly S., Wiedemann, Leanne M., Wu, Hong, Li, Linheng·2006·Nature

DOI 10.1038/nature04747

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Abstract

Haematopoietic stem cells (HSCs) must achieve a balance between quiescence and activation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell maintenance, yet little is known about the molecular events governing this balance. Phosphatase and tensin homologue (PTEN) functions as a negative regulator of the phosphatidylinositol-3-OH kinase (PI(3)K)-Akt pathway, which has crucial roles in cell proliferation, survival, differentiation and migration. Here we show that inactivation of PTEN in bone marrow HSCs causes their short-term expansion, but long-term decline, primarily owing to an enhanced level of HSC activation. PTEN-deficient HSCs engraft normally in recipient mice, but have an impaired ability to sustain haematopoietic reconstitution, reflecting the dysregulation of their cell cycle and decreased retention in the bone marrow niche. Mice with PTEN-mutant bone marrow also have an increased representation of myeloid and T-lymphoid lineages and develop myeloproliferative disorder (MPD). Notably, the cell populations that expand in PTEN mutants match those that become dominant in the acute myeloid/lymphoid leukaemia that develops in the later stages of MPD. Thus, PTEN has essential roles in restricting the activation of HSCs, in lineage fate determination, and in the prevention of leukaemogenesis.

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Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Self-citation
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., & Suda, T. (2004) · Cell · doi:10.1016/j.cell.2004.07.004 · Cited by 1,958
Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand
Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., Crystal, R. G., Besmer, P., Lyden, D. C., Moore, M. A. S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00754-7 · Cited by 1,744
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential
Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,323

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Janzen, V., & Scadden, D. T. (2006) · Nature · doi:10.1038/441418b · Cited by 26
Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications
Cardoso, B. A., Gírio, A., Henriques, C. M., Martins, L. R., Santos, C., Silva, A., & Barata, J. T. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008005000016 · Cited by 26
Toward ‘SMART’ stem cells
Cheng, T. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303066 · Cited by 26
Unraveling the Big Sleep: Molecular Aspects of Stem Cell Dormancy and Hibernation
Dias, I. B., Bouma, H. R., & Henning, R. H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.624950 · Cited by 28
Reactive Oxygen Species in Acute Lymphoblastic Leukaemia: Reducing Radicals to Refine Responses
Mannan, A., Germon, Z. P., Chamberlain, J., Sillar, J. R., Nixon, B., & Dun, M. D. (2021) · Antioxidants · doi:10.3390/antiox10101616 · Cited by 27
Cited2 Is Required for the Maintenance of Glycolytic Metabolism in Adult Hematopoietic Stem Cells
Du, J., Li, Q., Tang, F., Puchowitz, M., Fujioka, H., Dunwoodie, S. L., Danielpour, D., & Yang, Y. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0370 · Cited by 27
Rictor has a pivotal role in maintaining quiescence as well as stemness of leukemia stem cells in MLL-driven leukemia
Fang, Y., Yang, Y., Hua, C., Xu, S., Zhou, M., Guo, H., Wang, N., Zhao, X., Huang, L., Yu, F., et al. (2016) · Leukemia · doi:10.1038/leu.2016.223 · Cited by 26
PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity
Noguera, N. I., Piredda, M. L., Taulli, R., Catalano, G., Angelini, G., Gaur, G., Nervi, C., Voso, M. T., Lunardi, A., Pandolfi, P. P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11964 · Cited by 27
Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia
Liu, H., Feng, X., Ennis, K. N., Behrmann, C. A., Sarma, P. N., Jiang, T. T., Kofuji, S., Niu, L., Stratton, Y., Thomas, H. E., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.022 · Cited by 25
Attribution of the Hemispheric Asymmetries in Trends of Stratospheric Trace Gases Inferred From Microwave Limb Sounder (MLS) Measurements
Han, Y., Tian, W., Chipperfield, M. P., Zhang, J., Wang, F., Sang, W., Luo, J., Feng, W., Chrysanthou, A., & Tian, H. (2019) · Journal of Geophysical Research Atmospheres · doi:10.1029/2018jd029723 · Cited by 25
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MT1-MMP and RECK: opposite and essential roles in hematopoietic stem and progenitor cell retention and migration
Golan, K., Vagima, Y., Goichberg, P., Gur‐Cohen, S., & Lapidot, T. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0792-9 · Cited by 24
Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides
Elich, M., & Sauer, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00931 · Cited by 24
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Khwaja, A. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_71 · Cited by 23
Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice
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Zhang, J., & Ju, Z. (2010) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20190 · Cited by 25
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All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase
Maetzig, T., Kuehle, J., Schwarzer, A., Turan, S., Rothe, M., Chaturvedi, A., Morgan, M. A., Ha, T. C., Heuser, M., Hammerschmidt, W., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.057 · Cited by 24
Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism
Tessier, S., Martín-Martín, N., de Thé, H., Carracedo, A., & Lallemand-Breitenbach, V. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6898 · Cited by 23
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Tottone, L., Lancho, O., Loh, J.-W., Singh, A., Kimura, S., Roels, J., Kuchmiy, A. A., Strubbe, S., Lawlor, M. A., da Silva-Diz, V., et al. (2020) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-20-0201 · Cited by 24
PTEN in Regulating Hematopoiesis and Leukemogenesis
Wu, Y., Zhu, H., & Wu, H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036244 · Cited by 22
Self-citation
Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy
An, W., Nadeau, S. A., Mohapatra, B. C., Feng, D., Zutshi, N., Storck, M. D., Arya, P., Talmadge, J. E., Meza, J. L., Band, V., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3403 · Cited by 22
The circuitry between ribosome biogenesis and translation in stem cell function and ageing
Sharifi, S., da Costa, H. F. R., & Bierhoff, H. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111282 · Cited by 22
mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate
Wang, R., & Amoyel, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.863885 · Cited by 23
Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish
Dong, Z., Ren, C., Xia, Y. Q., Su, D., Du, T., Fan, H.-B., Yuan, H., Wang, L., Dong, M., Li, W., et al. (2014) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-7-17 · Cited by 22
Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN
Yu, H., Li, Y., Gao, C., Loison, F., Jia, Y., Lu, J., Silberstein, L. E., Pinkus, G. S., Ye, K., Chai, L., et al. (2010) · Leukemia · doi:10.1038/leu.2010.34 · Cited by 22
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
Porter, S. N., Cluster, A. S., Signer, R. A. J., Voigtmann, J., Monlish, D. A., Schuettpelz, L. G., & Magee, J. A. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.04.008 · Cited by 22

