Cited by 778Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

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Gut hormones and the regulation of energy homeostasis

Murphy, Kevin G., Bloom, Stephen R.·2006·Nature

DOI 10.1038/nature05484

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Abstract

Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy balance to key brain regions, including the hypothalamus and brainstem. Hunger and satiety represent coordinated responses to these signals, which include neural and hormonal messages from the gut. In recent years our understanding of how neural and hormonal brain-gut signalling regulates energy homeostasis has advanced considerably. Gut hormones have various physiological functions that include specifically targeting the brain to regulate appetite. New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs.

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See all 778

Authors: Murphy, K. G., & Bloom, S. R.
Affiliations: Imperial College London (GB)
ORCID: Murphy, Kevin G.
Bloom, Stephen R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-12
Volume: 444
Issue: 7121
Pages: 854-859
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05484
OpenAlex: W2078060668
Cited by: 778
References: 95
Citations by year: 2026: 24 · 2025: 21 · 2024: 25 · 2023: 31 · 2022: 32 · 2021: 47 · 2020: 39 · 2019: 38 · 2018: 47 · 2017: 52 · 2016: 33 · 2015: 42 · 2014: 51 · 2013: 60 · 2012: 45
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: gastrointestinal hormones, energy homeostasis, appetite regulation, hunger and satiety, hypothalamus, brainstem, dietary intake, energy expenditure, adiposity, anti-obesity drugs
MeSH terms: Animals, Appetite Regulation, Digestive System, Energy Metabolism, Homeostasis, Hormones, Humans

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Gut hormones and the regulation of energy homeostasis

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