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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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The role of autophagy during the early neonatal starvation period

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Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

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Brain RNA-Seq Profiling of the Mucopolysaccharidosis Type II Mouse Model

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PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis

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Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates

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GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ

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Ubiquitin dimers control the hydrolase activity of UCH-L3

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Autophagic Clearance of Sin Nombre Hantavirus Glycoprotein Gn Promotes Virus Replication in Cells

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Protein clearing pathways in ALS.

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Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3β in a SCA3 Drosophila Model

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Inhibition of calpain prevents NMDA‐induced cell death and β‐amyloid‐induced synaptic dysfunction in hippocampal slice cultures

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Etiology of Crohn’s disease: many roads lead to autophagy

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(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines

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Deficiency of Ube3a in Huntington's disease mice brain increases aggregate load and accelerates disease pathology

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Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury

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YKL-40 and neuron-specific enolase in neurodegeneration and neuroinflammation

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Nanoparticles Induce Autophagy via mTOR Pathway Inhibition and Reactive Oxygen Species Generation

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Role of the endolysosomal pathway and exosome release in tau propagation

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Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington’s Disease

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miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia

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The roles of the proteasome pathway in signal transduction and neurodegenerative diseases

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Plasmodium falciparum Erythrocytic Stage Parasites Require the Putative Autophagy Protein PfAtg7 for Normal Growth

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Enterovirus 71 VP1 Activates Calmodulin-Dependent Protein Kinase II and Results in the Rearrangement of Vimentin in Human Astrocyte Cells

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Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy

Nagathihalli, N. S., Singh, O. V., & Merchant, N. B. (2010) · Expert Review of Proteomics · doi:10.1586/epr.10.70 · Cited by 34

Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within Lysosomes

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Induction of autophagy and interleukin 6 secretion in bystander cells: metabolic cooperation for radiation-induced rescue effect?

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Modifications of autophagy influenced the Alzheimer-like changes in SH-SY5Y cells promoted by ultrafine black carbon

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Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts

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Improvement of skeletal muscle growth by GH/IGF growth-axis contributes to growth performance in commercial fleshy sturgeon

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Tubular lysosome induction couples animal starvation to healthy aging

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The Interplay between Autophagy and Aging

Pyo, J.-O., Yoo, S., & Jung, Y. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.5.333 · Cited by 36

N,N-diethyldithiocarbamate promotes oxidative stress prior to myelin structural changes and increases myelin copper content

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Chaperone-mediated autophagy: roles in neuroprotection

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Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus

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Erythropoietin and Bacillus Calmette–Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy

Senousy, M. A., Hanafy, M. E., Shehata, N., & Rizk, S. M. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00523 · Cited by 33

The clearance of misfolded proteins in neurodegenerative diseases by zinc metalloproteases: An inorganic perspective

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In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expression

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p32 regulates mitochondrial morphology and dynamics through parkin

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Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma

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Antioxidant activity of phenylethanoid glycosides on glutamate-induced neurotoxicity

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Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer’s Disease and Other Tauopathies

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Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation.

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Targeting Nrf2 by dihydro‐CDDO‐trifluoroethyl amide enhances autophagic clearance and viability of β‐cells in a setting of oxidative stress

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Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing

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Autophagy in Development and Differentiation

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Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

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Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases: a systematic review

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Does autophagy work in synaptic plasticity and memory?

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A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells

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Mitophagy in Ischaemia/Reperfusion Induced Cerebral Injury

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Aetiopathogenesis of Parkinson’s disease

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Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry

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Polymer Directed Protein Assemblies

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Discovery of neuroprotective compounds by machine learning approaches

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Dopamine exacerbates mutant Huntingtin toxicity via oxidative-mediated inhibition of autophagy in SH-SY5Y neuroblastoma cells: Beneficial effects of anti-oxidant therapeutics

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LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

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Computer-aided identification of degenerative neuromuscular diseases based on gait dynamics and ensemble decision tree classifiers

Fraiwan, L., & Hassanin, O. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252380 · Cited by 31

Glymphatic system dysfunction in patients with cluster headache

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Proteomics to study the diversity and dynamics of proteasome complexes: from fundamentals to the clinic

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Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia

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Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins

Chakrabarti, O., Rane, N. S., & Hegde, R. S. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0638 · Cited by 31

Role of Autophagy during Methamphetamine Neurotoxicity

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Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin

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A role for TOR signaling at every stage of plant life

Quilichini, T. D., Gao, P., Pandey, P. K., Xiang, D., Ren, M., & Datla, R. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz125 · Cited by 31

Harnessing Machine Learning To Unravel Protein Degradation in Escherichia coli

Nagar, N., Ecker, N., Loewenthal, G., Avram, O., Ben-Meir, D., Biran, D., Ron, E., & Pupko, T. (2021) · mSystems · doi:10.1128/msystems.01296-20 · Cited by 31

Brain-derived neurotrophic factor and the course of experimental cerebral malaria

Linares, M., Marín‐García, P., Pérez-Benavente, S., Sánchez‐Nogueiro, J., Puyet, A., Bautista, J. M., & Díez, A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.040 · Cited by 30

Cadmium induced redistribution of cholesterol by upregulating ABCA1 and downregulating OSBP

Wang, Y., Ji, X., Dai, S., Liu, H., Yan, D., Zhou, Y., Gu, J., & Shi, H. (2018) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2018.09.016 · Cited by 30

Autophagy in Rare (NonLysosomal) Neurodegenerative Diseases

Zatyka, M., Sarkar, S., & Barrett, T. G. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.02.012 · Cited by 30

Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

Homma, T., & Fujii, J. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1734588 · Cited by 32

2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy

Singhal, A., Krystofiak, E., Jerome, W. G., & Song, B. (2020) · Scientific Reports · doi:10.1038/s41598-020-65627-4 · Cited by 32

S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders

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An autophagy inhibitor enhances the inhibition of cell proliferation induced by a proteasome inhibitor in MCF-7 cells

Sun, S. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.590 · Cited by 30

Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells

Tzeng, Y.-C., Lee, L. Y., Chao, P., Lee, H., Wu, R. T., & Lin, A. M. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.004 · Cited by 31

Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway

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Transglutaminase type 2 in the regulation of proteostasis

D’Eletto, M., Rossin, F., Fedorova, O., Farrace, M. G., & Piacentini, M. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0217 · Cited by 32

Sodium dodecyl sulfate‐insoluble oligomers are involved in polyglutamine degeneration

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The Vacuole Import and Degradation Pathway Utilizes Early Steps of Endocytosis and Actin Polymerization to Deliver Cargo Proteins to the Vacuole for Degradation

Brown, C. R., Dunton, D., & Chiang, H.-L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028241 · Cited by 29

A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway

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Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system

Yin, P., Bai, D., Zhu, L., Deng, F., Guo, X., Li, B., Chen, L., Li, S., & Li, X. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113833 · Cited by 29

Autophagy and Apoptosis Induced in U87 MG Glioblastoma Cells by Hypericin-Mediated Photodynamic Therapy Can Be Photobiomodulated with 808 nm Light

Pevná, V., Wagnières, G., & Huntošová, V. (2021) · Biomedicines · doi:10.3390/biomedicines9111703 · Cited by 30

The amyloid state of proteins: A boon or bane?

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HIF‐1α Ameliorates Diabetic Neuropathic Pain via Parkin‐Mediated Mitophagy in a Mouse Model

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Intracellular accumulation of a mild‐denatured monomer of the human PrP fragment 90–231, as possible mechanism of its neurotoxic effects

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