Authors: Zhang, J., Grindley, J. C., Yin, T., Jayasinghe, S., He, X. C., Ross, J. T., Haug, J. S., Rupp, D., Porter-Westpfahl, K. S., Wiedemann, L. M., Wu, H., & Li, L.
Affiliations: Stowers Institute for Medical Research (US)
University of California, Los Angeles (US)
Corresponding author: Li, Linheng
ORCID: Zhang, Jiwang
Yin, Tong
Jayasinghe, Sachintha
He, Xi C.
Haug, Jeffrey S.
Wiedemann, Leanne M.
Wu, Hong
Li, Linheng
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-04-23
Volume: 441
Issue: 7092
Pages: 518-522
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04747
OpenAlex: W2057403210
Cited by: 817
References: 30
Citations by year: 2026: 7 · 2025: 6 · 2024: 9 · 2023: 19 · 2022: 18 · 2021: 30 · 2020: 22 · 2019: 29 · 2018: 24 · 2017: 29 · 2016: 48 · 2015: 40 · 2014: 58 · 2013: 61 · 2012: 55
FWCI: 43.78
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords: PTEN, hematopoietic stem cells, leukemia stem cells, PI3K/Akt signaling, stem cell self-renewal, HSC quiescence, lineage choice, myeloproliferative neoplasms, acute myeloid leukemia, acute lymphoblastic leukemia, rapamycin, bone marrow microenvironment, haematopoietic reconstitution
MeSH terms: Animals, Cell Count, Cell Cycle, Hematopoietic Stem Cells, Leukemia, Mutation, Gene Expression, Cell Lineage, Cyclin D1, Cell Proliferation, PTEN Phosphohydrolase, Mice

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

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