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Role of the endolysosomal pathway and exosome release in tau propagation

Yan, Minli, Zheng, Tingting·2021·Neurochemistry International
DOI 10.1016/j.neuint.2021.104988
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Abstract

The progressive deposition of misfolded and aggregated forms of Tau protein in the brain is a pathological hallmark of tauopathies, such as Alzheimer's disease (AD) and frontotemporal degeneration (FTD). The misfolded Tau can be released into the extracellular space and internalized by neighboring cells, acting as seeds to trigger the robust conversion of soluble Tau into insoluble filamentous aggregates in a prion-like manner, ultimately contributing to the progression of the disease. However, molecular mechanisms accountable for the propagation of Tau pathology are poorly defined. We reviewed the Tau processing imbalance in endosomal, lysosomal, and exosomal pathways in AD. Increased exosome release counteracts the endosomal-lysosomal dysfunction of Tau processing but increases the number of aggregates and the propagation of Tau. This review summarizes our current understanding of the underlying tauopathy mechanisms with an emphasis on the emerging role of the endosomal-lysosomal-exosome pathways in this process. The components CHMP6, TSG101, and other components of the ESCRT complex, as well as Rab GTPase such as Rab35 and Rab7A, regulate vesicle cargoes routing from endosome to lysosome and affect Tau traffic, degradation, or secretion. Thus, the significant molecular pathways that should be potential therapeutic targets for treating tauopathies are determined.

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  • Extracellular tau can be internalized and trafficked to endosomes and lysosomes.

    “Given that extracellular tau can be internalized and trafficked to endosomes and lysosomes (Yan and Zheng 2021), we determined whether SORLA modulation can alter tau trafficking and uptake in cultured neurons.”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Yan and Zheng 2021

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Metadata

Authors
Yan, M., & Zheng, T.
ORCID
Zheng, Tingting
Venue
Neurochemistry International
Publisher
Elsevier BV
Published
2021-05
Volume
145
Pages
104988
ISSN
0197-0186
DOI
10.1016/j.neuint.2021.104988
Cited by
36
References
26
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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